10 Best Hotels in Penrose, St. Louis for 2026

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Our top choices for Penrose hotels

A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

1. The West End

Central West End, 4.2 km from Penrose

Trevor

CA $144 total

includes taxes & fees

Nov 9 - Nov 10

2. Pear Tree Inn St. Louis Near Union Station

Downtown West, 5.8 km from Penrose

Samuwel

CA $172 total

includes taxes & fees

Nov 15 - Nov 16

A spacious indoor area with multiple dining tables and chairs, a fireplace, and a large artwork on the wall.

3. Hilton Garden Inn St. Louis Airport

8.6 km from Penrose

Sorrell

CA $169 total

includes taxes & fees

Nov 27 - Nov 28

An outdoor patio area with tables and chairs, string lights, and umbrellas.

4. Hotel Indigo St Louis - Central West End by IHG

Central West End, 4.3 km from Penrose

Gordon

CA $224 total

includes taxes & fees

Nov 22 - Nov 23

An indoor pool area with a hot tub, seating, and a stone wall.

5. Drury Plaza Hotel St. Louis Union Station

Downtown West, 6.1 km from Penrose

gina

CA $190 total

includes taxes & fees

Nov 15 - Nov 16

A modern living room with a fireplace, sofas, a coffee table, and a bookshelf.

6. AC Hotel St. Louis Central West End

Central West End, 4.3 km from Penrose

Janice

CA $239 total

includes taxes & fees

Nov 12 - Nov 13

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

7. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 6.5 km from Penrose

Edmond

CA $217 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a chair, a desk, and a large window.

8. Forest Park Hotel by MDR

The Hill, 7.8 km from Penrose

Kevan

CA $130 total

includes taxes & fees

Dec 8 - Dec 9

A modern lobby with a staircase, seating area, and wall-mounted artwork.

9. Moonrise Hotel

5.8 km from Penrose

Rebecca

CA $254 total

includes taxes & fees

Dec 1 - Dec 2

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

10. Comfort Inn & Suites Saint Louis Lafayette Square

The Gate, 7.1 km from Penrose

greg

CA $181 total

includes taxes & fees

Nov 29 - Nov 30

An outdoor dining area with a glass table and chairs, a neon sign, and a city view.

11. Aloft by Marriott St Louis Central West End

Central West End, 4.8 km from Penrose

Brittany

CA $188 total

includes taxes & fees

Nov 15 - Nov 16

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

12. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4.4 km from Penrose

Stephanie

CA $172 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio with a fire pit, seating, and a building in the background.

13. Courtyard by Marriott St. Louis Brentwood

9.9 km from Penrose

Anna

CA $204 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

14. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 5.5 km from Penrose

Ruth

CA $237 total

includes taxes & fees

Dec 6 - Dec 7

15. Drury Inn & Suites St. Louis Forest Park

8 km from Penrose

Tammy

CA $223 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a desk, a chair, and a television.

16. Clayton Plaza Hotel & Extended Stay

9.1 km from Penrose

Martha

CA $172 total

includes taxes & fees

Dec 6 - Dec 7

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

17. Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 7.3 km from Penrose

Tracy

CA $187 total

includes taxes & fees

Nov 27 - Nov 28

An outdoor patio area with seating, planters, and a grill.

18. Element by Marriott St. Louis Midtown

Midtown, 4.8 km from Penrose

Julie

CA $236 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel room with a large bed, a desk with a chair, a blue armchair, a sofa, a TV, and a large window offering a city view.

19. DoubleTree by Hilton St. Louis Forest Park

Central West End, 4.8 km from Penrose

Ronnie

CA $248 total

includes taxes & fees

Nov 15 - Nov 16

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

20. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 4.4 km from Penrose

Sara

CA $290 total

includes taxes & fees

Nov 22 - Nov 23

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Compare popular hotels in Penrose

Property	Star rating	Guest rating
The West End	2.0 star property	8.6 Excellent 709 reviews	View
Drury Plaza Hotel St. Louis Union Station	3.0 star property	9.4 Exceptional 1,611 reviews	View
Hampton Inn & Suites St. Louis at Forest Park	3.5 star property	9.4 Exceptional 1,002 reviews	View
Moonrise Hotel	4.0 star property	9.0 Wonderful 2,053 reviews	View
Pear Tree Inn St. Louis Near Union Station	3.0 star property	8.8 Excellent 2,282 reviews	View

Where to stay in Penrose

Find the best Penrose areas and neighborhoods for the activities you enjoy most. Learn more about Penrose

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top Penrose Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

Downtown West

10/10 Excellent

Lyle

Hampton Inn & Suites St. Louis at Forest Park

Dogtown

10/10 Excellent

Raffaele

Pear Tree Inn St. Louis Near Union Station

Downtown West

10/10 Excellent

Philip

The West End

Central West End

10/10 Excellent

Alexis Antonio

Hotel Indigo St Louis - Central West End by IHG

Central West End

10/10 Excellent

Kristina

An outdoor seating area with multiple tables and chairs, large umbrellas, and a built-in fire feature against a stone wall.

