Title: Book The Best Hotels in Santa Fe, FL for 2026 from CA $90 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Santa Fe](https://expedia.ca/Santa-Fe-Vacation-Rentals.d553248635975870004.Travel-Guide-VacationRentals)[Santa Fe Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Fe.d553248635975870004.Car-Rental-Guide)[Santa Fe Vacation Packages](https://expedia.ca/Santa-Fe.d553248635975870004.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Fe Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&amenities=POOL) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&lodging=APART_HOTEL) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&amenities=PETS) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&lodging=CABIN) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&lodging=APARTMENT) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&lodging=COTTAGE) Condo [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&lodging=CONDO) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Santa+Fe%2C+Florida%2C+United+States+of+America®ionId=553248635975870004&latLong=29.883575%2C-82.430391&adults=2&startDate=2026-02-22&d1=2026-02-22&endDate=2026-02-24&d2=2026-02-24&amenities=WATER_PARK) ## Check prices for these dates Tonight [Feb 8 - Feb 9](https://www.expedia.ca/Hotel-Search?regionId=553248635975870004&startDate=2026-02-08&endDate=2026-02-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 9 - Feb 10](https://www.expedia.ca/Hotel-Search?regionId=553248635975870004&startDate=2026-02-09&endDate=2026-02-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635975870004&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248635975870004&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Fe hotels ![Free daily full breakfast](https://images.trvl-media.com/lodging/91000000/90150000/90143200/90143200/baab3408.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90150000/90143200/90143200/8ccd2f93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/91000000/90150000/90143200/90143200/098782ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90150000/90143200/90143200/6efdf98c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Starke by IHG [](https://www.expedia.ca/Starke-Hotels-Holiday-Inn-Express-Starke.h90143200.Hotel-Information) Starke 9.6/10 Exceptional (478 reviews) "Fantastic place! Staff is outstanding, the rooms are super clean, and breakfast is great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim CA $144 CA $159 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Starke-Hotels-Holiday-Inn-Express-Starke.h90143200.Hotel-Information) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2390000/2384400/2384393/894b95a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible, Non Smoking (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2390000/2384400/2384393/f760ddb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2390000/2384400/2384393/5ca419d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2390000/2384400/2384393/b54c320d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Waldo Inn and Suites [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Waldo-Inn-And-Suites.h2384393.Hotel-Information) Waldo 8.8/10 Excellent (962 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy CA $139 CA $157 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Waldo-Inn-And-Suites.h2384393.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/95cd6e6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/88194727.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/d62bb37b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/fd018b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Gainesville near University [](https://www.expedia.ca/Gainesville-Hotels-Comfort-Suites-Gainesville.h54138132.Hotel-Information) Gainesville 9.2/10 Wonderful (1,226 reviews) "second stay, would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $135 CA $152 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/Gainesville-Hotels-Comfort-Suites-Gainesville.h54138132.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/e387508a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/cf87e7bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/w2878h1920x0y0-ae7e9910.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/9c03edaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Gainesville, FL [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) Gainesville 9.2/10 Wonderful (1,670 reviews) "Yes all very nice accommodations " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Louis CA $121 CA $136 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/8a6fa57c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/4d594d6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/4e0d3764.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking (Larger Room)](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/f246ff96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOM Hotel Gainesville, SureStay Collection by Best Western [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) Gainesville 8.4/10 Very good (1,816 reviews) "Awesome place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aristeo CA $118 CA $132 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/d9964af7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/c0d691ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/5e8d5ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/7954b6ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta by Wyndham Gainesville [](https://www.expedia.ca/Gainesville-Hotels-La-Quinta-By-Wyndham-Gainesville.h37760006.Hotel-Information) Gainesville 9.0/10 Wonderful (1,173 reviews) "Convenient location, great breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier CA $134 CA $151 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-La-Quinta-By-Wyndham-Gainesville.h37760006.