Title: Madre de Dios Region Vacation Rentals from CA $52: Short-Term Rentals for 2026 | Expedia.ca [Madre de Dios Region Hotels](https://expedia.ca/Destinations-In-Madre-De-Dios-Region.d6235175.Hotel-Destinations)[Madre de Dios Region Car Rentals](https://expedia.ca/Destinations-In-Madre-De-Dios-Region.d6235175.Car-Rental-Destinations)[Madre de Dios Region Vacations](https://expedia.ca/Madre-De-Dios-Region.d6235175.Destination-Travel-Guides) ![Paddling in the Peruvian Amazon #parks ](https://images.trvl-media.com/place/553248622106908538/a213e130-aa02-4189-958a-22853c352eba.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by nevin xavier ![](https://images.trvl-media.com/place/553248622106908538/a213e130-aa02-4189-958a-22853c352eba.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Our top choices for Madre de Dios Region vacation rentals ![Superior Cabin, Garden View](https://images.trvl-media.com/lodging/121000000/120160000/120160000/120159996/99053673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/121000000/120160000/120160000/120159996/24ae7db2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Cabin, Garden View](https://images.trvl-media.com/lodging/121000000/120160000/120160000/120159996/93d42281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Cabin, Garden View](https://images.trvl-media.com/lodging/121000000/120160000/120160000/120159996/065a715f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Explorers Inn [](https://www.expedia.ca/Tambopata-Hotels-Explorers-Inn.h120159996.Hotel-Information) Tambopata CA $372 CA $619 total Mar 26 - Mar 27 [](https://www.expedia.ca/Tambopata-Hotels-Explorers-Inn.h120159996.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103200000/103192900/103192809/w1437h1800x0y0-54243942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/104000000/103200000/103192900/103192809/36379e1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin, Multiple Beds, Ensuite, Garden View](https://images.trvl-media.com/lodging/104000000/103200000/103192900/103192809/42d626ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/104000000/103200000/103192900/103192809/fede9271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quirquincho House [](https://www.expedia.ca/Tambopata-Hotels-Quirquincho-House.h103192809.Hotel-Information) Tambopata 10/10 Exceptional (3 reviews) "Property was well maintained, neat and clean. The owner was very friendly and made us feel home.would suggest if you want to stay in a quiet place surrounded by nature." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) VIJAY CA $64 CA $92 total Mar 26 - Mar 27 [](https://www.expedia.ca/Tambopata-Hotels-Quirquincho-House.h103192809.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-08&endDate=2026-04-09®ionId=6235175&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Apartments [](https://www.expedia.ca/Hotel-Search?destination=Madre+de+Dios+Region%2C+Peru®ionId=6235175&latLong=-11.609331%2C-70.538518&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=APARTMENT) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Madre+de+Dios+Region%2C+Peru®ionId=6235175&latLong=-11.609331%2C-70.538518&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=VACATION_HOME) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Madre+de+Dios+Region%2C+Peru®ionId=6235175&latLong=-11.609331%2C-70.538518&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=COTTAGE) Cabins [](https://www.expedia.ca/Hotel-Search?destination=Madre+de+Dios+Region%2C+Peru®ionId=6235175&latLong=-11.609331%2C-70.538518&adults=2&startDate=2026-06-23&d1=2026-06-23&endDate=2026-06-26&d2=2026-06-26&lodging=CABIN) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Madre-De-Dios-Region.d6235175.Vacation-Rental-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Madre-De-Dios-Region.d6235175.Vacation-Rental-Destinations) ## Top Madre de Dios Region Hotel Reviews ![Libelula Hotel](https://images.trvl-media.com/lodging/92000000/91400000/91391300/91391298/c3141681_y.jpg) ### Libelula Hotel 10/10 Excellent "It's very good." [](https://expedia.ca/Tambopata-Hotels-Hospedaje-Libelula.h91391298.Hotel-Information) ![Inkaterra Reserva Amazonica](https://images.trvl-media.com/lodging/1000000/900000/894900/894833/03844af3_y.jpg) ### Inkaterra Reserva Amazonica 10/10 Excellent "Loved the location, staff, facilities, activities and