Title: 4 Stars Hotels in Center, Missouri from CA $272 - Find Cheap Center Hotels With 4 Stars | Expedia.ca [Center Travel Guide](https://expedia.ca/Center.dx553248634983556117)[Hotels in Center](https://expedia.ca/Center-Hotels.d553248634983556117.Travel-Guide-Hotels)[Vacation Rentals in Center](https://expedia.ca/Center-Vacation-Rentals.d553248634983556117.Travel-Guide-VacationRentals)[Flights to Center](https://expedia.ca/Cheap-Flights-To-Center.d553248634983556117.Travel-Guide-Flights)[Center Car Rentals](https://expedia.ca/Car-Rentals-In-Center.d553248634983556117.Car-Rental-Guide)[Center Vacation Packages](https://expedia.ca/Center.d553248634983556117.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Center, Missouri from CA $272 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Center 4 Star Hotels Tonight [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=553248634983556117&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248634983556117&startDate=2025-10-11&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248634983556117&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248634983556117&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Center 4 Star Hotels ![Deluxe Room](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/fb550013.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/4063c21a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite | Living area](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/1abb1816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/d6514417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lighthouse Inn & Suites Hannibal 8.8/10 Excellent (21) "Very nice room, close enough to walk to riverfront attractions. " CA $237 CA $272 total includes taxes & fees Oct 11 - Oct 12 [](https://www.expedia.ca/Hannibal-Hotels-Lighthouse-Inn-Suites.h105120258.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/15000000/14830000/14823300/14823290/2bf10c1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/15000000/14830000/14823300/14823290/f1ffb593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, Non Smoking (The Rosewood)](https://images.trvl-media.com/lodging/15000000/14830000/14823300/14823290/d79be89b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 Queen Bed, Non Smoking, Fireplace (Avie's Room)](https://images.trvl-media.com/lodging/15000000/14830000/14823300/14823290/e872c3e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Garth Woodside Mansion B&B Hannibal 9.6/10 Exceptional (19) "Was here eleven years ago owners have changed but still just as great as it was then, quite romantic place to celebrate our anniversary." [](https://www.expedia.ca/Hannibal-Hotels-Garth-Woodside-Mansion-Bed-And-Breakfast.h14823290.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Center-Hotels.s40-0-d553248634983556117.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Center-Hotels.s40-0-d553248634983556117.Travel-Guide-Filter-Hotels) ## Top Center Hotel Reviews ![Lighthouse Inn & Suites](//images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/fb550013_y.jpg) ### Lighthouse Inn & Suites 10/10 Excellent "Very nice room, close enough to walk to riverfront attractions. " [](https://expedia.ca/Hannibal-Hotels-Lighthouse-Inn-Suites.h105120258.Hotel-Information) ## Find out more about Center If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Center are calling your name. Known for providing first-rate service in amazing locations, each of the Center 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Center. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Center, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. 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