Title: Book The Best Hotels in Santee, NE for 2025 from CA $132 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d553248634983588478.Travel-Guide-VacationRentals)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d553248634983588478.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d553248634983588478.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santee, NE from CA $132 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santee Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-04&d1=2025-12-04&endDate=2025-12-06&d2=2025-12-06&travelerType=family_friendly) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-04&d1=2025-12-04&endDate=2025-12-06&d2=2025-12-06&lodging=CABIN) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-04&d1=2025-12-04&endDate=2025-12-06&d2=2025-12-06&amenities=PETS) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Santee%2C+Nebraska%2C+United+States+of+America®ionId=553248634983588478&latLong=42.84111%2C-97.850901&adults=2&startDate=2025-12-04&d1=2025-12-04&endDate=2025-12-06&d2=2025-12-06&amenities=WATER_PARK) ## Check prices for these dates Tonight [Nov 20 - Nov 21](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2025-11-20&endDate=2025-11-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 21 - Nov 22](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2025-11-21&endDate=2025-11-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 64 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/58d56b10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/fd537863.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/82dbed8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lewis and Clark Resort Yankton 8.8/10 Excellent (281) "Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $125 CA $132 total includes taxes & fees Dec 1 - Dec 2 [](https://www.expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-04&endDate=2025-12-05®ionId=553248634983588478&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotels.d553248634983588478.Travel-Guide-Hotels) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=HTG_BF_PROMO_553248634983588478) ### Stay near popular Santee attractions [](https://expedia.ca/Niobrara-State-Park-Hotels.0-l553248621532648826-0.Travel-Guide-Filter-Hotels) ![Niobrara featuring a river or creek and boating as well as a small group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/177000/177614-Niobrara.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Niobrara State Park Take photos of the iconic old railroad bridge and camp in the cabins at the confluence of the Niobrara and Missouri rivers. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648826) ## More cheap stays in Santee ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Lewis and Clark Resort 43496 Shore Drive Yankton SD CA $125 CA $132 total Dec 1 - Dec 2 includes taxes & fees 8.8/10 Excellent! (281 reviews) [](https://expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Santee Hunting Cabin!](https://images.trvl-media.com/lodging/122000000/121720000/121714900/121714833/795e9024_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Santee Hunting Cabin! Niobrara NE [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F12%2F2025&endDate=05%2F12%2F2025&selected=121714833&PinnedHotelID=121714833&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.ca/Niobrara-Hotels-Santee-Hunting-Cabin.h121714833.Hotel-Information) ![Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area.](https://images.trvl-media.com/lodging/123000000/122120000/122112900/122112850/00d8303f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Inviting 3-bedroom house near Gavins Point Dam and Lewis and Clark Lake area. Yankton SD [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F12%2F2025&endDate=05%2F12%2F2025&selected=122112850&PinnedHotelID=122112850&HadPinnedHotel=true®ionId=553248634983588478) [](https://expedia.ca/Yankton-Hotels-Inviting-3-Bedroom-House-Near-Gavins-Point-Dam-And-Lewis-And-Clark-Lake-Area.h122112850.Hotel-Information) ## Hotels in Santee with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 6 properties [](https://expedia.ca/3Star-Santee-Hotels.s30-0-d553248634983588478.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 1 properties [](https://expedia.ca/2Star-Santee-Hotels.s20-0-d553248634983588478.Travel-Guide-Filter-Hotels) ## Recent reviews of Santee hotels ![Lewis and Clark Resort](https://images.trvl-media.com/lodging/12000000/11270000/11268000/11267995/a76b5f6a_y.jpg) ### Lewis and Clark Resort 5/5 Excellent "Beautiful view, easy check in, and spacious accommodations! We loved our stay and can’t wait to come back!" A verified traveller stayed at Lewis and Clark Resort Posted 5 days ago [](https://expedia.ca/Vermillion-Hotels-Lewis-And-Clark-Resort.h11267995.Hotel-Information) ![Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha](https://images.trvl-media.com/lodging/35000000/34430000/34429200/34429107/4c2f576b_y.jpg) ### Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha 5/5 Excellent "This house works out perfectly for us. We stay there for hunting in the fall. It has a great kitchen and wonderful views. A big bonus is the large hot tub that looks out over the bluffs to the Missouri River.This is our 2nd year here for our trip and would recommend this for anyone hunting or fishing the area." A verified traveller stayed at Overlooks Lewis & Clark Lake/Missouri River Basin-3 Hours Northwest of Omaha Posted 13 days ago [](https://expedia.ca/Springfield-Hotels-Overlooks-Lewis-Clark-LakeMissouri-River-Basin-3-Hours-Northwest-Of-Omaha.h34429107.Hotel-Information) ![Charming Lake House within