Title: The 10 Best Hotels Near Louisville Science Center, Louisville from CA $125 | Expedia.ca [Downtown Louisville Travel Guide](https://expedia.ca/Louisville-Downtown-Louisville.dx6059557)[Louisville Science Center Car Rentals](https://expedia.ca/Car-Rentals-In-Louisville-Science-Center.d6062647.Car-Rental-Guide)[Louisville Science Center Vacations](https://expedia.ca/Louisville-Science-Center-Downtown-Louisville.d6062647.Vacation-Attraction) ![Louisville Science Center which includes outdoor art](https://images.trvl-media.com/place/6062647/6cb62b46-d29e-4c5d-8366-afc3a5f9c466.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Louisville Science Center, Louisville from CA $125 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 3 - Dec 4](https://www.expedia.ca/Hotel-Search?regionId=6062647&startDate=2025-12-03&endDate=2025-12-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 4 - Dec 5](https://www.expedia.ca/Hotel-Search?regionId=6062647&startDate=2025-12-04&endDate=2025-12-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6062647&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6062647&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Top Hotels Close to Louisville Science Center ![Exterior](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/8fba23fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/6374a86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/10c56810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/cf849375.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Distil, Autograph Collection Downtown Louisville, 0.9 km from Louisville Science Center 9.6/10 Exceptional (427) "Great location. Great restraunt, great staff. Pleasurable experience!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harrison CA $236 CA $278 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Louisville-Hotels-Hotel-Distil.h37765616.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/76841ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/a276c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Fireplace](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/86d15582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn 2.1 km from Louisville Science Center 9.8/10 Exceptional (120) "I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $258 CA $292 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) ![Deluxe Single Room, 1 King Bed, River View | View from room](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f322db40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f5558cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/15339a2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/c35cecf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Grady Downtown Louisville, 0.2 km from Louisville Science Center 9.4/10 Exceptional (1019) "The location was outstanding and atmosphere was very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Malcolm CA $194 CA $229 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/107000000/106570000/106567800/106567772/b6fa06fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed, Non Smoking, Private Bathroom](https://images.trvl-media.com/lodging/107000000/106570000/106567800/106567772/66d6b7e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/107000000/106570000/106567800/106567772/1a639488.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106570000/106567800/106567772/8c0d6edc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DuPont Mansion Bed & Breakfast Old Louisville, 2.8 km from Louisville Science Center 9.8/10 Exceptional (95) "Breakfast was wonderful, great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janie CA $180 CA $210 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Louisville-Hotels-DuPont-Mansion-Bed-Breakfast.h106567772.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville, 1.2 km from Louisville Science Center 9.4/10 Exceptional (1149) "I loved everything about this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven CA $165 CA $194 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/543b4092.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/7a697831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/93ff9364.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/0a1fd80c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cambria Hotel Louisville Downtown-Whiskey Row Downtown Louisville, 1.2 km from Louisville Science Center 9.4/10 Exceptional (1020) "Lovely hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy CA $111 CA $130 total includes taxes & fees Dec 24 - Dec 25 [](https://www.expedia.ca/Louisville-Hotels-CAMBRiA-Hotel-Louisville-Downtown-Whiskey-Row.h57959281.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/5c04f012.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/365889d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/c99cb08d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Billiards](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/6093a6c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Louisville Downtown, KY Downtown Louisville, 0.2 km from Louisville Science Center 9.2/10 Wonderful (1002) "Very good hotel, staff and location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $144 CA $169 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Louisville-Hotels-Homewood-Suites-By-Hilton-Louisville-Downtown.h21599840.Hotel-Information) ![Signature Suite, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/e9ed9b4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/cf9ffb28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/af58ac58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/91000000/90960000/90953600/90953532/56c60394.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stellar Suites East Market District, 2.2 km from Louisville Science Center 9.6/10 Exceptional (117) "Clean and great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg CA $145 CA $242 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Louisville-Hotels-Stellar-Suites.h90953532.