Title: The 10 Best Hotels Near Mission Hope Cancer Center, Santa Maria from CA $89 | Expedia.ca [Santa Maria Travel Guide](https://expedia.ca/Santa-Maria.dx3224)[Vacation Rentals in Santa Maria](https://expedia.ca/Santa-Maria-Vacation-Rentals.d3224.Travel-Guide-VacationRentals)[Flights to Santa Maria](https://expedia.ca/Cheap-Flights-To-Santa-Maria.d3224.Travel-Guide-Flights)[Things to do in Santa Maria](https://expedia.ca/Things-To-Do-In-Santa-Maria.d3224.Travel-Guide-Activities)[Mission Hope Cancer Center Car Rentals](https://expedia.ca/Car-Rentals-In-Mission-Hope-Cancer-Center.d553248621560560291.Car-Rental-Guide)[Mission Hope Cancer Center Vacations](https://expedia.ca/Mission-Hope-Cancer-Center-Santa-Maria.d553248621560560291.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Mission Hope Cancer Center, Santa Maria from CA $89 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2025-12-15&endDate=2025-12-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248621560560291&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Mission Hope Cancer Center hotels ![2 Queen Designer](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/a4111cf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Studio Suite - 114](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/9a46f872.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/a90fd08a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort ADA Suite - 112 | Living area](https://images.trvl-media.com/lodging/103000000/102800000/102791800/102791710/8b75e1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Avanti [](https://www.expedia.ca/Santa-Maria-Hotels-Hotel-Avanti.h102791710.Hotel-Information) 2.3 km from Mission Hope Cancer Center 9.0/10 Wonderful (282) "Very nicely remodeled hotel - excellent mattress. Front desk staff very nice. Would stay again if in area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey CA $115 CA $129 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Santa-Maria-Hotels-Hotel-Avanti.h102791710.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/fda3cb7d_edited_c5f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/1170bb3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/w5755h3835x5y5-f126bb4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking (Oversized Room;with Sofabed)](https://images.trvl-media.com/lodging/1000000/20000/15400/15345/ae1ae948.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Big America [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) 2.8 km from Mission Hope Cancer Center 8.8/10 Excellent (1003) "great place - clean n comfy beds " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy CA $143 CA $161 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/373b886f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/0396337b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/w1113h629x0y7-b1650579.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/272a77de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Santa Maria Inn [](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) 2.2 km from Mission Hope Cancer Center 8.4/10 Very good (1850) "Great place to stay the staff very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raffy CA $108 CA $121 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/1d9b8fce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, towels](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/5d8205ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/57a683d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/103000000/102600000/102593900/102593847/1cd435c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ECONOMY INN [](https://www.expedia.ca/Santa-Maria-Hotels-ECONOMY-INN.h102593847.Hotel-Information) 2.1 km from Mission Hope Cancer Center 8.0/10 Very good (73) "Decent hotel for the price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ydalid CA $88 CA $99 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Santa-Maria-Hotels-ECONOMY-INN.h102593847.Hotel-Information) ![Comfort Room](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/6a6be06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/8da79328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room | Bathroom](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/d675b652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/114000000/113750000/113740100/113740019/f7dcca67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa Motel [](https://www.expedia.ca/Santa-Maria-Hotels-Villa-Motel.h113740019.Hotel-Information) 2.4 km from Mission Hope Cancer Center 8.0/10 Very good (174) "Staff was very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) erika CA $94 CA $106 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Santa-Maria-Hotels-Villa-Motel.h113740019.Hotel-Information) ![Suite, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/26a4cc5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/08ea6b1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Jetted tub](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/74c6026d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/790000/789200/789178/92253927.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) 2.9 km from Mission Hope Cancer Center 7.8/10 Good (1000) "Great establishment and surrounding neighborhood. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julio CA $133 CA $150 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) ![Standard Room, 2 Double Beds](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/483bd489.