Title: Book the Best BUSINESS Hotels in Mission in 2026 | Expedia.ca [Hotels in Mission](https://expedia.ca/Mission-Hotels.d8743.Travel-Guide-Hotels)[Vacation Rentals in Mission](https://expedia.ca/Mission-Vacation-Rentals.d8743.Travel-Guide-VacationRentals)[Flights to Mission](https://expedia.ca/Cheap-Flights-To-Mission.d8743.Travel-Guide-Flights)[Mission Car Rentals](https://expedia.ca/Car-Rentals-In-Mission.d8743.Car-Rental-Guide)[Mission Vacation Packages](https://expedia.ca/Mission.d8743.Destination-Travel-Guides) ![Mission San Jose, San Antonio. San Antonio Missions National His](https://images.trvl-media.com/place/8743/82f5b89c-948f-48b1-adba-6838569194f3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Mission, TX from CA $93 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Business Hotels Tonight [Dec 26 - Dec 27](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 27 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2025-12-27&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Mission business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/6657c061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/01f48f12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/64aacab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible, Family)](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/bda949e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Mission at West McAllen [](https://www.expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) Mission 8.4/10 Very good (1003) "A good place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Francisco Donaciano CA $121 CA $137 total includes taxes & fees Jan 3 - Jan 4, 2026 [](https://www.expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/42d7cb05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![King studio suite](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/4fd1ce30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/f90e7132.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/1cbaa4ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Mission [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) Mission 8.8/10 Excellent (1001) "The breakfast was very delicious! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rafael CA $128 CA $145 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/f96b3571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/383826f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/d95d0e40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/de7e6509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Mission-McAllen Area by IHG [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Hotel-Suites-Mission-McAllen-Area.h892242.Hotel-Information) Mission 8.8/10 Excellent (1008) "Huge room and clean and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Normalee CA $141 CA $159 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Hotel-Suites-Mission-McAllen-Area.h892242.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/5ed5dec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/4806fab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, bed sheets](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/8e473d4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/860cfda5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel By Best Western Mission [](https://www.expedia.ca/McAllen-Hotels-SureStay-Hotel-By-Best-Western-Mission.h574470.Hotel-Information) Mission 8.0/10 Very good (689) "Spacious rooms! Hot showers! Awesome for what we needed" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Farah CA $82 CA $93 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/McAllen-Hotels-SureStay-Hotel-By-Best-Western-Mission.h574470.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/63000000/62990000/62988000/62987930/27ea9f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/63000000/62990000/62988000/62987930/e79a40bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room](https://images.trvl-media.com/lodging/63000000/62990000/62988000/62987930/c2fdb43c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/63000000/62990000/62988000/62987930/e85e21ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Shary Inn and Suites [](https://www.expedia.ca/Mission-Hotels-Shary-Inn-And-Suites.h62987930.Hotel-Information) Mission 8.4/10 Very good (1042) "Yes it was great. Been staying there for the past 15 years when I see my doctors." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan CA $98 CA $111 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Mission-Hotels-Shary-Inn-And-Suites.h62987930.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/104000000/103100000/103095400/103095324/b3dcce5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103100000/103095400/103095324/12830857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/104000000/103100000/103095400/103095324/2999f9d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/104000000/103100000/103095400/103095324/1f0c2e4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Hotel McAllen [](https://www.expedia.ca/McAllen-Hotels-Aloft-Mcallen.h103095324.Hotel-Information) McAllen 9.2/10 Wonderful (436) "The staff was friendly and the amenities were good, especially the pool table in the lobby." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donald CA $141 CA $162 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/McAllen-Hotels-Aloft-Mcallen.h103095324.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/425ff266.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/5ef2cdbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/69f21fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/b2ddf1f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Rio Grand by IHG [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Suites-Rio-Grand.h1418675.Hotel-Information) Rio Grande City 9.0/10 Wonderful (341) "The room was clean and the bed was comfortable. Staff was friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vilma CA $153 CA $189 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Suites-Rio-Grand.h1418675.Hotel-Information) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/482d6a89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/53956f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/9bb8623e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/d64dc8ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Rio Grande City [](https://www.expedia.ca/McAllen-Hotels-Quality-Inn-Suites.h883669.Hotel-Information) Rio Grande City 8.0/10 Very good (372) "Clean rooms, awesome staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karina CA $127 CA $143 total includes taxes & fees Jan 8 - Jan 9, 2026 [](https://www.expedia.ca/McAllen-Hotels-Quality-Inn-Suites.h883669.