The best area to stay in Esquipulas is around the Basilica of Esquipulas, as it's the heart of the town and where most of the activity for visitors takes place.
This central area is highly walkable and is focused on the magnificent Basilica, a significant pilgrimage site. The streets immediately surrounding the Basilica are where you'll find the majority of hotels, restaurants offering local cuisine, and shops selling religious artefacts and souvenirs. It's a compact area, making it easy to navigate on foot.
Solo travellers will find this area particularly convenient. With everything within a short walk, it's easy to explore the Basilica, attend services, and discover local eateries without needing transport. The concentration of amenities also means there are always people about, making it a comfortable place to be.
Couples looking for a cultural or spiritual retreat will also appreciate staying near the Basilica.