Uptown - Upper Duval
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
4/5(161 reviews)
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
4/5(54 reviews)
The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.
Key West Butterfly and Nature Conservatory
4.5/5(19 reviews)
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Key West Morning Snorkel Adventure with Bottomless Mimosas & Breakfast
CA $61
per adult
94% of travellers recommend
Historic Key West Old Town Trolley Hop-On Hop-Off Tour
CA $76
per adult
88% of travellers recommend
Key West Coral Reef Snorkel with Mimosas, Margaritas or Rum Punch
CA $75
per adult
86% of travellers recommend
Key West Sunset Sail with Live Music, Drinks and Appetizers!
CA $109
per traveller
92% of travellers recommend
Key West Rum & Reggae: Snorkel & Sunset Sail Combo
CA $75
per adult
88% of travellers recommend
Key West Afternoon At The Reef Snorkeling Adventure with Open Bar!
CA $65
per adult
90% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
The price is CA $308 per night from May 26 to May 27
CA $308
CA $447 total
May 26 - May 27
includes taxes & fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,342 reviews)
"Good place"
Reviewed on May 20, 2026
The Southernmost Inn - Adults Only
525 United Street Key West FL
The price is CA $218 per night from Jun 11 to Jun 12
CA $218
CA $307 total
Jun 11 - Jun 12
includes taxes & fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.4/10 Very Good! (1,366 reviews)
"Perfect location- quiet, yet right near Duval street in walking distance to everything. Breakfast and the afternoon wine and cheese was such a plus as was the swimming pools when wanting a quiet break! An excellent value!"
Reviewed on May 20, 2026
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street Key West FL
The price is CA $326 per night from Jun 15 to Jun 16
CA $326
CA $459 total
Jun 15 - Jun 16
includes taxes & fees
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,012 reviews)
"We were very pleased with our choice to stay at The Reach. It was perfect. Room was spotless and beds very comfortable. We booked a resort view room and view was awesome- not only did we have a view of the resort but also the pool and ocean. Staff was very attentive. Duval St is a 2 minute walk and ..."
Reviewed on May 20, 2026
Southwinds Motel
1321 Simonton Street Key West FL
The price is CA $185 per night from May 26 to May 27
CA $185
CA $255 total
May 26 - May 27
includes taxes & fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,356 reviews)
"The rooms were very clean and had everything we needed. Coffee pot/microwave/refrigerator was a plus - every hotel we look for has to have those three things. The staff was friendly and was able to check us in early. The only issue was the noise factor - our rooms were close to the front of the property ..."
Reviewed on May 21, 2026
Douglas House - Adults Only
419 Amelia St Key West FL
The price is CA $205 per night from Jun 9 to Jun 10
CA $205
CA $254 total
Jun 9 - Jun 10
includes taxes & fees
Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Ernest Hemingway Home and Museum ...
9.6/10 Exceptional! (390 reviews)
"Beautiful property, close to everything. The employee's were also super nice and attentive. We can't wait to come back!!"
Reviewed on May 19, 2026
Santa Maria Suites
1401 Simonton St Key West FL
The price is CA $438 per night from Jun 1 to Jun 2
CA $438
CA $586 total
Jun 1 - Jun 2
includes taxes & fees
Stay at this resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,008 reviews)
"A ++"
Reviewed on May 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighbourhoods around Uptown - Upper Duval
Old Town Key West
3.5/5(8 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Bahama Village
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Key West Historic District
4.5/5(157 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Florida Keys Beaches and Clarence S. Higgs Memorial Beach Park.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.
Uptown - Upper Duval
Explore a world of travel with Expedia
- Adults Only Resorts & in Downtown Key West
- Beach Hotel Hotels in Downtown Key West
- Boutique Hotels in Downtown Key West
- Casino Hotels in Downtown Key West
- Cheap Hotels in Downtown Key West
- Family Hotels in Downtown Key West
- Golf Hotels in Downtown Key West
- Historic Hotels in Downtown Key West
- Honeymoon Resorts and in Downtown Key West
- Hotels with a Pool in Downtown Key West
- Hotels with a Lazy River in Downtown Key West
- Hotels with Balconies in Downtown Key West
- Hotels with Free Airport Shuttle in Downtown Key West
- Hotels with Free Breakfast in Downtown Key West
- Hotels with Free Parking in Downtown Key West
- Hotels with Hot Tubs in Downtown Key West
- Hotels with Kitchenettes in Downtown Key West
- Hotels with smoking rooms in Downtown Key West
- Hotels with Waterslides in Downtown Key West
- Lgbt Friendly Hotels in Downtown Key West
- Luxury Hotels in Downtown Key West
- Pet-Friendly Hotels in Downtown Key West
- Romantic Hotels in Downtown Key West
- Scuba Diving Hotels in Downtown Key West
- Spa Hotels in Downtown Key West
- Waterpark Hotels in Downtown Key West
- Downtown Key West Hotels
- Hotels near Duval Street
- Hotels near Ernest Hemingway Home and Museum
- Hotels near Key West Butterfly and Nature Conservatory
- All Inclusive Resorts and in Key West
- Beach Hotel Hotels in Key West
- Cheap Hotels in Key West
- Key West Hotels
- Hotels near Key West Lighthouse and Keeper's Quarters Museum
- Adults Only Resorts & in Old Town Key West
- Beach Hotel Hotels in Old Town Key West
- Boutique Hotels in Old Town Key West
- Casino Hotels in Old Town Key West
- Cheap Hotels in Old Town Key West
- Family Hotels in Old Town Key West
- Historic Hotels in Old Town Key West
- Honeymoon Resorts and in Old Town Key West
- Hotels with Early Check-in in Old Town Key West
- Hotels with a Pool in Old Town Key West
- Hotels with a Lazy River in Old Town Key West
- Hotels with Bar in Old Town Key West
- Hotels with Free Airport Shuttle in Old Town Key West
- Hotels with Free Breakfast in Old Town Key West
- Hotels with Hot Tubs in Old Town Key West
- Hotels with Kitchenettes in Old Town Key West
- Hotels with Tennis Courts in Old Town Key West
- Lgbt Friendly Hotels in Old Town Key West
- Luxury Hotels in Old Town Key West
- Mountain Hotels in Old Town Key West
- Oceanfront Hotels in Old Town Key West
- Pet-Friendly Hotels in Old Town Key West
- Romantic Hotels in Old Town Key West
- Scuba Diving Hotels in Old Town Key West
- Shopping Hotels in Old Town Key West
- Old Town Key West Hotels
- Hotels near South Beach
- Hotels near Southernmost Point
- Visit Bahia Honda Key
- Visit Big Coppitt Key
- Visit Doctor's Arm
- Visit Big Pine Key
- Visit Big Torch Key
- Visit Boca Chica Key
- Visit Cow Key
- Visit Cudjoe Key
- Visit Dredgers Key
- Visit Duck Key
- Visit Fleming Key
- Visit Grassy Key
- Visit Bahama Village
- Visit Downtown Key West
- Visit Historic Seaport
- Visit Key West Historic District
- Key West Lighthouse and Keeper's Quarters Museum
- Visit Northside Resort
- Visit White Street Gallery District
- Key West Vacations
- Visit Key West
- Visit Little Torch Key
- Visit Lower Florida Keys
- Visit Marathon
- Visit Melody Key
- Visit No Name Key
- Visit No Name Key
- Visit Ramrod Key
- Visit Rockland Key
- South Beach
- Southernmost Point
- Visit Stock Island
- Visit Sugarloaf Key
- Visit Summerland Key
- All inclusive Vacation Packages Key West
