Distrito Santa Isabel Vacation Rentals from CA $115: Short-Term Rentals for 2026

Our top choices for Distrito Santa Isabel vacation rentals

A hotel room with a large bed, a second smaller bed, a view of a beach and pool, and a wooden ceiling.

1. Casa frente al mar - turtle cay marina

Nombre de Dios

CA $880 total

includes taxes & fees

Nov 15 - Nov 16

A covered outdoor dining area with a view of the beach and palm trees.

2. Caribbean getaway: beach cottage just on the sand

Palenque

Mirelys

CA $446 total

includes taxes & fees

Oct 29 - Oct 30

Two beige tents set up on a grassy area with palm trees in the background.

3. san blas luxury tour

Nusatupo

CA $171 total

includes taxes & fees

Oct 31 - Nov 1

A modern house with a covered patio, a lawn, and a view of the surrounding landscape.

4. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Puerto Lindo

CA $360 total

includes taxes & fees

Oct 29 - Oct 30

A modern cabin with a sloped roof, surrounded by trees, and a gravel path leading to the entrance.

5. Tiny Cabin

Panamá

CA $206 total

includes taxes & fees

Nov 12 - Nov 13

Overwater bungalows with thatched roofs and wooden railings, connected by a concrete walkway over clear water.

6. San Blas Private Oceanfront Cabin

Narganá

CA $539 total

includes taxes & fees

Oct 31 - Nov 1

A room with two wooden beds, a wooden chair, and a bamboo wall.

7. San Blas Tour Aridub

Narganá

CA $335 total

includes taxes & fees

Nov 12 - Nov 13

A modern hotel room with a balcony overlooking a pool and the ocean.

8. Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

Maria Chiquita

Will

CA $229 total

includes taxes & fees

Oct 29 - Oct 30

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Top Distrito Santa Isabel Hotel Reviews

B&B Lodgings

10/10 Excellent

"I had a wonderful experience staying at this hotel! Although it is a small hotel, the hospitality and personal attention were exceptional. The owner was absolutely amazing, welcoming, and attentive to every detail. The place was very clean, and I felt genuinely cared for throughout my stay. What impressed me the most was how thoughtful and helpful the owner was. They contacted me through WhatsApp to make sure I arrived at the correct location, offered to pick me up and drop me off, and even waited for me at the door. That level of kindness and hospitality truly made a difference and made me feel safe and welcome. I highly recommend this hotel to anyone looking for a clean, comfortable place with outstanding personal service. Sometimes, the smallest hotels offer the biggest hearts, and this place is a perfect example. I would absolutely stay here again!"

Caribbean Haven Of Nature 'Preci Beach'

10/10 Excellent

"This is a great place to slow down and enjoy the sea and on-site amenities, including a pool, hot tub, sand volleyball court, and kid-friendly play spaces. This is very much a home that the owners make available to guests. Cone, the on-site custodian, is available and helpful. It is somewhat remote and while getting there is a bit of a challenge, once there, the serene and peaceful setting allows you to really unwind. At no time, was safety a concern for any of us. If you are looking for a pristine, sterile location this may not be for you, but if you want to feel welcomed into someone’s beach house in a magnificent setting, this place is excellent."

Ranchos de Chalia

8/10 Good

"The hotel is a sleepy bed breakfast located close to the coast next to a tiny village. The property is older it could do a facelift. The single rooms are small, but functional. The air condition worked great. The pool was a big plus .The staff was very helpful and accommodating. My biggest concern was lack of communication when we tried via Expedia to get more information about directions and check-in. However, it worked ok in the end."

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent

"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "

Find out more about Distrito Santa Isabel

Everything you need to know about Distrito Santa Isabel vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Distrito Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Distrito Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Distrito Santa Isabel vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Distrito Santa Isabel. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Distrito Santa Isabel vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Distrito Santa Isabel vacation rentals we have selected for you start as low as CA $115 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Distrito Santa Isabel rentals

At Expedia, we put the best Distrito Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Distrito Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Distrito Santa Isabel vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Distrito Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Our top choices for Distrito Santa Isabel vacation rentals

1. Casa frente al mar - turtle cay marina

2. Caribbean getaway: beach cottage just on the sand

3. san blas luxury tour

4. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

5. Tiny Cabin

6. San Blas Private Oceanfront Cabin

7. San Blas Tour Aridub

8. Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

9. Cozy Cabin in the Misty Mountain

10. Private Over-Water Cabins on San Blas Island

11. A cozy and safe neighborhood near the airport

12. Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

13. Your country home, Menus de la Montaña, awaits you

14. BEAUTIFUL APARTMENT RIGHT BY THE OCEAN

15. La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

16. Hummingbird House/Casa de Colibri

Find vacation rentals that suit your style

Top Distrito Santa Isabel Hotel Reviews

B&B Lodgings

Caribbean Haven Of Nature 'Preci Beach'

Ranchos de Chalia

Ciel y Miel

Caribbean getaway: beach cottage just on the sand

Private Ocean-Front Cabin with private bathroom on San Blas Island

Konsenda San Blas

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Find out more about Distrito Santa Isabel