Title: The 10 Best Hotels Near Mission Hope Cancer Center, Santa Maria from CA $76 | Expedia.ca [Santa Maria Travel Guide](https://expedia.ca/Santa-Maria.dx3224)[Vacation Rentals in Santa Maria](https://expedia.ca/Santa-Maria-Vacation-Rentals.d3224.Travel-Guide-VacationRentals)[Flights to Santa Maria](https://expedia.ca/Cheap-Flights-To-Santa-Maria.d3224.Travel-Guide-Flights)[Things to do in Santa Maria](https://expedia.ca/Things-To-Do-In-Santa-Maria.d3224.Travel-Guide-Activities)[Mission Hope Cancer Center Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-Hope-Cancer-Center.d553248621560560291.Car-Rental-Guide)[Mission Hope Cancer Center Vacations](https://expedia.ca/Mission-Hope-Cancer-Center-Santa-Maria.d553248621560560291.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 18 - Mar 19](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2026-03-18&endDate=2026-03-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 19 - Mar 20](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2026-03-19&endDate=2026-03-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Mission Hope Cancer Center hotels ![2 Queen Designer](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/a4111cf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/a90fd08a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Designer](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/5b767704.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort ADA Suite - 112 | Living area](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/8b75e1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Avanti [](https://www.expedia.ca/Santa-Maria-Hotels-Hotel-Avanti.h102791710.Hotel-Information) 2.3 km from Mission Hope Cancer Center 9.0/10 Wonderful (308 reviews) "Recommend this place forsure. Great location and very modern style rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adi CA $132 CA $148 total includes taxes & fees Mar 19 - Mar 20 [](https://www.expedia.ca/Santa-Maria-Hotels-Hotel-Avanti.h102791710.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/fda3cb7d_edited_c5f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking (Oversized Room;with Sofabed)](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/ae1ae948.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:00 AM to 11:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/82a54fdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/1170bb3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Big America [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) 2.8 km from Mission Hope Cancer Center 8.8/10 Excellent (1,001 reviews) "Pool was enjoyable and clean rooms. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rosie CA $163 CA $183 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/373b886f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/w1113h629x0y7-b1650579.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/272a77de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/53eb999c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Santa Maria Inn [](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) 2.2 km from Mission Hope Cancer Center 8.4/10 Very good (1,983 reviews) "Nice clean rooms, staff was great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sonia CA $113 CA $127 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) ![Comfort Room](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/6a6be06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/8da79328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/d675b652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/51470230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa Motel [](https://www.expedia.ca/Santa-Maria-Hotels-Villa-Motel.h113740019.Hotel-Information) 2.4 km from Mission Hope Cancer Center 8.0/10 Very good (229 reviews) "Good staff, good room service " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Damien CA $83 CA $93 total includes taxes & fees Mar 20 - Mar 21 [](https://www.expedia.ca/Santa-Maria-Hotels-Villa-Motel.h113740019.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/1d9b8fce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/1cd435c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, towels](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/5d8205ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually furnished, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/043bfb7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ECONOMY INN [](https://www.expedia.ca/Santa-Maria-Hotels-ECONOMY-INN.h102593847.Hotel-Information) 2.1 km from Mission Hope Cancer Center 8.0/10 Very good (86 reviews) "Clean room lovely staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Salina CA $79 CA $89 total includes taxes & fees Mar 19 - Mar 20 [](https://www.expedia.ca/Santa-Maria-Hotels-ECONOMY-INN.h102593847.