Title: The 10 Best Hotels Near Florida Keys National Marine Sanctuary, Key West | Expedia.ca [Key West Travel Guide](https://expedia.ca/Key-West.dx1187)[Flights to Key West](https://expedia.ca/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.ca/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Florida Keys National Marine Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Florida-Keys-National-Marine-Sanctuary.d6163838.Car-Rental-Guide)[Florida Keys National Marine Sanctuary Vacations](https://expedia.ca/Florida-Keys-National-Marine-Sanctuary-Key-West.d6163838.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=6163838&startDate=2026-01-30&endDate=2026-01-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6163838&startDate=2026-01-31&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6163838&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6163838&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Top Florida Keys National Marine Sanctuary Hotel Reviews ![Douglas House](https://images.trvl-media.com/lodging/111000000/110490000/110488200/110488130/a2bf0992_y.jpg) ### Douglas House 10/10 Excellent "Every staff member we interacted with was great. The apartment was clean and spacious. The location is awesome & convenient to tourist attrations and many dining options. The pool area was clean and very comfortable. We highly recommend this property " [](https://expedia.ca/Key-West-Hotels-Douglas-House.h110488130.Hotel-Information) ![The Cabana Inn Key West - Adults Only](https://images.trvl-media.com/lodging/7000000/6580000/6576700/6576609/98bddc65_y.jpg) ### The Cabana Inn Key West - Adults Only 10/10 Excellent "Great Location and Very Friendly Staff! Would come back here again!" [](https://expedia.ca/Key-West-Hotels-The-Cabana-Inn-Key-West-Adults-Only.h6576609.Hotel-Information) ![The Southernmost Inn - Adults Only](https://images.trvl-media.com/lodging/5000000/4290000/4280800/4280752/2b7e8bad_y.jpg) ### The Southernmost Inn - Adults Only 10/10 Excellent "Very nice stay. No complaints. Loved it" [](https://expedia.ca/Key-West-Hotels-The-Southernmost-Inn-Adults-Only.h4280752.Hotel-Information) ![Duval House](https://images.trvl-media.com/lodging/1000000/910000/900500/900423/d8706fe9_y.jpg) ### Duval House 10/10 Excellent "The Duvall house was the icing on the cake for our stay in Key West. The staff was friendly (especially the gentleman that we spoke with for awhile), the grounds were so beautiful. Nice and clean, very comfortable beds, showers had great water pressure and hot water. We were surprised to be given an upgrade from a nice room in the rear to a suite that overlooked the Main Street with a balcony. Thank you so very much for that! The house is located in the central of downtown. Walking everywhere was a breeze. The town gets quiet about 10pm. We didn’t have a noise issue at all. The rear of the grounds offers a good size swimming pool and small gym. You can even bbq if you wanted. Perfect place for couples or ladies getaway. " [](https://expedia.ca/Key-West-Hotels-Duval-House.h900423.Hotel-Information) ![Pier House Resort & Spa](https://images.trvl-media.com/lodging/1000000/20000/19400/19307/c9267f77_y.jpg) ### Pier House Resort & Spa 10/10 Excellent "The management team was also great." [](https://expedia.ca/Key-West-Hotels-Pier-House-Resort-Spa.h19307.Hotel-Information) ![Lighthouse Hotel - Key West Historic Inns](https://images.trvl-media.com/lodging/2000000/1180000/1171100/1171079/2155599f_y.jpg) ### Lighthouse Hotel - Key West Historic Inns 10/10 Excellent "Great location. Cute heated pool. Charming rooms. Nice continental breakfast. Only improvement would be the AC units. They were loud." [](https://expedia.ca/Key-West-Hotels-Kimpton-Lighthouse-Hotel.h1171079.Hotel-Information) ![Southernmost Beach Resort and Guesthouses](https://images.trvl-media.com/lodging/1000000/870000/863400/863329/026f10af_y.jpg) ### Southernmost Beach Resort and Guesthouses 10/10 Excellent "Nice resort near the beach. The staff was very friendly. The check-in process was a little lengthy, but not overly so. 3 pools with bars nearby and daily activities. My particular room was a little smaller than what I am used to, but it was clean. Also, the shower could have been a little warmer, but it was fine. I liked having the coffee bar near my room. " [](https://expedia.ca/Key-West-Hotels-Southernmost-Beach-Resort.h863329.Hotel-Information) ![Caribbean House](https://images.trvl-media.com/lodging/97000000/96390000/96387000/96386935/2cfd2198_y.jpg) ### Caribbean House 10/10 Excellent "Fantastic highly recommend " [](https://expedia.ca/Key-West-Hotels-Caribbean-House.h96386935.Hotel-Information) ![Winslow's Bungalows - Key West Historic Inns](https://images.trvl-media.com/lodging/1000000/530000/529700/529611/7cf7d263_y.jpg) ### Winslow's Bungalows - Key West Historic Inns 10/10 Excellent "The employees are very friendly and helpful. The rooms are spotlessly clean and each room seems unique. This is a number of historical buildings all tied together with amazing tropical plantings. Our room which was on the second floor was very quiet. There are no elevators so if that is a problem, there are many first floor rooms. It is right in the Historic District and within walking distance of the waterfront and almost anything you want to visit. " [](https://expedia.ca/Key-West-Hotels-Kimpton-Winslows-Bungalows.h529611.Hotel-Information) ## Hotels near other Florida Keys National Marine Sanctuary