Title: Hotels by Independent in Mesopotamia from CA $81 | Expedia.ca [Mesopotamia Travel Guide](https://expedia.ca/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Rentals](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides) ![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in Mesopotamia from CA $81 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesopotamia Independent Hotels ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/c44de299.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/d08855c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/1950856d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/97000000/96450000/96446000/96445971/433c57ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson Plaza La Ribera Resistencia 9.2/10 Wonderful (104) "An outstanding hotel, new, in a very good environment, quite close to the city. Modern rooms, good technology, plus a very generous breakfast." CA $105 CA $105 total Nov 2 - Nov 3 [](https://www.expedia.ca/Resistencia-Hotels-Howard-Johnson-Plaza-La-Ribera.h96445971.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/13fc6ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/12ba074c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/09bc75f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/903afdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### InterTower Hotel Santa Fe 8.8/10 Excellent (203) "Excelent place to stay." CA $140 CA $140 total Oct 9 - Oct 10 [](https://www.expedia.ca/Santa-Fe-Hotels-InterTower-Hotel.h9845278.Hotel-Information) ![Indoor pool, open 10:00 AM to 5:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/153bae1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot stone massages, massages](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/3fc0ad02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot stone massages, massages](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/f09e615e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 10:00 AM to 5:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/72000000/71050000/71042900/71042838/52678907.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Zarate Zárate 8.4/10 Very good (93) "Room with very comfortable beds, which is the hotel's strongest point, service by the guys at breakfast very bad, no desire to work, bathroom located on the ground floor with a smell worse than a public bathroom in the city center, where I have already informed the management so that they can take action. Very nice pool for families. Good hotel for families on vacation and good breakfast!" CA $94 CA $94 total Oct 7 - Oct 8 [](https://www.expedia.ca/Zarate-Hotels-Days-Inn-Zarate.h71042838.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/c5d48d1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/1dcc67c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food court](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/1ce8f635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/962c6c78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Silos Hotel Santa Fe 9.4/10 Exceptional (26) "Unique, interesting, and very nice. Staff was outstanding. We will be back soon" CA $148 CA $148 total Oct 19 - Oct 20 [](https://www.expedia.ca/Santa-Fe-Parana-Hotels-Los-Silos-Hotel.h49086569.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/3b6899cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/6f7f5b2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/6fa88a7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/0fd9db67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pullman Rosario City Center Hotel Rosario 8.6/10 Excellent (272) "Nice" CA $169 CA $169 total Oct 7 - Oct 8 [](https://www.expedia.ca/Rosario-Hotels-Pullman-Rosario-City-Center-Hotel.h3023891.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/13000000/12380000/12370700/12370608/fdbaa5cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12380000/12370700/12370608/b5351e2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/13000000/12380000/12370700/12370608/49cd5e30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12380000/12370700/12370608/cd425dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gala Hotel y Convenciones Resistencia 9.2/10 Wonderful (133) "Close to the airport. Great price and luxurious." CA $82 CA $82 total Oct 7 - Oct 8 [](https://www.expedia.ca/Resistencia-Hotels-Gala-Hotel-Y-Convenciones.h12370608.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, steam room, body treatments, hot stone massages, facials](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/ef76fc3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/96c73453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/c45620e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Costarenas Hotel & Spa Colon 8.6/10 Excellent (57) CA $170 CA $170 total Oct 7 - Oct 8 [](https://www.expedia.ca/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Indoor pool, outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/138c0f23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cf8e0206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor spa tub](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/95a72f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hathor Concordia Concordia 8.6/10 Excellent (353) "Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful." CA $66 CA $81 total Nov 2 - Nov 3 [](https://www.expedia.ca/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/e7b50f9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, open 9:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/3f7af7b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/64dd1add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite (Parana)](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/8470c987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Puerto Norte Design Hotel Rosario 9.2/10 Wonderful (142) "Super comfortable and luxurious with amazing view of the river. The staff was courteous enough and parking was easy and right in front of the hotel. " CA $197 CA $197 total Nov 6 - Nov 7 [](https://www.expedia.ca/Rosario-Hotels-Puerto-Norte-Design-Hotel.h10633627.