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/0dff4e4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/19713bd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/57b6c63d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/20000000/19490000/19484600/19484503/93f8f773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Gainesville [](https://www.expedia.ca/Gainesville-Hotels-Drury-Inn-Suites-Gainesville.h19484503.Hotel-Information) Gainesville 9.6/10 Exceptional (1,378 reviews) "Great place to stay. Would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leo CA $144 CA $162 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Drury-Inn-Suites-Gainesville.h19484503.Hotel-Information) ![Standard Double Room](https://images.trvl-media.com/lodging/124000000/123750000/123741900/123741815/ab06a2ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/124000000/123750000/123741900/123741815/70c2cd09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Single Room](https://images.trvl-media.com/lodging/124000000/123750000/123741900/123741815/f4ca4c49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/124000000/123750000/123741900/123741815/ebc25a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Soho Inn Waldo [](https://www.expedia.ca/Waldo-Hotels-Soho-Inn-Waldo.h123741815.Hotel-Information) Waldo 6.4/10 (5 reviews) "Clean rooms ,checking in and out was a breeze,24 hour check in and on site Property manager.Simple Clean updated rooms with comfortable mattresses Great for a overnight stay or a weekend visit Rick the PM is a great guy and will ensure you are well situated " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Glenn CA $96 CA $108 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Waldo-Hotels-Soho-Inn-Waldo.h123741815.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/27000000/26950000/26940800/26940780/dfb2f417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/27000000/26950000/26940800/26940780/3f33ed8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/27000000/26950000/26940800/26940780/6f16a212.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/27000000/26950000/26940800/26940780/5247aa46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Indigo Gainesville-Celebration Pointe by IHG [](https://www.expedia.ca/Gainesville-Hotels-Hotel-Indigo-Gainesville-Celebration-Pointe.h26940780.Hotel-Information) Gainesville 9.0/10 Wonderful (1,002 reviews) "Excellent hotel with a beautiful and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $138 CA $157 total includes taxes & fees Mar 9 - Mar 10 [](https://www.expedia.ca/Gainesville-Hotels-Hotel-Indigo-Gainesville-Celebration-Pointe.h26940780.Hotel-Information) ![Desk, iron/ironing board, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/70ccd44a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/cba0289f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/e8bf5c2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/d8c6de93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites University/Shands [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) Gainesville 8.8/10 Excellent (1,098 reviews) "Clean room and nice staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $107 CA $128 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/26000000/25810000/25806200/25806113/207aa0de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8 AM to 10:00 PM, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/26000000/25810000/25806200/25806113/b9a96c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/26000000/25810000/25806200/25806113/6b521bb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25810000/25806200/25806113/7d23a0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Gainesville I-75 by IHG [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Gainesville-I-75.h25806113.Hotel-Information) Gainesville 9.4/10 Exceptional (1,005 reviews) "Clean room, very friendly staff, great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ena CA $183 CA $206 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Gainesville-Hotels-Holiday-Inn-Express-Suites-Gainesville-I-75.h25806113.Hotel-Information) ![Luxury Apartment, 2 Bedrooms, Lanai, Courtyard View | Private kitchen](https://images.trvl-media.com/lodging/93000000/92540000/92535400/92535326/02abb060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Design Studio Suite, 1 Queen Bed, Patio, Courtyard Area | Bathroom](https://images.trvl-media.com/lodging/93000000/92540000/92535400/92535326/39089dc4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Classic Studio, 1 Queen Bed, Kitchen, City View | Street view](https://images.trvl-media.com/lodging/93000000/92540000/92535400/92535326/72ee051a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/93000000/92540000/92535400/92535326/w997h664x0y3-a53eaa50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Depot Village [](https://www.expedia.ca/Gainesville-Hotels-Depot-Village.h92535326.Hotel-Information) Gainesville 9.6/10 Exceptional (85 reviews) "The cleanest room I have seen in years an amazing place to stay amazing people coffee shop on site perfect for a little getaway with downtown close by." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $48 CA $147 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Gainesville-Hotels-Depot-Village.h92535326.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/79000000/78550000/78547700/78547624/0d00e88d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/79000000/78550000/78547700/78547624/66c25aa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/79000000/78550000/78547700/78547624/a3709b54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/79000000/78550000/78547700/78547624/33d3a427.