Isla San Telmo Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
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    With over 300,000 hotels worldwide, it's easy to create a perfect package
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The Latest Isla San Telmo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jan 31 - Feb 6

    Decapolis Hotel Panama City + Flight

    San Francisco
    5 nights
    4.0 star property
    8.6/10 - Excellent (1,740 reviews)
    "Breakfast was excellent."
    Reviewed November 10, 2026
    Roundtrip • Montreal (YUL) - Panama City (PTY)
    YUL - PTY • 1 stop PTY - YUL • 1 stop
    CA $1,793
    CA $1,284
    per traveller
    found 1 day ago
    Decapolis Hotel Panama City
  • Dec 30 - Jan 6

    Megapolis Hotel Panamá + Flight

    San Francisco
    6 nights
    4.5 star property
    8.6/10 - Excellent (1,871 reviews)
    "Wonderful experience from start to finish. Hospital staff."
    Reviewed November 11, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 2 stops
    Save 100% on your flight
    CA $3,502
    CA $1,878
    per traveller
    found 2 days ago
    Megapolis Hotel Panamá
  • Dec 30 - Jan 6

    Casa Mallet by Wynwood House + Flight

    Casco Viejo
    6 nights
    3.5 star property
    9.8/10 - Exceptional (31 reviews)
    "I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!"
    Reviewed September 16, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 2 stops
    Save 100% on your flight
    CA $8,883
    CA $5,955
    per traveller
    found 2 days ago
    Casa Mallet by Wynwood House
  • Dec 30 - Jan 6

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen Airport
    6 nights
    4.0 star property
    8.6/10 - Excellent (1,807 reviews)
    "The best hotel when you need to stay near the airport in Panama. I booked this hotel for my mom, she had to stay overnight in Panama, before her next flight. Hotel offers shuttle services and the staff are always very helpful."
    Reviewed November 9, 2026
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 2 stops
    CA $2,229
    CA $1,519
    per traveller
    found 2 days ago
    Riande Aeropuerto Hotel & Casino
  • Jan 17 - Jan 21

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    3 nights
    4.0 star property
    9.0/10 - Wonderful (1,003 reviews)
    Roundtrip • Toronto (YTO) - Panama City (PTY)
    YYZ - PTY • 1 stop PTY - YYZ • 1 stop
    CA $2,149
    CA $1,476
    per traveller
    found 1 day ago
    Central Hotel Panama Casco Viejo

Frequently Asked Questions

How much does an Isla San Telmo vacation package cost?

Choose from any combination of car rentals, flights and hotels, and you can be vacationing in Isla San Telmo from just CA $1,284. And the more you bundle, the more you save. Your dream vacation has never been more affordable.

How do I get a cheap travel package to Isla San Telmo?

Booking an Isla San Telmo vacation package with Expedia is an easy way to save. We offer access to over 550 partner airlines and 1,000,000 hotels spread across the globe. With such a fabulous range to pick from, you'll have no trouble creating your ideal vacation.

How far in advance should I book my Isla San Telmo vacation?

Savvy travelers book early. Airlines generally advertise flights around a year prior to departure, and this is an excellent opportunity to pick up some rock-bottom prices. Just been told you should take all your vacation days next week? No problem! Expedia are never short on fantastic deals to send you off on the getaway of your dreams, at an affordable price.

What does an Expedia Isla San Telmo travel package include?

It's up to you! You can select from a range of Isla San Telmo bundles, such as a rental car, hotel and flight. You can also book a hotel with a flight, or a rental car and a flight. Once you've made your booking, you can add the fun stuff like activities and experiences. Whatever your perfect Isla San Telmo escape looks like, you'll save!

What should I know before booking an Isla San Telmo travel package?

When you book your hotels, flights and car rentals together, you'll land amazing discounts. Whether you're planning a wilderness getaway in a cabin or want to stay in a convenient hotel in the city, Expedia can make it happen for less.

Can I choose my airline with an Isla San Telmo Expedia vacation package?

Yes, definitely. Expedia has over 550 airline partners to choose from globally. With all that choice, finding the right carrier to take you to Isla San Telmo will be a breeze.

If I'm not able to travel, can I cancel my Isla San Telmo vacation package?

Certainly, and we'll help you every step of the way. You may be able to amend or cancel your Isla San Telmo vacation package at no cost if you booked in the last 24 hours. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If your circumstances suddenly change, take a look at our Customer Service Portal for more information.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.