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/1000000/990000/983700/983698/1521535a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, Kitchenette](https://images.trvl-media.com/lodging/1000000/990000/983700/983698/45533966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/990000/983700/983698/a11b7965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/990000/983700/983698/0da32baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Campana Campana 7.2/10 Good (95) "okay for shortterm stay" CA $133 CA $133 total Oct 12 - Oct 13 [](https://www.expedia.ca/Pilar-Hotels-Australis-Campana.h983698.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-20&endDate=2025-10-21®ionId=6208836&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels-Independent.0-0-d6208836--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesopotamia-Hotels-Independent.0-0-d6208836--bIndependent.Travel-Guide-Filter-Hotels) ## Top Mesopotamia Hotel Reviews ![Holiday Inn Express Rosario by IHG](//images.trvl-media.com/lodging/4000000/3250000/3243000/3242923/502819d5_y.jpg) ### Holiday Inn Express Rosario by IHG 10/10 Excellent "Clean room. Everything just like in the pictures. " [](https://expedia.ca/Rosario-Hotels-Holiday-Inn-Express-Rosario.h3242923.Hotel-Information) ![Costarenas Hotel & Spa](//images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01_y.jpg) ### Costarenas Hotel & Spa 2/10 Terrible "Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about remodeling hours. Felt uncomfortable when asked for manager’s name, and refused to give any other information. - Same receptionist reached out later to apologize and acknowledged we should have not been placed in those rooms to begin with. Offered to move us to “upgraded” rooms. - “Upgraded” rooms were even worse. One of the rooms was directly under the ones being remodeled and worked on. Noise began at 8 AM - The other two rooms did not have a functioning air conditioner. Staff gave poor excuse and just said to open windows. There’s tons of noise far into the night from motor bikes and people playing music right across the hotel. - Hotel breakfast was motel level at best. You get eggs swimming in water and some cut up ham. Toasters barely worked, and when staff was asked for replacement they appeared completely clueless. - The spa experience was good when it came to the massage. However “quiet” policy is not enforced and hearing toilets go off right next to the spa area don’t help with the experience. - Check out was the final straw. Desk staff was rude and dismissive of concerns, stating that the room “upgrade” was sufficient compensation for the troubles. " [](https://expedia.ca/Colon-Hotels-Costarenas-Hotel-Spa.h15362145.Hotel-Information) ![Holiday Inn Rosario by IHG](//images.trvl-media.com/lodging/1000000/580000/570400/570357/61653463_y.jpg) ### Holiday Inn Rosario by IHG 10/10 Excellent "Todo perfecto " [](https://expedia.ca/Rosario-Hotels-Holiday-Inn-Rosario.h570357.Hotel-Information) ![Esplendor by Wyndham Savoy Rosario](//images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51_y.jpg) ### Esplendor by Wyndham Savoy Rosario 10/10 Excellent "Excellent hotel Everything very comfortable, and convenient" [](https://expedia.ca/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information) ![Dazzler by Wyndham Rosario](//images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/65a9aa22_y.jpg) ### Dazzler by Wyndham Rosario 10/10 Excellent "Todo correcto" [](https://expedia.ca/Rosario-Hotels-Dazzler-By-Wyndham-Rosario.h20265319.Hotel-Information) ![Howard Johnson by Wyndham Rosario](//images.trvl-media.com/lodging/14000000/13520000/13514300/13514290/3d666cad_y.jpg) ### Howard Johnson by Wyndham Rosario 10/10 Excellent "Super conveniente por precio y calidad." [](https://expedia.ca/Rosario-Hotels-Howard-Johnson-Rosario.h13514290.Hotel-Information) ![Wyndham Garden Campana](//images.trvl-media.com/lodging/1000000/990000/983700/983698/1521535a_y.jpg) ### Wyndham Garden Campana 6/10 Okay "Televisor con problemas de funcionamiento. Ducha que baña todo el baño en lugar de ti. Ventana expuesta al paso de todo el público. " [](https://expedia.ca/Pilar-Hotels-Australis-Campana.h983698.Hotel-Information) ![O2 Hotel Gualeguaychú](//images.trvl-media.com/lodging/77000000/76460000/76459400/76459363/759ad5d8_y.jpg) ### O2 Hotel Gualeguaychú 8/10 Good "Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice. " [](https://expedia.ca/Gualeguaychu-Hotels-O2-Gualeguaychu.h76459363.Hotel-Information) ![Hathor Concordia](//images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg) ### Hathor Concordia 10/10 Excellent "Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful." [](https://expedia.ca/Concordia-Hotels-Hathor-Concordia.h4668235.Hotel-Information) ## Explore a world of travel with Expedia - More ways to book - [Book Independent in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/Mesopotamia-Hoteles-Independent.0-0-d6208836--bIndependent.Guia-filtrada-de-Hoteles)