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/3533fa91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/92253927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/5eb76be7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/a9e9e3b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) 2.9 km from Mission Hope Cancer Center 7.8/10 Good (1,002 reviews) "Good hotel, quiet and service also good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) vanda CA $130 CA $146 total includes taxes & fees Mar 19 - Mar 20 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) ![Standard Room, 2 Double Beds](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/483bd489.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/0e007283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/357603c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/bb2c1d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) 0.8 km from Mission Hope Cancer Center 6.8/10 (1,000 reviews) "Room nice staff friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) DARLENE CA $94 CA $106 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/8f653845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/w2000h1325x0y0-3dfbaa9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/693dc8c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/w2000h1120x0y0-aca4f3d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Santa Maria, CA - South [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h41946.Hotel-Information) 0.5 km from Mission Hope Cancer Center 5.8/10 (523 reviews) "You get what you pay for " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leitu CA $108 CA $122 total includes taxes & fees Apr 1 - Apr 2 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h41946.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/0d7c35a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/0f7b2fce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/d2f85309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/70982f53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) 3.6 km from Mission Hope Cancer Center 9.4/10 Exceptional (1,014 reviews) "Was great would definitely be coming back " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ismael CA $159 CA $179 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/718cc08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/330cc27f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/e01e83cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/w3837h2557x3y3-f6706a71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Santa Maria [](https://www.expedia.ca/Santa-Maria-Hotels-Homewood-Suites-By-Hilton-Santa-Maria.h12424.Hotel-Information) 3.5 km from Mission Hope Cancer Center 9.2/10 Wonderful (88 reviews) "Clean property, great staff and awesome breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pollavet CA $188 CA $212 total includes taxes & fees Apr 4 - Apr 5 [](https://www.expedia.ca/Santa-Maria-Hotels-Homewood-Suites-By-Hilton-Santa-Maria.h12424.Hotel-Information) ![Suite, 1 Bedroom (1 Queen Bed)](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/8c17c023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/029aed65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/127ce277.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/afc32ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Santa Maria by IHG [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) 3.3 km from Mission Hope Cancer Center 8.6/10 Excellent (1,000 reviews) "It was surprisingly great and the 2 girls during check inn were very professional and accomadating thank you" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) lupe CA $127 CA $143 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/e08330df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/0fe189f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/638e2e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Television](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/ce2a6de3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Solaire Inn & Suites [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Solaire-Inn-Suites.h2039849.Hotel-Information) 3.7 km from Mission Hope Cancer Center 8.2/10 Very good (1,001 reviews) "amazing place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eduardo CA $67 CA $76 total includes taxes & fees Mar 26 - Mar 27 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Solaire-Inn-Suites.h2039849.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/6644aec7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/97a8080c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/ee54a4c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/9fccf45d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Santa Maria, CA - North [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h996393.Hotel-Information) 3.4 km from Mission Hope Cancer Center 7.6/10 Good (1,151 reviews) "This place was great to stay for one two nights. Staff was super friendly! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Veronica [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h996393.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/c2079151.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/caf8168a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/10bd6760.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/8e543ea2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wine Stone Inn [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Wine-Stone-Inn.h39514495.Hotel-Information) 10.2 km from Mission Hope Cancer Center 9.8/10 Exceptional (622 reviews) "The hotel was very nice, and the staff helpful. The bar was a fun place to be in the evening. We had a wonderful time. ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Judy CA $208 CA $248 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Wine-Stone-Inn.h39514495.Hotel-Information) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/e6af4c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/w828h1104x0y344-75a8f006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/780dd7c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/2ed324bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Colonial Motel [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Colonial-Motel.h16152993.Hotel-Information) 3.4 km from Mission Hope Cancer Center 6.4/10 (192 reviews) "Clean rooms, smaller well kept motel in a good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darren CA $95 CA $107 total includes taxes & fees Mar 19 - Mar 20 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Colonial-Motel.h16152993.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/598df5cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/2c732443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/4ed108b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/33b4a0e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Hotel Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Radisson-Hotel-Santa-Maria.h433636.Hotel-Information) 6.8 km from Mission Hope Cancer Center 7.4/10 Good (1,332 reviews) "Clean room staff was really nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Veronica CA $139 CA $156 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Radisson-Hotel-Santa-Maria.h433636.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5180000/5175700/5175661/1d731cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/6000000/5180000/5175700/5175661/88414864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gazebo](https://images.trvl-media.com/lodging/6000000/5180000/5175700/5175661/2cb34bf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5180000/5175700/5175661/625f8ab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kaleidoscope Inn & Gardens [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Kaleidoscope-Inn-Gardens.h5175661.Hotel-Information) 11.5 km from Mission Hope Cancer Center 8.4/10 Very good (208 reviews) "The place was charming and the room very comfortable and spacious. It had everything you need. The only complaint I would have is that because it is an old Victorian, every window and door is loos and there is no insulation whatsoever. That means that you can hear every sound from every room and even with a breeze the windows and doors rattle all night. I guess that's what old Victorians are like." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christina CA $186 CA $209 total includes taxes & fees Mar 19 - Mar 20 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Kaleidoscope-Inn-Gardens.h5175661.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-01&endDate=2026-04-02®ionId=553248621560560291&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to Mission Hope Cancer Center | Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | ------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![2 Queen Designer](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/a4111cf9.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Hotel Avanti | 2.5 star property | 9.0Wonderful308 reviews | View | | | | | | | ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/fda3cb7d_edited_c5f0.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Best Western Plus Big America | 2.5 star property | 8.8Excellent1,001 reviews | View | | | | | | | ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/373b886f.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Historic Santa Maria Inn | 3.5 star property | 8.4Very good1,983 reviews | View | | | | | | | ![Comfort Room](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/6a6be06e.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Villa Motel | 2.0 star property | 8.0Very good229 reviews | View | | | | | | | ![Reception](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/1d9b8fce.