Book The Best Hotels in Six Mile, SC for 2026 from CA $92 - Fully Refundable Options

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Our top choices for Six Mile hotels

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

1. Lakeside Lodge Clemson

Seneca

Lori

CA $154

CA $191 total

includes taxes & fees

Sep 28 - Sep 29

A hotel reception area with two reception desks, a digital screen, and a tiled floor.

A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.

A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.

2. Comfort Inn & Suites Clemson - University Area

Clemson

Jinna M

CA $149

CA $165 total

includes taxes & fees

Oct 18 - Oct 19

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

3. Tru by Hilton Seneca Clemson

Seneca

Curtis

CA $150

CA $165 total

includes taxes & fees

Oct 11 - Oct 12

A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.

A hotel room with two beds, a desk, a television, and a clock on the wall.

A wall with a decorative design featuring a building, trees, and a sky with clouds.

4. Inn @ Clemson

Clemson

Terry

CA $101

CA $112 total

includes taxes & fees

Sep 29 - Sep 30

A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

A lobby with seating areas, a reception desk, and a patterned wall.

A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.

A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

5. Best Western Plus Clemson Hotel & Conference Center

Clemson

David

CA $149

CA $165 total

includes taxes & fees

Oct 4 - Oct 5

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

A hotel lobby with a long corridor, seating areas, and a reception desk.

A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.

A brick building with a sign reading "The Inn at Patrick Square".

6. The Inn at Patrick Square

Clemson

Christy

CA $211

CA $234 total

includes taxes & fees

Sep 28 - Sep 29

A modern kitchen area with a bar counter and seating.

A vending area with snacks and beverages, including chips and soda.

A modern bar area with high stools and a poolside view.

A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.

7. Hampton Inn Clemson-University Area

Clemson

Blaise

CA $150

CA $166 total

includes taxes & fees

Oct 5 - Oct 6

A golf course with a water body, trees, and a distant view of a bridge.

A modern building with a central entrance, surrounded by a well-maintained lawn and trees.

An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

8. Clemson University's James F. Martin Inn

Clemson

Jennifer

CA $211

CA $234 total

includes taxes & fees

Oct 1 - Oct 2

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

A spacious lobby with a high ceiling, a chandelier, framed artwork, a lamp, a sofa, and a view through large glass doors to an outdoor area.

9. Quality Inn Seneca US-123

Seneca

Julie

CA $107

CA $126 total

includes taxes & fees

Oct 4 - Oct 5

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

10. Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Angela

CA $183

CA $201 total

includes taxes & fees

Oct 4 - Oct 5

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A bar area with a counter, multiple chairs, and a display of bottles and glasses.

A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

11. The Abernathy of Clemson

Clemson

Robert

CA $210

CA $233 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

12. Best Western Seneca-Clemson

Seneca

Michelle

CA $132

CA $145 total

includes taxes & fees

Oct 28 - Oct 29

A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.

A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.

An outdoor patio with tables and chairs, a pool, and a view of trees.

A modern hotel room with a flat-screen TV, a desk with a chair, a kitchenette with a microwave, and a sofa.

13. Holiday Inn Express & Suites Clemson by IHG

Clemson

John

CA $182

CA $203 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living room with a sofa, armchairs, and a coffee table. There are two framed paintings on the wall and a large window providing natural light.

A swimming pool with lounge chairs and a lifeguard chair, surrounded by a fence and a building.

A gym with exercise equipment, a treadmill, and a mirror.

A breakfast area with a counter, coffee machines, and a sign for 'Breakfast Corner'.

14. Baymont by Wyndham Easley/Greenville

Easley

Douglas

CA $107

CA $119 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a large bed, a desk, a chair, a bathtub, and a large window.

A modern kitchen with a long counter, built-in appliances, and a dining area with a table and chairs.

A living room with a stone fireplace, a flat-screen TV, and two yellow armchairs.

A modern hotel lobby with a reception desk, seating area, and a dining space.

15. Days Inn by Wyndham Anderson

Anderson

Louis

CA $83

CA $92 total

includes taxes & fees

Sep 30 - Oct 1

A modern bar area with a menu board, bar stools, and a countertop with various items.

An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.

