Title: Best Hotels Near Main Street Hyannis, Hyannis from CA $108 | Expedia.ca [Hyannis Travel Guide](https://expedia.ca/Hyannis.dx1544)[Vacation Rentals in Hyannis](https://expedia.ca/Hyannis-Vacation-Rentals.d1544.Travel-Guide-VacationRentals)[Flights to Hyannis](https://expedia.ca/Cheap-Flights-To-Hyannis.d1544.Travel-Guide-Flights)[Things to do in Hyannis](https://expedia.ca/Things-To-Do-In-Hyannis.d1544.Travel-Guide-Activities)[Main Street Hyannis Car Rentals](https://expedia.ca/Car-Rentals-In-Main-Street-Hyannis.d6287458.Car-Rental-Guide)[Main Street Hyannis Vacations](https://expedia.ca/Main-Street-Hyannis-Hyannis.d6287458.Vacation-Attraction) ![Main Street Hyannis featuring street scenes as well as a couple](https://images.trvl-media.com/place/6287458/f083813a-eac6-4b18-a763-a901fa1ed4e5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Main Street Hyannis, Hyannis from CA $108 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6287458&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Main Street Hyannis hotels ![Terrace/patio](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/f27823ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/3fdd0247.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 2 Queen Beds, Harbour View | Living area](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/c85afb09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Anchor In Distinctive Waterfront Lodging [](https://www.expedia.ca/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) 0.6 km from Main Street Hyannis 9.4/10 Exceptional (1000) "Beautiful quaint hotel, with a nice view of the water. The place has a pool, a fire pit and nice spacious rooms. Would stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alberto CA $192 CA $259 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/056f2544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/75730e05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Voyager Escape King Elite](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/c366b6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/1000000/490000/480800/480770/6ac8a051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Uncommoner Hotel by Reverie Boutique Collection [](https://www.expedia.ca/West-Yarmouth-Hotels-Tidewater-Inn.h480770.Hotel-Information) 1.9 km from Main Street Hyannis 9.4/10 Exceptional (97) "Hotel was quiet and very clean , pool water was cool" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robyn CA $146 CA $167 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/West-Yarmouth-Hotels-Tidewater-Inn.h480770.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/df083265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/8c1d510e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/08564f33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/7700/7660/a974137b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Cod Hyannis [](https://www.expedia.ca/Hyannis-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Cod-Hyannis.h7660.Hotel-Information) 2.3 km from Main Street Hyannis 8.8/10 Excellent (657) "Great people, nice breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lorri CA $134 CA $153 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Cod-Hyannis.h7660.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/3168dc41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/4d737673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/85e7753a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/1600/1517/5cb65d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard By Marriott Cape Cod Hyannis [](https://www.expedia.ca/Hyannis-Hotels-Courtyard-By-Marriott-Cape-Cod-Hyannis.h1517.Hotel-Information) 1.7 km from Main Street Hyannis 8.8/10 Excellent (486) "Pretty nice location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saulius CA $169 CA $193 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Courtyard-By-Marriott-Cape-Cod-Hyannis.h1517.Hotel-Information) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/783b5af0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/146eb322.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/963d562c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/b70d15f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bayside Resort Hotel [](https://www.expedia.ca/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) 2.3 km from Main Street Hyannis 8.8/10 Excellent (1521) "excellent quality of food. Pool and hot tub fabulous" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deborah [](https://www.expedia.ca/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/9f940314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/5e37150d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/3e4f4967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/e8d49199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Doubletree by Hilton Cape Cod - Hyannis [](https://www.expedia.ca/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) 1 km from Main Street Hyannis 8.4/10 Very good (878) "Nice room, freindly staff. The downside is the food was pricey. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steffanie CA $142 CA $163 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/3bffd99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/906db676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/bbed7ace.