Guest Houses in Santa Fe
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Our top choices for Santa Fe guest houses

An outdoor patio with a grill, a fire pit, and wooden chairs.

A bar area with a wooden counter, multiple stools, and a sign reading "SWAMP HEAD INDEPENDENTLY FLORIDA".

A two-story house with a gabled roof, a front porch with a bench, and a string of lights.

A kitchen with a wooden countertop, a coffee maker, and a sink.

1. Walk to UF! Historic King Bed Loft w/ Private Deck

Walk to UF! Historic King Bed Loft w/ Private Deck

Gainesville

10.0 out of 10, Exceptional, (33 reviews)

10/10

Exceptional

(33 reviews)

"Amazing little place! It was very clean and a short walk to campus and Mid Town. Will stay again. "

Crystal F.

The price is CA $112

CA $112

CA $293 total

includes taxes & fees

Nov 18 - Nov 19

Walk to UF! Historic King Bed Loft w/ Private Deck

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Top reviews in Santa Fe

A hotel with a covered entrance, stone facade, and blue lighting accents.

A buffet with various food items, including omelets and baked goods, displayed in stainless steel containers.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

A hotel lobby with a reception desk, seating area, and a large window.

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

10/10 Excellent

Every thing was up to a Holiday Inn Express Standard until construction started in my hallway outside my door at 7:30 am. Stopped after a few minutes and started again at 8:30. We run businesses and don’t really understand this thinking… the hotel was not full. Why would you not re-carpet one floor at a time and put all guests on the other floors. Anyways… everything else was fine ! In a week or so when the Reno’s are done it should be back to normal 👍 A little farther from the highway,...

Charmaine

Reviewed January 21, 2025Reviewed January 21, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

A conference room with a long table, chairs, a projector screen, and a large window.

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

Hampton Inn & Suites Alachua I-75

Alachua

10/10 Excellent

Excellent

Long

Reviewed January 26, 2026Reviewed January 26, 2026

Hampton Inn & Suites Alachua I-75

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

Best Western Gateway Grand

Gainesville

10/10 Excellent

Awesome place, clean with friendly staff.

Herman

Reviewed July 18, 2026Reviewed July 18, 2026

Best Western Gateway Grand

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

A hotel room with a large window offering a view of a cityscape, a blue armchair, and a small table with a lamp.

Drury Inn & Suites Gainesville

Gainesville

10/10 Excellent

Spacious rooms, accommodating staff, free parking

Bilal

Reviewed October 5, 2026Reviewed October 5, 2026

Drury Inn & Suites Gainesville

An outdoor patio with stone walls, a wooden ceiling, and a built-in grill station.

A swimming pool with lounge chairs and a gazebo, surrounded by palm trees and a building with a stone facade.

A Holiday Inn Express building with a covered entrance, multiple floors, and a parking lot.

A modern indoor seating area with tables and chairs, a large pillar, and a television screen on the wall.

Holiday Inn Express & Suites Gainesville I-75 by IHG

Gainesville

10/10 Excellent

Great property the building was clean

Trevor

Reviewed February 18, 2026Reviewed February 18, 2026

Holiday Inn Express & Suites Gainesville I-75 by IHG

A hotel room with a bed, bedside tables, a TV, a window with curtains, and a wall with artwork.

A hotel lobby with a reception desk, seating area, and a glass display case with souvenirs.

A Sleep Inn & Suites hotel with a modern entrance, parking lot, and a clear sky.

A reception area with a green wall, a coffee machine, and a sign that reads 'Dream Cup'.

Sleep Inn & Suites University/Shands

Gainesville

10/10 Excellent

Always a great stay. Has become my go to spot for overnights in Gainesville. The staff are always welcoming and helpful, rooms are clean and have everything needed, the breakfast is hot and fresh with plenty of choices for everyone. Excited for the warmer months so we can swim in the pool again! Awesome as always.

Maureen

Reviewed December 14, 2025Reviewed December 14, 2025

Sleep Inn & Suites University/Shands

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

A living room with a curved sofa, a wooden cabinet, and a fish tank.

A hotel room with a patterned carpet, a sofa, a small table, a lamp, and a door with a notice.

A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.

Best Western Waldo Inn and Suites

Waldo

10/10 Excellent

Staff Jessica was wonderful!

Leslie

Reviewed November 13, 2025Reviewed November 13, 2025

Best Western Waldo Inn and Suites

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

A modern hotel lobby with a round table featuring two drinks, a sofa, and a colorful wall art piece.

A spacious lobby with modern furniture, large windows, and a colorful abstract wall.

A modern bar area with a marble countertop, bar stools, and pendant lighting.

Hyatt Place Gainesville Downtown

Downtown Gainesville

10/10 Excellent

Great location to the downtown area.

Adam

Reviewed March 24, 2025Reviewed March 24, 2025

Hyatt Place Gainesville Downtown

A large, two-story house with a porch, multiple windows, and a chimney.

A garden with a stone fountain, a gazebo, and a winding brick path.

A grand staircase with ornate carpet, a cozy sitting area with a sofa and chairs, and a large window with a view.

A cozy living room with a Christmas tree, a fireplace with stockings, and a view through a window.

Sweetwater Branch Inn

Gainesville

10/10 Excellent

Very nice environment. Great service. Excellent breakfast. Liked the history behind the property too.

Suresh

Reviewed November 18, 2025Reviewed November 18, 2025

Sweetwater Branch Inn

A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

A modern hotel lobby with a reception desk, seating area with chairs and ottomans, a large artwork, and a corridor leading to other rooms.

A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.

A fire pit area surrounded by stone tiles, with a metal fence in the background.

Comfort Suites Gainesville near University

Gainesville

10/10 Excellent

Staff really helpful

Reviewed November 2, 2026Reviewed November 2, 2026

Comfort Suites Gainesville near University

A modern bar area with a long counter, green bar stools, and a television displaying a golf game.

A modern kitchen with a central island, bar stools, pendant lighting, and a dining area with a sofa and chairs.

A modern hotel room with a large bed, a desk, a chair, and a TV mounted on the wall.

A Fairfield Inn & Suites Marriott hotel with a modern entrance, multiple floors, and a parking lot.

Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

10/10 Excellent

Very nice. Clean. Nice pool. Quiet

Julie

Reviewed March 12, 2026Reviewed March 12, 2026

Fairfield Inn & Suites by Marriott Gainesville I-75

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Search Guest Houses in Santa Fe from CA $111

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Santa Fe guest houses

1. Walk to UF! Historic King Bed Loft w/ Private Deck

Top reviews in Santa Fe

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

Explore a world of travel with Expedia