Title: Pamplico Vacation Rentals from CA $269: Short-Term Rentals for 2026 | Expedia.ca

[Hotels in Pamplico](https://expedia.ca/Pamplico-Hotels.d3000353197.Travel-Guide-Hotels)[Things to do in Pamplico](https://expedia.ca/Things-To-Do-In-Pamplico.d3000353197.Travel-Guide-Activities)[Pamplico Car Rentals](https://expedia.ca/Car-Rentals-In-Pamplico.d3000353197.Car-Rental-Guide)[Pamplico Vacation Packages](https://expedia.ca/Pamplico.d3000353197.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2026-02-20&endDate=2026-02-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 1 - May 3](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[May 29 - May 31](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Pamplico vacation rentals

![1 bedroom, iron/ironing board, travel crib, free WiFi](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/e767c5d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/08dcc409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/6185225b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95030000/95026900/95026870/ba3e11be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Cottage with easy access to local attractions-pet and kid friendly

[](https://www.expedia.ca/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

Sellers

9.6/10

Exceptional

(21 reviews)

"So charming. The hostess is very accommodating and willing. We felt very welcome. All the accoutrements are tasteful. We had plenty of what we needed for our little celebration. Not too far of a skirt to Flo-town for a bite and some dessert. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin

CA $129

CA $269 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Sellers-Hotels-Charming-Cottage-With-Easy-Access-To-Local-Attractions-Pet-And-Kid-Friendly.h95026870.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/6cc0ea0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/d976ad14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, shampoo](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/bd28d6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/95000000/94800000/94795100/94795059/b91b5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful Farm Getaway

[](https://www.expedia.ca/Mullins-Hotels-Peaceful-Farm-Getaway.h94795059.Hotel-Information)

Mullins

10/10

Exceptional

(32 reviews)

"Excellent Space. Loved It."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rodney

CA $185

CA $288 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Mullins-Hotels-Peaceful-Farm-Getaway.h94795059.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/8b91a232.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/61eb4d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, video games, DVD player](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/5beed59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/34000000/33750000/33743000/33742964/a212b9c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Secret SC Cabin on 100 acres Hot Tub Large Pond

[](https://www.expedia.ca/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information)

Marion

9.6/10

Exceptional

(180 reviews)

"Our stay at Rodney’s cabin was just what we needed... Some time alone on 100 acres. Other than the peaceful sound of the waterfall trickling to the pond, Mother Nature and animals can only be heard. The cabin is equipped with everything you need to enjoy your stay as you reconnect with one another and the great outdoors. Bring whatever flavors you like and learn to cook together on a Big Green Egg that Rodney has built into his outdoor kitchen!! We relaxed in the hot tub each night and can’t...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

michael l.

CA $277

CA $640 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Marion-Hotels-Secret-SC-Cabin-On-100-Acres-Hot-Tub-Large-Pond.h33742964.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/e827b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walking distance from one of South Carolina's top Medical centers.

[](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

Florence

9.8/10

Exceptional

(42 reviews)

"Everything was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra B.

CA $183

CA $319 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/90a72a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/8f4ad967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/b4721f87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/88000000/87660000/87657300/87657259/94a0d867.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Located in Marion. Only 1 hour from Myrtle Beach, 35 minutes from Florence!

[](https://www.expedia.ca/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information)

Marion

9.0/10

Wonderful

(6 reviews)

"It was a great place. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cindy N.

CA $274

CA $814 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Marion-Hotels-Located-In-Marion-Only-1-Hour-From-Myrtle-Beach.h87657259.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/48ab0078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/d5fef904.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/35e44181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122690000/122683200/122683191/fa8515b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

[](https://www.expedia.ca/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information)

Florence

9.6/10

Exceptional

(5 reviews)

CA $293

CA $376 total

includes taxes & fees

Feb 11 - Feb 12

[](https://www.expedia.ca/Florence-Hotels-Perfect-Stop-Near-I-95.h122683191.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/f2cc1121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

[](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

Florence

10/10

Exceptional

(43 reviews)

"I would definitely stay again! Great location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaDara D.

CA $309

CA $397 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/58e89181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/835fbd1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/4f69bc8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/125000000/124500000/124497200/124497136/8a82536c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Pinecone Retreat - Only 1 mile from i95

[](https://www.expedia.ca/Latta-Hotels-The-Pinecone-Retreat-Only-1-Mile-From-I95.h124497136.Hotel-Information)

Latta

CA $142

CA $185 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Latta-Hotels-The-Pinecone-Retreat-Only-1-Mile-From-I95.h124497136.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/c3d44dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/5d047f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/d9622cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/93bab7ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

[](https://www.expedia.ca/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

Florence

8.8/10

Excellent

(3 reviews)

"Convenient location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonney W.

CA $166

CA $644 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/124000000/123310000/123306900/123306889/w1290h1030x0y1-17e1f607.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/124000000/123310000/123306900/123306889/w1288h1595x0y0-2f7e23ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123310000/123306900/123306889/w1290h1024x0y0-52d6c3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123310000/123306900/123306889/w1290h1032x0y4-988dce41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lovely upscale 3-bedroom Loft apartment downtown Marion

[](https://www.expedia.ca/Marion-Hotels-Lovely-Upscale-3-Bedroom-Loft-Apartment-Downtown-Marion.h123306889.Hotel-Information)

Marion

CA $246

CA $304 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Marion-Hotels-Lovely-Upscale-3-Bedroom-Loft-Apartment-Downtown-Marion.h123306889.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23&regionId=3000353197&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America&regionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America&regionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America&regionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=COTTAGE)

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America&regionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2026-05-09&d1=2026-05-09&endDate=2026-05-12&d2=2026-05-12&lodging=CABIN)

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## Top Pamplico Hotel Reviews

![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg)

### Howard Johnson by Wyndham Florence

10/10 Excellent

"Always clean, 3rd time staying heading South. Breakfast is sufficient for busy travelers."

[](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695_y.jpg)

### La Quinta Inn & Suites by Wyndham Florence

10/10 Excellent

"Great breakfast, friendly staff. "

[](https://expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information)

![Residence Inn Marriott Florence](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg)

### Residence Inn Marriott Florence

10/10 Excellent

"The room was large and clean. New. The breakfast was great. I've stayed at Residence Inns a few times and have always had excellent experiences."

[](https://expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information)

![Home2 Suites by Hilton Florence, SC](https://images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/25ce2409_y.jpg)

### Home2 Suites by Hilton Florence, SC

10/10 Excellent

"Everything was excellent!!"

[](https://expedia.ca/Florence-Hotels-Home2-Suites-By-Hilton-Florence.h7271220.Hotel-Information)

![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg)

### TownePlace Suites by Marriott Florence

10/10 Excellent

"Staff is great "

[](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information)

![Hampton Inn & Suites Florence Center](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg)

### Hampton Inn & Suites Florence Center

10/10 Excellent

"Friendliness of front desk staff. Breakfast host was very pleasant too. "

[](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information)

![Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31_y.jpg)

### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

10/10 Excellent

"yes"

[](https://expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information)

![Hampton Inn & Suites Florence-North-I-95](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e_y.jpg)

### Hampton Inn & Suites Florence-North-I-95

10/10 Excellent

"Yes clean rooms and very nice staff "

[](https://expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information)

![Days Inn by Wyndham Florence/I-95 North](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/b1bbd639_y.jpg)

### Days Inn by Wyndham Florence/I-95 North

10/10 Excellent

"Great room and reasonable price "

[](https://expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information)

## Find out more about Pamplico

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Pamplico. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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