Title: 4 Stars Hotels in De Soto, Missouri  - Find Cheap De Soto Hotels With 4 Stars | Expedia.ca

[De Soto Travel Guide](https://expedia.ca/De-Soto.dx6085105)[Hotels in De Soto](https://expedia.ca/De-Soto-Hotels.d6085105.Travel-Guide-Hotels)[Vacation Rentals in De Soto](https://expedia.ca/De-Soto-Vacation-Rentals.d6085105.Travel-Guide-VacationRentals)[Flights to De Soto](https://expedia.ca/Cheap-Flights-To-De-Soto.d6085105.Travel-Guide-Flights)[De Soto Car Rentals](https://expedia.ca/Car-Rentals-In-De-Soto.d6085105.Car-Rental-Guide)[De Soto Vacation Packages](https://expedia.ca/De-Soto.d6085105.Destination-Travel-Guides)

![Kayaking down the Big River on a fall day! ](https://images.trvl-media.com/place/6085105/405982b2-f4d7-475b-927f-02fc53f853d1.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Jessica King

# 4 Stars Hotels in De Soto, Missouri 

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## Check availability on De Soto 4 Star Hotels

Tonight

[Dec 15 - Dec 16](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-15&endDate=2025-12-16&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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[Dec 16 - Dec 17](https://www.expedia.ca/Hotel-Search?regionId=6085105&startDate=2025-12-16&endDate=2025-12-17&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Learn more about De Soto

Get away to De Soto! Enjoy the local cuisine and more. 

[See all hotels in De Soto](https://www.expedia.ca/Hotel-Search?startDate=2025-12-29&endDate=2025-12-30&adults=2&regionId=6085105)

![Kayaking down the Big River on a fall day! ](https://images.trvl-media.com/place/6085105/405982b2-f4d7-475b-927f-02fc53f853d1.jpg?impolicy=fcrop&w=400&h=400&p=1&q=high)

Photo by Jessica King

## Top De Soto Hotel Reviews

## Find out more about De Soto

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in De Soto are calling your name. Known for providing first-rate service in amazing locations, each of the De Soto 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in De Soto. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in De Soto, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top De Soto hotels with 4 Stars provide everything you need to unwind in style.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in De Soto?

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### What's the difference between 5-star and 4-star hotels in De Soto?

### Does De Soto have any 4-star all-inclusive resorts?

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