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Our top choices for Santa Fe hotels

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.
A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.
A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.
A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Alachua
United States
Tobias
CA $150
CA $169 total
includes taxes & fees
Oct 5 - Oct 6
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
A modern kitchen area with a central counter, various food stations, and a chalkboard menu.
A reception desk with a "Welcome to the Sun Shine State" sign, a "Treats" sign, and a minibar area with a "Hilton" sign.

2. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
Alachua
United States
Pamela
CA $150
CA $168 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn & Suites Alachua I-75
A large, multi-story hotel with a central courtyard, palm trees, and an American flag.
A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.
A spacious lobby with a large painting, a fireplace, a piano, and multiple seating areas.
A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

3. Best Western Gateway Grand

Best Western Gateway Grand
Gainesville
United States
Jason
CA $131
CA $147 total
includes taxes & fees
Sep 28 - Sep 29
Best Western Gateway Grand
A fitness center with treadmills, exercise bikes, and weights.
A modern hotel room with a large bed, a desk, a chair, a TV, and a mural of a landscape.
A swimming pool with a clear blue water surface, surrounded by a brick deck and a metal fence.
A motel with a covered entrance, multiple parking spaces, and a fire extinguisher on the wall.

4. Clarion Pointe Alachua - Gainesville Area

Clarion Pointe Alachua - Gainesville Area
Alachua
United States
María Teresa
CA $85
CA $103 total
includes taxes & fees
Oct 18 - Oct 19
Clarion Pointe Alachua - Gainesville Area
A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.
A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.
A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.
A swimming pool with lounge chairs and umbrellas, a covered seating area, and a multi-story building with balconies.

5. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
Alachua
United States
Deborah
CA $107
CA $121 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Alachua - Gainesville Area
A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.
A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.
A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.
A hotel reception area with directional signs for elevators, floor 1, pool restrooms, and business center.

6. La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville
Gainesville
United States
Elizabeth
CA $136
CA $153 total
includes taxes & fees
Sep 28 - Sep 29
La Quinta by Wyndham Gainesville
A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.
A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.
A building with a Coca-Cola vending machine, a window with a 'OPEN' sign, and a red awning.
A bathroom with a large mirror, a sink, and a towel rack.

7. Palms Garden Inn

Palms Garden Inn
Lake City
United States
Sherry
CA $89
CA $100 total
includes taxes & fees
Oct 28 - Oct 29
Palms Garden Inn
A stone water feature with cascading water, surrounded by a brick wall and greenery.
A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.
A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.
A reception desk with a modern design, a ceiling fan, and a seating area with chairs and a table.

8. BlueGem Motel

BlueGem Motel
High Springs
United States
Wesley
CA $138
CA $156 total
includes taxes & fees
Oct 4 - Oct 5
BlueGem Motel
A hotel room with two beds, a desk, a chair, and a television.
A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.
A parking lot with marked lanes and a grassy area on one side.
A bathroom with a white sink, mirror, and towel rack.

9. Royal Inn

Royal Inn
Alachua
United States
Alec
CA $102
CA $115 total
includes taxes & fees
Sep 29 - Sep 30
Royal Inn
A multi-story hotel with a central entrance, palm trees, and a clear sky.
A modern living room with a green sofa, a round coffee table, and a fireplace.
A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.
A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.

10. Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
Gainesville
United States
sherry
CA $125
CA $141 total
includes taxes & fees
Oct 4 - Oct 5
Country Inn & Suites by Radisson, Gainesville, FL
A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.
A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.
An outdoor patio with tables and chairs, a stone wall, and a view of a street with trees and buildings.
A hotel room with two beds, a TV, a desk, and a chair.

11. Holiday Inn Express Starke by IHG

Holiday Inn Express Starke by IHG
Starke
United States
Judy
CA $156
CA $173 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Starke by IHG
A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.
A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.
A small building with a green roof, a covered porch with wicker chairs, and a table.
A row of motel buildings with a fire hydrant and trees in front.

12. High Springs Country Inn

High Springs Country Inn
High Springs
United States
Luis
CA $85
CA $95 total
includes taxes & fees
Oct 4 - Oct 5
High Springs Country Inn
A swimming pool with a metal ladder, surrounded by a white fence and green chairs.
A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.
A hotel room with a patterned carpet, a sofa, a small table, a lamp, and a door with a notice.
A living room with a curved sofa, a wooden cabinet, and a fish tank.

13. Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
Waldo
United States
Ana Laura
CA $192
CA $216 total
includes taxes & fees
Oct 5 - Oct 6
Best Western Waldo Inn and Suites
A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.
A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.
A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.
A hotel room with a living area, kitchenette, and a large mirror.

14. Hampton Inn Gainesville

Hampton Inn Gainesville
Gainesville
United States
Phillip
CA $123
CA $138 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Gainesville
A hotel entrance with a covered driveway, flag poles, and a well-lit facade.
A modern dining area with a wooden table, four chairs, and a fireplace.
A spacious lobby with a reception desk, seating areas, and potted plants.
A grocery store interior with shelves stocked with snacks, beverages, and packaged goods.