Walking Distance from Lake](https://images.trvl-media.com/lodging/28000000/27120000/27116700/27116625/d37f9a63_y.jpg) ### Charming Lake House within Walking Distance from Lake 5/5 Excellent "Nice place, lots of space. Different areas to hang out, play games, watch TV. Nice outdoor patio area. Good location, easy access to Lewis & Clark recreation area. " A verified traveller stayed at Charming Lake House within Walking Distance from Lake Posted 3 weeks ago [](https://expedia.ca/Vermillion-Hotels-Charming-Lake-House-Within-Walking-Distance-From-Lake.h27116625.Hotel-Information) ![Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake](https://images.trvl-media.com/lodging/105000000/104180000/104178500/104178423/a3df54c4_y.jpg) ### Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake 5/5 Excellent "Very nice cabin, very great location, we had a good time there, everyone there very friendly, planning on conning back again " A verified traveller stayed at Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake Posted 1 month ago [](https://expedia.ca/Crofton-Hotels-Cozy-Cabin-Near-Lewis-And-Clark-Lake-And-CJs-At-The-Lake.h104178423.Hotel-Information) ![Haven by the Lake](https://images.trvl-media.com/lodging/83000000/82960000/82951700/82951676/77c0b851_y.jpg) ### Haven by the Lake 5/5 Excellent "Great place to stay for our fishing trip! " A verified traveller stayed at Haven by the Lake Posted 1 month ago [](https://expedia.ca/Yankton-Hotels-Haven-By-The-Lake.h82951676.Hotel-Information) ![The Lake House - Lakeview with 6 bedrooms - Yankton, SD](https://images.trvl-media.com/lodging/36000000/35850000/35847300/35847221/0a799912_y.jpg) ### The Lake House - Lakeview with 6 bedrooms - Yankton, SD 5/5 Excellent "Great stay like always " A verified traveller stayed at The Lake House - Lakeview with 6 bedrooms - Yankton, SD Posted 1 month ago [](https://expedia.ca/Yankton-Hotels-The-Lake-House-Lakeview-With-6-Bedrooms-Yankton.h35847221.Hotel-Information) ![1two bedroom cabins that can be rented for one night or not.](https://images.trvl-media.com/lodging/115000000/114490000/114488800/114488772/w2048h1254x0y0-fb6eb671_y.jpg) ### 1two bedroom cabins that can be rented for one night or not. 5/5 Excellent "Stay was great. I would recommend staying there. Rooms are clean and we loved the amenities. If I’m in the area again i will seeing if they have openings " A verified traveller stayed at 1two bedroom cabins that can be rented for one night or not. Posted 2 months ago [](https://expedia.ca/Crofton-Hotels-1two-Bedroom-Cabins-That-Can-Be-Rented-For-One-Night-Or-Not.h114488772.Hotel-Information) ![Shady Creek Cabin - Family Friendly Getaway Near Lake](https://images.trvl-media.com/lodging/76000000/75620000/75612000/75611913/67639cf4_y.jpg) ### Shady Creek Cabin - Family Friendly Getaway Near Lake 5/5 Excellent "We had a wonderful time. The place was excellent. We enjoyed the gas fire pit and the house was clean and in great condition. I would recommend this to anyone!" A verified traveller stayed at Shady Creek Cabin - Family Friendly Getaway Near Lake Posted 2 months ago [](https://expedia.ca/Yankton-Hotels-Shady-Creek-Cabin-Family-Friendly-Getaway-Near-Lake.h75611913.Hotel-Information) ![ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18](https://images.trvl-media.com/lodging/33000000/32650000/32641200/32641183/7c39df5d_y.jpg) ### ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18 5/5 Excellent "Great house. The deck was a great spot for hanging out and entertaining. Good amenities. Good communication from host. Would rent again if we were back in the area " A verified traveller stayed at ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18 Posted 3 months ago [](https://expedia.ca/Yankton-Hotels-ThePinecone-Luxury-Vacation-Rental-Awesome-Deck-With-View-Amenities-For-2-18.h32641183.Hotel-Information) ## Frequently asked questions ### What are some of the best vacation rentals that Santee has to offer? > [Haven by the Lake](https://www.expedia.ca/Yankton-Hotels-Haven-By-The-Lake.h82951676.Hotel-Information): This vacation home near Santee offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. See all [vacation rentals in Santee](https://www.expedia.ca/Santee-Vacation-Rentals.d553248634983588478.Travel-Guide-VacationRentals). ### If I need to cancel my hotel reservation in Santee, will I receive a refund? > Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by [fully refundable](https://www.expedia.ca/Hotel-Search?regionId=553248634983588478&paymentType=FREE_CANCELLATION) to find flexible hotel deals in Santee. ### What is staying in Santee like? > Those traveling to Santee are sure to enjoy the sights to see and things to do. There are 64 hotels and other accommodations in the surrounding area. Find out more about [Santee](https://www.expedia.ca/Santee.dx553248634983588478). ### What are the top places to visit in Santee? > A favorite place to visit is [Lewis and Clark Lake](https://www.expedia.ca/Lewis-And-Clark-Lake-United-States-of-America.d553248635976196329.Vacation-Attraction). You'll also find [Niobrara State Park](https://www.expedia.ca/Niobrara-State-Park-Nebraska.d553248621532648826.Vacation-Attraction) and [Lewis and Clark Recreation Area](https://www.expedia.ca/Lewis-And-Clark-Recreation-Area-Yankton.d553248621593151470.Vacation-Attraction) in the area. Check out what more to see and do in Expedia's [Santee guide](https://www.expedia.ca/Santee.dx553248634983588478). ### What's the weather like in Santee? > The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 26°F. 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