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)ECONOMY INN | 2.5 star property | 8.0Very good86 reviews | View | | | | | | ## Top Mission Hope Cancer Center Hotel Reviews ![Edgewater Inn And Suites](https://images.trvl-media.com/lodging/1000000/900000/894000/893902/3beb869e_y.jpg) ### Edgewater Inn And Suites 10/10 Excellent "great location and friendly staff" [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ![Historic Santa Maria Inn](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/373b886f_y.jpg) ### Historic Santa Maria Inn 10/10 Excellent "Room service never clean the room in our 3 day stay, we had to ask for new towels and to clean, we got the towels but not the room to be clean part. Other than thay it was a great stay. " [](https://expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) ![Hampton Inn & Suites Arroyo Grande/Pismo Beach Area, CA](https://images.trvl-media.com/lodging/3000000/2480000/2470300/2470266/613cd319_y.jpg) ### Hampton Inn & Suites Arroyo Grande/Pismo Beach Area, CA 10/10 Excellent "Conveniently located near shopping and the beach. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Arroyo-GrandePismo-Beach-Area.h2470266.Hotel-Information) ![Best Western Casa Grande Inn](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/4cda8af4_y.jpg) ### Best Western Casa Grande Inn 10/10 Excellent "Was very nice. Would come back and stay here." [](https://expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![Aloha Inn](https://images.trvl-media.com/lodging/1000000/20000/14700/14623/3e6ea086_y.jpg) ### Aloha Inn 2/10 Terrible "Room flooded, didn't stay the night there as intended. Its been almost 2 weeks and have not been refunded my money. Would not recommend staying here" [](https://expedia.ca/San-Luis-Obispo-Hotels-Aloha-Inn.h14623.Hotel-Information) ![Hampton Inn & Suites Santa Maria](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/0d7c35a2_y.jpg) ### Hampton Inn & Suites Santa Maria 10/10 Excellent "Property was clean and well maintained. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) ![Cottage Inn By The Sea](https://images.trvl-media.com/lodging/1000000/160000/151000/150921/a9c907e0_y.jpg) ### Cottage Inn By The Sea 10/10 Excellent "Great location and very friendly staff." [](https://expedia.ca/San-Luis-Obispo-Hotels-Cottage-Inn-By-The-Sea.h150921.Hotel-Information) ![Oxford Suites Pismo Beach](https://images.trvl-media.com/lodging/1000000/10000/3100/3089/010bbafb_y.jpg) ### Oxford Suites Pismo Beach 10/10 Excellent "Lovely accomodations. We utilized the in town shuttle, the social hour, the breakfast, and the pool and enjoyed it all. The bed was very comfortable. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Oxford-Suites-Pismo-Beach.h3089.Hotel-Information) ![Days Inn by Wyndham Arroyo Grande/Pismo Beach](https://images.trvl-media.com/lodging/14000000/13280000/13279100/13279003/b5875520_y.jpg) ### Days Inn by Wyndham Arroyo Grande/Pismo Beach 10/10 Excellent "Nice friendly environment " [](https://expedia.ca/San-Luis-Obispo-Hotels-Pismo-View-Inn.h13279003.Hotel-Information) ## Hotels near other Mission Hope Cancer Center attractions ### Pacific Conservatory Theatre You can get tickets for a performance at Pacific Conservatory Theatre during your stay in Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6209504) ### Simas Park After visiting Simas Park, make a plan to see the other sights and activities in Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6200043) ### Natural History Museum 3.8/5 (52 reviews) You can spend an afternoon studying the exhibits at Natural History Museum during your travels in Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6209508) ### Regal Edwards Santa Maria & RPX You can take time to visit Regal Edwards Santa Maria & RPX during your travels to Santa Maria. Check out the shops and top-notch restaurants in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=941654002322817024) ### Santa Maria Valley Discovery Museum 5.0/5 (2 reviews) You can take time to visit Santa Maria Valley Discovery Museum during your travels to Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6200056) ### Santa Maria Valley Historical Society 4.0/5 (1 review) You can spend time studying the exhibits at Santa Maria Valley Historical Society during your travels in Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561135488) ### Santa Maria Civic Theatre You can get tickets for a performance at Santa Maria Civic Theatre during your stay in Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621556207167) ### Santa Maria Fairpark 4.1/5 (36 reviews) Take the family on an outing to Santa Maria Fairpark during your trip to Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621558560619) ## Frequently asked questions ### What are the top-rated hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America