A modern dining area with a bar, bar stools, and a patterned rug.

A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.

16. Courtyard Marriott Clemson

Clemson

kim

CA $190

CA $211 total

includes taxes & fees

Oct 4 - Oct 5

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A reception area with a counter, chairs, and a patterned rug.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

17. Hampton Inn & Suites Seneca-Clemson Area

Seneca

kendra

CA $174

CA $191 total

includes taxes & fees

Oct 4 - Oct 5

A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.

A gazebo with a tiled roof and wooden pillars, surrounded by a fence and potted plants.

A gazebo with a tiled roof and a surrounding gravel area.

A reception desk with a vase of flowers, framed pictures, and a printer.

18. Days Inn by Wyndham Clemson

Clemson

"While my room was very clean, there was a large stain on the upholstered chair by the window. The picture was missing the bottom part of the frame. The bathroom was old, with a cigarette stain on the tub. Staff were friendly and helpful but it took longer than usual to check in. There was no pepper in the breakfast area and the juice machine was broken. All said and done, I had what I needed. It is a poor economy for all which may explain the shortcomings."

Cynthia

CA $120

CA $133 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with two beds, a desk with a lamp, a TV, and a bathroom with a mirror and sink.

A laundry room with a brick wall, a washing machine, a dryer, and a refrigerator.

A dining area with tables and chairs, framed artwork on the wall, and a view through large windows.

A Quality Inn by Choice Hotels with a clear sky and autumn foliage in the background.

19. Quality Inn & Suites Easley - Greenville

Easley

Mariah

CA $91

CA $101 total

includes taxes & fees

Oct 11 - Oct 12

A modern hotel lobby with a reception desk, seating area, and a large conference table.

A multi-story hotel with a parking lot in front.

A modern hotel room with a bed, bedside tables, a desk, a chair, and a large window with a geometric curtain.

A snack display with various packaged foods in a store.

20. Microtel Inn & Suites by Wyndham Anderson/Clemson

Anderson

Kathi

CA $119

CA $132 total

includes taxes & fees

Sep 30 - Oct 1

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Stay near popular Six Mile attractions

Keowee Springs Golf Course

Enjoy a round of golf in Six Mile at Keowee Springs Golf Course.

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Mile Creek Park

Explore the great outdoors at Mile Creek Park, a lovely green space in Six Mile.

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Learn more about Six Mile

Lake Keowee offers pristine waters for boating, fishing, and swimming with several public access points around Six Mile. Hikers can explore nearby Table Rock State Park's trails leading to spectacular mountain views and refreshing waterfalls.

See all hotels in Six Mile

Top Six Mile Hotel Reviews

The Inn at Patrick Square

10/10 Excellent

"close proximity to restaurants, bars and coffee cafes"

The Shepherd Hotel Downtown Clemson

10/10 Excellent

"Great place to stay in the heart of Clemson. Great staff and great accommodations."

The Abernathy of Clemson

8/10 Good

"It was a great place to stay, fantastic location, they could do with upgrading the cafe/bar area, it isn’t in keeping with g with the rest of the hotel from a look and food perspective"

Days Inn by Wyndham Anderson

10/10 Excellent

"None"

Quality Inn Seneca US-123

8/10 Good

"The only issue i had was when I cut the heat on the smoke alarm went off which is understandable but I couldn't use the heat at all"

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"We were in town for parents weekend. Only reasonably priced accommodation. At first I was surprised at how remote the cabins were. But I understand it’s on purpose for people that want to disconnect and enjoy nature. We had no problem finding the place. It was clean. It was cozy. It was an adventure!"

Inn @ Clemson

10/10 Excellent

"Clean..friendly staff.. conveniently located"

WATERFRONT! 15 feet to Shoreline. Includes BOAT SLIP. FSBO on Zillow.

10/10 Excellent

"Great location and very helpful host."

Lake Keowee Lakefront Cove, Private Dock, Boat Parking, Kayaks & more

10/10 Excellent

"The house was perfect ,it had everything we needed. No need to bring anything from home just your clothes and food. It was so easy to clean and the beds were so comfortable.the walk to the dock was a bit steep for us but we are older. The water was low as is in a lot of other lakes. We did enjoy the fire pit area for relaxing."