15. Hilton Garden Inn Gainesville

Hilton Garden Inn Gainesville
Gainesville
United States
jose
CA $126
CA $142 total
includes taxes & fees
Sep 28 - Sep 29
Hilton Garden Inn Gainesville
A modern hotel lobby with a curved ceiling, a central seating area with a sofa and ottoman, a bar area, and a dining space with chairs and tables.
A modern hotel lobby with a breakfast bar, seating area, and a large window.
A hotel entrance with a sign reading "Springhill Suites by Marriott" and a modern building in the background.
A hotel reception area with a curved reception desk, a refrigerator stocked with beverages, and a wall with a blue abstract design.

16. SpringHill Suites by Marriott Gainesville

SpringHill Suites by Marriott Gainesville
Gainesville
United States
Robert
CA $121
CA $136 total
includes taxes & fees
Oct 1 - Oct 2
SpringHill Suites by Marriott Gainesville
A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.
A modern hotel lobby with a reception desk, seating area with chairs and ottomans, a large artwork, and a corridor leading to other rooms.
A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.
A fire pit area surrounded by stone tiles, with a metal fence in the background.

17. Comfort Suites Gainesville near University

Comfort Suites Gainesville near University
Gainesville
United States
thomas
CA $115
CA $134 total
includes taxes & fees
Oct 18 - Oct 19
Comfort Suites Gainesville near University
A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.
A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.
A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.
A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.

18. Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville
Gainesville
United States
Joan
CA $148
CA $167 total
includes taxes & fees
Oct 1 - Oct 2
Drury Inn & Suites Gainesville
A room with two beds, a TV, and a door.
A bathroom with a toilet, sink, and mirror.
A hotel room with a bed, a TV mounted on the wall, a remote control on a table, and a door leading to another room.
A covered corridor with a row of parked cars on one side and a building with blue trim on the other.

19. Soho Inn Waldo

Soho Inn Waldo
Waldo
United States
Brandie
CA $76
CA $86 total
includes taxes & fees
Sep 28 - Sep 29
Soho Inn Waldo
An outdoor patio with wicker furniture, stone walls, and a barbecue grill.
A modern dining area with a wooden table, blue upholstered chairs, and pendant lighting.
A modern hotel room with a flat-screen TV, a dining area with a table and chairs, a kitchenette, and a wardrobe with hanging space.
A modern living room with a sectional sofa, a standing lamp, a large window with sheer curtains, a flat-screen TV, and a built-in air conditioning unit.

20. TownePlace Suites by Marriott Gainesville Northwest

TownePlace Suites by Marriott Gainesville Northwest
Gainesville
United States
Tanya
CA $148
CA $167 total
includes taxes & fees
Sep 30 - Oct 1
TownePlace Suites by Marriott Gainesville Northwest
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Top Santa Fe Hotel Reviews

Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

10/10 Excellent
"Only thing I didn’t like was the breakfast vouchers that essentially cover nothing so don’t feel like you’re getting any perk all I really want you to do is go down and buy their breakfast"
John 1-night trip
Posted less than an hour ago
Hilton University of Florida Conference Center Gainesville
Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

10/10 Excellent
"Had a wonderful stay! The room was very clean!"
Suparna 4-night trip
Posted 16 hours ago
Drury Inn & Suites Gainesville
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"♥️❤️"
Jeysi 2-night trip
Posted 20 hours ago
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

10/10 Excellent
"Clean and safe good bedding good staff."
Jeff 1-night trip
Posted 1 day ago
Red Roof Inn PLUS+ Gainesville
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

8/10 Good
"Good breakfast but the trash bins by the elevators weren't cleaned out regularly and therefore smelled a bit funky."
Amanda 2-night trip
Posted 2 days ago
Comfort Suites Gainesville near University

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL
CA $85
CA $96 total
Oct 1 - Oct 2
includes taxes & fees
7.4/10 Good! (1,327 reviews)
Red Roof Inn PLUS+ Gainesville
Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL
CA $102
CA $115 total
Sep 30 - Oct 1
includes taxes & fees
Days Inn by Wyndham Gainesville University I-75
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL
CA $102
CA $115 total
Oct 4 - Oct 5
includes taxes & fees
HOM Hotel Gainesville, SureStay Collection by Best Western
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL
CA $107
CA $128 total
Oct 18 - Oct 19
includes taxes & fees
Sleep Inn & Suites University/Shands
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL
CA $108
CA $129 total
Oct 18 - Oct 19
includes taxes & fees
8.2/10 Very good! (1,100 reviews)
Comfort Inn Gainesville - University Area
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL
CA $115
CA $134 total
Oct 18 - Oct 19
includes taxes & fees
9.2/10 Wonderful! (1,504 reviews)
Comfort Suites Gainesville near University

Hotels in Santa Fe with star rating

Frequently asked questions

What's the best place for a stay in Santa Fe?
Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.
What are some of the best vacation rentals in Santa Fe?
Private Resort-Style Oasis, Pool, Lanai & Court – Backyard Paradise w/ BBQ: This vacation home rental outside of Santa Fe is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.
What is staying in Santa Fe like?
Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.
What are the top places to visit in Santa Fe?
Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.
What's the seasonal weather like in Santa Fe?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

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