Title: The 10 Best Hotels Near Mayo Clinic Florida, Jacksonville from CA $177 | Expedia.ca

  

[Jacksonville Travel Guide](https://expedia.ca/Jacksonville.dx602997)[Vacation Rentals in Jacksonville](https://expedia.ca/Jacksonville-Vacation-Rentals.d602997.Travel-Guide-VacationRentals)[Flights to Jacksonville](https://expedia.ca/Cheap-Flights-To-Jacksonville.d602997.Travel-Guide-Flights)[Things to do in Jacksonville](https://expedia.ca/Things-To-Do-In-Jacksonville.d602997.Travel-Guide-Activities)[Mayo Clinic Florida Car Rentals](https://expedia.ca/Car-Rentals-In-Mayo-Clinic-Florida.d6127706.Car-Rental-Guide)[Mayo Clinic Florida Vacations](https://expedia.ca/Mayo-Clinic-Florida-Jacksonville.d6127706.Vacation-Attraction)

![Jacksonville_MayoClinicFlorida_6127706_04](https://images.trvl-media.com/place/6127706/6901ae4a-327b-40c7-92f0-e912ea036578.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find hotels near Mayo Clinic Florida, Jacksonville from CA $177

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)

### 

Change your mind

Book hotels with free cancellation

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)

### 

Treat yourself

Sign in to save 10% or more on thousands of hotels

[Sign in](https://www.expedia.ca/login)

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)

### 

Be picky

Search almost a million properties worldwide

## Check prices for these dates

Tonight

[Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=6127706&startDate=2025-10-19&endDate=2025-10-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 20 - Oct 21](https://www.expedia.ca/Hotel-Search?regionId=6127706&startDate=2025-10-20&endDate=2025-10-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6127706&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6127706&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Top Hotels Close to Mayo Clinic Florida

![Reception](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/5b1f404a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/3b4310c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/c8f0b79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/8626ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

9.4/10

Exceptional

(431)

"Great facility to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gary

CA $222

CA $251 total

includes taxes & fees

Oct 24 - Oct 25

[](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/ce542e1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/9aa350fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/880c5015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/bb7e3270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

9.2/10

Wonderful

(528)

"Parking is easy and secure. The staff is friendly and professional. It’s close to shopping and dining and The Mayo Clinic. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Donna

CA $160

CA $181 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/Jacksonville-Hotels-TownePlace-Suites-By-Marriott-Jacksonville-East.h50557569.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/7227c750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/c1f6fa41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/1bf84034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/3000000/2890000/2880200/2880174/3168e049.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

9.0/10

Wonderful

(1007)

"It was a great stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maribel

CA $160

CA $181 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/Jacksonville-Hotels-Hampton-Inn-Suites-Jacksonville-Beach-BlvdMayo-Clinic.h2880174.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/7dde0660.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/5118a94e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/76ebbc62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/19700/19631/3cb87b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.3 km from Mayo Clinic Florida

8.4/10

Very good

(746)

"Nice hotel, close to shops and mayo clinic."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Judy

CA $226

CA $256 total

includes taxes & fees

Oct 25 - Oct 26

[](https://www.expedia.ca/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed (Additional Living Area) | Golf view](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/c476e2a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/1373ce48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/900000/898100/898066/0c1431da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.7 km from Mayo Clinic Florida

8.4/10

Very good

(1016)

"Pleasant check in with staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra

CA $160

CA $181 total

includes taxes & fees

Nov 8 - Nov 9

[](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information)

![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/a30920c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/693efe9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/0883e721.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/w3840h2481x0y3-86af0191.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Jacksonville At Mayo Clinic

0.8 km from Mayo Clinic Florida

10/10

Exceptional

(3)

"Great staff and rooms "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Albert

CA $229

CA $260 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/5d3207b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/b9c83c0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/3cc0c712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/68000000/67400000/67391300/67391288/w5565h3712x0y0-2f0fd935.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Element Jacksonville Beach

5.4 km from Mayo Clinic Florida

9.6/10

Exceptional

(503)

"Excellent breakfast"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

CA $178

CA $202 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Jacksonville-Hotels-Element-Jacksonville-Beach.h67391288.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/ac80791a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/d2b949ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/2040edc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/10ecbce2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

9.2/10

Wonderful

(1014)

"Will stay again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Camilla

CA $156

CA $177 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)

![BBQ/picnic area](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/ace2c9f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/03ea9367.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/311013a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch TV with cable channels](https://images.trvl-media.com/lodging/75000000/74610000/74603400/74603302/a57fa822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Salt Air Inn & Suites

7.8 km from Mayo Clinic Florida

9.8/10

Exceptional

(387)

"It was great, spacious, and well stocked."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Juan

CA $197

CA $224 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/Jacksonville-Hotels-Salt-Air-Inn-Suites.h74603302.Hotel-Information)

![On the beach, white sand, surfing, kayaking](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/863d9eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/25a6bffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/d7d8d02c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/d30ef697.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

9.0/10

Wonderful

(3293)

"Great stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris

CA $220

CA $249 total

includes taxes & fees

Oct 21 - Oct 22

[](https://www.expedia.ca/Jacksonville-Hotels-Margaritaville-Jacksonville-Beach.h51266293.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/w3837h2560x3y3-801b9f38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/9b491ef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 9 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/78bc0b87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/580000/570500/570425/41c5efd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

