Title: The 10 Best Hotels Near Lewis and Clark Interpretive Center, St. Louis from CA $93 | Expedia.ca [St. Louis Travel Guide](https://expedia.ca/St-Louis.dx178309)[Vacation Rentals in St. Louis](https://expedia.ca/St-Louis-Vacation-Rentals.d178309.Travel-Guide-VacationRentals)[Flights to St. Louis](https://expedia.ca/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.ca/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Lewis and Clark Interpretive Center Car Rentals](https://expedia.ca/Car-Rentals-In-Lewis-And-Clark-Interpretive-Center.d6285389.Car-Rental-Guide)[Lewis and Clark Interpretive Center Vacations](https://expedia.ca/Lewis-And-Clark-Interpretive-Center-St-Louis.d6285389.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 13 - Jan 14](https://www.expedia.ca/Hotel-Search?regionId=6285389&startDate=2026-01-13&endDate=2026-01-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 14 - Jan 15](https://www.expedia.ca/Hotel-Search?regionId=6285389&startDate=2026-01-14&endDate=2026-01-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6285389&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6285389&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Lewis and Clark Interpretive Center hotels ![Lobby lounge](https://images.trvl-media.com/lodging/10000000/9320000/9312600/9312525/8239b666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9320000/9312600/9312525/e5e9b43f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9320000/9312600/9312525/42939118.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/10000000/9320000/9312600/9312525/be14ccfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City [](https://www.expedia.ca/St-Louis-Hotels-Fairfield-Inn-Suites-St-Louis-Pontoon-BeachGranite-City.h9312525.Hotel-Information) 6.2 km from Lewis and Clark Interpretive Center 9.2/10 Wonderful (491 reviews) "This hotel was well kept,the breakfast was excellent. Stsff was friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dennis M CA $155 CA $172 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/St-Louis-Hotels-Fairfield-Inn-Suites-St-Louis-Pontoon-BeachGranite-City.h9312525.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/01153352.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/a1203ab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/d2d3f123.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/5dcf9c4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Pontoon Beach [](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-Pontoon-Beach.h2695352.Hotel-Information) 6.8 km from Lewis and Clark Interpretive Center 8.6/10 Excellent (813 reviews) "The hotel was good clean and pool was amazing breakfast was ok but overall I’ll recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Raeisha CA $119 CA $132 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/St-Louis-Hotels-Best-Western-Plus-Pontoon-Beach.h2695352.Hotel-Information) ![Room, 1 Queen Bed, Jetted Tub](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/16715ab0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/e175e4bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/05c93cf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/b16f9138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Lion Inn & Suites Pontoon Beach [](https://www.expedia.ca/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information) 5.6 km from Lewis and Clark Interpretive Center 7.8/10 Good (594 reviews) "There was a good toilet in the room very clean and nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $82 CA $93 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/42000000/41380000/41376800/41376730/0663024f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/42000000/41380000/41376800/41376730/34f77172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/42000000/41380000/41376800/41376730/5a2ddec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/42000000/41380000/41376800/41376730/9dffd14f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bel Air Motel [](https://www.expedia.ca/Collinsville-Hotels-BEL-AIR-MOTEL.h41376730.Hotel-Information) 6.3 km from Lewis and Clark Interpretive Center 8.6/10 Excellent (199 reviews) "The room was clean and the bed comfortable. Unfortunately the walls are thin enough to hear the nearby road traffic and neighboring rooms TVs through." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lawrence CA $110 CA $134 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/Collinsville-Hotels-BEL-AIR-MOTEL.h41376730.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17000/16917/b31b5fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/1000000/20000/17000/16917/c7e078e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/17000/16917/4bc8f180.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/17000/16917/76e638c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Edwardsville - St. Louis [](https://www.expedia.ca/St-Louis-Hotels-Comfort-Inn-Edwardsville-St-Louis.h16917.Hotel-Information) 9.4 km from Lewis and Clark Interpretive Center 8.4/10 Very good (819 reviews) "Great staff, breakfast was excellent and rooms were clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carlos CA $141 CA $162 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/St-Louis-Hotels-Comfort-Inn-Edwardsville-St-Louis.h16917.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8970000/8964000/8963997/330cc662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/9000000/8970000/8964000/8963997/b57accf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/9000000/8970000/8964000/8963997/db100dc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/9000000/8970000/8964000/8963997/52860e44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Edwardsville by IHG [](https://www.expedia.ca/Collinsville-Hotels-Holiday-Inn-Express-Suites-Edwardsville.h8963997.Hotel-Information) 10.9 km from Lewis and Clark Interpretive Center 9.2/10 Wonderful (829 reviews) "Had a great stay. Staff was wonderful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saqueyia CA $171 CA $196 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Collinsville-Hotels-Holiday-Inn-Express-Suites-Edwardsville.h8963997.