Title: Book the Best Clarksdale SPA Resorts from CA $116 - Spa Hotels in Clarksdale, MS | Expedia.ca [Hotels in Clarksdale](https://expedia.ca/Clarksdale-Hotels.d6640.Travel-Guide-Hotels)[Vacation Rentals in Clarksdale](https://expedia.ca/Clarksdale-Vacation-Rentals.d6640.Travel-Guide-VacationRentals)[Flights to Clarksdale](https://expedia.ca/Cheap-Flights-To-Clarksdale.d6640.Travel-Guide-Flights)[Clarksdale Car Rentals](https://expedia.ca/Car-Rentals-In-Clarksdale.d6640.Car-Rental-Guide)[Clarksdale Vacation Packages](https://expedia.ca/Clarksdale.d6640.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/3e4a4f54528b1ae1cd0c50edfbcf03ce.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Molly Bond # Find Spa Hotels in Clarksdale, MS from CA $116 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Clarksdale Spa Hotels Tonight [Oct 26 - Oct 27](https://www.expedia.ca/Hotel-Search?regionId=6640&startDate=2025-10-26&endDate=2025-10-27&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=6640&startDate=2025-10-27&endDate=2025-10-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6640&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6640&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Clarksdale Spa Hotels We don't have any properties that match your exact search [See all properties in Clarksdale](https://expedia.ca/Hotel-Search?startDate=2025-11-09&endDate=2025-11-10®ionId=6640&adults=2) ## Recommended hotels in Clarksdale ![Front of property](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/cc59a6f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/7467caab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/f4c15177.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Travelers Suite | Living area](https://images.trvl-media.com/lodging/35000000/34870000/34868100/34868083/33a8aa3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelers Hotel Clarksdale 9.8/10 Exceptional (273) "Though a bit different, there was a great artsy feel to the hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) T CA $213 CA $233 total includes taxes & fees Nov 26 - Nov 27 [](https://www.expedia.ca/Clarksdale-Hotels-Travelers-Hotel.h34868083.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/e34ceb08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/84d69b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/55faa465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/9000000/8280000/8273700/8273622/de175126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Clarksdale Clarksdale 8.2/10 Very good (326) "We would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew Ray CA $174 CA $190 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Clarksdale-Hotels-Hampton-Inn-Clarksdale.h8273622.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/766fdf07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/e98cafb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/94b5934f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/160000/151300/151227/e482f310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clarksdale 7.2/10 Good (696) "Good eggs and sausage" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $112 CA $122 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Clarksdale-Hotels-Quality-Inn.h151227.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/ecc9aaad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/20ac7e27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/bd258b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels, soap, shampoo](https://images.trvl-media.com/lodging/77000000/76040000/76031100/76031053/b529a7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Only a mile from historic downtown Clarksdale! Clarksdale 10/10 Exceptional (22) "The cottage was excellent. I would recommend staying there." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy CA $233 CA $308 total includes taxes & fees Nov 1 - Nov 2 [](https://www.expedia.ca/Clarksdale-Hotels-Only-A-Mile-From-Historic-Downtown-Clarksdale.h76031053.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/07f49a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/24dda261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/9ca3e71b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/97000000/96760000/96758600/96758575/93a6a6f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sunset Log Cabin Clarksdale 9.8/10 Exceptional (16) "Everything was perfect...Dog friendly...Our dogs enjoyed the big field outback" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) gina j. CA $161 CA $262 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Clarksdale-Hotels-Sunset-Log-Cabin.h96758575.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/9f913091.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/24c46089.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/5977ba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/79000000/79000000/78996000/78995934/w507h683x259y0-7231cbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage on riverbank one mile from Clarksdale in gated community Clarksdale 9.4/10 Exceptional (9) "It is a hidden gem. We loved the location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa H. CA $187 CA $310 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Clarksdale-Hotels-Cottage-On-The-Sunflower-River.h78995934.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/88000000/87720000/87715200/87715200/w506h683x258y0-f5f92a51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/88000000/87720000/87715200/87715200/w918h683x47y0-d04d85e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87720000/87715200/87715200/104def98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87720000/87715200/87715200/w907h683x58y0-bb3080c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sunflower Penthouse on the River in Clarksdale Clarksdale 9.2/10 Wonderful (20) "Beautiful setting very close to the town of blues! Beds were very comfortable & outdoor seating was lovely ! I would recommend staying there for a comfortable & convenient visit to Clarksdsle!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary B. CA $182 CA $304 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/Clarksdale-Hotels-The-Sunflower-Penthouse-On-The-River-In-Clarksdale.h87715200.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113150000/113140300/113140229/029d0d24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113150000/113140300/113140229/33354a52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/114000000/113150000/113140300/113140229/97d833e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113150000/113140300/113140229/d17187c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 1-bedroom house in fabulous Clarksdale with WiFi Clarksdale CA $210 CA $288 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Clarksdale-Hotels-Charming-1-Bedroom-House-In-Fabulous-Clarksdale-With-WiFi.h113140229.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/c0e992b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/3c683cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Smoking | Room amenity](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/09f42bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/160000/151300/151226/e3029007.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Americas Best Value Inn & Suites Clarksdale Clarksdale 5.8/10 (396) "Good location in town" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel CA $106 CA $116 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Clarksdale-Hotels-Americas-Best-Value-Inn-Suites-Clarksdale.h151226.Hotel-Information) ![Shower, towels, shampoo](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/92a31471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/3e64df31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City Single Room](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/fe1d9487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/39000000/38930000/38924500/38924451/82cb9926.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Auberge Clarksdale Blues Hostel Clarksdale 9.6/10 Exceptional (86) "great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mary CA $164 CA $175 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Clarksdale-Hotels-Auberge-Clarksdale-Blues-Hostel.h38924451.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-09&endDate=2025-11-10®ionId=6640&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Clarksdale Hotel Reviews ## Frequently asked questions ### Looking for a spa hotel in Clarksdale? > Forget the stress of everyday life and book yourself a hotel with a spa. Check out the live music scene and shopping in Clarksdale—your day trip starts here. Enjoy the entertainment choices and many popular restaurants during your vacation. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your holiday. ### What's there to see and do in Clarksdale? > Enjoy Clarksdale with a stop at Delta Blues Museum, Ground Zero Blues Club, and Hambone Art Gallery. If you have extra time while you're in the area, you might want to stop by Mississippi River and Red's Lounge. ### What is a Clarksdale spa hotel? > Spa hotels in Clarksdale provide lodging and have an on-site spa offering services such as facials and beauty treatments. Some also offer in-room treatments. 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