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/6cc9c6b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cape Sands Inn [](https://www.expedia.ca/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) 1.9 km from Main Street Hyannis 8.2/10 Very good (1016) "Clean room courteous staff and easy check in " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $94 CA $108 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/6128ed99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/c18bcef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/0fe4f63e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12500/12477/12aa0105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Hyannis by IHG [](https://www.expedia.ca/Hyannis-Hotels-Holiday-Inn-Hyannis-By-IHG.h12477.Hotel-Information) 2.9 km from Main Street Hyannis 8.2/10 Very good (977) "Check in was easy and the front desk person was wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anastasios CA $147 CA $169 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Hyannis-Hotels-Holiday-Inn-Hyannis-By-IHG.h12477.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/b37d6e5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/a26c3d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/015bb1aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/0874e47d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Hyannis - Cape Cod [](https://www.expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) 0.3 km from Main Street Hyannis 8.0/10 Very good (1000) "Well appointed lodging with very friendly and attentive staff. Perfect central location with easy walk to many local sights as well as convenient access to ferry terminal. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kerri CA $135 CA $155 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/0271fbcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/w6720h4476x0y4-c8befbe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/3225f1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Harbor Hotel [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) 0.6 km from Main Street Hyannis 8.0/10 Very good (1000) "Amazing place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mounir CA $158 CA $237 total includes taxes & fees Jan 13 - Jan 14, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f7fc1d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/4dfa52ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/ef69e045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Crown Victorian Suite](https://images.trvl-media.com/lodging/2000000/1120000/1119300/1119277/f84dd400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyannis Plaza Hotel [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) 0.9 km from Main Street Hyannis 7.0/10 Good (967) "good stay for night" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $85 CA $112 total includes taxes & fees Jan 13 - Jan 14, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Hyannis-Plaza-Hotel.h1119277.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/9d421872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/e9405833.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/0a9fa15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Resort [](https://www.expedia.ca/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) 0.3 km from Main Street Hyannis 8.2/10 Very good (44) "Room was very clean. Staff were courteous!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $143 CA $164 total includes taxes & fees Jan 7 - Jan 8, 2026 [](https://www.expedia.ca/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Family House, Private Bathroom, Pool View | Lounge](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/d6ef30c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Restaurant](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/ecad4998.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Lounge](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/f2591e0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, Private Bathroom, Pool View | Garden](https://images.trvl-media.com/lodging/120000000/119380000/119374000/119373964/9bd5f506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sal's Place [](https://www.expedia.ca/Hyannis-Hotels-Sals-Place.h119373964.Hotel-Information) 2.5 km from Main Street Hyannis CA $386 CA $607 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Hyannis-Hotels-Sals-Place.h119373964.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/ae47522f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/2b1f0d40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Multiple Beds](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/19b90fe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/13000000/12430000/12426900/12426891/023eb077.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Village Inn Cape Cod [](https://www.expedia.ca/Yarmouth-Port-Hotels-The-Village-Inn-Cape-Cod.h12426891.Hotel-Information) 6.1 km from Main Street Hyannis 10/10 Exceptional (222) "It was so charming, would definitely stay there again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyle CA $233 CA $266 total includes taxes & fees Dec 27 - Dec 28 [](https://www.expedia.ca/Yarmouth-Port-Hotels-The-Village-Inn-Cape-Cod.h12426891.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1160000/1159200/1159118/c2ed8a3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1160000/1159200/1159118/9803ffe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1160000/1159200/1159118/3b0ad9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1159200/1159118/67aecefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Brewster by the Sea Inn [](https://www.expedia.ca/Brewster-Hotels-Brewster-By-The-Sea-Inn.h1159118.Hotel-Information) 17.4 km from Main Street Hyannis 9.8/10 Exceptional (171) "Brewster By the Sea has it all - great location, amazing innkeeper, unbelievable breakfasts, and great rooms with perfect amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donna CA $438 CA $501 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Brewster-Hotels-Brewster-By-The-Sea-Inn.h1159118.