attractions ![Florida Keys Eco - Discovery Center which includes interior views](https://images.trvl-media.com/place/6069247/474d6adf-b186-47b4-a027-1e3a6d32dc25.jpg) ### Florida Keys Eco - Discovery Center 4.3/5 (128 reviews) Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6069247) ![Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com](https://images.trvl-media.com/place/6069245/fc7525f8-453d-41c7-bc20-e32416890fb1.jpg) ### Fort Zachary Taylor Historic State Park 4.4/5 (1,160 reviews) The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6069245) ![](https://images.trvl-media.com/place/1187/1201d89a-fb81-4e18-91c2-0cc24a30129f.jpg) ### Truman Beach Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635983989797) ![Jackson Square showing a garden](https://images.trvl-media.com/place/6249254/072a05e3-dca5-4abe-9f06-4e35b7787615.jpg) ### Jackson Square You can learn about the history of Key West with a stop at Jackson Square. Stroll along the beautiful beaches or discover the area's beautiful sunsets. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6249254) ![Harry S. Truman Little White House showing interior views and a house](https://images.trvl-media.com/place/6068605/08afa45c-9c33-4a64-914f-76a597bb6364.jpg) ### Harry S. Truman Little White House 4.4/5 (983 reviews) Visit the winter home of President Harry S. Truman to see where some of America’s most important post-war decisions were made. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6068605) ![Key West Lighthouse and Keeper\'s Quarters Museum which includes views, a coastal town and landscape views](https://images.trvl-media.com/place/501383/b0caa24d-4abc-4245-a009-f22e55fd5e86.jpg) ### Key West Lighthouse and Keeper's Quarters Museum 4.2/5 (543 reviews) Climb to the top of this historic lighthouse for unparalleled photo opportunities and then visit the former home of Key West’s lighthouse keepers. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=501383) ### USCGC Ingham Maritime Museum You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=801219351206326272) ### We Cycle Key West You can search for that perfect souvenir at We Cycle Key West during your trip to Key West. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=827848417466060800) ## Frequently asked questions ### What's the area like around Florida Keys National Marine Sanctuary? ### Where is the best place to stay close to Florida Keys National Marine Sanctuary? ### How many hotels will I be able to find near Florida Keys National Marine Sanctuary? ### If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund? ### What can I see and do near Florida Keys National Marine Sanctuary? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [4 Star Hotels in Key West ](https://www.expedia.ca/4Star-Key-West-Hotels.s40-0-d1187.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Key West ](https://www.expedia.ca/5Star-Key-West-Hotels.s50-0-d1187.Travel-Guide-Filter-Hotels) - [Hotels near Audubon House and Tropical Gardens ](https://www.expedia.ca/Audubon-House-And-Tropical-Gardens-Hotels.0-l6068599-0.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Adults-Only-Resorts.0-n553248621533115696-0-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [All Inclusive Resorts and in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-All-Inclusive-Hotel.0-n553248621533115696-0-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Beach-Hotel.0-n553248621533115696-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Boutique-Hotel.0-n553248621533115696-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Cheap-Hotels.0-n553248621533115696-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Couples-Resorts-Hotels.0-n553248621533115696-0-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Family-Hotel.0-n553248621533115696-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Honeymoon Resorts and in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Honeymoon-Hotels.0-n553248621533115696-0-tHoneymoonHotels.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Luxury-Hotel.0-n553248621533115696-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Oceanfront-Hotels.0-n553248621533115696-0-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - [Waterpark Hotels in Bahama Village ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels-Waterpark-Hotels.0-n553248621533115696-0-tWaterparkHotels.Travel-Guide-Filter-Hotels) - [Bahama Village Hotels ](https://www.expedia.ca/Bahama-Village-Key-West-Hotels.0-n553248621533115696-0.Travel-Guide-Filter-Hotels) - [Casa Marina Hotels ](https://www.expedia.ca/Casa-Marina-Key-West-Hotels.0-n864981993084186624-0.Travel-Guide-Filter-Hotels) - [Downtown Key West Hotels ](https://www.expedia.ca/Downtown-Key-West-Key-West-Hotels.0-n553248635976470405-0.Travel-Guide-Filter-Hotels) - [Hotels near Duval Street ](https://www.expedia.ca/Duval-Street-Hotels.0-l6068616-0.Travel-Guide-Filter-Hotels) - [Hotels near Ernest Hemingway Home and Museum ](https://www.expedia.ca/Ernest-Hemingway-Home-And-Museum-Hotels.0-l501376-0.Travel-Guide-Filter-Hotels) - [Hotels near Florida Keys Eco - Discovery Center ](https://www.expedia.ca/Florida-Keys-Eco-Discovery-Center-Hotels.0-l6069247-0.Travel-Guide-Filter-Hotels) - [Hotels near Fort Zachary Taylor Historic State Park ](https://www.expedia.ca/Fort-Zachary-Taylor-Historic-State-Park-Hotels.0-l6069245-0.Travel-Guide-Filter-Hotels) - [Hotels near Harry S. 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