Title: Book The Best Hotels in Mayo, SC for 2026 from CA $78 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Mayo](https://expedia.ca/Mayo-Vacation-Rentals.d553248634999378372.Travel-Guide-VacationRentals)[Mayo Car Rentals](https://expedia.ca/Car-Rentals-In-Mayo.d553248634999378372.Car-Rental-Guide)[Mayo Vacation Packages](https://expedia.ca/Mayo.d553248634999378372.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Mayo, SC from CA $78 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Mayo Resort [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=HOTEL_RESORT) Spa [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=SPA_ON_SITE) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=APART_HOTEL) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&travelerType=family_friendly) Ryokan [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=RYOKAN) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=OCEAN_VIEW) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CABIN) Farm [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=AGRITOURISM) Capsule hotel [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CAPSULE_HOTEL) Pool [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=POOL) Castle [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&lodging=CASTLE) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Mayo%2C+South+Carolina%2C+United+States+of+America®ionId=553248634999378372&latLong=35.084011%2C-81.859825&adults=2&startDate=2025-12-24&d1=2025-12-24&endDate=2025-12-26&d2=2025-12-26&amenities=HOT_TUB) ## Check prices for these dates Tonight [Dec 10 - Dec 11](https://www.expedia.ca/Hotel-Search?regionId=553248634999378372&startDate=2025-12-10&endDate=2025-12-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 11 - Dec 12](https://www.expedia.ca/Hotel-Search?regionId=553248634999378372&startDate=2025-12-11&endDate=2025-12-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248634999378372&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248634999378372&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mayo hotels ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2550000/2544000/2543902/128bf160.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2550000/2544000/2543902/42e16252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2550000/2544000/2543902/63e5477d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2550000/2544000/2543902/49f21b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Spartanburg-North by IHG [](https://www.expedia.ca/Spartanburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Spartanburg-North.h2543902.Hotel-Information) Spartanburg 8.6/10 Excellent (861) "The stay was great overall, room was exceptional in size and comfort. The noise from the highway was the only distraction but mainly because we do not ever have any. The staff was friendly and helpful. We would not hesitate to stay here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charmaine CA $134 CA $149 total includes taxes & fees Dec 26 - Dec 27 [](https://www.expedia.ca/Spartanburg-Hotels-Holiday-Inn-Express-Hotel-Suites-Spartanburg-North.h2543902.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, desk, blackout drapes](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/4c47e461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, desk, blackout drapes](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/e7d5d81c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/f343bb09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ECHO Suites Extended Stay by Wyndham Spartanburg [](https://www.expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) Spartanburg 8.2/10 Very good (289) "Nice hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kierra CA $99 CA $112 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/1ada0475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/8449a857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/fd1d83c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/b84eb75d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites At WestGate Mall [](https://www.expedia.ca/Spartanburg-Hotels-Comfort-Suites-At-WestGate-Mall.h2654329.Hotel-Information) Spartanburg 8.2/10 Very good (1000) "Easy parking, parking lot had good lighting felt safe Breakfast had great choices always hot, I always like their waffles Rooms clean and spacious, bed was comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald CA $136 CA $151 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Spartanburg-Hotels-Comfort-Suites-At-WestGate-Mall.h2654329.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/cd259adf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/0304ce09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/573947b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/c05bf676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Gaffney [](https://www.expedia.ca/Gaffney-Hotels-Hampton-Inn-Gaffney.h424882.Hotel-Information) Gaffney 8.8/10 Excellent (666) "Clean room, great staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) gary CA $121 CA $132 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Gaffney-Hotels-Hampton-Inn-Gaffney.h424882.