Fairfield Inn & Suites by Marriott St. Louis Downtown

Downtown West

10/10 Excellent

Belle hôtel, très propre, quand même bien situé, environ 25 minutes de marche du Busch Stadium et de l'Arche.L'option du petit déjeuner compris est quand même bien. Belle literie, par contre le lit est quand même assez dur, une meilleur qualité de matelas serais un plus.Les produits pour la douche sont super. Une option de café gratuit toutes la journées serait super. Le personnel est très gentil.

André

A rooftop terrace with rows of metal chairs and a view of city buildings.

Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

10/10 Excellent

This hotel checks all the boxes! The service and amenities are second to none for a standard fare hotel. The free, well prepared food options for supper and breakfast were great. Not to mention the three free adult drink coupons to use during supper. The pool, spa, and patio area were great for adults and kids! The room was very spacious and comfortable. We were really impressed with how fancy the room was. Bravo Drury! We will definitely stay here again in the event we are in St. Louis...

Paul

The Royal Sonesta Chase Park Plaza St. Louis

Central West End

10/10 Excellent

Excellent Hotel in a Perfect Location I had a wonderful stay at The Royal Sonesta Chase Park Plaza St. Louis. The location is excellent, especially if you need to visit Washington University or explore the Central West End. One of the best things about the hotel is that it is right across from Forest Park, a beautiful and enormous park where you can walk for a very long time and enjoy the scenery. The surrounding streets are also beautiful, clean, and pleasant to walk around. The hotel itself is...

Afsaneh

Hilton Garden Inn St. Louis Airport

Berkeley

10/10 Excellent

Anonymous traveller

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

The Knight Center at Washington University

St. Louis

10/10 Excellent

Carlos

Clayton Plaza Hotel & Extended Stay

Clayton

10/10 Excellent

Susan

Aloft by Marriott St Louis Central West End

Central West End

10/10 Excellent

Benjamin

Frequently Asked Questions

What's it like in Penrose?

Travelers are sure to enjoy a stay in St. Louis's Penrose neighborhood. Consider a visit to Julia Davis Branch Library as part of your Penrose travel plans.

If I need to cancel my hotel reservation in Penrose, will I receive a refund?

Yes! You'll find that most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then filter by "fully refundable" to view the top deals on offer in Penrose.

Where can I learn more about changing or cancelling my trip to Penrose?

For more details about changing or cancelling your trip to Penrose, head over to our customer service page.

What is there to do around this St. Louis neighborhood?

Julia Davis Branch Library is an attraction you might want to check out while you're in Penrose. Shelley House and Bellefontaine Cemetery are also worth a visit when you're out sightseeing in St. Louis.

Hotels in Penrose, St. Louis from CA $144

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Our top choices for Penrose hotels

1. The West End

2. Pear Tree Inn St. Louis Near Union Station

3. Hilton Garden Inn St. Louis Airport

4. Hotel Indigo St Louis - Central West End by IHG

5. Drury Plaza Hotel St. Louis Union Station

6. AC Hotel St. Louis Central West End

7. Hampton Inn & Suites St. Louis at Forest Park

8. Forest Park Hotel by MDR

9. Moonrise Hotel

10. Comfort Inn & Suites Saint Louis Lafayette Square

11. Aloft by Marriott St Louis Central West End

12. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

13. Courtyard by Marriott St. Louis Brentwood

14. Home2 Suites by Hilton St. Louis/Forest Park

15. Drury Inn & Suites St. Louis Forest Park

16. Clayton Plaza Hotel & Extended Stay

17. Hyatt Regency St. Louis at The Arch

18. Element by Marriott St. Louis Midtown

19. DoubleTree by Hilton St. Louis Forest Park

20. The Royal Sonesta Chase Park Plaza St. Louis

Compare popular hotels in Penrose

Where to stay in Penrose

Downtown St. Louis

Clayton

St. Charles Historic District

Central West End

Creve Coeur

Top Penrose Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

Frequently Asked Questions

What's it like in Penrose?

If I need to cancel my hotel reservation in Penrose, will I receive a refund?

Where can I learn more about changing or cancelling my trip to Penrose?

What is there to do around this St. Louis neighborhood?