All hotels in Southwest Illinois, Illinois
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
All hotels in Southwest Illinois, Illinois
We have found 688 Southwest Illinois Hotels
- Drury Inn & Suites Mt. Vernon
- Drury Inn & Suites St. Louis O'Fallon, IL
- Drury Inn & Suites St. Louis Fairview Heights
- Walker's Bluff Casino Resort
- Drury Inn & Suites Marion
- Super 8 by Wyndham O'Fallon
- Baymont by Wyndham Marion
- Town & Country Inn
- Quality Inn & Suites near St. Louis and I-255
- Drury Inn & Suites St. Louis Collinsville
- Comfort Suites Fairview Heights
- Comfort Suites Mount Vernon
- Red Lion Inn & Suites Pontoon Beach
- Best Western Marion Hotel
- La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
- Holiday Inn Express & Suites Mount Vernon, an IHG Hotel
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Best Western Saluki Inn
- Holiday Inn Express & Suites Edwardsville, an IHG Hotel
- Quality Inn & Suites Vandalia near I-70 and Hwy 51
- Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
- Comfort Inn Edwardsville - St. Louis
- Super 8 by Wyndham Mt. Vernon IL
- Home2 Suites by Hilton Carbondale
- Motel 6 Mount Vernon, IL
- Quality Inn & Suites Caseyville - St. Louis
- SureStay Hotel by Best Western Whittington Rend Lake
- Hampton Inn & Suites St. Louis-Edwardsville
- Comfort Inn Collinsville near St. Louis
- Red Lion Inn & Suites Caseyville
- Holiday Inn St. Louis Fairview Heights, an IHG Hotel
- Quality Inn Carbondale University area
- Quality Inn Mount Vernon, IL
- Baymont by Wyndham O'Fallon St. Louis Area
- Holiday Inn Express & Suites Vandalia, an IHG Hotel
- Americas Best Value Inn Collinsville St. Louis
- Red Roof Inn St Louis - Troy, IL
- Hotel 7 Inn Anna
- Rodeway Inn & Suites
- Motel 6 Marion, IL
- Hampton Inn St. Louis - Columbia
- Country Hearth Inn & Suites Edwardsville St. Louis
- Hampton Inn Carbondale
- Holiday Inn Express & Suites - O'Fallon /Shiloh, an IHG Hotel
- Days Inn by Wyndham Mount Vernon
- Days Inn & Suites by Wyndham Caseyville
- Holiday Inn Express Hotel & Suites Marion Northeast, an IHG Hotel
- Best Western Chester Hotel
- Country Inn & Suites by Radisson, Marion, IL
- Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
- Super 8 by Wyndham Greenville
- SureStay Hotel by Best Western Greenville
- Fairgrounds Inn
- Seasons Inn & Suites Highland
- Americas Best Value Inn & Suites Pinckneyville
- Hampton Inn Collinsville
- Comfort Inn & Suites Greenville I-70
- Super 8 by Wyndham Belleville St. Louis Area
- Country Garden & Suites
- Fairfield Inn by Marriott St. Louis Collinsville, IL
- Quality Inn & Suites Salem near I-57
- Motel 6 Caseyville, IL - Caseyville Il
- Holiday Inn Express & Suites Salem, an IHG Hotel
- Econo Lodge & Suites Granite City
- Four Points by Sheraton St Louis - Fairview Heights
- Wine Country Farmhouse On the Wine 🍷 Trail! Private Lake kayaks Fire Pit 🔥
- Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
- Best Western Plus Centralia Hotel & Suites
Let Expedia take you to the best Hotels in Southwest Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.