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/30c6b3be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/71b4e886.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/594a99d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8080000/8070400/8070312/0418d6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Hearth Inn & Suites Edwardsville St. Louis [](https://www.expedia.ca/St-Louis-Hotels-Country-Hearth-Inn-Suites-Edwardsville-St-Louis.h8070312.Hotel-Information) 10.8 km from Lewis and Clark Interpretive Center 8.6/10 Excellent (656 reviews) "The room was very clean and the staff is always friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynn CA $126 CA $145 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/St-Louis-Hotels-Country-Hearth-Inn-Suites-Edwardsville-St-Louis.h8070312.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/8731eb68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/1120bfaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/f9ce5b80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/424300/424254/f969f8e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Pontoon Beach [](https://www.expedia.ca/St-Louis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Pontoon-Beach.h424254.Hotel-Information) 6.9 km from Lewis and Clark Interpretive Center 7.6/10 Good (515 reviews) "The hotel staff was exceptionally accommodating. Would stay here over anywhere in the area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kari CA $124 CA $142 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/St-Louis-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Pontoon-Beach.h424254.Hotel-Information) ![Premium bedding, pillowtop beds, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1790000/1782700/1782652/c5296536.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1790000/1782700/1782652/1f22e905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/2000000/1790000/1782700/1782652/d03aecc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed, Accessible, Non Smoking (Efficiency)](https://images.trvl-media.com/lodging/2000000/1790000/1782700/1782652/6b921a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Inn & Suites Granite City - St. Louis [](https://www.expedia.ca/St-Louis-Hotels-Econo-Lodge-Suites-Granite-City.h1782652.Hotel-Information) 4.7 km from Lewis and Clark Interpretive Center 6.2/10 (246 reviews) "Overall the stay was adequate, right off the highway so convenient." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Henry CA $96 CA $110 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/St-Louis-Hotels-Econo-Lodge-Suites-Granite-City.h1782652.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27900/27892/593c4658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27900/27892/71cef1c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27900/27892/f1b39ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/27900/27892/b0825fa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Pontoon Beach [](https://www.expedia.ca/St-Louis-Hotels-Days-Inn-By-Wyndham-Pontoon-Beach.h27892.Hotel-Information) 6.6 km from Lewis and Clark Interpretive Center 6.2/10 (571 reviews) "Bed was soooooooo comfortable and front desk guy that checked me in was great as well " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maurice CA $86 CA $96 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/St-Louis-Hotels-Days-Inn-By-Wyndham-Pontoon-Beach.h27892.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/16000000/15800000/15799600/15799597/041ae03f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15800000/15799600/15799597/a87bd9eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/16000000/15800000/15799600/15799597/cde4a1f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/16000000/15800000/15799600/15799597/e708241b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites St. Louis/Alton [](https://www.expedia.ca/Collinsville-Hotels-Hampton-Inn-Suites-St-LouisAlton.h15799597.Hotel-Information) 14 km from Lewis and Clark Interpretive Center 9.0/10 Wonderful (649 reviews) "The staff were very professional and friendly. The breakfast had a great selection." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $158 CA $180 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Collinsville-Hotels-Hampton-Inn-Suites-St-LouisAlton.h15799597.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/31000000/30550000/30542500/30542475/7764b257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/31000000/30550000/30542500/30542475/e607fb50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/31000000/30550000/30542500/30542475/49515df4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/31000000/30550000/30542500/30542475/dad3479c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham St. Louis North [](https://www.expedia.ca/St-Louis-Hotels-Super-8-By-Wyndham-St-Louis-North.h30542475.Hotel-Information) 16.5 km from Lewis and Clark Interpretive Center 6.4/10 (573 reviews) "Clean, cozy and laid back" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dana CA $106 CA $124 total includes taxes & fees Jan 20 - Jan 21 [](https://www.expedia.ca/St-Louis-Hotels-Super-8-By-Wyndham-St-Louis-North.h30542475.