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Gainesville Downtown [](https://www.expedia.ca/Gainesville-Hotels-Hyatt-Place-Gainesville-Downtown.h78547624.Hotel-Information) Downtown Gainesville 9.2/10 Wonderful (1,134 reviews) "We stay here often" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frederick CA $150 CA $169 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Hyatt-Place-Gainesville-Downtown.h78547624.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/f6ecaf62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Hot Tub (Living Room;with Sofabed)](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/88146972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking, Balcony](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/db000e55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Gateway Grand [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) Gainesville 8.6/10 Excellent (1,415 reviews) "Great hotel. Would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brianne CA $128 CA $144 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1640000/1631400/1631322/6e6778e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1631400/1631322/1560249f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1640000/1631400/1631322/f7e7d47a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1640000/1631400/1631322/7d49c4d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Gainesville [](https://www.expedia.ca/Gainesville-Hotels-Hilton-Garden-Inn-Gainesville.h1631322.Hotel-Information) Gainesville 8.8/10 Excellent (1,003 reviews) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adriana CA $122 CA $138 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Hilton-Garden-Inn-Gainesville.h1631322.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/cc5c3b00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/9015d347.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/bc49fa4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn University [](https://www.expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) Gainesville 8.2/10 Very good (1,030 reviews) "Clean room, quiet, nice breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane CA $110 CA $132 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/82700/82677/5b4e3b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds (2 Rooms, Smoke Free)](https://images.trvl-media.com/lodging/1000000/90000/82700/82677/89df9492.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/90000/82700/82677/10598cf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/90000/82700/82677/0a8e44cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn PLUS+ Gainesville [](https://www.expedia.ca/Gainesville-Hotels-Red-Roof-Inn-PLUS-Gainesville.h82677.Hotel-Information) Gainesville 7.4/10 Good (1,247 reviews) "Would definitely stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $80 CA $90 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Gainesville-Hotels-Red-Roof-Inn-PLUS-Gainesville.h82677.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/1d4a6615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/35661d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/2dd8879c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Alachua I-75 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) Alachua 9.4/10 Exceptional (484 reviews) "We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5\. Will definitely stay again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Libbi CA $142 CA $160 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/13133f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/ff7eaa86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/66d2b782.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/49700/49617/d4e32e3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Gainesville [](https://www.expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) Gainesville 7.8/10 Good (1,004 reviews) "A good place to stay while traveling. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wayne CA $127 CA $143 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-DoubleTree-By-Hilton-Gainesville.h49617.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/440000/439800/439799/c37dfd5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/440000/439800/439799/1210da70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/439800/439799/1c3421f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/440000/439800/439799/5c4d5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Gainesville I-75 Hospital University Area [](https://www.expedia.ca/Gainesville-Hotels-Super-8-By-Wyndham-Gainesville.h439799.Hotel-Information) Gainesville 7.4/10 Good (1,012 reviews) "Good: Staff was very pleasant. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marianna CA $69 CA $77 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Gainesville-Hotels-Super-8-By-Wyndham-Gainesville.h439799.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23®ionId=553248635975870004&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Fe-Hotels.d553248635975870004.