
Sikeston Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
Photo by Ryan Coleman
- Plan, book, travel with confidence
Better together
Save up to CA $1,096 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Your Sikeston Vacation
There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.
Top Sikeston Vacation Deals
Price found within the past 48 hours. Click for updated prices.

Days Inn & Suites by Wyndham Cuba
Price was CA $993, price is now CA $895 per person
CA $895
per person
Nov 8 - Nov 15
found 10 hours ago
Roundtrip non-stop flight included
Montreal (YUL) to St. Louis (STL)
7.2/10 Good! (729 reviews)
The manager was helpful in recommending restaurants. The pool was very warm. Breakfast was good.
Reviewed on Jul. 29, 2025



Sikeston Hotel Deals

Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is CA $106 per night from Sep 5 to Sep 6
CA $106
CA $122 total
Sep 5 - Sep 6
includes taxes & fees

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is CA $116 per night from Sep 14 to Sep 15
CA $116
CA $132 total
Sep 14 - Sep 15
includes taxes & fees

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Sep 4 to Sep 5
CA $124
CA $142 total
Sep 4 - Sep 5
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other vacations you might like
- January Vacations and Deals
- February Vacations and Deals
- March Vacations and Deals
- April Vacations and Deals
- May Vacations and Deals
- June Vacations and Deals
- July Vacations and Deals
- August Vacations and Deals
- September Vacations and Deals
- October Vacations and Deals
- November Vacations and Deals
- December Vacations and Deals
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.