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/bb2c1d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/357603c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088174/566069da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) 0.8 km from Mission Hope Cancer Center 6.8/10 (1001) "Room was clean staff was nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly Dawn CA $98 CA $111 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/4000000/3910000/3900500/3900496/fa1a805c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Double Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/4000000/3910000/3900500/3900496/ab86549a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/4000000/3910000/3900500/3900496/00ff1326.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/3910000/3900500/3900496/aba63e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Buckboard Motel [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Buckboard-Motel.h3900496.Hotel-Information) 3 km from Mission Hope Cancer Center 6.8/10 (71) "Excellent place to rest excellent price " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carlos CA $86 CA $97 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Buckboard-Motel.h3900496.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/5663115a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/698d35f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/0261b95e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42000/41946/3c632139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Santa Maria, CA - South [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h41946.Hotel-Information) 0.5 km from Mission Hope Cancer Center 5.8/10 (510) "Room was nice and the owner and staff were helpful and kind." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason CA $105 CA $119 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h41946.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/0d7c35a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/0f7b2fce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Refrigerator | Bathroom](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/46a3a6b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/d2f85309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) 3.7 km from Mission Hope Cancer Center 9.4/10 Exceptional (1002) "Lovely hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adrian CA $148 CA $166 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2740000/2733300/2733222/f71ce1c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/3000000/2740000/2733300/2733222/e41940c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2740000/2733300/2733222/8771416f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2740000/2733300/2733222/be90ec77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Fairfield-Inn-Suites-By-Marriott-Santa-Maria.h2733222.Hotel-Information) 3.3 km from Mission Hope Cancer Center 8.6/10 Excellent (722) "Staff for breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kiari CA $154 CA $174 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Fairfield-Inn-Suites-By-Marriott-Santa-Maria.h2733222.Hotel-Information) ![Suite, 1 Bedroom (1 Queen Bed)](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/8c17c023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/11245da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/afc32ceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2620000/2618300/2618252/127ce277.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Santa Maria by IHG [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) 3.3 km from Mission Hope Cancer Center 8.6/10 Excellent (1000) "Clean room . Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derek CA $139 CA $156 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/w3836h2557x4y3-802a7eb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/e01e83cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/w3837h2557x3y3-4821fbb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/12500/12424/w3837h2557x3y3-19ccb77e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Santa Maria [](https://www.expedia.ca/Santa-Maria-Hotels-Homewood-Suites-By-Hilton-Santa-Maria.h12424.Hotel-Information) 3.5 km from Mission Hope Cancer Center 8.4/10 Very good (35) "Friendly staff and nice hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elisa CA $136 CA $153 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Santa-Maria-Hotels-Homewood-Suites-By-Hilton-Santa-Maria.h12424.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/e08330df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/6c756f86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/0fe189f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2040000/2039900/2039849/638e2e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Solaire Inn & Suites [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Solaire-Inn-Suites.h2039849.Hotel-Information) 3.6 km from Mission Hope Cancer Center 8.2/10 Very good (1002) "Clean Staff very helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sally CA $79 CA $89 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Solaire-Inn-Suites.h2039849.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/3309273d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/c1a3b732.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/04eff7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/1000000/996400/996393/01a88be6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Santa Maria, CA - North [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h996393.Hotel-Information) 3.4 km from Mission Hope Cancer Center 7.4/10 Good (1015) "Yes, the staff was courteous and the room although bare bones was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $105 CA $118 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h996393.