Otay Mesa
San Diego
Visit Otay Mesa
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is CA $196 per night from Jun 21 to Jun 22
CA $196
CA $223 total
Jun 21 - Jun 22
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,768 reviews)
"The hotel was first off very far from the beaches which was poorly advertised with traffic took us abut an hour to get there and another back then the elevator is super old gets stuck and shakes and the staff assures you it's normal (it's not their fault they have it serviced but we got stuck in ..."
Reviewed on Jun 14, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is CA $362 per night from Jul 1 to Jul 2
CA $362
CA $496 total
Jul 1 - Jul 2
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,818 reviews)
"Quick weekend get away for my boyfriend and I. The location was perfect for visiting San Diego. Close to everything an an amazing view of the bay. The staff were professional and kind. Would definitely stay here again."
Reviewed on Jun 15, 2026
The Sofia Hotel
150 W Broadway San Diego CA
The price is CA $171 per night from Jun 29 to Jun 30
CA $171
CA $237 total
Jun 29 - Jun 30
includes taxes & fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,247 reviews)
"Mi hijo Jorge esposa e hijo se hospedaron, me informaron que todo estuvo muy bien en hotel Sofia,"
Reviewed on Jun 14, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is CA $213 per night from Jun 29 to Jun 30
CA $213
CA $295 total
Jun 29 - Jun 30
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,205 reviews)
"Not clean and very old room"
Reviewed on Jun 15, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
The price is CA $118 per night from Jun 16 to Jun 17
CA $118
CA $136 total
Jun 16 - Jun 17
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,639 reviews)
"This place was a mess. I asked for a bottom floor because I have a bad hip. The girl said there were none available and that it wasn't a big deal because there were only like 12 steps. Apparently, she has no idea how hard that is. Then the keys didn't work. 3 more trips up and down the stairs. Then ..."
Reviewed on Jun 15, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is CA $198 per night from Jun 16 to Jun 17
CA $198
CA $298 total
Jun 16 - Jun 17
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,859 reviews)
"Great stay overall!"
Reviewed on Jun 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or The Promenade at Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Lyceum Theatre is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