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778042/9df0b21c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778042/e3af34d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778042/702f26bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1780000/1778100/1778042/02886966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites St. Louis-Edwardsville [](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-Suites-St-LouisEdwardsville.h1778042.Hotel-Information) 10.1 km from Lewis and Clark Interpretive Center 7.4/10 Good (74 reviews) "We enjoyed our stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $147 CA $164 total includes taxes & fees Jan 20 - Jan 21 [](https://www.expedia.ca/St-Louis-Hotels-Hampton-Inn-Suites-St-LouisEdwardsville.h1778042.Hotel-Information) ![Electric vehicle charging station](https://images.trvl-media.com/lodging/118000000/117680000/117670600/117670506/4721bb69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Towels, soap, toilet paper](https://images.trvl-media.com/lodging/118000000/117680000/117670600/117670506/w763h861x0y6-a9cfa0de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/118000000/117680000/117670600/117670506/323e9112.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/118000000/117680000/117670600/117670506/96db7472.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Budget Motel Granite City/St Louis Area [](https://www.expedia.ca/St-Louis-Hotels-Budget-Motel.h117670506.Hotel-Information) 4.7 km from Lewis and Clark Interpretive Center 6.4/10 (15 reviews) "Its nice here" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila CA $93 CA $101 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/St-Louis-Hotels-Budget-Motel.h117670506.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/fff178d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/e281e57d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/e26024c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42100/42035/8cf4bdc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites St. Louis Collinsville [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Collinsville.h42035.Hotel-Information) 15.4 km from Lewis and Clark Interpretive Center 9.6/10 Exceptional (1,005 reviews) "Great Experience, Great Staff!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyle CA $136 CA $156 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Collinsville.h42035.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/9000000/8070000/8068200/8068118/eb82a5b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/9000000/8070000/8068200/8068118/9aa7ebc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/9000000/8070000/8068200/8068118/1c212f3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, Smoking | Living area](https://images.trvl-media.com/lodging/9000000/8070000/8068200/8068118/e36ad470.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### First Western Inn [](https://www.expedia.ca/Collinsville-Hotels-First-Western-Inn.h8068118.Hotel-Information) 18.1 km from Lewis and Clark Interpretive Center 6.4/10 (362 reviews) "Nice stay. Price isn’t accurate on site they upcharge when you get there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Briai CA $92 CA $104 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/Collinsville-Hotels-First-Western-Inn.h8068118.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42036/74f5ebfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/42100/42036/25de2b88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/42100/42036/d64d88ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42036/bc563674.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn Collinsville St. Louis [](https://www.expedia.ca/Collinsville-Hotels-Americas-Best-Value-Inn-Collinsville-St-Louis.h42036.Hotel-Information) 15.8 km from Lewis and Clark Interpretive Center 6.4/10 (945 reviews) "Was a great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eddei CA $83 CA $96 total includes taxes & fees Jan 14 - Jan 15 [](https://www.expedia.ca/Collinsville-Hotels-Americas-Best-Value-Inn-Collinsville-St-Louis.h42036.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95820000/95814700/95814624/fb14d652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/96000000/95820000/95814700/95814624/623316d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/96000000/95820000/95814700/95814624/be648d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/96000000/95820000/95814700/95814624/557e85b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express and Suites Alton St Louis Area by IHG [](https://www.expedia.ca/Alton-Hotels-Holiday-Inn-Express-And-Suites-Alton-St-Louis-Area.h95814624.Hotel-Information) 13.8 km from Lewis and Clark Interpretive Center 9.2/10 Wonderful (165 reviews) "Staff and location were perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ileta CA $158 CA $180 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Alton-Hotels-Holiday-Inn-Express-And-Suites-Alton-St-Louis-Area.h95814624.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12100/12034/5df4d593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12100/12034/7b433a3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/12100/12034/7192cc21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12100/12034/9accebee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Great Rivers, an Ascend Collection Hotel [](https://www.expedia.ca/Alton-Hotels-The-Great-Rivers.h12034.Hotel-Information) 11.5 km from Lewis and Clark Interpretive Center 7.8/10 Good (762 reviews) "The hotel is being remodeled, so it's hard to give it a fair review." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $117 CA $133 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Alton-Hotels-The-Great-Rivers.h12034.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42045/38be0da4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42045/1e3d7d88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/42100/42045/1664fc77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/42100/42045/3e6f7a74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Alton near I-255 [](https://www.expedia.ca/Collinsville-Hotels-Comfort-Inn.h42045.Hotel-Information) 11.5 km from Lewis and Clark Interpretive Center 7.6/10 Good (510 reviews) "Perfect accommodations for a brief overnight stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steffany CA $99 CA $113 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Collinsville-Hotels-Comfort-Inn.h42045.