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville, < 0.1 km from Louisville Science Center 9.2/10 Wonderful (1000) " Loved our stay, would definitely plan to come back if we are ever in the area again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erica CA $194 CA $235 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/8f8322e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/22942c94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/5d16fd3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/65000000/64700000/64696100/64696084/995f4afb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Towneplace Suites By Marriott Louisville Downtown Downtown Louisville, 0.3 km from Louisville Science Center 9.2/10 Wonderful (506) "Great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina CA $135 CA $159 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Louisville-Hotels-Towneplace-Suites-By-Marriott-Louisville-Downtown.h64696084.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e108d0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/9798709f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel Downtown Louisville, 0.8 km from Louisville Science Center 9.2/10 Wonderful (1698) "Wonderful property and staff. Would love to stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hanna CA $233 CA $274 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/102000000/101360000/101356400/101356375/3b4a8f4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/102000000/101360000/101356400/101356375/5fcaea69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/102000000/101360000/101356400/101356375/9d53858a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/102000000/101360000/101356400/101356375/6f053941.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tempo By Hilton Louisville Downtown Nulu Phoenix Hill, 2.1 km from Louisville Science Center 9.4/10 Exceptional (810) "Love the hotel and will always stay there when visiting " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeremy CA $133 CA $156 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Louisville-Hotels-Tempo-By-Hilton-Louisville-Downtown-Nulu.h101356375.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/050ebd40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/f3e2f52d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/0f8921c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/37000000/36890000/36884900/36884898/4979ca88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Moxy Louisville Downtown Downtown Louisville, 0.9 km from Louisville Science Center 9.2/10 Wonderful (692) "Awesome location and the staff was super friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $145 CA $171 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Louisville-Hotels-Moxy-Louisville-Downtown.h36884898.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9c82234b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville, 0.5 km from Louisville Science Center 9.0/10 Wonderful (3814) "10/10 best hotel in Louisville " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $151 CA $178 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/95d9177a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/1e2d6baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/c7cb5a92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/437bf0ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Central Park Bed & Breakfast Old Louisville, 3 km from Louisville Science Center 9.4/10 Exceptional (56) "The room was beautiful, breakfast was delicious and the park across the street was lovely. I especially enjoyed having coffee on the back veranda." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cher CA $170 CA $198 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/5bea9d61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/4e79a8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/c4d1fb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Louisville Downtown Downtown Louisville, 0.8 km from Louisville Science Center 9.0/10 Wonderful (1101) "Clean, hotel was amazing, great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alana CA $167 CA $196 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/24000000/23540000/23530100/23530018/efc4acd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/24000000/23540000/23530100/23530018/22c1b1c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/24000000/23540000/23530100/23530018/8f9a3a30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/24000000/23540000/23530100/23530018/698ccea1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel Louisville Downtown East Market District, 2.1 km from Louisville Science Center 9.2/10 Wonderful (595) "Loved the Hotel and area around the Hotel. Great shopping and restaurants" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $132 CA $155 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Louisville-Hotels-AC-Hotel-Louisville-Downtown.h23530018.Hotel-Information) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/w2665h3837x3y3-e015ca48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served, American cuisine](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/91dde8b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, rooftop bar](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/8178d3c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/47891706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Genevieve part of JdV by Hyatt East Market District, 2.1 km from Louisville Science Center 9.2/10 Wonderful (1012) "Nice hotel and rooms. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $189 CA $222 total includes taxes & fees Dec 17 - Dec 18 [](https://www.expedia.ca/Louisville-Hotels-Hotel-Genevieve.h90942141.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/380612f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/84bc2f36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/70f22474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/13000000/12560000/12552800/12552757/bf3651e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Louisville Downtown by IHG Downtown Louisville, 0.2 km from Louisville Science Center 8.8/10 Excellent (1638) "Great staff, excellent continental breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $106 CA $125 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Louisville-Hotels-Holiday-Inn-Express-Suites-Louisville-Downtown.h12552757.