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/570000/564000/563985/2ee3e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/564000/563985/d4745a24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/570000/564000/563985/42a1d056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/570000/564000/563985/7cecf449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Town Center Inn [](https://www.expedia.ca/McAllen-Hotels-Best-Western-Town-Center-Inn.h563985.Hotel-Information) Weslaco 8.6/10 Excellent (963) "The staff was great and my stay was very relaxing." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila CA $107 CA $121 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/McAllen-Hotels-Best-Western-Town-Center-Inn.h563985.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/38000000/37150000/37140400/37140303/0bf72696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub](https://images.trvl-media.com/lodging/38000000/37150000/37140400/37140303/35d11c41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/38000000/37150000/37140400/37140303/a6bfa73f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/38000000/37150000/37140400/37140303/225f2e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Weslaco [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-Weslaco.h37140303.Hotel-Information) Weslaco 9.2/10 Wonderful (605) "Friendly staff, overall great cleanliness of the hotel and room, and excellent location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rosie CA $126 CA $142 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-Weslaco.h37140303.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-09&endDate=2026-01-10®ionId=8743&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Hotel Reviews ![Casa De Palmas, Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/10000/4200/4182/e7f1f019_y.jpg) ### Casa De Palmas, Trademark Collection by Wyndham 10/10 Excellent "Great place to stay! " [](https://expedia.ca/McAllen-Hotels-Casa-De-Palmas.h4182.Hotel-Information) ![Holiday Inn Express Hotel & Suites Mission-McAllen Area by IHG](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/f96b3571_y.jpg) ### Holiday Inn Express Hotel & Suites Mission-McAllen Area by IHG 10/10 Excellent "Huge room and clean and great location " [](https://expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Hotel-Suites-Mission-McAllen-Area.h892242.Hotel-Information) ![Hampton Inn & Suites Mission](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/42d7cb05_y.jpg) ### Hampton Inn & Suites Mission 10/10 Excellent "Clean great location " [](https://expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Mission at West McAllen](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/6657c061_y.jpg) ### La Quinta Inn & Suites by Wyndham Mission at West McAllen 10/10 Excellent "Yes" [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) ![The Bungalows on Shary, Mission-McAllen](https://images.trvl-media.com/lodging/1000000/890000/889800/889732/db1fb243_y.jpg) ### The Bungalows on Shary, Mission-McAllen 10/10 Excellent "Room was clean " [](https://expedia.ca/McAllen-Hotels-The-Bungalows-On-Shary.h889732.Hotel-Information) ![La Quinta Inn & Suites by Wyndham McAllen La Plaza Mall](https://images.trvl-media.com/lodging/17000000/16760000/16751500/16751444/eba79348_y.jpg) ### La Quinta Inn & Suites by Wyndham McAllen La Plaza Mall 10/10 Excellent "Very clean" [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-McAllen-La-Plaza-Mall.h16751444.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Pharr North McAllen](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100160/ad076405_y.jpg) ### La Quinta Inn & Suites by Wyndham Pharr North McAllen 10/10 Excellent "The staff was friendly and patience with me, but the Tv, phone, and fidge didnt work properly. I did report it to the front desk. Other then that my stay was nice." [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Pharr-North-McAllen.h1100160.Hotel-Information) ![Embassy Suites by Hilton McAllen Convention Center](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051919/a3a7f623_y.jpg) ### Embassy Suites by Hilton McAllen Convention Center 10/10 Excellent "Excellent service" [](https://expedia.ca/McAllen-Hotels-Embassy-Suites-By-Hilton-McAllen-Convention-Center.h15051919.Hotel-Information) ![Motel 6 McAllen, TX - East](https://images.trvl-media.com/lodging/1000000/200000/198200/198184/8647ead9_y.jpg) ### Motel 6 McAllen, TX - East 10/10 Excellent "Clean room. Good place to stay near all stores" [](https://expedia.ca/McAllen-Hotels-Motel-6-McAllen.h198184.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Mission cost? ### What are the best business-friendly hotels in Mission? ### How many business-friendly hotels are there in Mission? ### What are the best cheap business-friendly hotels in Mission? ### What are the top business-friendly motels in Mission? ### Are there any family-friendly hotels in Mission that are also business friendly? ### Why book your business-friendly hotel in Mission with Expedia? ### How can I find cheap business-friendly hotels in Mission? ### What is there to do in Mission near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Hotels near 17th Street Entertainment District ](https://www.expedia.ca/17th-Street-Entertainment-District-Hotels.0-l6336837-0.Travel-Guide-Filter-Hotels) - [B&B in Alton ](https://www.expedia.ca/Alton-Bed-And-Breakfast.d553248634998951781-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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