4.2 km from Mayo Clinic Florida

8.8/10

Excellent

(1017)

"Great stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gary

CA $171

CA $194 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/Jacksonville-Hotels-Hampton-Inn-JacksonvillePonte-Vedra-Beach-Mayo-Clinic-Area.h570425.Hotel-Information)

![On the beach](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/cd4b0791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/b0d3d74f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Balcony, Oceanfront (Balcony)](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/1fca4abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/120000/119100/119095/96744e03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Oceanfront

5.7 km from Mayo Clinic Florida

9.0/10

Wonderful

(1019)

"Had a great beachfront stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Grace

CA $173

CA $196 total

includes taxes & fees

Oct 27 - Oct 28

[](https://www.expedia.ca/Jacksonville-Hotels-Best-Western-Oceanfront.h119095.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892900/892823/5007c5d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892900/892823/272dd902.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![On the beach, white sand, sun loungers, beach umbrellas](https://images.trvl-media.com/lodging/1000000/900000/892900/892823/7f165ad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/900000/892900/892823/8d363a6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

9.0/10

Wonderful

(1004)

"Easy to walk to the beach and local restaurant"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Allen D

CA $237

CA $269 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Jacksonville-Hotels-Four-Points-By-Sheraton-Jacksonville-Beachfront.h892823.Hotel-Information)

![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/b159421b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/9142b85c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Room, Multiple Beds](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/69613519.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/16000000/15790000/15784700/15784631/c2598c1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Hotel Palms

7.8 km from Mayo Clinic Florida

9.6/10

Exceptional

(289)

"Our favorite spot "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lorraine

CA $237

CA $269 total

includes taxes & fees

Oct 20 - Oct 21

[](https://www.expedia.ca/Jacksonville-Hotels-The-Hotel-Palms.h15784631.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/910000/903900/903879/08b847ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/910000/903900/903879/9702a1f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/910000/903900/903879/46662c88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/910000/903900/903879/d3a5975c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ponte Vedra Inn & Club

6.3 km from Mayo Clinic Florida

9.4/10

Exceptional

(806)

"Fabulous staff, one friendly greeting, the restaurants are good, the beach is lovely, breakfast outstanding"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Simon

CA $398

CA $485 total

includes taxes & fees

Nov 13 - Nov 14

[](https://www.expedia.ca/Jacksonville-Hotels-Ponte-Vedra-Inn-Club.h903879.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/87906b5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/79469d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/78391f9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/112000000/111930000/111923700/111923614/3c303194.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

9.8/10

Exceptional

(33)

"Staff was friendly courteous, hotel was clean & well Kept"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Iker E.

CA $163

CA $185 total

includes taxes & fees

Nov 10 - Nov 11

[](https://www.expedia.ca/Jacksonville-Hotels-Towneplace-Suites-By-Marriott-Atlantic-Beach.h111923614.Hotel-Information)

![On the beach, windsurfing](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/4bcf2dc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 8:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/994db080.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/34788380.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/91000000/90180000/90176000/90175988/w3995h2667x0y0-516d4609.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

9.0/10

Wonderful

(607)

"Great beachfront property convenient to Jax Beach Pier."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Priscilla

CA $226

CA $256 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Jacksonville-Hotels-Springhill-Suites-By-Marriott-Jacksonville-Beach-Oceanfront.h90175988.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/a435d2ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/53a748b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/36e9c181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/35000000/34420000/34413500/34413457/dffb8ae9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.8 km from Mayo Clinic Florida

9.6/10

Exceptional

(1017)

"Always enjoy staying here when we come down from Va"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy

CA $196

CA $223 total

includes taxes & fees

Nov 2 - Nov 3

[](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-Town-Center.h34413457.Hotel-Information)

![Beach/ocean view](https://images.trvl-media.com/lodging/1000000/30000/25400/25311/3171b62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/1000000/30000/25400/25311/b5695ab7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Couples treatment rooms](https://images.trvl-media.com/lodging/1000000/30000/25400/25311/842c9ecf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Couples treatment rooms](https://images.trvl-media.com/lodging/1000000/30000/25400/25311/9849d1d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Lodge and Club at Ponte Vedra Beach

6.3 km from Mayo Clinic Florida

9.4/10

Exceptional

(683)

"Fitness center was World Class"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

CA $493

CA $591 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Jacksonville-Hotels-The-Lodge-And-Club-At-Ponte-Vedra-Beach.h25311.Hotel-Information)

![Sports facility](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/130353e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily buffet breakfast (USD 11 per person)](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/738eea9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/9810ef9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/30000000/29850000/29846500/29846486/0c9d3e26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

9.2/10

Wonderful

(1010)

"Always a great stay at this property!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Justin

CA $202

CA $229 total

includes taxes & fees

Nov 17 - Nov 18

[](https://www.expedia.ca/Jacksonville-Hotels-Hyatt-Place-Jacksonville-St-Johns-Town-Center.h29846486.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-02&endDate=2025-11-03&regionId=6127706&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMayo-Clinic-Florida-Hotels.0-l6127706-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMayo-Clinic-Florida-Hotels.0-l6127706-0.Travel-Guide-Filter-Hotels)