stands out with a stellar review rating of 9.0 and is situated only 3.7 km from Mission Hope Cancer Center. This hotel features an inviting outdoor pool and hot tub, perfect for unwinding after a day of activities. Guests enjoy free breakfast daily, along with premium rooms that include kitchen facilities and premium bedding for a restful night. The hotel also offers accessible parking and contactless check-in for added convenience. > > > [Hotel Avanti](https://expedia.ca/Santa-Maria-hotels-Hotel-Avanti.h102791710.Hotel-information) > > > Hotel Avanti, rated 9.0 by travellers, is conveniently located just 3.4 km from Mission Hope Cancer Center. This charming hotel features accessible parking and well-appointed accommodations with premium bedding for a comfortable stay. While it may be smaller in scale, its inviting atmosphere and commitment to traveler satisfaction make it a solid choice for those visiting the area. > > > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Hampton Inn & Suites Santa Maria is a welcoming 4-star hotel located just 4.3 km from Mission Hope Cancer Center, with an impressive review rating of 9.4\. This hotel offers an indoor pool for relaxation, a fitness centre for active travellers, and complimentary daily breakfast to start your day right. Guests will appreciate the convenience of in-room amenities including a refrigerator, microwave, and coffee maker, as well as accessible parking options. ### What hotels are within walking distance to Mission Hope Cancer Center? > [Days Inn by Wyndham Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) > > > Days Inn by Wyndham Santa Maria, rated 6.8 by travellers, is conveniently located just a 13-minute walk from Mission Hope Cancer Center. This hotel offers travellers a refreshing outdoor pool and complimentary daily breakfast, making it an inviting choice for travellers. Additional amenities include free parking, daily housekeeping, and convenient microwave access in rooms for easy snacks. Guests will appreciate the contactless check-in service and the nearby beach for relaxation. ### How much is a hotel near Mission Hope Cancer Center? ### What are the most popular family-friendly hotels near Mission Hope Cancer Center? > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Hampton Inn & Suites Santa Maria, situated only 4.3 km from Mission Hope Cancer Center, boasts an impressive review rating of 9.4\. This family-friendly hotel features an indoor pool, complimentary buffet breakfast, and cribs available for little ones. Additional amenities include a fitness centre and free parking, making it a convenient choice for family travellers. > > > [Candlewood Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) > > > Candlewood Suites Santa Maria by IHG is a great choice for families, located just 4.5 km from Mission Hope Cancer Center. With a review rating of 8.6, this hotel offers family-friendly amenities such as connecting rooms, a microwave, and a sofa bed. Guests can also enjoy a 24-hour fitness centre and free toiletries, ensuring a comfortable stay for the whole family. > > > [Holiday Inn & Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Holiday-Inn-Hotel-And-Suites-Santa-Maria.h12424.Hotel-Information) > > > Holiday Inn & Suites Santa Maria by IHG is located 4.5 km from Mission Hope Cancer Center and is rated 7.4 by travellers. This 3-star hotel is perfect for families, offering amenities like connecting rooms, a kitchen, and an accessible outdoor pool. Guests can also take advantage of the hot tub and fitness facilities, ensuring a fun and relaxing stay for everyone. ### What are the best affordable hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is situated a mere 3.7 km away from Mission Hope Cancer Center and boasts a strong travellers' rating of 9.0\. This family-friendly hotel offers a range of amenities, including an outdoor pool, hot tub, and free breakfast to start the day off right. Guests can take advantage of free WiFi, spacious rooms with premium bedding, and the convenience of on-site parking, ensuring a pleasant and budget-friendly stay. > > > [Hotel Avanti](https://expedia.ca/Santa-Maria-hotels-Hotel-Avanti.h102791710.Hotel-information) > > > Just 3.4 km from Mission Hope Cancer Center, Hotel Avanti is a cozy option with a 9.0 review rating from travellers. This hotel provides essential amenities such as free WiFi and accessible parking facilities. Guests can also enjoy a comfortable stay with premium bedding and roll-in shower options, making it a practical choice for those needing a relaxing retreat. > > > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Located just 4.3 km from Mission Hope Cancer Center, Hampton Inn & Suites Santa Maria offers a welcoming place with a remarkable review rating of 9.4\. Families will appreciate the indoor pool and complimentary breakfast, which