Title: Book the Best BUSINESS Hotels in Mission in 2026 | Expedia.ca [Hotels in Mission](https://expedia.ca/Mission-Hotels.d8743.Travel-Guide-Hotels)[Vacation Rentals in Mission](https://expedia.ca/Mission-Vacation-Rentals.d8743.Travel-Guide-VacationRentals)[Flights to Mission](https://expedia.ca/Cheap-Flights-To-Mission.d8743.Travel-Guide-Flights)[Mission Car Rentals](https://expedia.ca/Car-Rentals-In-Mission.d8743.Car-Rental-Guide)[Mission Vacation Packages](https://expedia.ca/Mission.d8743.Destination-Travel-Guides) ![Mission San Jose, San Antonio. San Antonio Missions National His](https://images.trvl-media.com/place/8743/82f5b89c-948f-48b1-adba-6838569194f3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/8743/82f5b89c-948f-48b1-adba-6838569194f3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Business Hotels Tonight [Feb 15 - Feb 16](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2026-02-15&endDate=2026-02-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Feb 16 - Feb 17](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2026-02-16&endDate=2026-02-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=8743&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Mission business-friendly hotels ![Desk, bed sheets](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/04b297b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/af2eb8e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/4806fab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/5ed5dec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel By Best Western Mission [](https://www.expedia.ca/McAllen-Hotels-SureStay-Hotel-By-Best-Western-Mission.h574470.Hotel-Information) Mission 8.0/10 Very good (703 reviews) "I enjoyed a lot the breakfast. You can make your own waffle which has the shape of the Texas state 🙂" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angel CA $54 CA $62 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/McAllen-Hotels-SureStay-Hotel-By-Best-Western-Mission.h574470.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/01f48f12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible, Family)](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/ae910cb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/64aacab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/0159e2b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Mission at West McAllen [](https://www.expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) Mission 8.4/10 Very good (1,002 reviews) "The location was beside the lovely wedding venue which made its location ideal. They were able to accommodate our large groups." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ryan CA $104 CA $118 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/6ec28d98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/383826f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/76cf40ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/900000/892300/892242/037da74e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Mission-McAllen Area by IHG [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Hotel-Suites-Mission-McAllen-Area.h892242.Hotel-Information) Mission 8.8/10 Excellent (1,001 reviews) "Great breakfast, perfect room layout with more than enough space, and staff was extremely friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Xan CA $114 CA $129 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Hotel-Suites-Mission-McAllen-Area.h892242.Hotel-Information) ![King studio suite | Private kitchen](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/74451aca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/5ca069a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/w656h504x16y8-959adda0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/b6391220.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Mission [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) Mission 8.8/10 Excellent (1,001 reviews) "Clean room and bathroom. Courteous staff both at reception desk and breakfast station. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adelina CA $144 CA $164 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/2b0c86c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/6086f788.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/d1d51452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/890000/883700/883669/47f7084c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Rio Grande City [](https://www.expedia.ca/McAllen-Hotels-Quality-Inn-Suites.h883669.Hotel-Information) Rio Grande City 8.0/10 Very good (392 reviews) "The room was very clean and spacious! The bed was comfy! Everyone was very nice! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacqueline CA $100 CA $112 total includes taxes & fees Feb 28 - Mar 1 [](https://www.expedia.ca/McAllen-Hotels-Quality-Inn-Suites.h883669.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/425ff266.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/a423992a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/2247f5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418675/69f21fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Rio Grand by IHG [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Suites-Rio-Grand.h1418675.Hotel-Information) Rio Grande City 9.0/10 Wonderful (361 reviews) "Comfortable stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eduardo CA $125 CA $157 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/McAllen-Hotels-Holiday-Inn-Express-Suites-Rio-Grand.h1418675.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/5000000/4920000/4919400/4919333/9ca264bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, Accessible, Non Smoking (King Bed)](https://images.trvl-media.com/lodging/5000000/4920000/4919400/4919333/9d1aa34c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4920000/4919400/4919333/ebe79622.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4920000/4919400/4919333/84e469ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Weslaco Inn by Capital O Near Mercedes [](https://www.expedia.ca/McAllen-Hotels-Weslaco-Inn-WeslacoMercedes.h4919333.Hotel-Information) Weslaco 8.2/10 Very good (594 reviews) "Clean room & great parking." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Belia CA $81 CA $104 total includes taxes & fees Feb 19 - Feb 20 [](https://www.expedia.ca/McAllen-Hotels-Weslaco-Inn-WeslacoMercedes.h4919333.Hotel-Information) ![Standard Room, 1 King Bed, Smoking, Jetted Tub](https://images.trvl-media.com/lodging/4000000/3450000/3445700/3445631/d64ac784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/4000000/3450000/3445700/3445631/ef274953.