## Top Mayo Clinic Florida Hotel Reviews

![Margaritaville Jacksonville Beach](//images.trvl-media.com/lodging/52000000/51270000/51266300/51266293/863d9eb6_y.jpg)

### Margaritaville Jacksonville Beach

10/10 Excellent

"Beautiful resort "

[](https://expedia.ca/Jacksonville-Hotels-Margaritaville-Jacksonville-Beach.h51266293.Hotel-Information)

![Hampton Inn Jacksonville Beach/Oceanfront](//images.trvl-media.com/lodging/1000000/30000/26800/26716/c86000c3_y.jpg)

### Hampton Inn Jacksonville Beach/Oceanfront

10/10 Excellent

"Not a great view"

[](https://expedia.ca/Jacksonville-Hotels-Hampton-Inn-Jacksonville-BeachOceanfront.h26716.Hotel-Information)

![Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!](//images.trvl-media.com/lodging/110000000/109790000/109790000/109789908/w1167h759x3y0-df701213_y.jpg)

### Beautiful 3 bedroom, 2 bathroom Beach Bungalow in Jacksonville Beach!

10/10 Excellent

"Our stay was perfect from start to finish. Great location for what we were in town for. Owner was VERY prompt to answer any questions and extremely nice and helpful when I asked about where to eat and watch some football! We will definitely stay here again when we are in Jacksonville!"

[](https://expedia.ca/Jacksonville-Hotels-Beautiful-3-Bedroom.h109789908.Hotel-Information)

![Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](//images.trvl-media.com/lodging/1000000/900000/898100/898066/0fcbe763_y.jpg)

### Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Awesome staff. Very happy with the place. I look forward to many returns. "

[](https://expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information)

![Hilton Jacksonville At Mayo Clinic](//images.trvl-media.com/lodging/117000000/116230000/116226000/116225907/a30920c9_y.jpg)

### Hilton Jacksonville At Mayo Clinic

10/10 Excellent

"Great location "

[](https://expedia.ca/Jacksonville-Hotels-Hilton-Jacksonville-At-Mayo-Clinic.h116225907.Hotel-Information)

![Residence Inn By Marriott Jacksonville - Mayo Clinic Area](//images.trvl-media.com/lodging/60000000/59850000/59846400/59846313/5b1f404a_y.jpg)

### Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent

"The lights seem to be out in the parking lot. It was extremely dark in the morning and hard to see to get to car. Seems unsafe. Lights need to be turned on. Otherwise, excellent stay"

[](https://expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)

![Holiday Inn Express Jacksonville Beach by IHG](//images.trvl-media.com/lodging/2000000/1820000/1818400/1818369/ac80791a_y.jpg)

### Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent

"Large rooms, nice breakfast and coffee set - ups. Friendly Staffers. Good location. Convenient, easy parking "

[](https://expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)

![New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach](//images.trvl-media.com/lodging/118000000/117050000/117041900/117041879/ad8ee1d1_y.jpg)

### New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach

10/10 Excellent

"House is large and comfortable. Very clean, seems freshly decorated. Host was very accommodating. Quiet neighborhood. "

[](https://expedia.ca/Jacksonville-Hotels-New-2-Miles-2Mayo-Clinic-Intracoastal-Water-Views-Mins-To-JaxBeach.h117041879.Hotel-Information)

![TownePlace Suites by Marriott Jacksonville East](//images.trvl-media.com/lodging/51000000/50560000/50557600/50557569/ce542e1c_y.jpg)

### TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Parking is easy and secure. The staff is friendly and professional. It’s close to shopping and dining and The Mayo Clinic. "

[](https://expedia.ca/Jacksonville-Hotels-TownePlace-Suites-By-Marriott-Jacksonville-East.h50557569.Hotel-Information)

## Hotels near other Mayo Clinic Florida attractions

[](https://www.expedia.ca/Adventure-Landing-Hotels.0-l6128080-0.Travel-Guide-Filter-Hotels)

### Adventure Landing

4.1/5 (157 reviews)

This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6128080)

[](https://www.expedia.ca/Windsor-Parke-Golf-Club-Hotels.0-l6068663-0.Travel-Guide-Filter-Hotels)

### Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6068663)

[](https://www.expedia.ca/Windsor-Commons-Shopping-Center-Hotels.0-l553248621558033805-0.Travel-Guide-Filter-Hotels)

### Windsor Commons Shopping Center

You can enjoy retail therapy at Windsor Commons Shopping Center during your trip to Jacksonville. Experience the area's entertainment choices and acclaimed theater scene.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621558033805)

[](https://www.expedia.ca/Harbor-City-Municipal-Golf-Course-Hotels.0-l553248621563220206-0.Travel-Guide-Filter-Hotels)

### Harbor City Municipal Golf Course

Enjoy a round of golf in Jacksonville at Harbor City Municipal Golf Course. Amble around the area's beautiful beaches or attend a sporting event.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621563220206)

[](https://www.expedia.ca/Cradle-Creek-Preserve-Hotels.0-l553248621561766841-0.Travel-Guide-Filter-Hotels)

### Cradle Creek Preserve

Explore the great outdoors at Cradle Creek Preserve, a lovely green space in Jacksonville Beach. Amble around this family-friendly area's beautiful beaches and enjoy its top-notch restaurants.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621561766841)