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/366fdd27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/b61b6541.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/5bdfdac3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6700000/6697800/6697712/32aabc06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Escape Inn [](https://www.expedia.ca/South-Yarmouth-Hotels-The-Escape-Inn.h6697712.Hotel-Information) 7.6 km from Main Street Hyannis 9.4/10 Exceptional (653) "One of the best hotels I stayed at " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $111 CA $127 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/South-Yarmouth-Hotels-The-Escape-Inn.h6697712.Hotel-Information) ![Oceanfront Efficiency, 1 King Bed](https://images.trvl-media.com/lodging/16000000/15370000/15369000/15368979/13f44770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Kitchenette](https://images.trvl-media.com/lodging/16000000/15370000/15369000/15368979/bf866f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15370000/15369000/15368979/61444c45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Kitchenette](https://images.trvl-media.com/lodging/16000000/15370000/15369000/15368979/eefd9ab3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Chatham Tides [](https://www.expedia.ca/South-Chatham-Hotels-Chatham-Tides.h15368979.Hotel-Information) 20.9 km from Main Street Hyannis 9.4/10 Exceptional (667) "We had such an amazing stay at Chatham Tides! The room was incredibly clean and very cozy. Check-in was easy and the staff was helpful and friendly. We were pleasantly surprised at the view and how quaint everything felt. We will definitely be visiting again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $209 CA $240 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/South-Chatham-Hotels-Chatham-Tides.h15368979.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/30f6a06a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/e05c3d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/0ad12b76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b82acf26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Margaritaville Resort Cape Cod [](https://www.expedia.ca/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) 3.3 km from Main Street Hyannis 8.8/10 Excellent (412) "The entire place was spotless and rooom beet pleasant. Staff was super friendly and the Landshark Bar was excellent. Highly recommend a stay here ! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen [](https://www.expedia.ca/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Private beach nearby, beach bar](https://images.trvl-media.com/lodging/12000000/11630000/11621700/11621632/4270e26b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/12000000/11630000/11621700/11621632/d67fc379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/12000000/11630000/11621700/11621632/f0ed7d64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/12000000/11630000/11621700/11621632/c3910e28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Club at New Seabury [](https://www.expedia.ca/Mashpee-Hotels-The-Club-At-New-Seabury.h11621632.Hotel-Information) 19.4 km from Main Street Hyannis 9.0/10 Wonderful (339) "Very relaxing, loved the different clubs available; beach, pool, tennis, playground for the little ones, bars and food. Some shops were closed due to being off season, but still enjoyed our stay. Looking forward to booking again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose O. [](https://www.expedia.ca/Mashpee-Hotels-The-Club-At-New-Seabury.h11621632.Hotel-Information) ![Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/40000000/39030000/39022700/39022601/ce1bc2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/40000000/39030000/39022700/39022601/db957636.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/40000000/39030000/39022700/39022601/4ecc6037.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite](https://images.trvl-media.com/lodging/40000000/39030000/39022700/39022601/f0b28600.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sandy Neck Motel [](https://www.expedia.ca/East-Sandwich-Hotels-Sandy-Neck-Motel.h39022601.Hotel-Information) 12.8 km from Main Street Hyannis 8.8/10 Excellent (143) "Loved the area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica [](https://www.expedia.ca/East-Sandwich-Hotels-Sandy-Neck-Motel.h39022601.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28®ionId=6287458&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Main Street Hyannis Hotel Reviews ![Bayside Resort Hotel](https://images.trvl-media.com/lodging/1000000/900000/896700/896697/85f07916_y.jpg) ### Bayside Resort Hotel 10/10 Excellent "everything" [](https://expedia.ca/West-Yarmouth-Hotels-Bayside-Resort-Hotel.h896697.Hotel-Information) ![Comfort Inn Hyannis - Cape Cod](https://images.trvl-media.com/lodging/2000000/1250000/1240500/1240460/f7a87ca8_y.jpg) ### Comfort Inn Hyannis - Cape Cod 10/10 Excellent "Well appointed lodging with very friendly and attentive staff. Perfect central location with easy walk to many local sights as well as convenient access to ferry terminal. " [](https://expedia.ca/Hyannis-Hotels-Comfort-Inn.h1240460.Hotel-Information) ![Courtyard Resort](https://images.trvl-media.com/lodging/116000000/115250000/115243800/115243739/5d7ebe6e_y.jpg) ### Courtyard Resort 10/10 Excellent "Room was very clean. Staff were courteous!" [](https://expedia.ca/Hyannis-Hotels-Courtyard-Resort.h115243739.Hotel-Information) ![Doubletree by Hilton Cape Cod - Hyannis](https://images.trvl-media.com/lodging/1000000/50000/40500/40461/9f940314_y.jpg) ### Doubletree