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Florida Keys National Marine Sanctuary Vacation Packages (Flight + Hotel)
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Top things to do in Florida Keys National Marine Sanctuary

Top Hotels Close to Florida Keys National Marine Sanctuary

Southernmost Beach Resort
Southernmost Beach Resort
4 out of 5
1319 Duval Street, Key West, FL
The price is CA $401 per night from Jan 19 to Jan 20

Located in Key West Historic District, this beachfront hotel is in the city center and within a 10-minute walk of South Beach and Southernmost Point. Fort Zachary ...

4.2/5Excellent! (2,641 reviews)

"Always a great experience and the staff is 5 star! I have stayed here many times."…"

Reviewed on Jan. 9, 2021

Southernmost Beach Resort
Crowne Plaza Key West-La Concha
Crowne Plaza Key West-La Concha
4 out of 5
430 Duval St, Key West, FL
The price is CA $191 per night from Jan 19 to Jan 20

Located in Key West Historic District, this romantic hotel is within a 10-minute walk of Duval Street, Harry S. Truman Little White House, and Mel Fisher Maritime ...

4/5Very Good! (1,119 reviews)

"Nice property but could use some updating. Staff was great and helpful. Location was 5 stars and that was what mattered most to us."…"

Reviewed on Jan. 14, 2021

Crowne Plaza Key West-La Concha
Margaritaville Key West Resort & Marina
Margaritaville Key West Resort & Marina
4 out of 5
245 Front Street, Key West, FL
Free cancellationReserve now, pay when you stay
The price is CA $410 per night from Jan 24 to Jan 25

Located in Old Town, this hotel is steps from Custom House Museum, Duval Street, and Mallory Square. Key West Shipwreck Museum and Harry S. Truman Little White ...

4.3/5Excellent! (1,075 reviews)

"Great location, close to everything! Great restaurant in the hotel"…"

Reviewed on Dec. 2, 2020

Margaritaville Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Read travel guides and advice on visiting Florida Keys National Marine Sanctuary

Image for A Weekend in Key West

A Weekend in Key West

A Weekend in Key West
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A Key West Christmas: Top Recommendations

A Key West Christmas: Top Recommendations
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Best Beaches for a Winter Retreat

Best Beaches for a Winter Retreat

Popular places to visit in Florida Keys National Marine Sanctuary

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Florida Keys National Marine Sanctuary Vacation Packages (Flight + Hotel)

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Best Lodging Options Near Florida Keys National Marine Sanctuary

Southernmost Beach Resort
Southernmost Beach Resort
4 out of 5
1319 Duval Street, Key West, FL
The price is CA $401 per night from Jan 19 to Jan 20
Southernmost Beach Resort
Crowne Plaza Key West-La Concha
Crowne Plaza Key West-La Concha
4 out of 5
430 Duval St, Key West, FL
The price is CA $191 per night from Jan 19 to Jan 20
Crowne Plaza Key West-La Concha
Margaritaville Key West Resort & Marina
Margaritaville Key West Resort & Marina
4 out of 5
245 Front Street, Key West, FL
The price is CA $410 per night from Jan 24 to Jan 25
Margaritaville Key West Resort & Marina
The Cabana Inn Key West-Adults Only
The Cabana Inn Key West-Adults Only
3 out of 5
413 Applerouth Lane, Key West, FL
The price is CA $215 per night from Jan 20 to Jan 21
The Cabana Inn Key West-Adults Only
Marrero's Guest Mansion
Marrero's Guest Mansion
3.5 out of 5
410 Fleming Street, Key West, FL
The price is CA $240 per night from Jan 17 to Jan 18
Marrero's Guest Mansion
Hyatt Centric Key West Resort and Spa
Hyatt Centric Key West Resort and Spa
4 out of 5
601 Front St, Key West, FL
The price is CA $416 per night from Jan 27 to Jan 28
Hyatt Centric Key West Resort and Spa
The Southernmost Inn-Adults Only
The Southernmost Inn-Adults Only
2.5 out of 5
525 United Street, Key West, FL
The price is CA $190 per night from Jan 20 to Jan 21
The Southernmost Inn-Adults Only
Pier House Resort & Spa
Pier House Resort & Spa
4 out of 5
1 Duval St, Key West, FL
The price is CA $419 per night from Jan 19 to Jan 20
Pier House Resort & Spa
Ocean Key Resort - A Noble House Resort
Ocean Key Resort - A Noble House Resort
4 out of 5
Zero Duval St., Key West, FL
The price is CA $618 per night from Jan 19 to Jan 20
Ocean Key Resort - A Noble House Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.