[](https://www.expedia.ca/Jacksonville-Beach-Golf-Club-Hotels.0-l553248621561766896-0.Travel-Guide-Filter-Hotels)

### Jacksonville Beach Golf Club

3.9/5 (58 reviews)

Enjoy a round of golf in Jacksonville Beach at Jacksonville Beach Golf Club. Wander the beautiful beaches and seaside in this family-friendly area.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621561766896)

[](https://www.expedia.ca/South-Beach-Park-And-Sunshine-Playground-Hotels.0-l553248621561892262-0.Travel-Guide-Filter-Hotels)

### South Beach Park and Sunshine Playground

4.3/5 (44 reviews)

South Beach Park and Sunshine Playground is just one of the places to see in Jacksonville Beach, so why not enjoy the other things to explore during your travels? Stroll along the seaside or experience the acclaimed theater scene in this family-friendly area.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621561892262)

[](https://www.expedia.ca/Gonzales-Park-Hotels.0-l553248621558033757-0.Travel-Guide-Filter-Hotels)

### Gonzales Park

4.1/5 (31 reviews)

Gonzales Park is just one of the places to see in Jacksonville Beach, so why not enjoy the other things to explore during your travels? Stroll along the seaside or experience the acclaimed theater scene in this romantic area.

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621558033757)

## Frequently asked questions

### What are the top-rated hotels near Mayo Clinic Florida?

> Finding the perfect stay near Mayo Clinic Florida can enhance your visit, especially when exploring top-rated hotels that offer comfort and convenience.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> Residence Inn By Marriott Jacksonville - Mayo Clinic Area is situated within an 18-minute walking distance from Mayo Clinic Florida and has a solid review rating of 9.4. This 3-star hotel provides travellers with a complimentary buffet breakfast each morning, alongside amenities such as an outdoor pool and a well-equipped fitness centre available 24/7. The presence of a kitchen in every room, complete with a refrigerator and microwave, allows travellers to prepare meals at their convenience, enhancing their stay in Jacksonville.
> 
>   
> 
> [Element Jacksonville Beach](https://www.expedia.ca/Jacksonville-Hotels-Element-Jacksonville-Beach.h67391288.Hotel-Information)
> 
>   
> 
> Element Jacksonville Beach is a delightful 3-star hotel located just 8.0 km from Mayo Clinic Florida, with an impressive review rating of 9.6. This hotel offers a variety of amenities including an outdoor pool, a fitness centre, and free breakfast—ideal for travellers looking for a refreshing stay. Unique features like a hydromassage showerhead and a fully equipped kitchen with a dishwasher and stovetop elevate the experience, making it a great choice for travellers seeking both relaxation and functionality.
> 
>   
> 
> [Holiday Inn Express Jacksonville Beach by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)
> 
>   
> 
> Holiday Inn Express Jacksonville Beach by IHG is just 6.9 km from Mayo Clinic Florida, with an excellent review rating of 9.2. This inviting hotel features an outdoor pool and offers a daily buffet breakfast to start the day right. Guests will appreciate the free internet access and the relaxing terrace, while the nearby a nearby beach adds an enjoyable outdoor experience to their visit.

### What hotels are within walking distance to Mayo Clinic Florida?

> Discover the convenience of staying near Mayo Clinic Florida with these top-rated hotels that provide comfort and accessibility for your visit.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> Residence Inn By Marriott Jacksonville - Mayo Clinic Area is a welcoming 3-star hotel just an 18-minute walk from Mayo Clinic Florida, rated 9.4 by travellers. Guests appreciate the spacious rooms featuring kitchen amenities such as a dishwasher and microwave, along with the convenience of free daily breakfast. The outdoor pool and 24-hour fitness centre provide great options for relaxation and exercise, while the garden area enhances the overall ambiance.
> 
>   
> 
> [Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches](https://www.expedia.ca/Jacksonville-Hotels-Courtyard-By-Marriott-Jacksonville-At-Mayo-Clinic-CampusBeaches.h19631.Hotel-Information)
> 
>   
> 
> Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches offers a prime location only 3 minutes from Mayo Clinic Florida, a review rating of 8.4. This 3-star hotel features an outdoor pool and a well-equipped fitness centre, ensuring travellers have ample opportunities to unwind. With modern amenities like premium bedding and a snack bar, visitors can enjoy a comfortable stay close to their medical appointments.

### How much is a hotel near Mayo Clinic Florida?

> Staying near Mayo Clinic Florida is a treat, with plenty of hotels from CA $177 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, especially in peak season. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a trip during weekends or around public holidays.

### What are the most popular family-friendly hotels near Mayo Clinic Florida?

> For families visiting Mayo Clinic Florida, these top-rated hotels offer a perfect blend of comfort and convenience during your stay in Jacksonville.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> Residence Inn By Marriott Jacksonville - Mayo Clinic Area, rated 9.4 by travellers, is only an 18-minute walk from Mayo Clinic Florida. This 3-star hotel is designed with families in mind, offering spacious suites with kitchen facilities and free rollaway beds. Guests can take advantage of the outdoor pool, 24-hour fitness centre, and complimentary breakfast to start their day right.
> 
>   
> 
> [Holiday Inn Express Jacksonville Beach by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)
> 
>   
> 
> Holiday Inn Express Jacksonville Beach by IHG offers a family-friendly experience just 6.9 km from Mayo Clinic Florida, with a great traveler rating score of 9.2. Families will appreciate the free cribs, connecting rooms, and outdoor pool. Additional amenities include a complimentary breakfast served daily and easy access to the nearby beach, making it a great option for relaxation after a visit to the clinic.
> 
>   
> 
> [Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information)
> 
>   
> 
> Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG is a family-friendly hotel located just 4.8 km from Mayo Clinic Florida. With a review rating of 8.4, this hotel features amenities such as free cribs, connecting rooms, and complimentary buffet breakfast, ensuring a comfortable stay for families. Guests can also enjoy an outdoor pool and easy access to nearby shopping and golf courses.