by Hilton Cape Cod - Hyannis 10/10 Excellent "Everything was great . One comforter on the bed was a little dirty. We liked everything else." [](https://expedia.ca/Hyannis-Hotels-Doubletree-By-Hilton-Cape-Cod-Hyannis.h40461.Hotel-Information) ![Hyannis Travel Inn](https://images.trvl-media.com/lodging/2000000/1380000/1379200/1379109/fe11d49f_y.jpg) ### Hyannis Travel Inn 10/10 Excellent "Very kind staff. Functional, clean room. Had an early bus and they let me take a few things for breakfast the night before." [](https://expedia.ca/Hyannis-Hotels-Hyannis-Travel-Inn.h1379109.Hotel-Information) ![Hyannis Harbor Hotel](https://images.trvl-media.com/lodging/1000000/60000/55000/54945/741b5772_y.jpg) ### Hyannis Harbor Hotel 10/10 Excellent "Perfect hotel" [](https://expedia.ca/Hyannis-Hotels-Hyannis-Harbor-Hotel.h54945.Hotel-Information) ![Anchor In Distinctive Waterfront Lodging](https://images.trvl-media.com/lodging/8000000/7650000/7640900/7640889/7438dff7_y.jpg) ### Anchor In Distinctive Waterfront Lodging 10/10 Excellent "I believe Sandi at the desk gave me the best greeting and welcome I have ever received from a hotel. She wasn't 'corporate' but very personable. She didn't just tell us about the breakfast, the pool, etc...she took us in a small tour to show us. The room where we had breakfast was very homey with a roaring fire in the fireplace. " [](https://expedia.ca/Hyannis-Hotels-Anchor-In-Distinctive-Waterfront-Lodging.h7640889.Hotel-Information) ![Margaritaville Resort Cape Cod](https://images.trvl-media.com/lodging/1000000/20000/12900/12897/b57e0b1f_y.jpg) ### Margaritaville Resort Cape Cod 10/10 Excellent "The entire place was spotless and rooom beet pleasant. Staff was super friendly and the Landshark Bar was excellent. Highly recommend a stay here ! " [](https://expedia.ca/Hyannis-Hotels-Cape-Codder-Resort-And-Spa.h12897.Hotel-Information) ![Cape Sands Inn](https://images.trvl-media.com/lodging/2000000/1340000/1330200/1330174/aa954682_y.jpg) ### Cape Sands Inn 10/10 Excellent "Clean room, great rate easy checkin and easy checkout. Will stay again. " [](https://expedia.ca/West-Yarmouth-Hotels-Cape-Sands-Inn.h1330174.Hotel-Information) ## Hotels near other Main Street Hyannis attractions ![John F. Kennedy Hyannis Museum showcases bronze statue and historic architecture in Hyannis Massachusetts](https://images.trvl-media.com/place/6070185/b92268d1-27eb-4055-a07b-800040c40061.jpg) ### John F. Kennedy Hyannis Museum 4.4/5 (259 reviews) Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6070185) ![Cape Cod Maritime Museum which includes a bay or harbor and signage](https://images.trvl-media.com/place/553248635146342095/6c8cea24-96a8-41da-86a8-64397b473956.jpg) ### Cape Cod Maritime Museum You can spend an afternoon exploring the galleries in Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the seaside in this family-friendly area, or check out its seafood restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635146342095) ![St. Francis Xavier Church featuring signage and a church or cathedral](https://images.trvl-media.com/place/6286986/d75d0252-a6d7-4bb9-9dd9-82f6c06a49ac.jpg) ### St. Francis Xavier Church 4.4/5 (45 reviews) After visiting St. Francis Xavier Church, make a plan to see the other sights and activities in Hyannis. Wander the beautiful beaches and waterfront in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286986) ![John F. Kennedy Memorial which includes flowers](https://images.trvl-media.com/place/6286978/9b85082f-75c6-4ae3-ac16-7a3f1c71a2a9.jpg) ### John F. Kennedy Memorial 4.5/5 (110 reviews) Take a moment to reflect on John F. Kennedy’s defining role in American politics, as well as his untimely death, at this poignant memorial. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6286978) ### Hyannis Armory Learn about the local history of Hyannis when you take a trip to Hyannis Armory. Wander the waterfront and beautiful beaches in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=950930054190297088) ### Hyannis Youth & Community Center You can take time to visit Hyannis Youth & Community Center during your travels to Hyannis. Stroll along the beautiful beaches or visit the shops in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635976357139) ### Zion Union Heritage Museum You can spend an afternoon exploring the galleries in Zion Union Heritage Museum during your travels in Hyannis. Make time to visit the area's shops, or simply enjoy its seafood restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=724958852913086464) ### Commotion Charters Enjoy an outing to Commotion Charters during your stay in Hyannis. Attend a sporting event or simply enjoy the seafood restaurants while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532666521) ## Frequently asked questions ### What's the area like around Main Street Hyannis? ### What's the best hotel to stay near Main Street Hyannis? ### How many hotels can I expect to find close to Main Street Hyannis? ### If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund? ### What can I see and do near Main Street Hyannis? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Hyannis ](https://www.expedia.ca/4Star-Hyannis-Hotels.s40-0-d1544.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Hyannis ](https://www.expedia.ca/5Star-Hyannis-Hotels.s50-0-d1544.Travel-Guide-Filter-Hotels) - [B&B in Barnstable County ](https://www.expedia.ca/Barnstable-County-Bed-And-Breakfast.d553248635976434260-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Barnstable Hotels ](https://www.expedia.ca/Barnstable-Hotels.d9658.Travel-Guide-Hotels) - 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