Title: Hotels by Best Western in Los Osos from CA $149 | Expedia.ca [Los Osos Travel Guide](https://expedia.ca/Los-Osos.dx9873)[Hotels in Los Osos](https://expedia.ca/Los-Osos-Hotels.d9873.Travel-Guide-Hotels)[Vacation Rentals in Los Osos](https://expedia.ca/Los-Osos-Vacation-Rentals.d9873.Travel-Guide-VacationRentals)[Flights to Los Osos](https://expedia.ca/Cheap-Flights-To-Los-Osos.d9873.Travel-Guide-Flights)[Things to do in Los Osos](https://expedia.ca/Things-To-Do-In-Los-Osos.d9873.Travel-Guide-Activities)[Los Osos Car Rentals](https://expedia.ca/Car-Rentals-In-Los-Osos.d9873.Car-Rental-Guide)[Los Osos Vacation Packages](https://expedia.ca/Los-Osos.d9873.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/82ae60cf1761badedca5aae03e4e0866.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Los Osos from CA $149 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 15 - Oct 16](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-15&endDate=2025-10-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-16&endDate=2025-10-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Los Osos Best Western Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLos-Osos-Hotels-Best-Western.0-0-d9873--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLos-Osos-Hotels-Best-Western.0-0-d9873--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Los Osos Hotel Reviews ![Apple Farm](//images.trvl-media.com/lodging/1000000/40000/39500/39435/f5438f41_y.jpg) ### Apple Farm 10/10 Excellent "Love it here!!" [](https://expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![SeaCrest OceanFront Hotel](//images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/w3000h1999x0y0-15b2e131_y.jpg) ### SeaCrest OceanFront Hotel 10/10 Excellent "The beach view was beautiful and breathtaking. If you're looking for peace and serenity ✨️ 😌 this is it. The parking lot had construction on the pavement because it was blocked off with a black tarp so we couldn't park next to our room so that was the downside. I think the continental breakfast is made just for kids only not for adults. Not a hearty breakfast just enough to get by." [](https://expedia.ca/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ![Madonna Inn](//images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/1ea42b7b_y.jpg) ### Madonna Inn 10/10 Excellent "Absolutely amazing stay" [](https://expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Sandcastle Hotel on the Beach](//images.trvl-media.com/lodging/1000000/50000/41000/40915/89d1e3f1_y.jpg) ### Sandcastle Hotel on the Beach 10/10 Excellent "Nice beach view by fireplace " [](https://expedia.ca/San-Luis-Obispo-Hotels-Sandcastle-Hotel-On-The-Beach.h40915.Hotel-Information) ![Edgewater Inn And Suites](//images.trvl-media.com/lodging/1000000/900000/894000/893902/3d1c5694_y.jpg) ### Edgewater Inn And Suites 10/10 Excellent "Clean rooms across from pool & jacuzzi " [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ![Harbor House Inn Morro Bay](//images.trvl-media.com/lodging/1000000/80000/79600/79558/3e3fd2a1_y.jpg) ### Harbor House Inn Morro Bay 10/10 Excellent "My room 204 was on the end with a direct view of Morro Rock and a fabulous sunset view. Easy walk to shops and restaurants and for the slightly more energetic, the Morro Rock. Most of all, it is so accommodating to dogs. They give you a goodie bag with treats, poop bags and a card that lists dog friendly restaurants. Best of all, is the dog washing station complete with shampoo, conditioner and soap so you can take your pooch to the beach without worrying about bringing in a lot of sand. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Harbor-House-Inn-Morro-Bay.h79558.Hotel-Information) ![Best Western Casa Grande Inn](//images.trvl-media.com/lodging/1000000/30000/23100/23008/e16ece78_y.jpg) ### Best Western Casa Grande Inn 10/10 Excellent "Good place to crash after a long day out and about. Nothing special but what we needed. We would stay here again " [](https://expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![Spyglass Inn](//images.trvl-media.com/lodging/1000000/50000/41300/41235/44c3350f_y.jpg) ### Spyglass Inn 10/10 Excellent "The only negative is that if you’re expecting a Romantic Fireplace in your room … forget it, it’s gas and barely had any warm glow to it … " [](https://expedia.ca/San-Luis-Obispo-Hotels-Spyglass-Inn.h41235.Hotel-Information) ![Oxford Suites Pismo Beach](//images.trvl-media.com/lodging/1000000/10000/3100/3089/b427747a_y.jpg) ### Oxford Suites Pismo Beach 10/10 Excellent "Lovely hotel. Pool and hot tub were nice. Breakfast was good. Property was nice. 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