### Which hotels near Mayo Clinic Florida offer the best views?

> Discover top-rated hotels near Mayo Clinic Florida that not only provide comfort but also stunning views.
> 
>   
> 
> [Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information)
> 
>   
> 
> Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG is a welcoming 3-star hotel located just 4.8 km from Mayo Clinic Florida, rated 8.4 by travellers. This hotel features an outdoor pool with golf course views, perfect for relaxation after a day of appointments. Guests can enjoy a complimentary buffet breakfast daily, along with access to fitness facilities and free self-parking. A nearby shopping centre adds to the convenience, making it an ideal choice for those seeking both comfort and scenic views.

### What are the best affordable hotels near Mayo Clinic Florida?

> Finding affordable and comfortable accommodations near Mayo Clinic Florida is essential for travellers seeking a smooth experience. Here are some top-rated options that cater to both convenience and budget.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> Residence Inn By Marriott Jacksonville - Mayo Clinic Area is a 3-star hotel situated a short 18-minute walk from Mayo Clinic Florida, with a great traveler rating score of 9.4. This hotel is perfect for families, offering free breakfast daily and a kitchen in each suite for convenient meal preparation. Additional amenities include an outdoor pool, 24-hour fitness facilities, and free self-parking, making it a practical choice for extended stays or quick visits alike.
> 
>   
> 
> [Element Jacksonville Beach](https://www.expedia.ca/Jacksonville-Hotels-Element-Jacksonville-Beach.h67391288.Hotel-Information)
> 
>   
> 
> Element Jacksonville Beach is a 3-star hotel located just 8.0 km from Mayo Clinic Florida, with an impressive review rating of 9.6. This family-friendly hotel offers complimentary breakfast options, including a cooked breakfast and free WiFi, ensuring a pleasant start to your day. Guests can enjoy amenities such as an outdoor pool, fitness centre, and fully-equipped kitchens in select rooms, making it an ideal choice for those looking for a comfortable and affordable stay.
> 
>   
> 
> [Holiday Inn Express Jacksonville Beach by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)
> 
>   
> 
> Holiday Inn Express Jacksonville Beach by IHG is located 6.9 km from Mayo Clinic Florida and has a solid review rating of 9.2. This hotel provides a complimentary buffet breakfast and free WiFi, suiting families and budget-conscious travellers. Guests can also take advantage of the outdoor pool, free self-parking, and nearby beach access, ensuring a relaxing and enjoyable experience during their stay.

### Are there any hotels with pools close to Mayo Clinic Florida?

> For those seeking a refreshing dip during their stay near Mayo Clinic Florida, there are excellent hotels with pools in Jacksonville. Here are some top-rated options to consider.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> Just an 18-minute walk from Mayo Clinic Florida, the 3-star Residence Inn By Marriott Jacksonville offers a fantastic outdoor pool equipped with sun loungers and a poolside bar, perfect for relaxation after a long day. Rated 9.4 by travellers, this hotel features free buffet breakfast, a fitness centre available 24/7, and spacious rooms complete with kitchen facilities, making it ideal for both short and extended stays.
> 
>   
> 
> [Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Hampton-Inn-JacksonvillePonte-Vedra-Beach-Mayo-Clinic-Area.h570425.Hotel-Information)
> 
>   
> 
> Located 5.6 km from Mayo Clinic Florida, the Hampton Inn features an inviting outdoor pool with accessible options and sun loungers, rated 8.8 by travellers. Guests can enjoy a complimentary breakfast daily and access to fitness facilities. With nearby beach access, this hotel offers a blend of relaxation and convenience, perfect for those needing nearby the clinic.
> 
>   
> 
> [Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Suites-Jacksonville-SE-Med-Ctr-Area.h898066.Hotel-Information)
> 
>   
> 
> Situated 4.8 km from Mayo Clinic Florida, the Holiday Inn Express boasts an outdoor pool surrounded by sun loungers and umbrellas, rated 8.4 by travellers. Guests can indulge in a free breakfast each morning and benefit from modern amenities including a fitness centre. This hotel is a great choice for those looking for comfort and convenience close to medical facilities.