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18800/18704/034bcb90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18800/18704/e1ab73fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18800/18704/53dee440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/18800/18704/73eada7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Gaffney I-85 [](https://www.expedia.ca/Gaffney-Hotels-Quality-Inn-Gaffney-I-85.h18704.Hotel-Information) Gaffney 7.6/10 Good (352) "My stay was pleasant and the breakfast was as expected. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharon CA $73 CA $82 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Gaffney-Hotels-Quality-Inn-Gaffney-I-85.h18704.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/41700/41656/9b1f8ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/50000/41700/41656/5c52e049.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 2 Single Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/41700/41656/afb8d6f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/50000/41700/41656/4c5b23e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HomeTowne Studios by Red Roof Spartanburg - Asheville Highway [](https://www.expedia.ca/Spartanburg-Hotels-HomeTowne-Studios-By-Red-Roof-Spartanburg-Asheville-Highway.h41656.Hotel-Information) Spartanburg 5.2/10 (433) "There were roaches " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Demetrius CA $82 CA $91 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Spartanburg-Hotels-HomeTowne-Studios-By-Red-Roof-Spartanburg-Asheville-Highway.h41656.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/d8b2892f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/f5139881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, blackout drapes](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/bd03801f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.6/10 Excellent (414) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $96 CA $104 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/120000/116600/116563/6e11f252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/120000/116600/116563/e75f0989.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/116600/116563/22b029ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/120000/116600/116563/668ebde9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn by Wyndham Duncan/Spartanburg [](https://www.expedia.ca/Duncan-Hotels-Microtel-Inn-By-Wyndham-DuncanSpartanburg.h116563.Hotel-Information) Duncan 7.2/10 Good (519) "Staff was very accommodating. The whole place was clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) RAYFIELD CA $105 CA $116 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Duncan-Hotels-Microtel-Inn-By-Wyndham-DuncanSpartanburg.h116563.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/a3b8adf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/e7b52d93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/b3b1b4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Spartanburg [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) Spartanburg 9.2/10 Wonderful (818) "Excellent hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jairo CA $132 CA $146 total includes taxes & fees Dec 28 - Dec 29 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Coffee shop](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/a78c349a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/d8583276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/3180d623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/c9a89e89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Points by Sheraton Spartanburg [](https://www.expedia.ca/Spartanburg-Hotels-Four-Points-By-Sheraton-Spartanburg.h28087.Hotel-Information) Spartanburg 9.4/10 Exceptional (432) "The room was very nice and the staff was very professional " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John T CA $165 CA $183 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Spartanburg-Hotels-Four-Points-By-Sheraton-Spartanburg.h28087.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/910000/900200/900173/9a6364f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds](https://images.trvl-media.com/lodging/1000000/910000/900200/900173/4d6b1e3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/910000/900200/900173/c3da6451.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/910000/900200/900173/d3d5e3fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG [](https://www.expedia.ca/Spartanburg-Hotels-Holiday-Inn-Express-I-26-Us-29-At-Westgate-Mall.h900173.Hotel-Information) Spartanburg 8.8/10 Excellent (709) "Very nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dave CA $123 CA $137 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Spartanburg-Hotels-Holiday-Inn-Express-I-26-Us-29-At-Westgate-Mall.h900173.