The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
A covered outdoor seating area with wicker furniture and a wooden railing.
A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.
A living room with a sofa, armchair, coffee table, fireplace, and large windows.

1. Louisville Bourbon Inn

Louisville Bourbon Inn
Old Louisville, 2.9 km from Louisville Science Center
United States
Roy
CA $392
CA $455 total
includes taxes & fees
Oct 25 - Oct 26
Louisville Bourbon Inn
A wooden staircase with a balustrade leading to a landing.
A brick building with a covered porch, columns, and potted plants.
A two-story brick building with a white porch and a sign reading "Hotel".
A bedroom with a bed, a dresser, a television, and a desk with a lamp.

2. Market Street Inn

Market Street Inn
2.1 km from Louisville Science Center
United States
Holly
CA $311
CA $351 total
includes taxes & fees
Oct 28 - Oct 29
Market Street Inn
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A room with a red velvet sofa, a blue armchair, and a small round table with books.
A living room with a sofa, a fireplace, a staircase, and a chandelier.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

3. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from Louisville Science Center
United States
Casey
CA $256
CA $297 total
includes taxes & fees
Nov 2 - Nov 3
DuPont Mansion Bed & Breakfast
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
A bar with shelves of liquor bottles and a bartender preparing drinks.

4. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Heather
CA $321
CA $377 total
includes taxes & fees
Nov 8 - Nov 9
Hotel Distil, Autograph Collection
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.
A grand lobby with ornate ceiling, large windows, and classic furniture.

5. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from Louisville Science Center
United States
John
CA $201
CA $237 total
includes taxes & fees
Oct 25 - Oct 26
The Brown Hotel
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.
A modern restaurant interior with a staircase, round tables, and a brick wall.
A building with a sign reading "THE GRADY" at the entrance.

6. The Grady

The Grady
Downtown Louisville, 0.2 km from Louisville Science Center
United States
Donna
CA $219
CA $258 total
includes taxes & fees
Nov 19 - Nov 20
The Grady
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.
A modern interior with a fireplace, bookshelves, and seating areas.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

7. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Kristan
CA $286
CA $336 total
includes taxes & fees
Nov 16 - Nov 17
Omni Louisville Hotel
A classical gold statue in front of a multi-story building with large windows and a brick facade.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

8. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville, < 0.1 km from Louisville Science Center
United States
Matt
CA $226
CA $273 total
includes taxes & fees
Nov 16 - Nov 17
21c Museum Hotel Louisville
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".
A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.
A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

9. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2.1 km from Louisville Science Center
United States
Addison
CA $166
CA $195 total
includes taxes & fees
Oct 29 - Oct 30
Tempo By Hilton Louisville Downtown Nulu
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.
A modern hotel room with a large bed, a city view, and a unique headboard design.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Cameron
CA $206
CA $243 total
includes taxes & fees
Nov 9 - Nov 10
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
An outdoor seating area with wicker furniture and a fire pit.
A modern living room with a sofa, armchairs, a coffee table, and a TV.
A modern lounge area with seating, tables, and a view of the city through large windows.
A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

11. Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
Downtown Louisville, 0.3 km from Louisville Science Center
United States
Derek
CA $136
CA $160 total
includes taxes & fees
Nov 8 - Nov 9
Towneplace Suites By Marriott Louisville Downtown
A modern bar area with a circular bar, multiple seating options, and a large screen.
A modern lobby with a fireplace, seating area, and a reception desk.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

12. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from Louisville Science Center
United States
Sarah
CA $146
CA $171 total
includes taxes & fees
Nov 11 - Nov 12
Cambria Hotel Louisville Downtown-Whiskey Row
A covered patio with a stone wall, a glass table, and a bench.
A grand room with a fireplace, a staircase, and a chandelier.
Staircase
A garden pathway with a lantern, potted plants, and a white fence.

13. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 3 km from Louisville Science Center
United States
Nicole
CA $216
CA $251 total
includes taxes & fees
Nov 16 - Nov 17
Central Park Bed & Breakfast
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern coffee shop interior with a central island, wooden counter, and large windows.
A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

14. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Anthony
CA $185
CA $218 total
includes taxes & fees
Nov 15 - Nov 16
Aloft by Marriott Louisville Downtown
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern living room with a sofa, ottomans, a coffee table, and a rug.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.
A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

15. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Alicia
CA $169
CA $199 total
includes taxes & fees
Nov 15 - Nov 16
Moxy Louisville Downtown
Bar (on property)
A bedroom with a bed, a chair, a TV, and a window with curtains.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A brightly lit grocery store with yellow shelving and a central checkout counter.

16. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2.1 km from Louisville Science Center
United States
Tyler
CA $214
CA $252 total
includes taxes & fees
Oct 29 - Oct 30
Hotel Genevieve part of JdV by Hyatt
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A balcony with a view of a river, a bridge, and a cityscape.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

17. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from Louisville Science Center
United States
Judy
CA $197
CA $232 total
includes taxes & fees
Nov 8 - Nov 9
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
A modern hotel room with a living area, a dining area, and a bedroom.
A hotel dining area with long tables, booths, and a bar.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.

18. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Frances
CA $206
CA $243 total
includes taxes & fees
Nov 15 - Nov 16
Embassy Suites Louisville Downtown
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A modern bar area with glass partitions, bar stools, and a variety of bottles.
A modern hotel room with a large window offering a city view, a cozy seating area with a sofa and chairs, a dining table with lamps, and a wooden floor.
A reception area with marble counters, modern pendant lighting, and potted orchids.

19. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Ricardo
CA $277
CA $326 total
includes taxes & fees
Nov 8 - Nov 9
Louisville Marriott Downtown
A modern lobby with a central seating area, a reception desk, and a large screen.
A modern dining area with blue and red seating, wooden tables, and decorative hanging lamps.
A hotel room with two beds, a wooden headboard, bedside lamps, a small table, and a patterned rug.
A modern lobby with a curved sofa, a round orange ottoman, and a seating area with chairs and a table.

20. Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG
Downtown Louisville, 0.2 km from Louisville Science Center
United States
evelyn
CA $166
CA $195 total
includes taxes & fees
Nov 4 - Nov 5
Holiday Inn Express & Suites Louisville Downtown by IHG
View all properties

Compare popular hotels close to Louisville Science Center

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.
Louisville Bourbon Inn
10.0
Exceptional
25 reviews
View
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
125 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
150 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
511 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,402 reviews
View

Top Louisville Science Center Hotel Reviews

Omni Louisville Hotel

Omni Louisville Hotel

8/10 Good
"Good"
Nicole 1-night trip
Posted 8 hours ago
Omni Louisville Hotel
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"If you love ORIGINALITY this is the place!!! We absolutely loved our stay …. funky, innovative and simply refreshing. The inspiring art is an absolute treat. Great taste and finally not another copycat hotel. AND the service was excellent, bed super comfortable, lovely bathroom and we couldn’t have been happier. If you haven’t tried it. It’s an absolute must!!!"
Petra 1-night trip
Posted 8 hours ago
21c Museum Hotel Louisville
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"Easy quick check in.excellent location of room to event.ease of check in and check out."
Jackie 2-night trip
Posted 9 hours ago
Galt House Hotel Trademark Collection by Wyndham
Holiday Inn Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

10/10 Excellent
"Very clean, modern facility for a quick overnight. I did not use many of the amenities due to the shortness of my stay. Staff was very friendly and helpful."
Edward 1-night trip
Posted 12 hours ago
Holiday Inn Louisville Downtown by IHG
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good
"Loved the area and the staff"
evelyn 1-night trip
Posted 13 hours ago
Holiday Inn Express & Suites Louisville Downtown by IHG
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent
"A five star hotel with a three star budget. This place was wonderful in all ways. So thankful to have found them"
Mark 3-night trip
Posted 14 hours ago
Homewood Suites by Hilton Louisville Downtown, KY
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent
"déjeuner hors pair en plus de l'endroit propre et agréable"
Denise 2-night trip
Posted 15 hours ago
Towneplace Suites By Marriott Louisville Downtown
The Grady

The Grady

10/10 Excellent
"Lovely boutique hotel. Great location, very nice staff. Only issue was trying to get into on-site restaurant which was always booked up."
Nancy 4-night trip
Posted 2 days ago
The Grady
Suite 7 City Loft Escape with River Views! By Hollyhock

Suite 7 City Loft Escape with River Views! By Hollyhock

10/10 Excellent
"Great location- super responsive host - clean and great view of the river."
Jim M. 3-night trip
Posted 3 weeks ago
Suite 7 City Loft Escape with River Views! By Hollyhock

Other attractions near Louisville Science Center

A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
See properties
A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
See properties
The Frazier History Museum with red doors and a tree in front.

Frazier International History Museum

9.4/10 (10 reviews)
Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.
See properties
The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
See properties

Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its lively festivals.
See properties

Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
See properties

SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
See properties

Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's lively festivals or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Louisville Science Center?
Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 292 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Louisville Science Center?
Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.
How many hotels can I expect to find close to Louisville Science Center?
Expedia has 292 hotels and other accommodations within a mile from Louisville Science Center.
If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.
What can I see and do near Louisville Science Center?
21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

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