The entrance to the Kentucky Science Center with a large circular structure in the foreground.

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Our top choices for Louisville Science Center hotels

A wooden staircase with a balustrade leading to a landing.
A bedroom with a bed, a dresser, a television, and a desk with a lamp.
A brick building with a covered porch, columns, and potted plants.
A two-story brick building with a white porch and a sign reading "Hotel".

1. Market Street Inn

Market Street Inn
2.1 km from Louisville Science Center
United States
Holly
CA $244
CA $276 total
includes taxes & fees
Sep 21 - Sep 22
Market Street Inn
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.
A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.
A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

2. Stellar Suites

Stellar Suites
East Market District, 2.2 km from Louisville Science Center
United States
Brad
CA $137
CA $231 total
includes taxes & fees
Sep 3 - Sep 4
Stellar Suites
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.
A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.
A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

3. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Jasmine
CA $317
CA $373 total
includes taxes & fees
Sep 13 - Sep 14
Hotel Distil, Autograph Collection
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
A living room with a sofa, a fireplace, a staircase, and a chandelier.
A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.
An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

4. DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
Old Louisville, 2.8 km from Louisville Science Center
United States
Casey
CA $196
CA $227 total
includes taxes & fees
Sep 6 - Sep 7
DuPont Mansion Bed & Breakfast
A grand lobby with ornate columns, plush seating, and a chandelier.
A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.
A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".
A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

5. The Brown Hotel

The Brown Hotel
Downtown Louisville, 1.2 km from Louisville Science Center
United States
Rachel
CA $186
CA $219 total
includes taxes & fees
Sep 7 - Sep 8
The Brown Hotel
A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.
A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".
A building with a sign reading "THE GRADY" at the entrance.
A modern restaurant interior with a staircase, round tables, and a brick wall.

6. The Grady

The Grady
Downtown Louisville, 0.2 km from Louisville Science Center
United States
Garrett
CA $259
CA $304 total
includes taxes & fees
Sep 4 - Sep 5
The Grady
A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.
A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.
A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.
A spacious lobby with a large seating area, a chandelier, and a patterned rug.

7. Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
Downtown Louisville, 0.2 km from Louisville Science Center
United States
Jon
CA $170
CA $200 total
includes taxes & fees
Sep 9 - Sep 10
Homewood Suites by Hilton Louisville Downtown, KY
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A modern interior with a fireplace, bookshelves, and seating areas.
A lobby with a marble floor, a reception desk, and a large chandelier.
A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

8. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Kara
CA $273
CA $321 total
includes taxes & fees
Sep 7 - Sep 8
Omni Louisville Hotel
An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.
A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.
A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.
A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

9. Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
Phoenix Hill, 2.1 km from Louisville Science Center
United States
Maria
CA $141
CA $166 total
includes taxes & fees
Sep 7 - Sep 8
Tempo By Hilton Louisville Downtown Nulu
An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.
A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.
A modern hotel room with a large bed, a city view, and a unique headboard design.
A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

10. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Breeana
CA $274
CA $323 total
includes taxes & fees
Sep 13 - Sep 14
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
A brick building with outdoor seating and a fire pit.
A modern hotel room with a sofa, a small desk, a microwave, and a TV.
A modern bar area with a wooden counter, bar stools, and a variety of bottles and glasses.
An indoor swimming pool with clear water, surrounded by blue chairs and tables, and a tiled floor.

11. TownePlace Suites by Marriott Louisville North

TownePlace Suites by Marriott Louisville North
2.2 km from Louisville Science Center
United States
Lisa
CA $186
CA $210 total
includes taxes & fees
Sep 21 - Sep 22
TownePlace Suites by Marriott Louisville North
A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.
A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.
A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.
A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

12. AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
East Market District, 2.1 km from Louisville Science Center
United States
David
CA $169
CA $199 total
includes taxes & fees
Sep 7 - Sep 8
AC Hotel Louisville Downtown
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.
A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.
A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

13. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville, 0.5 km from Louisville Science Center
United States
Jacob
CA $221
CA $260 total
includes taxes & fees
Sep 4 - Sep 5
Galt House Hotel Trademark Collection by Wyndham
A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.
A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.
A cozy living room with a fireplace, a black leather sofa, and a patterned rug.
A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

14. Moxy Louisville Downtown

Moxy Louisville Downtown
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Nina
CA $145
CA $170 total
includes taxes & fees
Sep 7 - Sep 8
Moxy Louisville Downtown
A covered patio with a stone wall, a glass table, and a bench.
A garden pathway with a lantern, potted plants, and a white fence.
A stone house with a balcony, a front door, and a staircase leading to the entrance.
A grand room with a fireplace, a staircase, and a chandelier.

15. Central Park Bed & Breakfast

Central Park Bed & Breakfast
Old Louisville, 3 km from Louisville Science Center
United States
Angie
CA $166
CA $193 total
includes taxes & fees
Sep 7 - Sep 8
Central Park Bed & Breakfast
A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.
A yellow coffee shop counter with a menu board above, displaying various coffee and food items.
A bar area with a wooden bar counter, two stools, a chandelier, and a mirror.
A bedroom with a bed, a chair, a TV, and a window with curtains.

16. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
East Market District, 2.1 km from Louisville Science Center
United States
Rebekah
CA $188
CA $221 total
includes taxes & fees
Sep 9 - Sep 10
Hotel Genevieve part of JdV by Hyatt
An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.
A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.
A modern bar area with sofas, tables, and a bar stocked with bottles.
A modern coffee shop interior with a central island, wooden counter, and large windows.

