Title: Book The Best Hotels in Mayo River, VA for 2025 from CA $74 - Fully Refundable Options - Expedia.ca [Mayo River Travel Guide](https://expedia.ca/Mayo-River.dx553248635976006279)[Vacation Rentals in Mayo River](https://expedia.ca/Mayo-River-Vacation-Rentals.d553248635976006279.Travel-Guide-VacationRentals)[Flights to Mayo River](https://expedia.ca/Cheap-Flights-To-Mayo-River.d553248635976006279.Travel-Guide-Flights)[Mayo River Car Rentals](https://expedia.ca/Car-Rentals-In-Mayo-River.d553248635976006279.Car-Rental-Guide)[Mayo River Vacation Packages](https://expedia.ca/Mayo-River.d553248635976006279.Destination-Travel-Guides) ![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ed Mayfield # Find hotels in Mayo River, VA from CA $74 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Mayo River Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&travelerType=family_friendly) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&lodging=CABIN) Farm [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&lodging=AGRITOURISM) Pool [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&amenities=POOL) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&lodging=APARTMENT) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&amenities=PETS) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Mayo+River%2C+Virginia%2C+United+States+of+America®ionId=553248635976006279&latLong=36.63869%2C-80.126018&adults=2&startDate=2025-12-02&d1=2025-12-02&endDate=2025-12-04&d2=2025-12-04&lodging=COTTAGE) ## Check prices for these dates Tonight [Nov 18 - Nov 19](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-11-18&endDate=2025-11-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 19 - Nov 20](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-11-19&endDate=2025-11-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=553248635976006279&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 275 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Exterior](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/d7ce6da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Tree House, 1 King Bed (Cooper's Hawk, Adults Only)](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/0892b487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/84ebd106.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds (Fairway)](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/347c008f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lodge at Primland, Auberge Collection Meadows Of Dan 9.0/10 Wonderful (25) "The resort is an experience. The staff were helpful and genuine. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melinda CA $573 CA $709 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information) ![Double Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/580000/571000/570926/34cebbf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/580000/571000/570926/30ed950c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/580000/571000/570926/9c1ae94c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/580000/571000/570926/c7511140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Eden Eden 8.6/10 Excellent (549) "Room is very nice and clean and the staff is very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian CA $115 CA $128 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Reidsville-Hotels-Baymont-By-Wyndham-Eden.h570926.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/20000/10900/10801/35d81c0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, soundproofing, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/1000000/20000/10900/10801/4dc21da4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/20000/10900/10801/ef81763d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/10900/10801/0f261a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Ridgeway Martinsville Area Ridgeway 6.6/10 (189) "Great room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Faye CA $96 CA $106 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Martinsville-Hotels-Travelodge-By-Wyndham-Ridgeway-Martinsville-Area.h10801.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/20000/12800/12704/9373a79c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12800/12704/e1172395.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12800/12704/0c10463b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/12800/12704/23224694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Martinsville Martinsville 6.4/10 (477) "It's been my husband and my spot to get away from home for a little time to ourselves." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ericka CA $85 CA $95 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Martinsville-Hotels-Econo-Lodge.h12704.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/96000000/95840000/95832200/95832103/d7bc649f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room](https://images.trvl-media.com/lodging/96000000/95840000/95832200/95832103/a6854b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/96000000/95840000/95832200/95832103/e47dfbbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room | In-room dining](https://images.trvl-media.com/lodging/96000000/95840000/95832200/95832103/8456d7a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn Ridgeway 6.0/10 (56) "Close to race track" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wanda [](https://www.expedia.ca/Ridgeway-Hotels-4520-Greensboro-Rd.h95832103.