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/75c3dac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge, alfresco dining, open daily](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/bd09d7bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/2016aea9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Corner](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/fd28caf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott Spartanburg [](https://www.expedia.ca/Spartanburg-Hotels-AC-Hotel-By-Marriott-Spartanburg.h19218492.Hotel-Information) Spartanburg 9.2/10 Wonderful (585) "Just would like more parking. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nyeenner CA $165 CA $183 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Spartanburg-Hotels-AC-Hotel-By-Marriott-Spartanburg.h19218492.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/d02ac737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/e845fce6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/1b324965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/b1fdad7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Spartanburg Northwest [](https://www.expedia.ca/Spartanburg-Hotels-Best-Western-Spartanburg-Northwest.h19764.Hotel-Information) Spartanburg 8.2/10 Very good (816) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jamie CA $117 CA $129 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Spartanburg-Hotels-Best-Western-Spartanburg-Northwest.h19764.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/283600/283578/57c4ccac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/290000/283600/283578/83db464e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/290000/283600/283578/4d612a6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/1000000/290000/283600/283578/a8807d24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Gaffney at I-85 [](https://www.expedia.ca/Gaffney-Hotels-Sleep-Inn-Gaffney.h283578.Hotel-Information) Gaffney 7.6/10 Good (329) "Room was clean and staff was very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $93 CA $104 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Gaffney-Hotels-Sleep-Inn-Gaffney.h283578.Hotel-Information) ![Suite, Non Smoking (2 King Beds)](https://images.trvl-media.com/lodging/1000000/50000/43500/43458/d3086cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/43500/43458/c4574646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/43500/43458/4345ddf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/50000/43500/43458/94a1c4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn & Suites Duncan [](https://www.expedia.ca/Duncan-Hotels-Days-Inn-Suites-By-Wyndham-DuncanSpartanburg.h43458.Hotel-Information) Duncan 7.0/10 Good (350) "The staff was amazing as well as the room was very clean as well " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Clarissa CA $81 CA $91 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Duncan-Hotels-Days-Inn-Suites-By-Wyndham-DuncanSpartanburg.h43458.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/eac10fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/6f095093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 9:30 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/331b91d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/8062e000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Spartanburg-North I-85 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) Spartanburg 8.8/10 Excellent (1000) "Convenient location, nice coffee station in lobby, good breakfast, room was average, good enough for one night stopover as I needed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John M CA $105 CA $117 total includes taxes & fees Jan 9 - Jan 10, 2026 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42900/42865/e3871f21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/42900/42865/w2880h1919x0y1-55053bc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42900/42865/0387cb3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/50000/42900/42865/3dacf371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Spartanburg Northwest [](https://www.expedia.ca/Spartanburg-Hotels-Howard-Johnson-By-Wyndham-Spartanburg-Expo-Center.h42865.Hotel-Information) Spartanburg 7.0/10 Good (808) "Breakfast offerings were good, but limited in choices. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert CA $100 CA $111 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Spartanburg-Hotels-Howard-Johnson-By-Wyndham-Spartanburg-Expo-Center.h42865.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/42000000/41180000/41178800/41178711/20020112.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/42000000/41180000/41178800/41178711/7aaf2b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/42000000/41180000/41178800/41178711/96ecfa12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/42000000/41180000/41178800/41178711/05640f7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### USA Economy Lodge [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-USA-Economy-Lodge.h41178711.Hotel-Information) Spartanburg 7.6/10 Good (79) "Loved it very quiet and pleasant " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tameesha [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-USA-Economy-Lodge.h41178711.