Otay Mesa
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
CA $56
per adult
Crossing Borders: Tijuana Day Trip from San Diego
CA $131
per adult
94% of travellers recommend
From Tijuana: Valle de Guadalupe Private Winery Tour
CA $171
per adult
From Tijuana: Valle de Guadalupe Shared Winery Tour
CA $117
per adult
100% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
CA $35
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
The price is CA $184 per night from Aug 23 to Aug 24
CA $184
CA $210 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is CA $274 per night from Aug 23 to Aug 24
CA $274
CA $388 total
Aug 23 - Aug 24
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is CA $259 per night from Sep 7 to Sep 8
CA $259
CA $375 total
Sep 7 - Sep 8
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,816 reviews)
"Exceptional stay. Clean, comfortable, well planned rooms. The only challenge was there was lots of construction - which is a positive because they're obviously keeping up on maintaining and upgrading the property, however the pool situation is a bit of cluster. There is a smaller pool open currently ..."
Reviewed on Aug 22, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is CA $188 per night from Aug 26 to Aug 27
CA $188
CA $266 total
Aug 26 - Aug 27
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (6,278 reviews)
"Location was great, near restaurants and entertainment. Great view of harbor from our room."
Reviewed on Aug 22, 2026
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
The price is CA $226 per night from Aug 30 to Aug 31
CA $226
CA $300 total
Aug 30 - Aug 31
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is CA $244 per night from Sep 1 to Sep 2
CA $244
CA $349 total
Sep 1 - Sep 2
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,252 reviews)
"Staff was wonderful and helpful. Food and both restaurants attached to the hotel was amazing."
Reviewed on Aug 22, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
