Title: Mayo Clinic Florida in Jacksonville - Tours and Activities | Expedia.ca [Mayo Clinic Florida Hotels](https://expedia.ca/Mayo-Clinic-Florida-Hotels.0-l6127706-0.Travel-Guide-Filter-Hotels)[Flights to Jacksonville](https://expedia.ca/Cheap-Flights-To-Jacksonville.d602997.Travel-Guide-Flights)[Things to do in Jacksonville](https://expedia.ca/Things-To-Do-In-Jacksonville.d602997.Travel-Guide-Activities)[Mayo Clinic Florida Car Rentals](https://expedia.ca/Car-Rentals-In-Mayo-Clinic-Florida.d6127706.Car-Rental-Guide)[Jacksonville Vacation Packages](https://expedia.ca/Jacksonville.d602997.Destination-Travel-Guides) # Mayo Clinic Florida Tours and Activities ![Jacksonville_MayoClinicFlorida_6127706_04](https://images.trvl-media.com/place/6127706/6901ae4a-327b-40c7-92f0-e912ea036578.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Jacksonville_MayoClinicFlorida_6127706_04](https://images.trvl-media.com/place/6127706/6901ae4a-327b-40c7-92f0-e912ea036578.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Pretty ](https://images.trvl-media.com/place/1674/ff36dd76-37b9-42ae-b52f-1d2de567c1a6.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Beautiful campus and today is the day!](https://images.trvl-media.com/place/1674/24525ca6-f687-4913-a18c-ec870cf42632.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mayo clinic](https://images.trvl-media.com/place/1674/34ed20de-d7f2-4282-a622-a16f9bef1701.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mayo Clinic Florida Activities [Jacksonville travel guide](https://expedia.ca/Jacksonville.dx602997) --- --- ## Plan a trip to see Mayo Clinic Florida Price found within the past 48 hours. Click for updated prices. ![Beachside Motel](https://images.trvl-media.com/lodging/3000000/2680000/2675400/2675315/857fa80c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Beachside Motel CA $1,109 per person May 4 - May 9 found 2 hours ago Roundtrip non-stop flight included Toronto (YYZ) to Jacksonville (JAX) 9.2/10 Wonderful! (1,000 reviews) Although the property is older, it is well-maintained and we had an ocean view room that was amazing because you had a full view of the ocean! The value was good! And location awesome! If you’re on a budget and like good value in a comfy place to stay, this is your place Reviewed on Jan 27, 2026 ![Hammock Beach Golf Resort & Spa](https://images.trvl-media.com/lodging/1000000/1000000/994200/994170/efacd58c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hammock Beach Golf Resort & Spa CA $3,302 per person Apr 22 - Apr 28 found 1 day ago Roundtrip flight included Halifax (YHZ) to Daytona Beach (DAB) 8.4/10 Very Good! (1,000 reviews) Room was beautiful and kids loved the pool and beach. Staff was very friendly and accommodating. Would definitely stay again. Reviewed on Feb 18, 2026 ### Popular places to visit ![Adventure Landing featuring landscape views and a waterpark](https://images.trvl-media.com/place/6128080/d5ece32b-2982-4da4-b8a3-571cbc40c377.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Adventure Landing This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark. [](https://expedia.ca/Adventure-Landing-Jacksonville.d6128080.Vacation-Attraction) ![Beach access, Huguenot Memorial Park in Duval County, Atlantic Ocean, Florida](https://images.trvl-media.com/place/553248621558033368/c8f597db-a1d5-4eee-bca9-4c53a802b60e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Huguenot Park Huguenot Park is just one of the places to see in Jacksonville Beach, so why not enjoy the other things to explore during your travels? Experience the entertainment choices and acclaimed theater scene in this family-friendly area. [](https://expedia.ca/Huguenot-Park-Jacksonville.d553248621558033368.Vacation-Attraction) ![Miami beach, Florida lifeguard building hut by Atlantic ocean coast at sunrise with nobody on sand and still water reflection](https://images.trvl-media.com/place/553248635056397210/29db297c-3780-446c-b2df-31e281f679e5.