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088159/2e33c020.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088159/03ce2fba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![One king sofabed ns | Living area](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088159/750f98db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088159/bff8383c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Spartanburg-I-26-Westgate Mall [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Suites-Spartanburg-I-26-Westgate-Mall.h1088159.Hotel-Information) Spartanburg 8.6/10 Excellent (982) "Room was spotless, staff was very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anne-Marie CA $148 CA $165 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Spartanburg-Hotels-Hampton-Inn-Suites-Spartanburg-I-26-Westgate-Mall.h1088159.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/1000000/20000/14600/14575/b794d25e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14575/2da8b248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/20000/14600/14575/2f94c8d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14600/14575/270047da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Spartanburg – I-26 [](https://www.expedia.ca/Spartanburg-Hotels-Red-Roof-Inn-Spartanburg.h14575.Hotel-Information) Spartanburg 7.0/10 Good (740) "Any property was very clean the room very clean we were very pleased stuff excellent.. Good to know that they are pet family friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danny CA $85 CA $95 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Spartanburg-Hotels-Red-Roof-Inn-Spartanburg.h14575.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-24&endDate=2025-12-25®ionId=553248634999378372&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMayo-Hotels.d553248634999378372.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMayo-Hotels.d553248634999378372.Travel-Guide-Hotels) ## More cheap stays in Mayo ![Days Inn by Wyndham Spartanburg Waccamaw](https://images.trvl-media.com/lodging/1000000/30000/26200/26192/67411a8e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Spartanburg Waccamaw 101 Outlet Rd Spartanburg SC CA $79 CA $88 total Dec 13 - Dec 14 includes taxes & fees 7.2/10 Good! (773 reviews) [](https://expedia.ca/Spartanburg-Hotels-Days-Inn-By-Wyndham-Spartanburg-Waccamaw.h26192.Hotel-Information) ![Holiday Inn Express Gaffney by IHG](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Gaffney by IHG 1031 HYATT STREET Gaffney SC CA $96 CA $104 total Dec 23 - Dec 24 includes taxes & fees 8.6/10 Excellent! (414 reviews) [](https://expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### ECHO Suites Extended Stay by Wyndham Spartanburg 490 W Blackstock Road Spartanburg SC CA $99 CA $112 total Dec 14 - Dec 15 includes taxes & fees 8/10 Very Good! (289 reviews) [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Hampton Inn Gaffney](https://images.trvl-media.com/lodging/1000000/430000/424900/424882/cd259adf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Gaffney 115 Nancy Creek Rd Gaffney SC CA $121 CA $132 total Dec 21 - Dec 22 includes taxes & fees 8.6/10 Excellent! (665 reviews) [](https://expedia.ca/Gaffney-Hotels-Hampton-Inn-Gaffney.h424882.Hotel-Information) ![Tru by Hilton Spartanburg](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tru by Hilton Spartanburg 103 Franklin Avenue Spartanburg SC CA $132 CA $146 total Dec 28 - Dec 29 includes taxes & fees 9/10 Wonderful! (817 reviews) [](https://expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Comfort Suites At WestGate Mall](https://images.trvl-media.com/lodging/3000000/2660000/2654400/2654329/1ada0475_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites At WestGate Mall 458 West Blackstock Road Spartanburg SC CA $136 CA $151 total Jan 4 - Jan 5, 2026 includes taxes & fees 8.2/10 Very Good! (1,001 reviews) [](https://expedia.ca/Spartanburg-Hotels-Comfort-Suites-At-WestGate-Mall.h2654329.Hotel-Information) ## Hotels in Mayo with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 28 properties [](https://expedia.ca/3Star-Mayo-Hotels.s30-0-d553248634999378372.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 87 properties [](https://expedia.ca/2Star-Mayo-Hotels.s20-0-d553248634999378372.Travel-Guide-Filter-Hotels) ## Recent reviews of Mayo hotels ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg) ### ECHO Suites Extended Stay by Wyndham Spartanburg 5/5 Excellent "I was impressed upon entrance to the lobby! Everything was clean in neat and the receptionist was AWESOME!" A verified traveller stayed at ECHO Suites Extended Stay by Wyndham Spartanburg Posted 2 days ago [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Tru by Hilton Spartanburg](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d_y.jpg) ### Tru by Hilton Spartanburg 5/5 Excellent "Very friendly professional staff during check-in. Clean rooms and a nice breakfast each morning. " A verified traveller stayed at Tru by Hilton Spartanburg Posted 3 days