features a delightful buffet spread. Guests can also enjoy free WiFi, accessible self-parking, and in-room conveniences like a refrigerator and coffee maker, making it an excellent choice for a comfortable stay. ### Are there any hotels with pools close to Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is situated just 3.7 km from Mission Hope Cancer Center and offers a delightful outdoor pool for travellers to enjoy. With a stellar review rating of 9.0, this hotel features a complimentary buffet breakfast, accessible pool, and convenient in-room amenities like refrigerators and microwaves. It's an ideal choice for travellers seeking a top-rated stay close to all the action. > > > [Travelodge by Wyndham Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) > > > Travelodge by Wyndham Santa Maria is located only 4.3 km from Mission Hope Cancer Center and boasts an outdoor pool perfect for a refreshing dip. Guests appreciate the complimentary breakfast and free parking, alongside amenities like a terrace and nearby hiking options. Rated 7.8 by travellers, this hotel combines convenience with comfort for a satisfying stay. > > > [Holiday Inn & Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Holiday-Inn-Hotel-And-Suites-Santa-Maria.h12424.Hotel-Information) > > > Holiday Inn & Suites Santa Maria by IHG is a 3-star hotel located just 4.5 km from Mission Hope Cancer Center, featuring an inviting outdoor pool with sun loungers for relaxation. Travellers can enjoy additional amenities such as a hot tub, fitness facilities, and in-room kitchenettes, making it a family-friendly choice. This hotel has a review rating of 7.4, ensuring a pleasant stay for all travellers. ### What are the best pet-friendly hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is a highly-rated pet-friendly hotel, situated 3.7 km from Mission Hope Cancer Center. Rated 9.0 by travellers, this hotel allows pets and offers complimentary breakfast along with an outdoor pool and hot tub for relaxation. Guests appreciate the spacious rooms equipped with refrigerators and microwaves, making it a practical choice for families traveling with pets. > > > [Historic Santa Maria Inn](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) > > > Historic Santa Maria Inn, a charming 3.5-star hotel, is located just 3.4 km from Mission Hope Cancer Center. With a review rating of 8.4, this hotel welcomes pets and features a dog exercise area for your furry companions. Guests can also enjoy amenities such as an outdoor pool, hot tub, and 24-hour fitness facilities, making it a delightful stay for both pets and people. > > > [Candlewood Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) > > > Candlewood Suites Santa Maria by IHG is a 3-star hotel located 4.5 km from Mission Hope Cancer Center, a review rating of 8.6\. This hotel is pet-friendly and provides essential amenities such as kitchenettes in rooms, making it ideal for longer stays. Guests can also take advantage of the 24-hour fitness facilities and self-parking options, ensuring a comfortable and convenient experience. ### Can I book a fully refundable hotel close to Mission Hope Cancer Center? ### Can I find Expedia discounts for hotels near Mission Hope Cancer Center? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Santa Maria ](https://www.expedia.ca/4Star-Santa-Maria-Hotels.s40-0-d3224.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Santa Maria ](https://www.expedia.ca/5Star-Santa-Maria-Hotels.s50-0-d3224.Travel-Guide-Filter-Hotels) - [Arroyo Grande Hotels ](https://www.expedia.ca/Arroyo-Grande-Hotels.d6261.Travel-Guide-Hotels) - [Hotels near Blacklake Golf Resort ](https://www.expedia.ca/Blacklake-Golf-Resort-Hotels.0-l6207570-0.Travel-Guide-Filter-Hotels) - [Hotels near Cambria Winery ](https://www.expedia.ca/Cambria-Winery-Hotels.0-l553248621532639594-0.Travel-Guide-Filter-Hotels) - [Central Coast California Hotels ](https://www.expedia.ca/Central-Coast-California-Hotels.d6055477.Travel-Guide-Hotels) - [Hotels near Cypress Ridge Golf Course ](https://www.expedia.ca/Cypress-Ridge-Golf-Course-Hotels.0-l553248621532639597-0.Travel-Guide-Filter-Hotels) - [Hotels near Foxen Canyon Wine Trail ](https://www.expedia.ca/Foxen-Canyon-Wine-Trail-Hotels.0-l553248621533113618-0.Travel-Guide-Filter-Hotels) - [Grover Beach Hotels ](https://www.expedia.ca/Grover-Beach-Hotels.d55742.Travel-Guide-Hotels) - [Hotels near Grover Beach Station ](https://www.expedia.ca/Grover-Beach-Station-Hotels.d6195612.Travel-Guide-Hotels) - [Guadalupe Hotels ](https://www.expedia.ca/Guadalupe-Hotels.d6204275.Travel-Guide-Hotels) - [Hotels near Lopez Lake Recreation Area ](https://www.expedia.ca/Lopez-Lake-Recreation-Area-Hotels.0-l553248621532640032-0.Travel-Guide-Filter-Hotels) - [Los Alamos Hotels ](https://www.expedia.ca/Los-Alamos-Hotels.d177448.Travel-Guide-Hotels) - [Hotels near Marian