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/c2079151.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/8e543ea2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/10bd6760.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/40000000/39520000/39514500/39514495/caf8168a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wine Stone Inn [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Wine-Stone-Inn.h39514495.Hotel-Information) 10.2 km from Mission Hope Cancer Center 9.8/10 Exceptional (600) "Room was super clean and roomy ...bed was very comfortable! Love the decor in the entire hotel. Staff was friendly and accommodating. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) shannon CA $216 CA $258 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Wine-Stone-Inn.h39514495.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/598df5cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/a0ecc1ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/33b4a0e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/440000/433700/433636/2c732443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Hotel Santa Maria [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Radisson-Hotel-Santa-Maria.h433636.Hotel-Information) 6.8 km from Mission Hope Cancer Center 7.6/10 Good (1327) "Very nice hotel. It is currently being renovated." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elsa CA $136 CA $153 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Radisson-Hotel-Santa-Maria.h433636.Hotel-Information) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/e6af4c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/w828h1104x0y344-75a8f006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/780dd7c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/17000000/16160000/16153000/16152993/db2f7b23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Colonial Motel [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Colonial-Motel.h16152993.Hotel-Information) 3.4 km from Mission Hope Cancer Center 6.4/10 (164) "I recomendar this place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Everarda CA $117 CA $131 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Colonial-Motel.h16152993.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-28&endDate=2025-12-29®ionId=553248621560560291&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Hope Cancer Center Hotel Reviews ![Historic Santa Maria Inn](https://images.trvl-media.com/lodging/1000000/30000/20400/20393/53eb999c_y.jpg) ### Historic Santa Maria Inn 10/10 Excellent "My stay was great!" [](https://expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) ![Best Western Casa Grande Inn](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/e16ece78_y.jpg) ### Best Western Casa Grande Inn 10/10 Excellent "Check in was fast and the staff was very professional and friendly. Hotel is absolutely beautiful!" [](https://expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![SeaCrest OceanFront Hotel](https://images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/w3000h1999x0y0-15b2e131_y.jpg) ### SeaCrest OceanFront Hotel 10/10 Excellent "Everything was amazing ! I love staying at Seacrest " [](https://expedia.ca/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ![Edgewater Inn And Suites](https://images.trvl-media.com/lodging/1000000/900000/894000/893902/3d1c5694_y.jpg) ### Edgewater Inn And Suites 10/10 Excellent "Clean rooms" [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ![Village Inn ](https://images.trvl-media.com/lodging/115000000/114590000/114580800/114580787/705a0cba_y.jpg) ### Village Inn 10/10 Excellent "Everything was clean very nice grounds Pool and Jacuzzi Restaurant and Bar was Great and very convenient right off freeway!" [](https://expedia.ca/Lompoc-Hotels-Village-Inn.h114580787.Hotel-Information) ![Oxford Suites Pismo Beach](https://images.trvl-media.com/lodging/1000000/10000/3100/3089/b427747a_y.jpg) ### Oxford Suites Pismo Beach 10/10 Excellent "Rooms are always perfectly cleaned, customer service at check in is fantastic and breakfast staff is courteous and attentive. We only stay here for leisure, business or our water polo competition events. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Oxford-Suites-Pismo-Beach.h3089.Hotel-Information) ![Hampton Inn & Suites Santa Maria](https://images.trvl-media.com/lodging/39000000/38230000/38230000/38229980/1cf0eed4_y.jpg) ### Hampton Inn & Suites Santa Maria 10/10 Excellent "Yes" [](https://expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) ![Hilton Garden Inn San Luis Obispo/Pismo Beach](https://images.trvl-media.com/lodging/2000000/1620000/1619200/1619196/2231ae59_y.jpg) ### Hilton Garden Inn San Luis Obispo/Pismo Beach 10/10 Excellent "Check in was a breeze and everything was comfortable and clean." [](https://expedia.ca/San-Luis-Obispo-Hotels-Hilton-Garden-Inn-San-Luis-Obispo-Pismo-Beach.h1619196.Hotel-Information) ![Inn at the Pier Pismo Beach, Curio Collection by Hilton](https://images.trvl-media.com/lodging/19000000/18680000/18676000/18675941/w3838h2559x2y0-97fcea63_y.jpg) ### Inn at the Pier Pismo Beach, Curio Collection by Hilton 10/10 Excellent "We had the perfect beach view and came in town for the Holiday Harmony event! Our boys had a blast! Breakfast was