Mesopotamia Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $1,096 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with Corrientes. Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favourite with Mesopotamia travellers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're travelling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

Top Mesopotamia Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Infinito Hotel

Infinito Hotel

3 out of 5
Palermo
Price was CA $1,916, price is now CA $1,383 per person
CA $1,383
per person
May 15 - May 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Buenos Aires (EZE)
7.8/10 Good! (222 reviews)
A mi me encanto. Me gusto mucho la area, el staff, y fue comodo.

Reviewed on Oct 3, 2025

Algodon Mansion

Algodon Mansion

5 out of 5
Buenos Aires Central Business District
Price was CA $3,719, price is now CA $2,312 per person
CA $2,312
per person
May 15 - May 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Buenos Aires (EZE)
9.6/10 Exceptional! (112 reviews)
What a fabulous hotel to stay in. We had a wonderful vacation. Our suite was very quiet, spacious and well appointed. The concierge team stood out and coordinated day trips and dinners. These experiences made our trip to Buenos Aires extra special. Highly recommend staying at the Algodon Mansion.

Reviewed on Feb 15, 2026

Krista Boutique Hotel

Krista Boutique Hotel

4 out of 5
Palermo
Price was CA $2,300, price is now CA $1,605 per person
CA $1,605
per person
May 15 - May 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Buenos Aires (EZE)
9.2/10 Wonderful! (340 reviews)
Overall a very nice hotel, good location in Palermo SOHO, great breakfast, good, quiet central aircon, rooms towards the back very quiet.

Reviewed on Apr 2, 2026

Casa Lucia Member of Melia Collection

Casa Lucia Member of Melia Collection

5 out of 5
El Centro
Price was CA $2,808, price is now CA $2,013 per person
CA $2,013
per person
May 15 - May 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Buenos Aires (EZE)
9.6/10 Exceptional! (128 reviews)
Very nice hotel, excellent location, great staff. Our flight back home was delayed for 48 hours, and Guadalupe and Kevin from the hotel Front Desk were of great help in sorting out this problem. The hotel has a very nice restaurant. Our waiter, Sara provided great service

Reviewed on Mar 20, 2026

Sofitel Buenos Aires Recoleta

Sofitel Buenos Aires Recoleta

5 out of 5
Buenos Aires Central Business District
Price was CA $3,207, price is now CA $2,301 per person
CA $2,301
per person
May 15 - May 20
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Buenos Aires (EZE)
9.2/10 Wonderful! (618 reviews)
This was my first time staying at this hotel. With a stay in Rio prior to this one, would recommend this hotel over all the hotels I have stayed at except a few. I won’t name them but to give a quick insight. Irene stayed at Four Seasons in NYC, St. Regis Hong Kong, JW NYC, and Sofitel is a close second to these. The staff was wonderfully attentive. Look forward to coming back next year.

Reviewed on Apr 6, 2026

Ready to book your vacation to Mesopotamia?

 

Choose your dates

Mesopotamia Hotel Deals

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is CA $161 per night from May 3 to May 4
CA $161
CA $161 total
May 3 - May 4
10/10 Exceptional! (24 reviews)
I had a great experience at this Marriott hotel in Corrientes. The property is exactly as described — beautiful, well-maintained, and with an excellent location. I stayed there for a wedding, and everything was outstanding. The service was incredible from start to finish, and the staff was always ...

Reviewed on Mar 24, 2026

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is CA $69 per night from Apr 14 to Apr 15
CA $69
CA $69 total
Apr 14 - Apr 15
7.6/10 Good! (81 reviews)
Nice

Reviewed on Apr 2, 2026

O2 Hotel Gualeguaychú
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
Fully refundableReserve now, pay when you stay
The price is CA $158 per night from May 10 to May 11
CA $158
CA $158 total
May 10 - May 11
8.8/10 Excellent! (6 reviews)
The best place to stay in Corrientes! Amazing views

Reviewed on Apr 7, 2026

Turismo Hotel Casino
See all 510 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Mesopotamia

Parque Nacional El Palmar, Entre Rios, Argentina.

El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.

El Palmar National Park

Frequently asked questions

Can I cancel my flight booking to Mesopotamia due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airline you're considering. If you've already reserved your flight to Mesopotamia, make use of our Customer Service Portal. It will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Mesopotamia that have flexible change policies?
Search for your bargain flights to Mesopotamia, then tick the "No change fee" box directly underneath the "Flexible change policies" heading. It's that easy. We know that plans change and flexibility is essential, so you can book with confidence with Expedia.
What are some of the general tips for travelers to Mesopotamia during the COVID-19 outbreak?
If it's your first time traveling during the COVID-19 pandemic, you'll notice a range of new rules and restrictions in place. Take note of these tips and make your escape to Mesopotamia a smooth one:
  • Research if any travel restrictions apply to your destination and origin before booking. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Keep your face mask on even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • Instead of handing a TSA employee your boarding pass, position it directly on the scanner yourself. When that's done, hold it up for inspection.
  • You're permitted to take one container of hand sanitizer up to 12 oz (350 ml) in your hand luggage. This will need to be taken out for screening.
  • Place any personal items (phone, wallet and keys for example) in your carry-on rather than a bin to minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA employee to handle and inspect your belongings.

Which airlines fly to Mesopotamia?
Book your ticket with LATAM Airlines and then start putting together your Mesopotamia travel itinerary. This top airline provides 143 flights each month to Ministro Pistarini Intl. Airport (EZE), a major gateway.
How can I find cheap tickets to Mesopotamia?
One of the easiest ways to snare cheap tickets to Mesopotamia is to be flexible with your dates. Search for your flights, then click "flexible dates" above the results. It will bring up the cheapest prices for nearby days. The lowest price for a flight to Mesopotamia in the last seven days was . Booking ahead will generally help you get an even better deal.
How much is a flight to Mesopotamia?
You could have scored a return ticket to Mesopotamia from anywhere between and in the last seven days. For one-way trips leaving from (), the lowest amount paid during this period was just .
What are the most popular airports to fly into in Mesopotamia?
Book your flight to Ministro Pistarini Intl. Airport (EZE) and sample all that Mesopotamia has to offer. As the region's main entry point, around 850 flights land here each month.
When is the cheapest time to fly to Mesopotamia?
Leave for Mesopotamia early on in the week and you'll usually be rewarded more economical fares. Tuesday is typically the cheapest day to get on a plane, followed closely by Monday. If you'd like to avoid the most expensive flights, keep clear of Saturdays.
How much is a plane ticket to Mesopotamia?
Seats to Mesopotamia ranged from to in the last seven days. Normally, the earlier you make a reservation, the better the deal.
Which airlines with flights to Mesopotamia employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have adopted new precautionary measures to help their passengers and crew get back in the air. Here are some good examples:
  • Aerolineas Argentinas - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.
  • LATAM Airlines - this airline is known for providing passenger masks and capped capacity flights.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.