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/21a274da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/19f71be3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/d9d00b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673133/97cd53e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Louisville Downtown Downtown Louisville, 0.9 km from Louisville Science Center 9.0/10 Wonderful (1001) "The first night our lock on our door stopped working, so we were locked out. They were very accommodating to get us a different room for the evening and got us whatever we needed! Very nice place to stay downtown!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $135 CA $159 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Louisville-Hotels-Aloft-Louisville-Downtown.h11673133.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-18&endDate=2025-12-19®ionId=6062647&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Louisville Science Center Hotel Reviews ![Homewood Suites by Hilton Louisville Downtown, KY](https://images.trvl-media.com/lodging/22000000/21600000/21599900/21599840/5c04f012_y.jpg) ### Homewood Suites by Hilton Louisville Downtown, KY 10/10 Excellent "Can’t recommend enough. The customer service was amazing, my family and I get to see each other once year so we met at this hotel and the staff welcomed each guest, consistently asked if we needed anything and just made us feel at home. We will stay again for sure. " [](https://expedia.ca/Louisville-Hotels-Homewood-Suites-By-Hilton-Louisville-Downtown.h21599840.Hotel-Information) ![The Grady](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f322db40_y.jpg) ### The Grady 10/10 Excellent "This is a beautiful hotel with super friendly staff…it would be a ten but I would give it an eight due to windows being drafty and the mattress being a little too firm." [](https://expedia.ca/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Hilton Garden Inn Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9220000/9215400/9215348/d064e9c8_y.jpg) ### Hilton Garden Inn Louisville Downtown 10/10 Excellent "Staff was courteous. Great location. Will stay here again. " [](https://expedia.ca/Louisville-Hotels-Hilton-Garden-Inn-Louisville-Downtown.h9215348.Hotel-Information) ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Beautiful hotel friendly staff huge room comfy bed. Expensive parking but not their fault. Would book again " [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Embassy Suites Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0_y.jpg) ### Embassy Suites Louisville Downtown 10/10 Excellent "Everything was great" [](https://expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Cambria Hotel Louisville Downtown-Whiskey Row](https://images.trvl-media.com/lodging/58000000/57960000/57959300/57959281/0d68ea56_y.jpg) ### Cambria Hotel Louisville Downtown-Whiskey Row 10/10 Excellent "Great Stay" [](https://expedia.ca/Louisville-Hotels-CAMBRiA-Hotel-Louisville-Downtown-Whiskey-Row.h57959281.Hotel-Information) ![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg) ### Hyatt Regency Louisville 10/10 Excellent "Room was perfect! Staff members were friendly. Amenities were well kept! We would stay again. " [](https://expedia.ca/Louisville-Hotels-Hyatt-Regency-Louisville.h326983.Hotel-Information) ![The Brown Hotel](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de_y.jpg) ### The Brown Hotel 10/10 Excellent "Everyone was kind. The rooms were great. Beautiful place to stay " [](https://expedia.ca/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Omni Louisville Hotel](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b_y.jpg) ### Omni Louisville Hotel 10/10 Excellent "Nice place" [](https://expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ## Hotels near other Louisville Science Center attractions ![Exploration of Louisville Slugger Museum in Downtown Louisville, Kentucky on a Sunny Day](https://images.trvl-media.com/place/6062643/51fb1d89-9725-43b9-9f70-fb542b492925.jpg) ### Louisville Slugger Museum 4.5/5 (1,200 reviews) Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062643) ![A great stop! This has to be one of the best museums I’ve been about somebody! Great stop and a fantastic life!](https://images.trvl-media.com/place/3108/7c78e7c9-eac0-4b50-9e66-c8627c15b771.jpg) Photo by Corey Dargan ### Muhammad Ali Center 4.3/5 (298 reviews) One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062649) ![Frazier International History Museum](https://images.trvl-media.com/place/6062645/f15343bb-d94c-489f-93a1-061de9db7d6f.jpg) ### Frazier International History Museum Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062645) ![Kentucky Center for the Performing Arts](https://images.trvl-media.com/place/6062653/7002efac-f43e-4dcd-8f15-f5c426433d39.jpg) ### Kentucky Center for the Performing Arts Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062653) ### Kentucky Museum of Art and Craft You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062657) ### Golden Statue of David Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=866963824899928064) ### SAR Genealogical Research Library: NSSAR Library You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621558115021) ### Louisville Glassworks You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's fascinating museums or attend a sporting event. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6062655) ## Frequently asked questions ### What's the area like around Louisville Science Center? ### What's the best place to stay near Louisville Science Center? ### How many hotels can I expect to find close to Louisville Science Center? ### If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund? ### What can I see and do near Louisville Science Center? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [Hotels near 21c Museum Hotel ](https://www.expedia.ca/21c-Museum-Hotel-Hotels.0-l553248621559724956-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Louisville ](https://www.expedia.ca/4Star-Louisville-Hotels.s40-0-d603002.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Louisville ](https://www.expedia.ca/5Star-Louisville-Hotels.s50-0-d603002.Travel-Guide-Filter-Hotels) - [Hotels near Belle of Louisville ](https://www.expedia.ca/Belle-Of-Louisville-Hotels.0-l6062661-0.Travel-Guide-Filter-Hotels) - 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