Downtown

Seneca

Boat Ride on Lake Hartwell
Sunset along the shoreline of Lake Keowee, SC.

Stay near popular Downtown attractions

The Gauntlet

You can enjoy a show at The Gauntlet during your stay in Seneca.
See properties

Downtown Hotel Deals

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
The price is CA $118 per night from Jun 21 to Jun 22
CA $118
CA $139 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (713 reviews)
"Room was easy access to the parking bathroom was accessible for person with limited walking ability staff was very friendly and helpful the pool was not open"

Reviewed on Jun 9, 2026

Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd Anderson SC
The price is CA $92 per night from Jul 13 to Jul 14
CA $92
CA $102 total
Jul 13 - Jul 14
includes taxes & fees
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,017 reviews)
"The room was clean… but very musky smelling. Not like the pictures. Okay for the price."

Reviewed on Jun 13, 2026

Days Inn by Wyndham Anderson
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
The price is CA $198 per night from Jun 16 to Jun 17
CA $198
CA $220 total
Jun 16 - Jun 17
includes taxes & fees
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9.8/10 Exceptional! (816 reviews)
"Staff was very friendly and helpful."

Reviewed on Jun 11, 2026

The Shepherd Hotel Downtown Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
The price is CA $133 per night from Jun 16 to Jun 17
CA $133
CA $148 total
Jun 16 - Jun 17
includes taxes & fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,005 reviews)
"Some of the security lights were out."

Reviewed on Jun 13, 2026

Best Western Plus Clemson Hotel & Conference Center
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
The price is CA $152 per night from Jul 10 to Jul 11
CA $152
CA $189 total
Jul 10 - Jul 11
includes taxes & fees
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,013 reviews)
"Pool was great, close to town. Room was well stocked with kitchen stuff. Loved the gym as well. One of the front desk employees was not very nice to a guest coming in. Room wasn't ready and he wasn't happy. She told him she couldn't help that staff had called in sick and they were short staffed. ..."

Reviewed on Jun 11, 2026

Lakeside Lodge Clemson
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd Clemson SC
The price is CA $124 per night from Jun 14 to Jun 15
CA $124
CA $138 total
Jun 14 - Jun 15
includes taxes & fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,008 reviews)
"While the rooms were fine, we found an outdated bath/shower area and also TV as well. The beds and linens were comfortable and nice, but this is just an older hotel."

Reviewed on Jun 11, 2026

Inn @ Clemson
See all 1,335 properties in Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown

Find the best Downtown areas and neighborhoods for the activities you enjoy most. Learn more about Downtown
Learn more about Downtown

Serenity Bay

Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
Female Kayaker on Lake Keowee at Sunset

Pine Ridge Point

While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby.

Indian Oaks

While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like The Gauntlet and Seneca Historic District.

Keowee Plantation

When in Keowee Plantation, you can plan a visit to The Gauntlet and Seneca Historic District, some noteworthy sights in the nearby area.

Downtown

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