Popular airlines from Des Moines to San Diego
American AirlinesAmerican Airlines
Alaska AirlinesAlaska Airlines
DeltaDelta
Frontier AirlinesFrontier Airlines
UnitedUnited
Southwest AirlinesSouthwest Airlines
- Plan, book, fly with confidence
- Be in the knowGet alerts if flight prices drop or rise*
- Book smarterSave up to 30% on select hotels after you book a flight*
Cheap flights from Des Moines (DSM) to San Diego (SAN)
Prices were available within the past 7 days and start at CA $437 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Find the cheapest month to fly from Des Moines (DSM) to San Diego (SAN)
November is typically the cheapest month to fly
From CA $184 - CA $760 per traveller.
Graph displaying average flight prices per month
Nearby Cities
Expedia's Latest Trends
Flights
- Flights from Las Vegas to Anaheim
- Flights from Vancouver to Maui
- Flights from Bellingham to Anaheim
- Flights from Vancouver to Stockton
- Flights from Vancouver to Kauai
- Flights from Ottawa to Las Vegas
- Flights from Windsor Locks to Banff
- Flights from Buffalo to Destin
- Flights from Ottawa to Maui
- Flights from Toronto to Maui
- Flights from Hamilton to St. Petersburg - Clearwater
- Flights from Toronto to Destin
- Flights from Buffalo to Clearwater
- Flights from Honolulu to Maui
- Flights from Ottawa to St. Petersburg - Clearwater
- Flights from Calgary to Maui
- Flights from Toronto to Bentonville
- Flights from Vancouver to Tahoe City
*Available to Expedia members.