food. " [](https://expedia.ca/Las-Piedras-Hotels-Inkaterra-Reserva-Amazonica.h894833.Hotel-Information) ![Inkaterra Hacienda Concepcion](https://images.trvl-media.com/lodging/16000000/15480000/15471000/15470957/efba8ad8_y.jpg) ### Inkaterra Hacienda Concepcion 10/10 Excellent "It felt like it was probably one of the comfiest ways to experience the Amazon. Great staff, knowledgeable guides, all transportation taken care of. Would definitely recommend Inkaterra! " [](https://expedia.ca/Tambopata-Hotels-Inkaterra-Hacienda-Concepcion.h15470957.Hotel-Information) ![La Fauna Hotel](https://images.trvl-media.com/lodging/47000000/46500000/46499600/46499505/5c812fb5_y.jpg) ### La Fauna Hotel 10/10 Excellent "Great oasis in the middle of Puerto Maldonado. 100% recommend. Close to everything in town and easy to book tours from agents nearby… thank you so much for looking after us. Excellent value too" [](https://expedia.ca/Tambopata-Hotels-El-Fauno-Hostel.h46499505.Hotel-Information) ![Villa Hermosa de Tambopata](https://images.trvl-media.com/lodging/27000000/26720000/26711100/26711015/ee755fd0_y.jpg) ### Villa Hermosa de Tambopata 6/10 Okay "The hosts were very polite, and tried their best to communicate even though they dont speak English. The rooms are older and a little rough. Water is available in the kitchen for drinking. " [](https://expedia.ca/Tambopata-Hotels-Villa-Hermosa-De-Tambopata.h26711015.Hotel-Information) ![Ecolucerna Lodge Tambopata](https://images.trvl-media.com/lodging/17000000/16760000/16754800/16754742/bee31092_y.jpg) ### Ecolucerna Lodge Tambopata 10/10 Excellent "we had a beautiful time at the lodge. the staff makes this property amazing! the food was so good, they are organized and friendly. same as other reviewers as no hot water, but its so hot out that a cool shower feels amazing! " [](https://expedia.ca/Tambopata-Hotels-Ecolucerna-Lodge.h16754742.Hotel-Information) ![Hacienda Herrera Tambopata](https://images.trvl-media.com/lodging/30000000/29880000/29871500/29871476/207faf8c_y.jpg) ### Hacienda Herrera Tambopata 10/10 Excellent "This was a beautiful place. We had a very nice time. The staff were very welcoming and friendly and we really enjoyed the meals." [](https://expedia.ca/Tambopata-Hotels-Hacienda-Herrera-Tambopata.h29871476.Hotel-Information) ![Posada Amazonas](https://images.trvl-media.com/lodging/5000000/4210000/4208500/4208434/5170737b_y.jpg) ### Posada Amazonas 10/10 Excellent "Posadas was a lovely jungle lodge. The staff were friendly and helpful with amazing service. Beautiful setting and Rainforest Expeditions made our transportation and excursions smooth and flawless. Food was fresh and delicious satisfying to the taste buds. The jungle sounds were wonderful to wake up to and helped to send you off to sleep. I highly recommend and would love to return sometime. A lot of wildlife just around the lodge." [](https://expedia.ca/Tambopata-Hotels-Posada-Amazonas.h4208434.Hotel-Information) ![Tronco Tambopata Adventure](https://images.trvl-media.com/lodging/90000000/89160000/89151200/89151158/3ab57a45_y.jpg) ### Tronco Tambopata Adventure 10/10 Excellent "The guides for the tours were very knowledgeable. The food was great and plentiful. The people were kind and hospitable. " [](https://expedia.ca/Tambopata-Hotels-Tronco-Tambopata-Adventure.h89151158.Hotel-Information) ## Find out more about Madre de Dios Region **Everything you need to know about** **Madre de Dios Region** **vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Madre de Dios Region vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Madre de Dios Region vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Madre de Dios Region vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Madre de Dios Region. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Madre de Dios Region vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. The selection of Madre de Dios Region vacation rentals we have selected for you start as low as CA $52 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Madre de Dios Region rentals** At Expedia, we put the best Madre de Dios Region vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Madre de Dios Region rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Madre de Dios Region vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Madre de Dios Region. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.