Regional Medical Center ](https://www.expedia.ca/Marian-Regional-Medical-Center-Hotels.0-l553248621560560290-0.Travel-Guide-Filter-Hotels) - [Hotels near Monarch Butterfly Grove ](https://www.expedia.ca/Monarch-Butterfly-Grove-Hotels.0-l6134090-0.Travel-Guide-Filter-Hotels) - [Hotels near Monarch Dunes Golf Club ](https://www.expedia.ca/Monarch-Dunes-Golf-Club-Hotels.0-l6207579-0.Travel-Guide-Filter-Hotels) - [Nipomo Hotels ](https://www.expedia.ca/Nipomo-Hotels.d183001.Travel-Guide-Hotels) - [Hotels near North Beach Campground ](https://www.expedia.ca/North-Beach-Campground-Hotels.0-l6180647-0.Travel-Guide-Filter-Hotels) - [Hotels near Oceano Dunes State Vehicular Recreation Area ](https://www.expedia.ca/Oceano-Dunes-State-Vehicular-Recreation-Area-Hotels.0-l6134092-0.Travel-Guide-Filter-Hotels) - [Oceano Hotels ](https://www.expedia.ca/Oceano-Hotels.d6023566.Travel-Guide-Hotels) - [Orcutt Hotels ](https://www.expedia.ca/Orcutt-Hotels.d3000428439.Travel-Guide-Hotels) - [Hotels near Oso Flaco Lake ](https://www.expedia.ca/Oso-Flaco-Lake-Hotels.0-l553248621532639570-0.Travel-Guide-Filter-Hotels) - [Hotels near Pacific Dunes Ranch Riding Stables ](https://www.expedia.ca/Pacific-Dunes-Ranch-Riding-Stables-Hotels.0-l553248621532639571-0.Travel-Guide-Filter-Hotels) - [Hotels near Pismo Beach Premium Outlets ](https://www.expedia.ca/Pismo-Beach-Premium-Outlets-Hotels.0-l6128096-0.Travel-Guide-Filter-Hotels) - [Hotels near Pismo Dunes Natural Preserve ](https://www.expedia.ca/Pismo-Dunes-Natural-Preserve-Hotels.0-l6180015-0.Travel-Guide-Filter-Hotels) - [Hotels near Pismo State Beach ](https://www.expedia.ca/Pismo-State-Beach-Hotels.0-l6179970-0.Travel-Guide-Filter-Hotels) - [Hotels near Rancho Sisquoc Winery ](https://www.expedia.ca/Rancho-Sisquoc-Winery-Hotels.0-l553248621532639629-0.Travel-Guide-Filter-Hotels) - [Apartments in Santa Maria ](https://www.expedia.ca/Santa-Maria-Apartments.d3224-aaApartments.Travel-Guide-Accommodation) - [B&B in Santa Maria ](https://www.expedia.ca/Santa-Maria-Bed-And-Breakfast.d3224-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Condo Rentals in Santa Maria ](https://www.expedia.ca/Santa-Maria-Condos.d3224-aaCondos.Travel-Guide-Accommodation) - [Cottages in Santa Maria ](https://www.expedia.ca/Santa-Maria-Cottages.d3224-aaCottages.Travel-Guide-Accommodation) - [Hostels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hostels.d3224-aaHostels.Travel-Guide-Accommodation) - [All Inclusive Resorts and in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-All-Inclusive-Hotel.0-0-d3224-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Beach-Hotel.0-0-d3224-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Boutique-Hotel.0-0-d3224-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Casino-Hotel.0-0-d3224-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Cheap-Hotels.0-0-d3224-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Hilton-Hotels.0-0-d3224--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Hotel.0-0-d3224-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Hotels-With-Bar.0-0-d3224-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d3224-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Hotels-With-Hot-Tubs.0-0-d3224-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Hotels-With-Smoking-Rooms.0-0-d3224-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Luxury-Hotel.0-0-d3224-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Pet-Friendly-Hotel.0-0-d3224-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Spa-Hotel.0-0-d3224-tSpaHotel.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Waterpark-Hotels.0-0-d3224-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Hotels-Wyndham-Extra-Holidays.0-0-d3224--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Santa Maria Hotels ](https://www.expedia.ca/Santa-Maria-Hotels.d3224.Travel-Guide-Hotels) - [Motels in Santa Maria ](https://www.expedia.ca/Santa-Maria-Motels.d3224-aaMotels.Travel-Guide-Accommodation) - [Hotels near Santa Maria Public ](https://www.expedia.ca/Santa-Maria-Public-Airport-Hotels.0-aSMX-0.Travel-Guide-Filter-Hotels) - [Resorts in Santa Maria ](https://www.expedia.ca/Santa-Maria-Resort-Hotels.d3224-aaResortHotels.Travel-Guide-Accommodation) - [Villas in Santa Maria ](https://www.expedia.ca/Santa-Maria-Villas.d3224-aaVillas.Travel-Guide-Accommodation) - [Hotels near Vandenberg Air Force Base ](https://www.expedia.ca/Vandenberg-Air-Force-Base-Hotels.0-l6198538-0.Travel-Guide-Filter-Hotels) - [Vandenberg Village Hotels ](https://www.expedia.ca/Vandenberg-Village-Hotels.d553248635975847497.Travel-Guide-Hotels) - [Hotels near Yang Sheng Foot Spa ](https://www.expedia.ca/Yang-Sheng-Foot-Spa-Hotels.0-l553248621532639586-0.Travel-Guide-Filter-Hotels) - [Flights to Santa Maria ](https://www.expedia.ca/Cheap-Flights-To-Santa-Maria.d3224.Travel-Guide-Flights) - [Flights from