delicious! " [](https://expedia.ca/San-Luis-Obispo-Hotels-Inn-At-The-Pier.h18675941.Hotel-Information) ## Hotels near other Mission Hope Cancer Center attractions ### Pacific Conservatory Theatre You can get tickets for a performance at Pacific Conservatory Theatre during your stay in Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6209504) ### Simas Park After visiting Simas Park, make a plan to see the other sights and activities in Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6200043) ### Natural History Museum 3.8/5 (52 reviews) You can spend an afternoon studying the exhibits at Natural History Museum during your travels in Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6209508) ### Regal Edwards Santa Maria & RPX You can take time to visit Regal Edwards Santa Maria & RPX during your travels to Santa Maria. Check out the shops and top-notch restaurants in this family-friendly area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=941654002322817024) ### Santa Maria Valley Discovery Museum 5.0/5 (2 reviews) You can take time to visit Santa Maria Valley Discovery Museum during your travels to Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6200056) ### Santa Maria Valley Historical Society 4.0/5 (1 review) You can spend time studying the exhibits at Santa Maria Valley Historical Society during your travels in Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561135488) ### Santa Maria Civic Theatre You can get tickets for a performance at Santa Maria Civic Theatre during your stay in Santa Maria. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621556207167) ### Santa Maria Fairpark 4.1/5 (36 reviews) Take the family on an outing to Santa Maria Fairpark during your trip to Santa Maria. While in this romantic area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621558560619) ## Frequently asked questions ### What are the top-rated hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America stands out with a stellar review rating of 9.0 and is situated only 3.7 km from Mission Hope Cancer Center. This hotel features an inviting outdoor pool and hot tub, perfect for unwinding after a day of activities. Guests enjoy free breakfast daily, along with premium rooms that include kitchen facilities and premium bedding for a restful night. The hotel also offers accessible parking and contactless check-in for added convenience. > > > [Hotel Avanti](https://expedia.ca/Santa-Maria-hotels-Hotel-Avanti.h102791710.Hotel-information) > > > Hotel Avanti, rated 9.0 by travellers, is conveniently located just 3.4 km from Mission Hope Cancer Center. This charming hotel features accessible parking and well-appointed accommodations with premium bedding for a comfortable stay. While it may be smaller in scale, its inviting atmosphere and commitment to traveler satisfaction make it a solid choice for those visiting the area. > > > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Hampton Inn & Suites Santa Maria is a welcoming 4-star hotel located just 4.3 km from Mission Hope Cancer Center, with an impressive review rating of 9.4\. This hotel offers an indoor pool for relaxation, a fitness centre for active travellers, and complimentary daily breakfast to start your day right. Guests will appreciate the convenience of in-room amenities including a refrigerator, microwave, and coffee maker, as well as accessible parking options. ### What hotels are within walking distance to Mission Hope Cancer Center? > [Days Inn by Wyndham Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Days-Inn-By-Wyndham-Santa-Maria.h1088174.Hotel-Information) > > > Days Inn by Wyndham Santa Maria, rated 6.8 by travellers, is conveniently located just a 13-minute walk from Mission Hope Cancer Center. This hotel offers travellers a refreshing outdoor pool and complimentary daily breakfast, making it an inviting choice for travellers. Additional amenities include free parking, daily housekeeping, and convenient microwave access in rooms for easy snacks. Guests will appreciate the contactless check-in service and the nearby beach for relaxation. ### How much is a hotel near Mission Hope Cancer Center? ### What are the most popular family-friendly hotels near Mission Hope Cancer Center? > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Hampton Inn & Suites Santa Maria, situated only 4.3 km from Mission Hope Cancer Center, boasts an impressive review rating of 9.4\. This family-friendly hotel features an indoor pool, complimentary buffet breakfast, and cribs available for little ones. Additional amenities include a fitness centre and free parking, making it a convenient choice for family travellers. > > > [Candlewood Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) > > > Candlewood Suites Santa Maria by IHG is a great choice for families, located just 4.5 km from Mission Hope Cancer Center. With a review rating of 8.6, this hotel offers family-friendly amenities such as connecting rooms, a microwave, and a sofa bed. Guests can also enjoy a 24-hour fitness centre and free toiletries, ensuring a comfortable stay for the whole family. > > > [Holiday Inn & Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Holiday-Inn-Hotel-And-Suites-Santa-Maria.h12424.Hotel-Information) > > > Holiday Inn & Suites Santa Maria by IHG is located 4.5 km from Mission Hope Cancer Center and is rated 7.4 by travellers. This 3-star hotel is perfect for families, offering amenities like connecting rooms, a kitchen, and an accessible outdoor pool. Guests can also take advantage of the hot tub and fitness facilities, ensuring a fun and relaxing stay for everyone. ### What