Title: Book the Best Cairo SPA Resorts from CA $91 - Spa Hotels in Cairo, IL | Expedia.ca [Hotels in Cairo](https://expedia.ca/Cairo-Hotels.d6626.Travel-Guide-Hotels)[Vacation Rentals in Cairo](https://expedia.ca/Cairo-Vacation-Rentals.d6626.Travel-Guide-VacationRentals)[Flights to Cairo](https://expedia.ca/Cheap-Flights-To-Cairo.d6626.Travel-Guide-Flights)[Cairo Car Rentals](https://expedia.ca/Car-Rentals-In-Cairo.d6626.Car-Rental-Guide)[Cairo Vacation Packages](https://expedia.ca/Cairo.d6626.Destination-Travel-Guides) ![Cairo Ohio River Bridge traversing over the Ohio River at sunset](https://images.trvl-media.com/place/6626/5a2a2e7f-cbef-414c-a9c1-20af7a0fca3a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Cairo, IL from CA $91 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cairo Spa Hotels Tonight [Dec 1 - Dec 2](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-01&endDate=2025-12-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 2 - Dec 3](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-02&endDate=2025-12-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-05&endDate=2025-12-07&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-12&endDate=2025-12-14&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cairo Spa Hotels No exact matches found, but these alternatives could be just right ## Recommended hotels in Cairo ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 Cairo 6.6/10 (272) "Break fast was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Uma CA $101 CA $112 total includes taxes & fees Jan 2 - Jan 3, 2026 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO Charleston 6.6/10 (611) "Staff was great! Room was nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lana CA $82 CA $91 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/cde4423c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/fa992d12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/074a1dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Charleston - Sikeston Charleston 6.8/10 (406) "The staff was very friendly and accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arturo CA $92 CA $102 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/9b8cfc2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/3a420a79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/16f008b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/a98ba719.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet Country Stay: Modern Home Near Paducah Cunningham CA $169 CA $405 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122892138.Hotel-Information) ![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/2b61a8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/e769dedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/d436dcb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston Charleston 6.8/10 (103) "Middle of nowhere hotel was ok" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $85 CA $94 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming cottage overlooking Lake Acre Dongola 10/10 Exceptional (100) "Location was great, everything was great for what we were there for. Already booked again for November. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) carlton h. CA $189 CA $397 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90930000/90923000/90922960/8049aee8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90930000/90923000/90922960/de0a70e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90930000/90923000/90922960/df4ed428.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90930000/90923000/90922960/29a54441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Home just minutes from Interstate and Mall Kevil 10/10 Exceptional (20) "We enjoyed staying here very much. Clean and close to where we wanted to be!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Becky C. CA $154 CA $262 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Paducah-Hotels-Charming-Home.h90922960.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/8a1aff87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/e22587fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/6520deeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/88161c16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 3-bedroom house near ball park in quiet neighborhood Bardwell 10/10 Exceptional (11) "Quaint stay to see Grand and kids. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila C. CA $126 CA $224 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/df1f8854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/23c71fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/3bc4c831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy cabins on beautiful Horseshoe Lake Olive Branch 9.8/10 Exceptional (35) "Beautiful place, host was kind and and quick to respond to messages " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa W. CA $157 CA $196 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/d70c82b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/b3100701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rested Duck Mallard Room Olive Branch 9.2/10 Wonderful (25) "This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mike b. CA $157 CA $196 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-16&endDate=2025-12-17®ionId=6626&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AFFINITY_BF_PROMO_6626) ## Top Cairo Hotel Reviews ![Eagle Inn Charleston](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a_y.jpg) ### Eagle Inn Charleston 10/10 Excellent "Furniture missing knobs. No chair!!??? No coffee!!?? No breakfast. Nice location. Nice staff!! " [](https://expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Cairo? > Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Cairo—your day trip starts here. Enjoy the opera and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation. ### What's there to see and do in Cairo? > When you're in Cairo, enjoy exploring the sights and attractions here including Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have a little extra time during your trip, you might want to check out Ballard Wildlife Management Area and Columbus-Belmont State Park. ### What is a Cairo spa hotel? > Spa hotels in Cairo provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. 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