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Honeymoon Hotels in Southern Minnesota

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Stay at this B&B in Winona. Enjoy free parking, a business center, and daily housekeeping. Popular attractions Winona Arts Center and Watkins Heritage Museum ...

9.8/10 Exceptional! (520 reviews)

"Richard was fantastic"

Reviewed on Jul 2, 2026

Residence Inn by Marriott Rochester Mayo Clinic Area

441 W Center St Nw Rochester MN

4 min walk from Mayo Clinic

Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.6/10 Excellent! (209 reviews)

"Mayo Clinic in Rochester Minnesota is impressive. We were able to walk from our hotel through a pedestrian tunnel system to get to the hospital with access to other clinic buildings, restaurants and shopping. Very convenient for patients and families during the harsh Minnesota winters.I’m"

Reviewed on May 26, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

Book a stay at this spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...

9.2/10 Wonderful! (1,005 reviews)

"The best place to stay by far in Red Wing. Centrally located in downtown including adjacent to the Amtrak station which is how we arrived. They also have good bikes for rent - perfect as we didn’t have a car. Well maintained historic facility with interesting old photos, plaques, and artifacts everywhere ..."

Reviewed on Jul 3, 2026

See all 1,204 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.