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Oceanfront Park Explore the great outdoors at Oceanfront Park, a lovely green space in Jacksonville Beach. Experience the area's entertainment choices and acclaimed theater scene. [](https://expedia.ca/Oceanfront-Park-Jacksonville.d553248635056397210.Vacation-Attraction) #### Windsor Parke Golf Club Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event. [](https://expedia.ca/Windsor-Parke-Golf-Club-Jacksonville.d6068663.Vacation-Attraction) #### Windsor Commons Shopping Center You can enjoy retail therapy at Windsor Commons Shopping Center during your trip to Jacksonville. Experience the area's great live music and entertainment choices. [](https://expedia.ca/Windsor-Commons-Shopping-Center-Southside.d553248621558033805.Vacation-Attraction) #### Harbor City Municipal Golf Course Enjoy a round of golf in Jacksonville at Harbor City Municipal Golf Course. Amble around the area's beautiful beaches or attend a sporting event. [](https://expedia.ca/Harbor-City-Municipal-Golf-Course-Southside.d553248621563220206.Vacation-Attraction) --- ## Best Lodging Options Near Mayo Clinic Florida ## Check availability on hotels close to Mayo Clinic Florida [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=2026-02-18&endDate=2026-02-19)[Feb 18 - Feb 19](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=2026-02-18&endDate=2026-02-19) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=2026-02-19&endDate=2026-02-20)[Feb 19 - Feb 20](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=2026-02-19&endDate=2026-02-20) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026)[Feb 20 - Feb 22](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026)[Feb 27 - Mar 1](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=6127706&startDate=27%2F02%2F2026&endDate=01%2F03%2F2026) ![Hilton Jacksonville At Mayo Clinic](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/a30920c9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hilton Jacksonville At Mayo Clinic 4745 Transformation Way Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information) ![Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/7dde0660_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches 14390 Mayo Boulevard Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information) ![Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/5b1f404a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Residence Inn By Marriott Jacksonville - Mayo Clinic Area 4905 SAN PABLO ROAD SOUTH Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information) ![Margaritaville Jacksonville Beach](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/863d9eb6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Margaritaville Jacksonville Beach 715 1st St N Jacksonville Beach FL [](https://expedia.ca/Jacksonville-Hotels-Margaritaville-Jacksonville-Beach.h51266293.Hotel-Information) ![New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach](https://images.trvl-media.com/lodging/118000000/117050000/117041900/117041879/ad8ee1d1_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-New-2-Miles-2Mayo-Clinic-Intracoastal-Water-Views-Mins-To-JaxBeach.h117041879.Hotel-Information) ![Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard](https://images.trvl-media.com/lodging/89000000/88400000/88398100/88398052/db3a0da5_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-Big-Wheelchair-Accessible-Home-Close-To-BeachMayo-With-Zen-Den-And-Fenced-Yard.h88398052.Hotel-Information) ![SMV Palm Escape Retreat nr Mayo](https://images.trvl-media.com/lodging/116000000/115630000/115627900/115627883/ec3ea57d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### SMV Palm Escape Retreat nr Mayo Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-SMV-Palm-Escape-Retreat-Nr-Mayo.h115627883.Hotel-Information) ![Comfy Mayo Retreat; Heated Pool, Close to Beach](https://images.trvl-media.com/lodging/68000000/67200000/67195700/67195679/5cb6747d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Comfy Mayo Retreat; Heated Pool, Close to Beach Jacksonville Beach FL [](https://expedia.ca/Jacksonville-Hotels-Intracoastal-Paradise-With-Private-Pool.h67195679.Hotel-Information) ![Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG 4791 Windsor Commons Ct Jacksonville FL [](https://expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information) [See all 1,898 properties in Mayo Clinic Florida](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6127706) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=DX_POI_Spring_PROMO_6127706)