Title: Book the Best Seneca LUXURY Hotels - Upscale Hotels in Seneca, SC | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Find luxury hotels in Seneca, SC ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Luxury Hotels Tonight [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-09-29&endDate=2025-09-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 30 - Oct 1](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-09-30&endDate=2025-10-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-10&endDate=2025-10-12&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca Luxury Hotels ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/347fe1fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/3c50d204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/270-2efd6ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 Downtown 8.0/10 Very good (644) "Staff was friendly very clean " CA $105 CA $129 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-13&endDate=2025-10-14®ionId=6548&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Seneca Hotel Reviews ![Quality Inn Seneca Clemson Area US-123](//images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Staff was friendly very clean " [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury holiday in Seneca? > Expedia can help you get a flight to Greenville-Spartanburg Intl. Airport (GSP) airport, and then you can select from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to get what you want to make your stay special. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that Seneca offers. While you're visiting, you might want to think about enjoying the sporting events and university, which Seneca is known for. ### When can I expect good weather in Seneca? > Planning for the weather is an important factor for making your trip to Seneca a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches. ### What's there to see and do in Seneca? > Enjoy all that Seneca has to offer and visit Keowee Reservoir, Lake Keowee, and Keowee Key Golf Course. 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