### What are the best pet-friendly hotels near Mayo Clinic Florida?

> Searching for the best pet-friendly hotels near Mayo Clinic Florida? Look no further, as these top-rated options ensure a comfortable stay for both you and your furry companions.
> 
>   
> 
> [Residence Inn By Marriott Jacksonville - Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Residence-Inn-By-Marriott-Jacksonville-East.h59846313.Hotel-Information)
> 
>   
> 
> The Residence Inn By Marriott Jacksonville - Mayo Clinic Area is just an 18-minute walk from Mayo Clinic Florida and boasts an impressive review rating of 9.4. This 3-star hotel welcomes pets with amenities such as in-room pet accommodations and service animals. Guests can enjoy a complimentary buffet breakfast, an outdoor pool, and a well-equipped fitness centre, making it a great choice for travellers seeking comfort and convenience.
> 
>   
> 
> [Holiday Inn Express Jacksonville Beach by IHG](https://www.expedia.ca/Jacksonville-Hotels-Holiday-Inn-Express-Jacksonville-Beach.h1818369.Hotel-Information)
> 
>   
> 
> Located 6.9 km from Mayo Clinic Florida, the Holiday Inn Express Jacksonville Beach by IHG is a fantastic option for pet owners, rated 9.2 by travellers. This hotel allows pets and offers amenities like free breakfast and an outdoor pool. Guests will appreciate the nearby sandy beach, making it perfect for leisurely walks with their dogs after a day at the clinic.
> 
>   
> 
> [Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area](https://www.expedia.ca/Jacksonville-Hotels-Hampton-Inn-JacksonvillePonte-Vedra-Beach-Mayo-Clinic-Area.h570425.Hotel-Information)
> 
>   
> 
> The Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area is a pet-friendly haven situated just 5.6 km from Mayo Clinic Florida, with a great traveler rating score of 8.8. This hotel features in-room pet accommodations and a complimentary breakfast. Guests can unwind at the outdoor pool or explore the nearby beach, ensuring a pleasant stay for both pets and their owners.

### Can I book a fully refundable hotel close to Mayo Clinic Florida?

> Most bookings on Expedia are refundable if canceled within 24-48 hours of arrival, though this depends on the hotel's individual cancellation policy, which you should check in your booking confirmation. If free cancellation is available, you can cancel directly through your Expedia account by going to "My Trips" and selecting your reservation. To find fully refundable hotel options, simply enter "Mayo Clinic Florida", set your travel dates, and use the "Fully refundable" filter under "Deals & Discounts" on the results page. Alternatively, explore [deals with free cancellation](https://www.expedia.ca/deals/free-cancellation) options on Expedia.

### Can I find Expedia discounts for hotels near Mayo Clinic Florida?

> Sign in to your account to unlock instant savings and access Member Prices on Expedia. Members always get our best prices, so join for free and look for great discounts on top hotels near Mayo Clinic Florida.