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/ee448a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/25a4e0d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/de713ac1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/9f72338d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Scottish Inns Collinsville-Martinville Collinsville 6.8/10 (274) "I liked everything about the place I really enjoyed my stay hoping to revisit " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ruhia CA $66 CA $74 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/Martinsville-Hotels-Scottish-Inns-Collinsville-Martinville.h154773.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42800/42735/f228f500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42800/42735/83b78e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/42800/42735/bcacb4e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/1000000/50000/42800/42735/27086093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Eden Eden 8.6/10 Excellent (431) "Hotel was clean and comfortable. Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rodney CA $151 CA $169 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Reidsville-Hotels-Hampton-Inn-Eden.h42735.Hotel-Information) ![Deluxe Room](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/e5c62df7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/37620728.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/1a577c12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/e6cbb0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Floyd Floyd 9.6/10 Exceptional (488) "Clean room, friendly staff, lovely artwork, short walk to restaurants. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathryn CA $169 CA $186 total includes taxes & fees Nov 19 - Nov 20 [](https://www.expedia.ca/Floyd-Hotels-Hotel-Floyd.h8986854.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/43100/43095/c2d0654a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/43100/43095/df0b8433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/43100/43095/a70ec908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/43100/43095/w3840h2360x0y0-8fdb7914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Martinsville Martinsville 8.8/10 Excellent (485) "Very nice stay even for short stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack CA $207 CA $230 total includes taxes & fees Nov 30 - Dec 1 [](https://www.expedia.ca/Martinsville-Hotels-Hampton-Inn-Martinsville.h43095.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/13000000/12770000/12764600/12764520/796ec9c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Refrigerator & Microwave (Smoking)](https://images.trvl-media.com/lodging/13000000/12770000/12764600/12764520/1c477489.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12770000/12764600/12764520/4aeb503b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/13000000/12770000/12764600/12764520/0412020c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eden Inn Motel Eden 6.6/10 (186) "I felt safe,rooms clean and it was walking distance to get something to eat. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bobby CA $88 CA $98 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Reidsville-Hotels-Eden-Inn-Motel.h12764520.Hotel-Information) ![Fireplace](https://images.trvl-media.com/lodging/101000000/100150000/100143400/100143353/5f79a23d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining room](https://images.trvl-media.com/lodging/101000000/100150000/100143400/100143353/6cec13e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Crescent Moon Room](https://images.trvl-media.com/lodging/101000000/100150000/100143400/100143353/c4a1338d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Crescent Moon Room | Living area](https://images.trvl-media.com/lodging/101000000/100150000/100143400/100143353/a74928f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Moonlight Manor Bed and Breakfast Floyd 9.8/10 Exceptional (41) "It was a beautiful setting with deer in the front year to the clean and welcome B&B. The hosts were friendly and the breakfast was delicious. We are planning on going back in the spring." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $253 CA $279 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Floyd-Hotels-Moonlight-Manor-Bed-And-Breakfast.h100143353.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/17000000/16110000/16104100/16104080/12c53bc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shared kitchen](https://images.trvl-media.com/lodging/17000000/16110000/16104100/16104080/aee5ccde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16110000/16104100/16104080/17fb78d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Romance Suite](https://images.trvl-media.com/lodging/17000000/16110000/16104100/16104080/70ccfa2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hunter House Bed and Breakfast Madison 9.4/10 Exceptional (36) "Wonderful hosts!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MILO CA $242 CA $266 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Reidsville-Hotels-Hunter-House-Bed-And-Breakfast.h16104080.