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/4000000/3450000/3445700/3445631/081c19c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3450000/3445700/3445631/f9fca0dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Executive Inn [](https://www.expedia.ca/McAllen-Hotels-Executive-Inn.h3445631.Hotel-Information) Edinburg 8.2/10 Very good (410 reviews) "A very convenient place to stay in town" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martin R CA $75 CA $85 total includes taxes & fees Feb 16 - Feb 17 [](https://www.expedia.ca/McAllen-Hotels-Executive-Inn.h3445631.Hotel-Information) ![Room, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/70000/63100/63040/7d53f659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, soundproofing, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/70000/63100/63040/66fb042f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 11:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/63100/63040/7a506285.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/70000/63100/63040/7e3329e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Weslaco [](https://www.expedia.ca/McAllen-Hotels-Super-8-By-Wyndham-Weslaco.h63040.Hotel-Information) Weslaco 8.4/10 Very good (1,001 reviews) "Very recommended place to stay, fair price and very friendly and helpful staff. Comfortable and clean room " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mohammad CA $70 CA $79 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/McAllen-Hotels-Super-8-By-Wyndham-Weslaco.h63040.Hotel-Information) ![Suite, 2 Queen Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2810000/2804100/2804093/e7b5b979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2810000/2804100/2804093/431de832.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/3000000/2810000/2804100/2804093/302e3fe6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2810000/2804100/2804093/eb9895e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Donna near I-2 [](https://www.expedia.ca/McAllen-Hotels-Comfort-Inn-Suites-Donna-Near-I-2.h2804093.Hotel-Information) Donna 8.8/10 Excellent (638 reviews) "Great staff very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luci CA $98 CA $111 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/McAllen-Hotels-Comfort-Inn-Suites-Donna-Near-I-2.h2804093.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-01&endDate=2026-03-02®ionId=8743&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_8743) ## Top Mission Hotel Reviews ![The Bungalows on Shary, Mission-McAllen](https://images.trvl-media.com/lodging/1000000/890000/889800/889732/db1fb243_y.jpg) ### The Bungalows on Shary, Mission-McAllen 10/10 Excellent "Great experience! The rooms were clean and the staff friendly. Too many perks to list." [](https://expedia.ca/McAllen-Hotels-The-Bungalows-On-Shary.h889732.Hotel-Information) ![La Quinta Inn & Suites by Wyndham McAllen La Plaza Mall](https://images.trvl-media.com/lodging/17000000/16760000/16751500/16751444/eba79348_y.jpg) ### La Quinta Inn & Suites by Wyndham McAllen La Plaza Mall 10/10 Excellent "Clean" [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-McAllen-La-Plaza-Mall.h16751444.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Mission at West McAllen](https://images.trvl-media.com/lodging/2000000/1580000/1572400/1572320/6657c061_y.jpg) ### La Quinta Inn & Suites by Wyndham Mission at West McAllen 10/10 Excellent "Convenient " [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Mission-At-West-McAllen.h1572320.Hotel-Information) ![Hampton Inn & Suites Mission](https://images.trvl-media.com/lodging/3000000/2950000/2943100/2943096/42d7cb05_y.jpg) ### Hampton Inn & Suites Mission 10/10 Excellent "Stayed in a newly renovated floor" [](https://expedia.ca/McAllen-Hotels-Hampton-Inn-And-Suites-Mission.h2943096.Hotel-Information) ![Casa De Palmas, Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/10000/4200/4182/e7f1f019_y.jpg) ### Casa De Palmas, Trademark Collection by Wyndham 10/10 Excellent "Yes the room was spotless staff very nice and the hotel is beautiful! " [](https://expedia.ca/McAllen-Hotels-Casa-De-Palmas.h4182.Hotel-Information) ![SureStay Hotel By Best Western Mission](https://images.trvl-media.com/lodging/1000000/580000/574500/574470/5ed5dec2_y.jpg) ### SureStay Hotel By Best Western Mission 10/10 Excellent "Clean room" [](https://expedia.ca/McAllen-Hotels-SureStay-Hotel-By-Best-Western-Mission.h574470.Hotel-Information) ![Embassy Suites by Hilton McAllen Convention Center](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051919/a3a7f623_y.jpg) ### Embassy Suites by Hilton McAllen Convention Center 10/10 Excellent "amenities, breakfast and manager's happy hour" [](https://expedia.ca/McAllen-Hotels-Embassy-Suites-By-Hilton-McAllen-Convention-Center.h15051919.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Pharr North McAllen](https://images.trvl-media.com/lodging/2000000/1110000/1100200/1100160/ad076405_y.jpg) ### La Quinta Inn & Suites by Wyndham Pharr North McAllen 10/10 Excellent "Clean hotel and decent breakfast" [](https://expedia.ca/McAllen-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Pharr-North-McAllen.h1100160.Hotel-Information) ![Wyndham Garden McAllen at La Plaza Mall](https://images.trvl-media.com/lodging/13000000/12860000/12850100/12850009/1f905e71_y.jpg) ### Wyndham Garden McAllen at La Plaza Mall 10/10 Excellent "The staff was great. Was loud outside so moved to another room and were nice to deal with. Great breakfast ea h day included. The ladies who cooked were wonderful " [](https://expedia.ca/McAllen-Hotels-Wyndham-Garden-McAllen-At-La-Plaza-Mall.h12850009.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Mission cost? ### What are the best business-friendly hotels in Mission? ### How many business-friendly hotels are there in Mission? ### What are the best cheap business-friendly hotels in Mission? ### What are the top business-friendly motels in Mission? ### Are there any family-friendly hotels in Mission that are also business friendly? ### Why book your business-friendly hotel in Mission with Expedia? ### How can I find cheap business-friendly hotels in Mission? ### What is there to do in Mission near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Hotels near 17th Street Entertainment District ](https://www.expedia.ca/17th-Street-Entertainment-District-Hotels.0-l6336837-0.Travel-Guide-Filter-Hotels) - 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