Cairo Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
Aug 15 - Aug 17
In two weeks
Aug 22 - Aug 24
In one month
Sep 5 - Sep 7
In two months
Oct 3 - Oct 5

Browse Select Cairo Vacation Homes

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Exterior

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10.0 out of 10, Exceptional, (174)
"This cozy quiet farmhouse was the perfect place to stay for my boyfriend and I’s first getaway together. We will definitely come back again! "
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
Property grounds

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!

2.0 star property
9.8 out of 10, Exceptional, (18)
"Great place to stay. "
Welcome campers, hikers, fishermen, girls' weekend wine getaways!!
Charming Home just minutes from Interstate and Mall
Exterior detail

Charming Home just minutes from Interstate and Mall

10.0 out of 10, Exceptional, (20)
"Came to town to fish the river. It was a nice place. Clean and quiet "
The price is CA $152
CA $258 total
includes taxes & fees
Aug 18 - Aug 19
Charming Home just minutes from Interstate and Mall
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
Fridge, microwave, oven, stovetop

Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***

10.0 out of 10, Exceptional, (15)
"We had a wonderful stay. The fishing, fire pit, and area attractions made for a great Labor Day weekend. Would definitely recommend and stay here again!"
Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
Charming 3-bedroom house near ball park in quiet neighborhood
Fridge, microwave, oven, stovetop

Charming 3-bedroom house near ball park in quiet neighborhood

10.0 out of 10, Exceptional, (9)
"clean, comfortable and convenient to town. Would definitely stay again."
The price is CA $124
CA $236 total
includes taxes & fees
Aug 6 - Aug 7
Charming 3-bedroom house near ball park in quiet neighborhood
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Cairo Hotel Reviews

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

10/10 Excellent
"My stay went well."
Connie 1-night trip
Posted 1 day ago
Quality Inn Charleston - Sikeston