## Explore a world of travel with Expedia

-   Lodging
-   Flights
-   Packages
-   Cars
-   Vacation Rental
-   Other

-   [5 Star Hotels in Jacksonville Beach](https://www.expedia.ca/5Star-Jacksonville-Beach-Hotels.s50-0-d8196.Travel-Guide-Filter-Hotels)
-   [Hotels near Adventure Landing](https://www.expedia.ca/Adventure-Landing-Hotels.0-l6128080-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Atlantic Beach](https://www.expedia.ca/Atlantic-Beach-Hotels.0-l814781859718029312-0.Travel-Guide-Filter-Hotels)
-   [Atlantic Beach Hotels](https://www.expedia.ca/Atlantic-Beach-Hotels.d6588.Travel-Guide-Hotels)
-   [Atlantic Highlands Hotels](https://www.expedia.ca/Atlantic-Highlands-Jacksonville-Hotels.0-n553248635976470837-0.Travel-Guide-Filter-Hotels)
-   [Condo Rentals in Beach Cities Jacksonville](https://www.expedia.ca/Beach-Cities-Jacksonville-Condos.d6062930-aaCondos.Travel-Guide-Accommodation)
-   [All Inclusive Resorts and in Beach Cities Jacksonville](https://www.expedia.ca/Beach-Cities-Jacksonville-Hotels-All-Inclusive-Hotel.0-0-d6062930-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in Beach Haven](https://www.expedia.ca/Beach-Haven-Jacksonville-Hotels-Cheap-Hotels.0-n553248635976471209-0-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Beach Haven](https://www.expedia.ca/Beach-Haven-Jacksonville-Hotels-Luxury-Hotel.0-n553248635976471209-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in Beach Haven](https://www.expedia.ca/Beach-Haven-Jacksonville-Hotels-Oceanfront-Hotels.0-n553248635976471209-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Beach Haven Hotels](https://www.expedia.ca/Beach-Haven-Jacksonville-Hotels.0-n553248635976471209-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Beaches Town Center](https://www.expedia.ca/Beaches-Town-Center-Hotels.0-l553248634825431779-0.Travel-Guide-Filter-Hotels)
-   [Deerwood Hotels](https://www.expedia.ca/Deerwood-Jacksonville-Hotels.0-n553248635976478676-0.Travel-Guide-Filter-Hotels)
-   [Dolphin's Cove Hotels](https://www.expedia.ca/Dolphins-Cove-Jacksonville-Hotels.0-n553248635976472614-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Florida State College - South Campus](https://www.expedia.ca/Florida-State-College-South-Campus-Hotels.0-l553248621561892275-0.Travel-Guide-Filter-Hotels)
-   [Golden Glades - The Woods Hotels](https://www.expedia.ca/Golden-Glades-The-Woods-Jacksonville-Hotels.0-n553248635976475925-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Huguenot Park](https://www.expedia.ca/Huguenot-Park-Hotels.0-l553248621558033368-0.Travel-Guide-Filter-Hotels)
-   [Adults Only Resorts & in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Adults-Only-Resorts.0-n553248635976480347-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
-   [All Inclusive Resorts and in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-All-Inclusive-Hotel.0-n553248635976480347-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Beach Hotel Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Beach-Hotel.0-n553248635976480347-0-tBeachHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Cheap-Hotels.0-n553248635976480347-0-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with an Indoor Pool in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Hotels-With-Indoor-Pool.0-n553248635976480347-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Luxury-Hotel.0-n553248635976480347-0-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Oceanfront-Hotels.0-n553248635976480347-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Pet-Friendly-Hotel.0-n553248635976480347-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Isle of Palms](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels-Spa-Hotel.0-n553248635976480347-0-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Isle of Palms Hotels](https://www.expedia.ca/Isle-Of-Palms-Jacksonville-Hotels.0-n553248635976480347-0.Travel-Guide-Filter-Hotels)
-   [Aparthotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Apart-Hotels.d8196-aaApartHotels.Travel-Guide-Accommodation)
-   [Apartments in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Apartments.d8196-aaApartments.Travel-Guide-Accommodation)
-   [B&B in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Bed-And-Breakfast.d8196-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Chalets in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Chalets.d8196-aaChalets.Travel-Guide-Accommodation)
-   [Condo Rentals in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Condos.d8196-aaCondos.Travel-Guide-Accommodation)
-   [Cottages in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Cottages.d8196-aaCottages.Travel-Guide-Accommodation)
-   [Hotels near Jacksonville Beach Golf Club](https://www.expedia.ca/Jacksonville-Beach-Golf-Club-Hotels.0-l553248621561766896-0.Travel-Guide-Filter-Hotels)
-   [Guest Houses in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Guest-Houses.d8196-aaGuestHouses.Travel-Guide-Accommodation)
-   [Hostels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hostels.d8196-aaHostels.Travel-Guide-Accommodation)
-   [All Inclusive Resorts and in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-All-Inclusive-Hotel.0-0-d8196-tAllInclusiveHotel.Travel-Guide-Filter-Hotels)
-   [Beach Hotel Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Beach-Hotel.0-0-d8196-tBeachHotel.Travel-Guide-Filter-Hotels)
-   [Boutique Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Boutique-Hotel.0-0-d8196-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
-   [Business Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Business-Hotel.0-0-d8196-tBusinessHotel.Travel-Guide-Filter-Hotels)
-   [Casino Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Casino-Hotel.0-0-d8196-tCasinoHotel.Travel-Guide-Filter-Hotels)
-   [Cheap Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Cheap-Hotels.0-0-d8196-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Hotels & Resorts for Couples in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Couples-Resorts-Hotels.0-0-d8196-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
-   [Family Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Family-Hotel.0-0-d8196-tFamilyHotel.Travel-Guide-Filter-Hotels)
-   [Four Seasons Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Four-Seasons.0-0-d8196--bFourSeasons.Travel-Guide-Filter-Hotels)
-   [Golf Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Golf-Hotel.0-0-d8196-tGolfHotel.Travel-Guide-Filter-Hotels)
-   [Hilton Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hilton-Hotels.0-0-d8196--bHiltonHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with a Pool in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotel-With-Pool.0-0-d8196-tHotelwithPool.Travel-Guide-Filter-Hotels)
-   [Hotels with Balconies in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Balconies.0-0-d8196-tHotelswithBalconies.Travel-Guide-Filter-Hotels)
-   [Hotels with Bar in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Bar.0-0-d8196-tHotelswithBar.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Airport Shuttle in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d8196-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Breakfast in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Free-Breakfast.0-0-d8196-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Hot-Tubs.0-0-d8196-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Hotels with Kitchenettes in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Hotels-With-Kitchenettes.0-0-d8196-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels)
-   [Lgbt Friendly Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-LGBT-Friendly-Hotel.0-0-d8196-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Luxury-Hotel.0-0-d8196-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Oceanfront-Hotels.0-0-d8196-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Pet-Friendly-Hotel.0-0-d8196-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Shopping Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Shopping-Hotel.0-0-d8196-tShoppingHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Spa-Hotel.0-0-d8196-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Waterpark Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Waterpark-Hotels.0-0-d8196-tWaterparkHotels.Travel-Guide-Filter-Hotels)
-   [Hotel Wedding Venues Hotels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Hotels-Wedding-Hotels.0-0-d8196-tWeddingHotels.Travel-Guide-Filter-Hotels)
-   [Jacksonville Beach Hotels](https://www.expedia.ca/Jacksonville-Beach-Hotels.d8196.Travel-Guide-Hotels)
-   [Motels in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Motels.d8196-aaMotels.Travel-Guide-Accommodation)
-   [Hotels near Jacksonville Beach Pier](https://www.expedia.ca/Jacksonville-Beach-Pier-Hotels.0-l6196768-0.Travel-Guide-Filter-Hotels)
-   [Vacation Homes in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Private-Vacation-Homes.d8196-aaPrivateVacationHomes.Travel-Guide-Accommodation)
-   [Resorts in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Resort-Hotels.d8196-aaResortHotels.Travel-Guide-Accommodation)
-   [Townhomes in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Townhomes.d8196-aaTownhomes.Travel-Guide-Accommodation)
-   [Villas in Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach-Villas.d8196-aaVillas.Travel-Guide-Accommodation)
-   [Hotels near Marsh Landing Country Club](https://www.expedia.ca/Marsh-Landing-Country-Club-Hotels.0-l553248621532654550-0.Travel-Guide-Filter-Hotels)
-   [Neptune Beach Hotels](https://www.expedia.ca/Neptune-Beach-Hotels.d8913.Travel-Guide-Hotels)
-   [North Beach Hotels](https://www.expedia.ca/North-Beach-Jacksonville-Hotels.0-n553248635976481218-0.Travel-Guide-Filter-Hotels)
-   [Old Ponte Vedra Beach Hotels](https://www.expedia.ca/Old-Ponte-Vedra-Beach-Jacksonville-Hotels.0-n553248635976472744-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Players by the Sea](https://www.expedia.ca/Players-By-The-Sea-Hotels.0-l553248621532654556-0.Travel-Guide-Filter-Hotels)
-   [Ponte Vedra Beach Hotels](https://www.expedia.ca/Ponte-Vedra-Beach-Hotels.d10018.Travel-Guide-Hotels)
-   [Sans Pareil Hotels](https://www.expedia.ca/Sans-Pareil-Jacksonville-Hotels.0-n553248635975852002-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Sawgrass Country Club](https://www.expedia.ca/Sawgrass-Country-Club-Hotels.0-l553248621532654542-0.Travel-Guide-Filter-Hotels)
-   [Sawgrass Hotels](https://www.expedia.ca/Sawgrass-Jacksonville-Hotels.0-n553248635077630095-0.Travel-Guide-Filter-Hotels)
-   [Hotels near Sawgrass Village](https://www.expedia.ca/Sawgrass-Village-Hotels.0-l553248621561892260-0.Travel-Guide-Filter-Hotels)
-   [Southeast Jacksonville Hotels](https://www.expedia.ca/Southeast-Jacksonville-Hotels.d6062932.Travel-Guide-Hotels)
-   [Southside Hotels](https://www.expedia.ca/Southside-Jacksonville-Hotels.0-n553248635976480888-0.Travel-Guide-Filter-Hotels)
-   [Hotels near St. Johns Town Center](https://www.expedia.ca/St-Johns-Town-Center-Hotels.0-l6127793-0.Travel-Guide-Filter-Hotels)
-   [Hotels near TPC Sawgrass](https://www.expedia.ca/TPC-Sawgrass-Hotels.0-l6091127-0.Travel-Guide-Filter-Hotels)
-   [Hotels near University of North Florida](https://www.expedia.ca/University-Of-North-Florida-Hotels.0-l6127797-0.Travel-Guide-Filter-Hotels)