Watsonville to Santa Maria ](https://www.expedia.ca/lp/flights/10460/3224/watsonville-to-santa-maria) - [Flights from Evansville to Santa Maria ](https://www.expedia.ca/lp/flights/1179/3224/evansville-to-santa-maria) - [Flights from Jamestown to Santa Maria ](https://www.expedia.ca/lp/flights/1709/3224/jamestown-to-santa-maria) - [Flights from Amsterdam to Santa Maria ](https://www.expedia.ca/lp/flights/178229/3224/amsterdam-to-santa-maria) - [Flights from Anchorage to Santa Maria ](https://www.expedia.ca/lp/flights/178230/3224/anchorage-to-santa-maria) - [Flights from Miami to Santa Maria ](https://www.expedia.ca/lp/flights/178286/3224/miami-to-santa-maria) - [Flights from Ottawa to Santa Maria ](https://www.expedia.ca/lp/flights/178296/3224/ottawa-to-santa-maria) - [Flights from Vancouver to Santa Maria ](https://www.expedia.ca/lp/flights/178315/3224/vancouver-to-santa-maria) - [Flights from Düsseldorf to Santa Maria ](https://www.expedia.ca/lp/flights/180001/3224/dusseldorf-to-santa-maria) - [Flights from Edmonton to Santa Maria ](https://www.expedia.ca/lp/flights/180002/3224/edmonton-to-santa-maria) - [Flights from Québec City to Santa Maria ](https://www.expedia.ca/lp/flights/180017/3224/quebec-city-to-santa-maria) - [Flights from Mahón to Santa Maria ](https://www.expedia.ca/lp/flights/180560/3224/mahon-to-santa-maria) - [Flights from St. John's to Santa Maria ](https://www.expedia.ca/lp/flights/181832/3224/st-johns-to-santa-maria) - [Flights from Meekatharra to Santa Maria ](https://www.expedia.ca/lp/flights/2334/3224/meekatharra-to-santa-maria) - [Flights from Minneapolis to Santa Maria ](https://www.expedia.ca/lp/flights/2426/3224/minneapolis-to-santa-maria) - [Flights from Wichita Falls to Santa Maria ](https://www.expedia.ca/lp/flights/3254/3224/wichita-falls-to-santa-maria) - [Flights from Tok to Santa Maria ](https://www.expedia.ca/lp/flights/3457/3224/tok-to-santa-maria) - [Flights from Waterloo to Santa Maria ](https://www.expedia.ca/lp/flights/364/3224/waterloo-to-santa-maria) - [Flights from Moncton to Santa Maria ](https://www.expedia.ca/lp/flights/4051/3224/moncton-to-santa-maria) - [Flights from Comox to Santa Maria ](https://www.expedia.ca/lp/flights/4052/3224/comox-to-santa-maria) - [Flights from Saskatoon to Santa Maria ](https://www.expedia.ca/lp/flights/4117/3224/saskatoon-to-santa-maria) - [Flights from Salinas to Santa Maria ](https://www.expedia.ca/lp/flights/500230/3224/salinas-to-santa-maria) - [Flights from Silay City to Santa Maria ](https://www.expedia.ca/lp/flights/553248635924197738/3224/silay-city-to-santa-maria) - [Flights from Bnei Shimon to Santa Maria ](https://www.expedia.ca/lp/flights/553248635974515963/3224/bnei-shimon-to-santa-maria) - [Flights from Punta Cana to Santa Maria ](https://www.expedia.ca/lp/flights/601906/3224/punta-cana-to-santa-maria) - [Flights from Buffalo to Santa Maria ](https://www.expedia.ca/lp/flights/602674/3224/buffalo-to-santa-maria) - [Flights from Niagara Falls to Santa Maria ](https://www.expedia.ca/lp/flights/602721/3224/niagara-falls-to-santa-maria) - [Flights from Mobile to Santa Maria ](https://www.expedia.ca/lp/flights/602984/3224/mobile-to-santa-maria) - [Flights from Pullman to Santa Maria ](https://www.expedia.ca/lp/flights/6054423/3224/pullman-to-santa-maria) - [Flights from Show Low to Santa Maria ](https://www.expedia.ca/lp/flights/6054779/3224/show-low-to-santa-maria) - [Flights from Beaumont to Santa Maria ](https://www.expedia.ca/lp/flights/667/3224/beaumont-to-santa-maria) - [Flights from Dhanbad to Santa Maria ](https://www.expedia.ca/lp/flights/6817/3224/dhanbad-to-santa-maria) - [Flights from Cartagena to Santa Maria ](https://www.expedia.ca/lp/flights/926/3224/cartagena-to-santa-maria) - [Flights from Sidney to Santa Maria ](https://www.expedia.ca/lp/flights/9614/3224/sidney-to-santa-maria) - [Flights from Savoy to Santa Maria ](https://www.expedia.ca/lp/flights/9817/3224/savoy-to-santa-maria) - [Santa Maria Vacations ](https://www.expedia.ca/Santa-Maria.d3224.Destination-Travel-Guides) - [Visit Santa Maria ](https://www.expedia.ca/Santa-Maria.dx3224) - [Alamo Rent A Car Rental Cars in Santa Maria ](https://www.expedia.ca/Alamo-Rent-A-Car-Car-Rentals-In-Santa-Maria.d3224-c6.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Santa Maria ](https://www.expedia.ca/Budget-Car-Rentals-In-Santa-Maria.d3224-c39.Car-Rental-Guide-Suppliers) - [Car rental Santa Maria ](https://www.expedia.ca/Car-Rentals-In-Santa-Maria.d3224.Car-Rental-Guide) - [Fox Rental Cars Rental Cars in Santa Maria ](https://www.expedia.ca/Fox-Rental-Cars-Car-Rentals-In-Santa-Maria.d3224-c19.Car-Rental-Guide-Suppliers) - [Santa Maria Vacation Rentals ](https://www.expedia.ca/Santa-Maria-Vacation-Rentals.d3224.Travel-Guide-VacationRentals) - [Things to do in Santa Maria ](https://www.expedia.ca/Things-To-Do-In-Santa-Maria.d3224.Travel-Guide-Activities)