ago [](https://expedia.ca/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG](https://images.trvl-media.com/lodging/1000000/910000/900200/900173/9a6364f5_y.jpg) ### Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG 5/5 Excellent "Room was very clean. Great value for your money but the breakfast is not good." A verified traveller stayed at Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG Posted 3 days ago [](https://expedia.ca/Spartanburg-Hotels-Holiday-Inn-Express-I-26-Us-29-At-Westgate-Mall.h900173.Hotel-Information) ![Holiday Inn Express Gaffney by IHG](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000_y.jpg) ### Holiday Inn Express Gaffney by IHG 5/5 Excellent "Clean room" A verified traveller stayed at Holiday Inn Express Gaffney by IHG Posted 6 days ago [](https://expedia.ca/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Hampton Inn Spartanburg-North I-85](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/eac10fcf_y.jpg) ### Hampton Inn Spartanburg-North I-85 5/5 Excellent "Very nice breakfast. Clean and spacious lobby, great for visiting with friends. Complementary coffee all day. Great clean comfortable room. Would definitely stay there again." A verified traveller from fairbanks stayed at Hampton Inn Spartanburg-North I-85 Posted 6 days ago [](https://expedia.ca/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) ![AC Hotel by Marriott Spartanburg](https://images.trvl-media.com/lodging/20000000/19220000/19218500/19218492/75c3dac7_y.jpg) ### AC Hotel by Marriott Spartanburg 5/5 Excellent "Just would like more parking. " A verified traveller from Sandy Springs stayed at AC Hotel by Marriott Spartanburg Posted 7 days ago [](https://expedia.ca/Spartanburg-Hotels-AC-Hotel-By-Marriott-Spartanburg.h19218492.Hotel-Information) ![Best Western Spartanburg Northwest](https://images.trvl-media.com/lodging/1000000/20000/19800/19764/d02ac737_y.jpg) ### Best Western Spartanburg Northwest 5/5 Excellent "Great place" A verified traveller stayed at Best Western Spartanburg Northwest Posted 7 days ago [](https://expedia.ca/Spartanburg-Hotels-Best-Western-Spartanburg-Northwest.h19764.Hotel-Information) ![Hampton Inn & Suites Spartanburg-I-26-Westgate Mall](https://images.trvl-media.com/lodging/2000000/1090000/1088200/1088159/2e33c020_y.jpg) ### Hampton Inn & Suites Spartanburg-I-26-Westgate Mall 5/5 Excellent "We didnt like the cold indoor-heated pool. But, we loved the hotel itself." A verified traveller stayed at Hampton Inn & Suites Spartanburg-I-26-Westgate Mall Posted 10 days ago [](https://expedia.ca/Spartanburg-Hotels-Hampton-Inn-Suites-Spartanburg-I-26-Westgate-Mall.h1088159.Hotel-Information) ![Hilton Garden Inn Spartanburg](https://images.trvl-media.com/lodging/32000000/31360000/31356900/31356806/ff5159b8_y.jpg) ### Hilton Garden Inn Spartanburg 5/5 Excellent "Clean Rooms and Very Friendly Staff. Always a yearly visit over Thanksgiving Holiday." A verified traveller stayed at Hilton Garden Inn Spartanburg Posted 10 days ago [](https://expedia.ca/Spartanburg-Hotels-Hilton-Garden-Inn-Spartanburg.h31356806.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Mayo? > This area is the heart of Mayo, offering the most convenience and access to local amenities. Main Street runs through the middle of the town, and you'll find the majority of Mayo's shops, local eateries, and community services clustered along this thoroughfare. It's a compact and walkable area, making it easy to get around without a car. > > > Couples looking for a relaxed retreat will appreciate staying near Main Street. They can enjoy leisurely strolls, discover local crafts, and dine at the few local restaurants. The proximity to local parks and the community centre also offers opportunities for quiet recreation. > > > For solo travellers, staying central around Main Street provides easy access to everything Mayo has to offer. ### When is the best time to go to Mayo? > During these periods, the weather is pleasantly mild, with comfortable temperatures and lower humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and azaleas, while autumn offers colourful foliage, enhancing the scenic beauty of the region. > > > For travellers who enjoy comfortable weather for golf, hiking, or visiting local farms and orchards, these seasons are perfect. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Mayo hotel booking with Expedia? ### How much is the nightly rate at a Mayo hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [Anglewood Hotels ](https://www.expedia.ca/Anglewood-Hotels.d553248635975857985.Travel-Guide-Hotels) - [Blacksburg Hotels ](https://www.expedia.ca/Blacksburg-Hotels.d183936.Travel-Guide-Hotels) - [Cheap Hotels in Boiling Springs ](https://www.expedia.ca/Boiling-Springs-Hotels-Cheap-Hotels.0-0-d6278956-tCheapHotels.Travel-Guide-Filter-Hotels) - [Boiling Springs Hotels ](https://www.expedia.ca/Boiling-Springs-Hotels.d6278956.Travel-Guide-Hotels) - [Campobello Hotels ](https://www.expedia.ca/Campobello-Hotels.d6336224.Travel-Guide-Hotels) - 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