-   [Flights to Jacksonville Beach](https://www.expedia.ca/Cheap-Flights-To-Jacksonville-Beach.d8196.Travel-Guide-Flights)
-   [Flights from Ottawa to Jacksonville Beach](https://www.expedia.ca/lp/flights/178296/8196/ottawa-to-jacksonville-beach)
-   [Flights from Toronto to Jacksonville Beach](https://www.expedia.ca/lp/flights/178314/8196/toronto-to-jacksonville-beach)

-   [Adventure Landing](https://www.expedia.ca/Adventure-Landing-Jacksonville.d6128080.Vacation-Attraction)
-   [Visit Beach Cities Jacksonville](https://www.expedia.ca/Beach-Cities-Jacksonville.dx6062930)
-   [Jacksonville Beach Vacations](https://www.expedia.ca/Jacksonville-Beach.d8196.Destination-Travel-Guides)
-   [Visit Jacksonville Beach](https://www.expedia.ca/Jacksonville-Beach.dx8196)
-   [Visit Isle of Palms](https://www.expedia.ca/Jacksonville-Isle-Of-Palms.dx553248635976480347)
-   [Visit Sans Pareil](https://www.expedia.ca/Jacksonville-Sans-Pareil.dx553248635975852002)

-   [Avis Rental Cars in Jacksonville Beach](https://www.expedia.ca/Avis-Car-Rentals-In-Jacksonville-Beach.d8196-c41.Car-Rental-Guide-Suppliers)
-   [Car rental Jacksonville Beach](https://www.expedia.ca/Car-Rentals-In-Jacksonville-Beach.d8196.Car-Rental-Guide)
-   [Discount Quebec Rental Cars in Beach Cities Jacksonville](https://www.expedia.ca/Discount-Quebec-Car-Rentals-In-Beach-Cities-Jacksonville.d6062930-c1137.Car-Rental-Guide-Suppliers)
-   [Hertz Rental Cars in Jacksonville Beach](https://www.expedia.ca/Hertz-Car-Rentals-In-Jacksonville-Beach.d8196-c40.Car-Rental-Guide-Suppliers)
-   [Payless Rental Cars in Jacksonville Beach](https://www.expedia.ca/Payless-Car-Rentals-In-Jacksonville-Beach.d8196-c38.Car-Rental-Guide-Suppliers)

-   [Jacksonville Beach Vacation Rentals](https://www.expedia.ca/Jacksonville-Beach-Vacation-Rentals.d8196.Travel-Guide-VacationRentals)

-   [Things to do in Jacksonville Beach](https://www.expedia.ca/Things-To-Do-In-Jacksonville-Beach.d8196.Travel-Guide-Activities)