Cheap flights from Indianapolis to San Diego from CA $140

View CA $140 flight on Mon, Sep. 22, 2025Opens in a new window

Popular airlines from Indianapolis to San Diego

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Cheap flights from Indianapolis (IND) to San Diego (SAN)

Prices were available within the past 7 days and start at CA $140 for one-way flights and CA $276 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $276 Roundtrip, found 5 days ago
CA $276
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $276 found 5 days ago
Spirit Airlines
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $330 Roundtrip, found 5 days ago
CA $330
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $330 found 5 days ago
Alaska Airlines
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $409 Roundtrip, found 5 days ago
CA $409
Roundtrip
found 5 days ago
Select Alaska Airlines flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $409 found 5 days ago
Delta
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $411 Roundtrip, found 5 days ago
CA $411
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $411 found 5 days ago
American Airlines
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $427 Roundtrip, found 5 days ago
CA $427
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $427 found 5 days ago
Alaska Airlines
Mon, Sep. 22 - Fri, Sep. 26
IND
Indianapolis
SAN
San Diego
CA $441 Roundtrip, found 5 days ago
CA $441
Roundtrip
found 5 days ago
Select Alaska Airlines flight, departing Mon, Sep. 22 from Indianapolis to San Diego, returning Fri, Sep. 26, priced at CA $441 found 5 days ago

Find the cheapest month to fly from Indianapolis (IND) to San Diego (SAN)

September is typically the cheapest month to fly

From CA $139 - CA $292 per traveller.

Graph displaying average flight prices per month

*Available to Expedia members.