Title: Seneca Villas from CA $2,706 | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [May 22 - May 24](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jun 19 - Jun 21](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca villas ![Exterior](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/5efbc53f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining tables](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/b71e7956.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/96d7fead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/92000000/91910000/91908600/91908503/5c2269e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Southern Elegance near Downtown Pickens [](https://www.expedia.ca/Pickens-Hotels-Grand-Southern-Elegance-Near-Downtown-Pickens.h91908503.Hotel-Information) Pickens CA $1,596 CA $2,706 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Pickens-Hotels-Grand-Southern-Elegance-Near-Downtown-Pickens.h91908503.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-15&endDate=2026-03-16®ionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AA_SPRING_PROMO_6548) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=CABIN) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=COTTAGE) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=VACATION_HOME) Apartments [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=APARTMENT) Condos [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=CONDO) Aparthotels [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=APART_HOTEL) Villas [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=VILLA) Houseboats [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=HOUSE_BOAT) Chalets [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-30&d1=2026-05-30&endDate=2026-06-02&d2=2026-06-02&lodging=CHALET) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Great having a washer and dry available and the breakfast staff was amazing and very nice." [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Fairfield Inn & Suites Seneca Clemson Univ Area ](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894_y.jpg) ### Fairfield Inn & Suites Seneca Clemson Univ Area 10/10 Excellent "Very good " [](https://expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Clean room, great service!" [](https://expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "it smelled good and it was clean " [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "All great" [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Always clean and friendly! " [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![New to VRBO! Big water views, private dock, pool table, 15 min Clemson!](https://images.trvl-media.com/lodging/58000000/57950000/57941100/57941024/fbdc7d33_y.jpg) ### New to VRBO! Big water views, private dock, pool table, 15 min Clemson! 10/10 Excellent "Fabulous house - big water views!New home - beautiful bathrooms & kitchen.Well equipped kitchen - lots of space - wonderful outdoor lounge areas.Host very helpful.Will definitely book a return visit!" [](https://expedia.ca/Anderson-Hotels-Large.h57941024.Hotel-Information) ![Perfect Lake Hartwell Getaway - Gorgeous Lake Views!](https://images.trvl-media.com/lodging/38000000/37750000/37749500/37749425/391b1689_y.jpg) ### Perfect Lake Hartwell Getaway - Gorgeous Lake Views! 10/10 Excellent "Host was very responsive. House was clean. Would stay here again. " [](https://expedia.ca/Anderson-Hotels-Perfect-Lake-Hartwell-Getaway-Gorgeous-Lake-Views.h37749425.Hotel-Information) ![Best Western Seneca-Clemson](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0_y.jpg) ### Best Western Seneca-Clemson 10/10 Excellent "Customer Service is always great. Always have a good variety of breakfast. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ## Find out more about Seneca ## Seneca Villas information | Number of reviews | | | ----------------- | --------- | | Accommodation | 9 Villas | | Lowest Price | CA $2,706 | | Highest Price | CA $2,706 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central ](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central ](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Central ](https://www.expedia.ca/Central-Hotels-Boutique-Hotel.0-0-d10503-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Central ](https://www.expedia.ca/Central-Hotels-Business-Hotel.0-0-d10503-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central ](https://www.expedia.ca/Central-Hotels-Golf-Hotel.0-0-d10503-tGolfHotel.Travel-Guide-Filter-Hotels) - 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