17. Aloft by Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown
Downtown Louisville, 0.9 km from Louisville Science Center
United States
Angela
CA $162
CA $191 total
includes taxes & fees
Sep 6 - Sep 7
Aloft by Marriott Louisville Downtown
A modern bar area with a circular bar, multiple seating options, and a large screen.
A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.
A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.
A modern lobby with a fireplace, seating area, and a reception desk.

18. Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
Downtown Louisville, 1.2 km from Louisville Science Center
United States
Hallie
CA $157
CA $185 total
includes taxes & fees
Sep 6 - Sep 7
Cambria Hotel Louisville Downtown-Whiskey Row
A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.
A modern bar area with a long counter, multiple chairs, and a bookshelf filled with bottles.
An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.
A hotel dining area with long tables, booths, and a bar.

19. Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Spencer
CA $216
CA $254 total
includes taxes & fees
Sep 6 - Sep 7
Embassy Suites Louisville Downtown
A modern building with a restaurant on the ground floor, featuring large windows and outdoor seating.
A spacious lobby with a bar area, seating arrangements, and a visible kitchen bar.
A modern bar area with glass partitions, bar stools, and a variety of bottles.
A reception area with marble counters, modern pendant lighting, and potted orchids.

20. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville, 0.8 km from Louisville Science Center
United States
Lisa
CA $238
CA $280 total
includes taxes & fees
Sep 7 - Sep 8
Louisville Marriott Downtown
View all properties

Compare popular hotels close to Louisville Science Center

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A wooden staircase with a balustrade leading to a landing.
Market Street Inn
9.8
Exceptional
124 reviews
View
A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.
Stellar Suites
9.6
Exceptional
147 reviews
View
An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.
Hotel Distil, Autograph Collection
9.6
Exceptional
499 reviews
View
A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.
DuPont Mansion Bed & Breakfast
9.6
Exceptional
146 reviews
View
A grand lobby with ornate columns, plush seating, and a chandelier.
The Brown Hotel
9.4
Exceptional
1,294 reviews
View

Top Louisville Science Center Hotel Reviews

Holiday Inn Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

8/10 Good
"My stay started off rough with ants and dirty walls. Management stepped in and changed my room and it was much better. The hotel is in a good location. I thinks it needs some updates to bring it into modern day. Thank you staff for fast thinking."
Troy 4-night trip
Posted less than an hour ago
Holiday Inn Louisville Downtown by IHG
Omni Louisville Hotel

Omni Louisville Hotel

10/10 Excellent
"Clean room."
Tracie 1-night trip
Posted less than an hour ago
Omni Louisville Hotel
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent
"The staff was amazing. The front desk people were extremely nice and helpful. Renee at the front desk made amazing food recommendations. The staff in the 1st floor hotel restaurant were also very friendly and the breakfast quesadillas were great. This hotel is in a great location for all the bars, distilleries, and restaurants downtown. Place was clean and well kept. Highly recommend."
Dale 4-night trip
Posted 4 hours ago
Cambria Hotel Louisville Downtown-Whiskey Row
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

8/10 Good
"Our room was clean, the bed very comfortable, and the breakfast was delicious. We were happy with our stay."
Linda 1-night trip
Posted 5 hours ago
Embassy Suites Louisville Downtown
The Grady

The Grady

10/10 Excellent
"Great stay!"
Alicia 3-night trip
Posted 6 hours ago
The Grady
Moxy Louisville Downtown

Moxy Louisville Downtown

10/10 Excellent
"Great place to stay."
Todd 2-night trip
Posted 2 days ago
Moxy Louisville Downtown
Hilton Garden Inn Louisville Downtown

Hilton Garden Inn Louisville Downtown

10/10 Excellent
"Great, nice, clean hotel & close to the Louisville Palace, only a 2 minute walk."
Myla 1-night trip
Posted 4 days ago
Hilton Garden Inn Louisville Downtown
21c Museum Hotel Louisville

21c Museum Hotel Louisville

10/10 Excellent
"Great staff!"
Candice 1-night trip
Posted 9 days ago
21c Museum Hotel Louisville

Other attractions near Louisville Science Center

A wall of wooden baseball bats organized by size and weight.

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
See properties
A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
See properties
A vintage car and a wooden barrel with a sign reading "Spirits of the Bluegrass Prohibition Kentucky" on a brick wall.

Frazier International History Museum

9.4/10 (10 reviews)
Get to know Louisville with a visit to this esteemed museum. It’s a great spot for social interaction as well.
See properties
The Kentucky Center for the Performing Arts building facade with large glass windows and a prominent sign.

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)
Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your travels in Louisville. Stroll along the area's riverfront or experience its great live music.
See properties

Golden Statue of David

Find out about the history of Louisville when you take a trip to Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.
See properties

SAR Genealogical Research Library: NSSAR Library

You can spend an afternoon browsing the exhibits at SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.
See properties

Louisville Glassworks

You can spend an afternoon studying the exhibits at Louisville Glassworks in Louisville. Experience the area's acclaimed theater scene or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Louisville Science Center?
Louisville Science Center is located in an area of Louisville known for its beautiful river views, sporting events, and great live music scene. If you're looking for a convenient place to stay, check out the 293 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Louisville Science Center?
Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.
How many hotels can I expect to find close to Louisville Science Center?
Expedia has 293 hotels and other accommodations within a mile from Louisville Science Center.
If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and get a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to review the best deals near Louisville Science Center.
What can I see and do near Louisville Science Center?
21c Museum Hotel, Louisville Slugger Museum, and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row, and Big Four Bridge. You can catch a show at Louisville Palace, Derby Dinner Playhouse, and Headliners Music Hall.

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