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Fe-Hotels.d553248635975870004.Travel-Guide-Hotels) ## Top Santa Fe Hotel Reviews ![Holiday Inn Express Starke by IHG](https://images.trvl-media.com/lodging/91000000/90150000/90143200/90143200/05f2862e_y.jpg) ### Holiday Inn Express Starke by IHG 10/10 Excellent "Clean rooms, great staff and good breakfast " [](https://expedia.ca/Starke-Hotels-Holiday-Inn-Express-Starke.h90143200.Hotel-Information) ![Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/fce767a1_y.jpg) ### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Perfect tiny house experience. Cute, clean and nice for dog walking." [](https://expedia.ca/High-Springs-Hotels-Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information) ![Country Inn & Suites by Radisson, Gainesville, FL](https://images.trvl-media.com/lodging/2000000/1290000/1289100/1289043/8584a629_y.jpg) ### Country Inn & Suites by Radisson, Gainesville, FL 10/10 Excellent "Great location. Great breakfast. Awesome staff" [](https://expedia.ca/Gainesville-Hotels-Country-Inn-Suites-By-Radisson.h1289043.Hotel-Information) ![Days Inn by Wyndham Gainesville University I-75](https://images.trvl-media.com/lodging/1000000/20000/19600/19555/d3372ae4_y.jpg) ### Days Inn by Wyndham Gainesville University I-75 10/10 Excellent "Room was very nice, comfortable bed. Refrigerator and microwave give it a homey touch and parking is easy." [](https://expedia.ca/Gainesville-Hotels-Days-Inn-By-Wyndham-Gainesville-University-I-75.h19555.Hotel-Information) ![La Quinta by Wyndham Gainesville](https://images.trvl-media.com/lodging/38000000/37770000/37760100/37760006/d9964af7_y.jpg) ### La Quinta by Wyndham Gainesville 10/10 Excellent "Room, great. Staff, excellent " [](https://expedia.ca/Gainesville-Hotels-La-Quinta-By-Wyndham-Gainesville.h37760006.Hotel-Information) ![Comfort Suites Gainesville near University](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/d62bb37b_y.jpg) ### Comfort Suites Gainesville near University 10/10 Excellent "Clean room. Did not appreciate having to go back out to my car in the cold to put a tag on my dashboard. Breakfast needs some work. " [](https://expedia.ca/Gainesville-Hotels-Comfort-Suites-Gainesville.h54138132.Hotel-Information) ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg) ### Comfort Inn University 10/10 Excellent "Room was very clean, no bad smells and everyone was super nice. If we could change one thing, it would be a softer couch!!" [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![Best Western Gateway Grand](https://images.trvl-media.com/lodging/1000000/160000/151100/151041/9a241e09_y.jpg) ### Best Western Gateway Grand 10/10 Excellent "Clean room and very friendly staff." [](https://expedia.ca/Gainesville-Hotels-Best-Western-Gateway-Grand.h151041.Hotel-Information) ![Hyatt Place Gainesville Downtown](https://images.trvl-media.com/lodging/79000000/78550000/78547700/78547624/894304b9_y.jpg) ### Hyatt Place Gainesville Downtown 10/10 Excellent "Clean spacious, conveniently located for my needs" [](https://expedia.ca/Gainesville-Hotels-Hyatt-Place-Gainesville-Downtown.h78547624.Hotel-Information) ## More cheap stays in Santa Fe ![Red Roof Inn PLUS+ Gainesville](https://images.trvl-media.com/lodging/1000000/90000/82700/82677/5b4e3b0e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Red Roof Inn PLUS+ Gainesville 3500 Southwest 42nd St Gainesville FL CA $80 CA $90 total Feb 9 - Feb 10 includes taxes & fees 7.4/10 Good! (1,245 reviews) [](https://expedia.ca/Gainesville-Hotels-Red-Roof-Inn-PLUS-Gainesville.h82677.Hotel-Information) ![Days Inn by Wyndham Gainesville University I-75](https://images.trvl-media.com/lodging/1000000/20000/19600/19555/d3372ae4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Gainesville University I-75 920 Nw 69th Ter Gainesville FL CA $87 CA $98 total Feb 11 - Feb 12 includes taxes & fees 5.6/10 (1,001 reviews) [](https://expedia.ca/Gainesville-Hotels-Days-Inn-By-Wyndham-Gainesville-University-I-75.h19555.Hotel-Information) ![Sleep Inn & Suites University/Shands](https://images.trvl-media.com/lodging/2000000/1940000/1932400/1932346/3c8617a9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn & Suites University/Shands 4110 SW 40th Boulevard Gainesville FL CA $107 CA $128 total Feb 15 - Feb 16 includes taxes & fees 8.6/10 Excellent! (1,094 reviews) [](https://expedia.ca/Gainesville-Hotels-Sleep-Inn-Suites-UniversityShands.h1932346.Hotel-Information) ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/800000/793600/793525/78ca2e85_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn University 3440 SW 40th Blvd Gainesville FL CA $110 CA $132 total Feb 15 - Feb 16 includes taxes & fees 8.2/10 Very Good! (1,028 reviews) [](https://expedia.ca/Gainesville-Hotels-Comfort-Inn-University.h793525.Hotel-Information) ![HOM Hotel Gainesville, SureStay Collection by Best Western](https://images.trvl-media.com/lodging/1000000/210000/200800/200755/07c3ba53_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOM Hotel Gainesville, SureStay Collection by Best Western 3905 Sw 43Rd St Gainesville FL CA $118 CA $132 total Feb 15 - Feb 16 includes taxes & fees 8.4/10 Very Good! (1,812 reviews) [](https://expedia.ca/Gainesville-Hotels-HOM-Hotel-Gainesville.h200755.Hotel-Information) ![Comfort Suites Gainesville near University](https://images.trvl-media.com/lodging/55000000/54140000/54138200/54138132/d62bb37b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites Gainesville near University 2603 SW 13TH STREET Gainesville FL CA $135 CA $152 total Feb 11 - Feb 12 includes taxes & fees 9/10 Wonderful! (1,225 reviews) [](https://expedia.ca/Gainesville-Hotels-Comfort-Suites-Gainesville.h54138132.Hotel-Information) ## Hotels in Santa Fe with star rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 3 properties [](https://expedia.ca/4Star-Santa-Fe-Hotels.s40-0-d553248635975870004.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 60 properties [](https://expedia.ca/3Star-Santa-Fe-Hotels.s30-0-d553248635975870004.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 119 properties [](https://expedia.ca/2Star-Santa-Fe-Hotels.s20-0-d553248635975870004.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What's the best place for a stay in Santa Fe? ### What are some of the best vacation rentals in Santa Fe? ### If I need to cancel my hotel reservation in Santa Fe, will I receive a refund? ### What is staying in Santa Fe like? ### What are the top places to visit in Santa Fe? ### What's the seasonal weather like in Santa Fe? ## Explore a world of travel with Expedia - 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