Title: Book the Best Mesilla SPA Resorts from CA $164 - Spa Hotels in Mesilla, NM | Expedia.ca [Hotels in Mesilla](https://expedia.ca/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Vacation Rentals in Mesilla](https://expedia.ca/Mesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.ca/Mesilla.d132684.Destination-Travel-Guides) ![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Mesilla, NM from CA $164 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mesilla Spa Hotels Tonight [Nov 18 - Nov 19](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-18&endDate=2025-11-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 19 - Nov 20](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-19&endDate=2025-11-20&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-21&endDate=2025-11-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=132684&startDate=2025-11-28&endDate=2025-11-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Mesilla Spa Hotels ![Indoor pool](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/eae97133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/abf3b389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/bf4a0d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Las Cruces I-25 North Las Cruces 9.2/10 Wonderful (1000) "Great location great breakfast friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $154 CA $183 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1650000/1647600/1647510/1ac5e06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1650000/1647600/1647510/eaecc7d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1650000/1647600/1647510/49f03181.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1650000/1647600/1647510/9b12f75d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel and Suites Las Cruces by IHG Las Cruces 8.0/10 Very good (1002) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martin and Nancy CA $142 CA $164 total includes taxes & fees Dec 5 - Dec 6 [](https://www.expedia.ca/Las-Cruces-Hotels-Holiday-Inn-Express-Hotel-And-Suites-Las-Cruces.h1647510.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-02&endDate=2025-12-03®ionId=132684&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Mesilla Hotel Reviews ![Hampton Inn & Suites Las Cruces I-25](//images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/b0473335_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "Easy check in, breakfast was great. The sheets came off the corners of the mattress, need bigger sheets. Unfortunately, there were a couple of kids (maybe just one?) who stayed next to us on the 4th floor. They arrived at 11:19pm and for the next hour, there were doors slamming, yelling, screaming, stomping, running, the kid(s) was out of control and VERY disruptive. Woke us up out of our sleep. I felt sorry for the people with a room under them, as they were VERY noisy sideway, the floor vibrated with their activity." [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Comfort Suites Las Cruces I-25 North](//images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5_y.jpg) ### Comfort Suites Las Cruces I-25 North 10/10 Excellent "All of the above!" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Staybridge Suites Las Cruces by IHG](//images.trvl-media.com/lodging/2000000/1410000/1407200/1407181/e6d0a748_y.jpg) ### Staybridge Suites Las Cruces by IHG 10/10 Excellent "Yes, very nice room" [](https://expedia.ca/Las-Cruces-Hotels-Staybridge-Suites-Las-Cruces.h1407181.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-10](//images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a_y.jpg) ### Hampton Inn & Suites Las Cruces I-10 10/10 Excellent "No issues at all." [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![Hotel Encanto de Las Cruces](//images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent "Courteous staff, spacious room, great location. The style and atmosphere at this hotel is amazing. " [](https://expedia.ca/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Quality Inn & Suites Las Cruces - University Area](//images.trvl-media.com/lodging/1000000/50000/43200/43177/d64502c0_y.jpg) ### Quality Inn & Suites Las Cruces - University Area 10/10 Excellent "GREAT staff. I had three snafus, two on my end, one at the hotel. They fixed all three quick and easily, with kindness and flexibility. Convenient location, clean, comfortable beds. A real nice stay for a few nights, will be back!" [](https://expedia.ca/Las-Cruces-Hotels-Quality-Inn-Suites-Las-Cruces-University-Area.h43177.Hotel-Information) ![Springhill Suites By Marriott Las Cruces](//images.trvl-media.com/lodging/1000000/210000/203700/203622/ee15ba4f_y.jpg) ### Springhill Suites By Marriott Las Cruces 10/10 Excellent "The staff was very friendly. The property was basically clean. " [](https://expedia.ca/Las-Cruces-Hotels-Springhill-Suites-By-Marriott-Las-Cruces.h203622.Hotel-Information) ![Comfort Inn & Suites Las Cruces Mesilla](//images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c_y.jpg) ### Comfort Inn & Suites Las Cruces Mesilla 10/10 Excellent "Fit in well with the local culture" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Mesilla? > Treat yourself to some pampering and book a hotel with a spa. Check out the theater scene and restaurants in Mesilla—your day trip starts here. Spa hotels are the perfect way to break out of your routine and add a layer of luxury to your holiday. ### What's there to see and do in Mesilla? > Experience all that Mesilla has to offer when you visit Mesillia Plaza, Rio Grande, and San Albino Basilica. If you have extra time while you're in the area, you might want to stop by Fountain Theatre and Fountain Theater. ### What is a Mesilla spa hotel? > Spa hotels in Mesilla feature on-site spas offering services like couples massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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