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-27&endDate=2026-01-28®ionId=6285389&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Lewis and Clark Interpretive Center Hotel Reviews ![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/78b2a688_y.jpg) ### Drury Plaza Hotel St. Louis at the Arch 10/10 Excellent "First time staying at a Drury hotel. Room was spacious and clean. Breakfast was better than most. Could make a meal of happy hour food which exceeded our expectations. Staff were super friendly and helpful. Highly recommended." [](https://expedia.ca/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![Hilton Pennywell St. Louis at the Arch](https://images.trvl-media.com/lodging/2000000/1160000/1152200/1152198/3695993c_y.jpg) ### Hilton Pennywell St. Louis at the Arch 10/10 Excellent "Good place " [](https://expedia.ca/St-Louis-Hotels-Hilton-St-Louis-Downtown-At-The-Arch.h1152198.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758_y.jpg) ### 21C Museum Hotel St Louis 10/10 Excellent "The hotel is beautiful! And most importantly, the bed was very comfortable. It has a fridge in the room, which most boutique hotels lack, so that was convenient. I would stay here again." [](https://expedia.ca/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![St. Louis Union Station Hotel, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/8800/8738/171d52f3_y.jpg) ### St. Louis Union Station Hotel, Curio Collection by Hilton 10/10 Excellent "The room was spotless and very comfortable. Staff was friendly. What a wonderful Christmas experience. We’ll definitely do it again next year." [](https://expedia.ca/St-Louis-Hotels-St-Louis-Union-Station-Hotel.h8738.Hotel-Information) ![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/335a172e_y.jpg) ### Hyatt Regency St. Louis at The Arch 10/10 Excellent "We didn’t have breakfast or go to the bar. " [](https://expedia.ca/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information) ![Marriott St. Louis Grand](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/4c313173_y.jpg) ### Marriott St. Louis Grand 10/10 Excellent "Clean room. AC/Heat worked great." [](https://expedia.ca/St-Louis-Hotels-Marriott-St-Louis-Grand.h904712.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/0bb9dbf3_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 10/10 Excellent "Great hotel " [](https://expedia.ca/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![Courtyard by Marriott St. Louis Downtown/Convention Center](https://images.trvl-media.com/lodging/1000000/850000/848500/848402/b44eefea_y.jpg) ### Courtyard by Marriott St. Louis Downtown/Convention Center 10/10 Excellent "Beautiful room, very clean, friendly staff, great stay!" [](https://expedia.ca/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-DowntownConvention-Center.h848402.Hotel-Information) ![Home2 Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/77000000/76520000/76510800/76510729/104b5741_y.jpg) ### Home2 Suites by Hilton St. Louis Downtown 10/10 Excellent "Was good " [](https://expedia.ca/St-Louis-Hotels-Home2-Suites-St-Louis-Downtown.h76510729.Hotel-Information) ## Hotels near other Lewis and Clark Interpretive Center attractions ### Lewis and Clark Confluence Tower Bring a camera when you climb this tower, which offers fantastic views across the Mississippi River and provides insight into a fascinating piece of history. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648630) ### Lewis and Clark State Memorial Park Explore the great outdoors at Lewis and Clark State Memorial Park, a lovely green space in Hartford. Discover the area's museums and monuments. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911403821536997376) ### Hartford Park After visiting Hartford Park, make a plan to see the other sights and activities in Hartford. Discover the area's museums and monuments. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911404232178233344) ### Hartford City Hall Hartford City Hall is just one of the places to see in Hartford, so why not enjoy the other things to explore during your travels? Amble around the area's riverfront or experience its museums. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911406494470467584) ### Jones-Confluence Point State Park You can take time to visit Jones-Confluence Point State Park during your travels to West Alton. You can attend a sporting event while in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648631) ### Dads Club Park Explore the great outdoors at Dads Club Park, a lovely green space in South Roxana. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911404787942391808) ### South Roxana Dad's Club Park South Roxana Dad's Club Park is just one of the places to see in South Roxana, so why not enjoy the other things to explore during your travels? [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911400513623646208) ## Frequently asked questions ### What's the area like around Lewis and Clark Interpretive Center? ### Where is the best place to stay close to Lewis and Clark Interpretive Center? ### How many hotels are there near Lewis and Clark Interpretive Center? ### If I need to cancel the hotel reservation for my stay near Lewis and Clark Interpretive Center, will I receive a refund? ### What can I see and do near Lewis and Clark Interpretive Center? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [5 Star Hotels in East Alton ](https://www.expedia.ca/5Star-East-Alton-Hotels.s50-0-d99033.Travel-Guide-Filter-Hotels) - [B&B in Alton ](https://www.expedia.ca/Alton-Bed-And-Breakfast.d6108-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Alton ](https://www.expedia.ca/Alton-Guest-Houses.d6108-aaGuestHouses.Travel-Guide-Accommodation) - 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