Title: Seneca Villas from CA $2,629 | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Search Seneca Villa Rentals from CA $2,629 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-05&endDate=2025-12-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-01-02&endDate=2026-01-04&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-01-30&endDate=2026-02-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Seneca Villas ![Exterior](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/2766306d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/f2c1860f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/96d7fead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/5c2269e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Southern Elegance near Downtown Pickens Pickens CA $1,513 CA $2,629 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Pickens-Hotels-Grand-Southern-Elegance-Near-Downtown-Pickens.h91908503.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27®ionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![Lakeside Lodge Clemson](//images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Always a solid choice at a great rate. " [](https://expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!](//images.trvl-media.com/lodging/102000000/101790000/101785400/101785318/5553129d_y.jpg) ### Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy! 10/10 Excellent "The cabin is in a very private area. Great place to relax. At the end of a cove so very safe to play in the water. No boats flying by. The provided paddleboards and kayaks were perfect. Definitely a house we will be renting again very soon" [](https://expedia.ca/Seneca-Hotels-Lakefront-Cabin-On-Lake-Keowee-Kayaks.h101785318.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Staff were friendly and helpful. Room was clean. Parking easy and plentiful. Would definitely go back there if visiting the area again!! Loved the steak, eggs and biscuit breakfast on Sunday morning!!" [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Tru by Hilton Seneca Clemson](//images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Clean room, staff was great, will always stay at this hotel in Clemson. Best place to stay!" [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Postcard Cabins Lake Hartwell](//images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/296ab501_y.jpg) ### Postcard Cabins Lake Hartwell 10/10 Excellent "Beautiful, peaceful setting. The staff returned texts almost immediately with suggestions for fishing and promptly got us more towels. No complaints....we would definitely stay again. " [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. ](//images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/be98782f_y.jpg) ### 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. 10/10 Excellent "Plenty of space for whole family ( all seniors). Beautiful view. Everything you need for your stay. Jim and Gail made check in a breeze. Rent yourself a boat and explore the lake! Or just relax on the deck. Took a trip to the lost sea in Tennessee. Perfect lake house!" [](https://expedia.ca/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information) ![Best Western Seneca-Clemson](//images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0_y.jpg) ### Best Western Seneca-Clemson 10/10 Excellent "We had a nice stay. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Large family home with dock on Lake Keowee! ](//images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/816aa8b2_y.jpg) ### Large family home with dock on Lake Keowee! 10/10 Excellent "Very good experience. Very nice property. Owner very responsive. " [](https://expedia.ca/Seneca-Hotels-Large-Family-Home-With-Dock-On-Lake-Keowee.h33743502.Hotel-Information) ![Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub](//images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/6343a107_y.jpg) ### Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub 10/10 Excellent "Beautiful home with beautiful view of the lake." [](https://expedia.ca/Seneca-Hotels-Beautiful-Waterfront-Home-On-A-Private-Cove-In-Lake-Keowee-W-Hot-Tub.h61640625.Hotel-Information) ## Find out more about Seneca ## Seneca Villas information | Number of reviews | | | --- | --- | | Accommodation | 9 Villas | | Lowest Price | CA $2,629 | | Highest Price | CA $2,629 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Central](https://www.expedia.ca/Central-Hotels-Boutique-Hotel.0-0-d10503-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Central](https://www.expedia.ca/Central-Hotels-Business-Hotel.0-0-d10503-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central](https://www.expedia.ca/Central-Hotels-Golf-Hotel.0-0-d10503-tGolfHotel.Travel-Guide-Filter-Hotels) - 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