Cheap flights from Des Moines to Bay Area from CA $213

View CA $213 flight on Thu, Aug. 28, 2025Opens in a new window

Popular airlines from Des Moines to Bay Area

  • American Airlines

    American Airlines

  • Alaska Airlines

    Alaska Airlines

  • Delta

    Delta

  • United

    United

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • payments icon

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap flights from Des Moines (DSM) to Bay Area (SJC)

Prices were available within the past 7 days and start at CA $213 for one-way flights and CA $1,048 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,048 Roundtrip, found 14 hours ago
CA $1,048
Roundtrip
found 14 hours ago
Select United flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,048 found 14 hours ago
United
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,094 Roundtrip, found 14 hours ago
CA $1,094
Roundtrip
found 14 hours ago
Select United flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,094 found 14 hours ago
United
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,108 Roundtrip, found 14 hours ago
CA $1,108
Roundtrip
found 14 hours ago
Select United flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,108 found 14 hours ago
Delta
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,139 Roundtrip, found 14 hours ago
CA $1,139
Roundtrip
found 14 hours ago
Select Delta flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,139 found 14 hours ago
American Airlines
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,200 Roundtrip, found 14 hours ago
CA $1,200
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,200 found 14 hours ago
Alaska Airlines
Fri, Aug. 1 - Sat, Aug. 2
DSM
Des Moines
SFO
San Francisco
CA $1,215 Roundtrip, found 14 hours ago
CA $1,215
Roundtrip
found 14 hours ago
Select Alaska Airlines flight, departing Fri, Aug. 1 from Des Moines to San Francisco, returning Sat, Aug. 2, priced at CA $1,215 found 14 hours ago

Find the cheapest month to fly from Des Moines (DSM) to San Francisco (SFO)

September is typically the cheapest month to fly

From CA $162 - CA $594 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.