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/5a1d33a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/a762e12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/5614f725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![56-inch TV with cable channels, Netflix, Hulu](https://images.trvl-media.com/lodging/1000000/670000/665100/665072/f05e692b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Martinsville Martinsville 6.8/10 (613) "had a fun stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kaden CA $138 CA $155 total includes taxes & fees Nov 25 - Nov 26 [](https://www.expedia.ca/Martinsville-Hotels-Baymont-By-Wyndham-Martinsville.h665072.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/96000000/95010000/95002100/95002016/ca5d4730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Double Room](https://images.trvl-media.com/lodging/96000000/95010000/95002100/95002016/83cc02c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95010000/95002100/95002016/613f6b69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/96000000/95010000/95002100/95002016/6adc13a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Virginian Motel Stuart 6.2/10 (55) "Very nice rooms, and staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heidi [](https://www.expedia.ca/Stuart-Hotels-Virginian-Motel.h95002016.Hotel-Information) ![Lounge](https://images.trvl-media.com/lodging/92000000/91330000/91324500/91324436/63dda0e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91330000/91324500/91324436/w1199h799x1y1-df9c8350.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/92000000/91330000/91324500/91324436/w1199h799x1y1-cc2949d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/92000000/91330000/91324500/91324436/w1175h799x1y1-03963b8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Oakdale Inn Martinsville 9.8/10 Exceptional (20) "Beautiful house, great hostess and excellent breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $202 CA $227 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Martinsville-Hotels-The-Oakdale-Inn.h91324436.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/102000000/101230000/101227000/101226990/0877213b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/102000000/101230000/101227000/101226990/12ae2ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101230000/101227000/101226990/05f9fe93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/102000000/101230000/101227000/101226990/bf6b92bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Relax Inn Collinsville 5.8/10 (26) "Good motel. Nice service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arian CA $76 CA $84 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Collinsville-Hotels-Relax-Inn.h101226990.Hotel-Information) ![House | Private kitchen](https://images.trvl-media.com/lodging/113000000/112770000/112765400/112765345/00f6ddd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112770000/112765400/112765345/5bca12d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Private spa tub](https://images.trvl-media.com/lodging/113000000/112770000/112765400/112765345/c2dd2c5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 bedrooms, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/113000000/112770000/112765400/112765345/6f7f10dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### King Bed Pet Friendly BBQ Grill Peaceful Madison 8.0/10 Very good (1) CA $65 CA $423 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Madison-Hotels-King-Bed-Pet-Friendly-BBQ-Grill-Peaceful.h112765345.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-02&endDate=2025-12-03®ionId=553248635976006279&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels) ## Learn more about Mayo River Head to sights like Reynolds Homestead as you discover the local area in Mayo River. [See all hotels in Mayo River](https://www.expedia.ca/Hotel-Search?startDate=2025-12-02&endDate=2025-12-03&adults=2®ionId=553248635976006279) ![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high) Photo by Ed Mayfield ### Stay near popular Mayo River attractions [](https://expedia.ca/Reynolds-Homestead-Hotels.0-l553248621561864249-0.Travel-Guide-Filter-Hotels) ![Reynolds Homestead](https://mediaim.expedia.com/destination/2/ac85320632397c4aea5435f87c30ad05.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Reynolds Homestead You can study the exhibits at Reynolds Homestead, a museum with a story of its own, during your travels to Patrick Springs. Amble around the area's forest or visit its spas. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561864249) ## More cheap stays in Mayo River ![Scottish Inns Collinsville-Martinville](https://images.trvl-media.com/lodging/1000000/160000/154800/154773/ee448a9a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Scottish Inns Collinsville-Martinville 2357 Virginia Ave Collinsville VA CA $66 CA $74 total Nov 19 - Nov 20 includes taxes & fees 6.8/10 (274 reviews) [](https://expedia.ca/Martinsville-Hotels-Scottish-Inns-Collinsville-Martinville.h154773.Hotel-Information) ![Hotel Floyd](https://images.trvl-media.com/lodging/9000000/8990000/8986900/8986854/e5c62df7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Floyd 300 Rick Lewis Way Floyd VA CA $169 CA $186 total Nov 19 - Nov 20 includes taxes & fees 9.6/10 Exceptional! (486 reviews) [](https://expedia.ca/Floyd-Hotels-Hotel-Floyd.h8986854.Hotel-Information) ![Baymont by Wyndham Eden](https://images.trvl-media.com/lodging/1000000/580000/571000/570926/34cebbf3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont by Wyndham Eden 716 Linden Dr Eden NC CA $115 CA $128 total Nov 30 - Dec 1 includes taxes & fees 8.4/10 Very Good! (548 reviews) [](https://expedia.ca/Reidsville-Hotels-Baymont-By-Wyndham-Eden.h570926.Hotel-Information) ![Hampton Inn Martinsville](https://images.trvl-media.com/lodging/1000000/50000/43100/43095/c2d0654a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Martinsville 50 Hampton Dr Martinsville VA CA $207 CA $230 total Nov 30 - Dec 1 includes taxes & fees 8.8/10 Excellent! (485 reviews) [](https://expedia.ca/Martinsville-Hotels-Hampton-Inn-Martinsville.h43095.Hotel-Information) ![Hampton Inn Eden](https://images.trvl-media.com/lodging/1000000/50000/42800/42735/f228f500_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Eden 724 S Van Buren Rd Eden NC CA $151 CA $169 total Dec 7 - Dec 8 includes taxes & fees 8.6/10 Excellent! (431 reviews) [](https://expedia.ca/Reidsville-Hotels-Hampton-Inn-Eden.h42735.Hotel-Information) ![Travelodge by Wyndham Ridgeway Martinsville Area](https://images.trvl-media.com/lodging/1000000/20000/10900/10801/35d81c0c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travelodge by Wyndham Ridgeway Martinsville Area 3841 Greensboro Rd Ridgeway VA CA $96 CA $106 total Nov 24 - Nov 25 includes taxes & fees 6.6/10 (189 reviews) [](https://expedia.ca/Martinsville-Hotels-Travelodge-By-Wyndham-Ridgeway-Martinsville-Area.h10801.Hotel-Information) ## Hotels in Mayo River with star-rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 1 properties [](https://expedia.ca/5Star-Mayo-River-Hotels.s50-0-d553248635976006279.Travel-Guide-Filter-Hotels) ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 1 properties [](https://expedia.ca/4Star-Mayo-River-Hotels.s40-0-d553248635976006279.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 23 properties [](https://expedia.ca/3Star-Mayo-River-Hotels.s30-0-d553248635976006279.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 26 properties [](https://expedia.ca/2Star-Mayo-River-Hotels.s20-0-d553248635976006279.Travel-Guide-Filter-Hotels) ## Recent reviews of Mayo River hotels ### Baymont by Wyndham Eden 5/5 Excellent "Very nice stay. Very clean, remodeled, you can tell there has been upgrades. Very quiet, no traffic noise or door slamming. Breakfast was good, especially the biscuit & gravy. A+" A verified traveller stayed at Baymont by Wyndham Eden Posted 3 days ago [](https://expedia.ca/Reidsville-Hotels-Baymont-By-Wyndham-Eden.h570926.Hotel-Information) ![Relax Inn](//images.trvl-media.com/lodging/102000000/101230000/101227000/101226990/0877213b_y.jpg) ### Relax Inn 5/5 Excellent "Courteous staff comfy bed" A verified traveller stayed at Relax Inn Posted 6 days ago [](https://expedia.ca/Collinsville-Hotels-Relax-Inn.h101226990.Hotel-Information) ### The Lodge at Primland, Auberge Collection 5/5 Excellent "The resort is an experience. The staff were helpful and genuine. " A verified traveller stayed at The Lodge at Primland, Auberge Collection Posted 9 days ago [](https://expedia.ca/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information) ### Travel Inn 5/5 Excellent "Clean room, friendly and helpful staff" A verified traveller stayed at Travel Inn Posted 10 days ago [](https://expedia.ca/Ridgeway-Hotels-4520-Greensboro-Rd.h95832103.Hotel-Information) ### Creekside Cottage Near Floyd, VA, and Blue Ridge Parkway with deck and gas grill 5/5 Excellent "Beautiful location!!!!" A verified traveller stayed at Creekside Cottage Near Floyd, VA, and Blue Ridge Parkway with deck and gas grill Posted 12 days ago [](https://expedia.ca/Hillsville-Hotels-Creekside-Cottage-Near-Blue-Ridge-Parkway.h25115051.Hotel-Information) ### Hotel Floyd 5/5 Excellent "Clean room, friendly staff, lovely artwork, short walk to restaurants. " A verified traveller stayed at Hotel Floyd Posted 13 days ago [](https://expedia.ca/Floyd-Hotels-Hotel-Floyd.h8986854.Hotel-Information) ### Hampton Inn Martinsville 5/5 Excellent "Such a pleasant staff! They had a nice breakfast too. The room was very comfy. I would recommend staying at this hotel" A verified traveller stayed at Hampton Inn Martinsville Posted 13 days ago [](https://expedia.ca/Martinsville-Hotels-Hampton-Inn-Martinsville.h43095.Hotel-Information) ### Comfort Inn Martinsville 5/5 Excellent "had a fun stay " A verified traveller stayed at Comfort Inn Martinsville Posted 2 weeks ago [](https://expedia.ca/Martinsville-Hotels-Baymont-By-Wyndham-Martinsville.h665072.Hotel-Information) ### Travelodge by Wyndham Ridgeway Martinsville Area 5/5 Excellent "Great room" A verified traveller stayed at Travelodge by Wyndham Ridgeway Martinsville Area Posted 2 weeks ago [](https://expedia.ca/Martinsville-Hotels-Travelodge-By-Wyndham-Ridgeway-Martinsville-Area.h10801.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [4 Star Hotels in Martinsville](https://www.expedia.ca/4Star-Martinsville-Hotels.s40-0-d6056947.Travel-Guide-Filter-Hotels) - [Ararat Hotels](https://www.expedia.ca/Ararat-Hotels.d6132850.Travel-Guide-Hotels) - 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