Find luxury hotels in Mesa, CO

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Mesa Luxury Hotels

Tonight
Aug 6 - Aug 7
Tomorrow
Aug 7 - Aug 8
This weekend
Aug 8 - Aug 10
Next weekend
Aug 15 - Aug 17

Top Mesa Luxury Hotels

Top Mesa Hotel Reviews

Wine Country Inn Palisade

Wine Country Inn Palisade

10/10 Excellent
"Very nice hotel, the location was perfect. Close to the wineries, the pool was great and their winery was amazing. I really recommend this trip and this hotel! Better than expected!!"
Maria 1-night trip
Posted 1 day ago
Wine Country Inn Palisade

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Mesa?
Use Expedia to arrange your flight to Grand Junction Regional Airport (GJT) airport or Montrose Regional Airport (MTJ) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Mesa has to offer. Mesa has some interesting things to see and do including Powderhorn Resort and Grand Mesa National Forest, so you might want to take in the local sights during your visit.
When can I expect good weather in Mesa?
Planning for the weather is a good way to make your trip to Mesa relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 69°F, while the coldest months are January and December with an average of 27°F. Average annual precipitation for Mesa is 17 inches.
What's there to see and do in Mesa?
Take in some sights and attractions while you're in Mesa by visiting Powderhorn Resort, Grand Mesa National Forest, and High Country Orchards. If you have extra time while you're in the area, you might want to see Colorado Cellars Winery - Rocky Mountain Vineyards - Colorado Mountain Wineyard and Vega State Park.