are the best affordable hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is situated a mere 3.7 km away from Mission Hope Cancer Center and boasts a strong travellers' rating of 9.0\. This family-friendly hotel offers a range of amenities, including an outdoor pool, hot tub, and free breakfast to start the day off right. Guests can take advantage of free WiFi, spacious rooms with premium bedding, and the convenience of on-site parking, ensuring a pleasant and budget-friendly stay. > > > [Hotel Avanti](https://expedia.ca/Santa-Maria-hotels-Hotel-Avanti.h102791710.Hotel-information) > > > Just 3.4 km from Mission Hope Cancer Center, Hotel Avanti is a cozy option with a 9.0 review rating from travellers. This hotel provides essential amenities such as free WiFi and accessible parking facilities. Guests can also enjoy a comfortable stay with premium bedding and roll-in shower options, making it a practical choice for those needing a relaxing retreat. > > > [Hampton Inn & Suites Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hampton-Inn-Suites-Santa-Maria.h38229980.Hotel-Information) > > > Located just 4.3 km from Mission Hope Cancer Center, Hampton Inn & Suites Santa Maria offers a welcoming place with a remarkable review rating of 9.4\. Families will appreciate the indoor pool and complimentary breakfast, which features a delightful buffet spread. Guests can also enjoy free WiFi, accessible self-parking, and in-room conveniences like a refrigerator and coffee maker, making it an excellent choice for a comfortable stay. ### Are there any hotels with pools close to Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is situated just 3.7 km from Mission Hope Cancer Center and offers a delightful outdoor pool for travellers to enjoy. With a stellar review rating of 9.0, this hotel features a complimentary buffet breakfast, accessible pool, and convenient in-room amenities like refrigerators and microwaves. It's an ideal choice for travellers seeking a top-rated stay close to all the action. > > > [Travelodge by Wyndham Santa Maria](https://www.expedia.ca/San-Luis-Obispo-Hotels-Travelodge-By-Wyndham-Santa-Maria.h789178.Hotel-Information) > > > Travelodge by Wyndham Santa Maria is located only 4.3 km from Mission Hope Cancer Center and boasts an outdoor pool perfect for a refreshing dip. Guests appreciate the complimentary breakfast and free parking, alongside amenities like a terrace and nearby hiking options. Rated 7.8 by travellers, this hotel combines convenience with comfort for a satisfying stay. > > > [Holiday Inn & Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Holiday-Inn-Hotel-And-Suites-Santa-Maria.h12424.Hotel-Information) > > > Holiday Inn & Suites Santa Maria by IHG is a 3-star hotel located just 4.5 km from Mission Hope Cancer Center, featuring an inviting outdoor pool with sun loungers for relaxation. Travellers can enjoy additional amenities such as a hot tub, fitness facilities, and in-room kitchenettes, making it a family-friendly choice. This hotel has a review rating of 7.4, ensuring a pleasant stay for all travellers. ### What are the best pet-friendly hotels near Mission Hope Cancer Center? > [Best Western Plus Big America](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Plus-Big-America.h15345.Hotel-Information) > > > Best Western Plus Big America is a highly-rated pet-friendly hotel, situated 3.7 km from Mission Hope Cancer Center. Rated 9.0 by travellers, this hotel allows pets and offers complimentary breakfast along with an outdoor pool and hot tub for relaxation. Guests appreciate the spacious rooms equipped with refrigerators and microwaves, making it a practical choice for families traveling with pets. > > > [Historic Santa Maria Inn](https://www.expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) > > > Historic Santa Maria Inn, a charming 3.5-star hotel, is located just 3.4 km from Mission Hope Cancer Center. With a review rating of 8.4, this hotel welcomes pets and features a dog exercise area for your furry companions. Guests can also enjoy amenities such as an outdoor pool, hot tub, and 24-hour fitness facilities, making it a delightful stay for both pets and people. > > > [Candlewood Suites Santa Maria by IHG](https://www.expedia.ca/San-Luis-Obispo-Hotels-Candlewood-Suites-Santa-Maria.h2618252.Hotel-Information) > > > Candlewood Suites Santa Maria by IHG is a 3-star hotel located 4.5 km from Mission Hope Cancer Center, a review rating of 8.6\. This hotel is pet-friendly and provides essential amenities such as kitchenettes in rooms, making it ideal for longer stays. Guests can also take advantage of the 24-hour fitness facilities and self-parking options, ensuring a comfortable and convenient experience. ### Can I book a fully refundable hotel close to Mission Hope Cancer Center? ### Can I find Expedia discounts for hotels near Mission Hope Cancer Center? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Santa Maria ](https://www.expedia.ca/4Star-Santa-Maria-Hotels.s40-0-d3224.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Santa Maria ](https://www.expedia.ca/5Star-Santa-Maria-Hotels.s50-0-d3224.Travel-Guide-Filter-Hotels) - [Arroyo Grande Hotels ](https://www.expedia.ca/Arroyo-Grande-Hotels.d6261.Travel-Guide-Hotels) - [Hotels near Blacklake Golf Resort ](https://www.expedia.ca/Blacklake-Golf-Resort-Hotels.0-l6207570-0.Travel-Guide-Filter-Hotels) - [Hotels near Cambria Winery ](https://www.expedia.ca/Cambria-Winery-Hotels.0-l553248621532639594-0.Travel-Guide-Filter-Hotels) - 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