Book The Best Hotels in Melrose, OH for 2026 from CA $151 - Fully Refundable Options

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Melrose hotels

1. Quality Inn Defiance

Defiance

Katie

CA $208 total

includes taxes & fees

Jun 21 - Jun 22

Hypo-allergenic bedding, desk, laptop workspace, blackout drapes

2. Microtel Inn & Suites by Wyndham Delphos

Delphos

Larry

CA $155 total

includes taxes & fees

Jul 5 - Jul 6

3. Hampton Inn Defiance

Defiance

Jeannette

CA $237 total

includes taxes & fees

Jul 5 - Jul 6

4. Holiday Inn Express Hotel & Suites Van Wert by IHG

Van Wert

Karen

CA $268 total

includes taxes & fees

Jun 21 - Jun 22

5. Super 8 by Wyndham Defiance

Defiance

James

CA $151 total

includes taxes & fees

Jun 28 - Jun 29

Desk, laptop workspace, iron/ironing board, free WiFi

6. Comfort Inn Van Wert

Van Wert

Teresa

CA $194 total

includes taxes & fees

Jul 9 - Jul 10

7. Fountain Inn

Van Wert

Virendra

CA $205 total

includes taxes & fees

Jun 19 - Jun 20

8. Holiday Inn Express Hotel & Suites Defiance by IHG

Defiance

Shawn

CA $220 total

includes taxes & fees

Jul 5 - Jul 6

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Top Melrose Hotel Reviews

Microtel Inn & Suites by Wyndham Delphos

10/10 Excellent

"Very nice place to stay"

Holiday Inn Express Hotel & Suites Van Wert by IHG

8/10 Good

"Overall the hotel was excellent. Great breakfast and coffee. However, my room wasn’t cleaned for two days and everyday I had to have my room key reprogrammed. The first day the front desk said my room wasn’t marked clean but they would make sure it was cleaned the next day. When it wasn’t cleaned the second day I was told it was because the do not disturb sign was on the door. It was, until we left for the entire day (around 11am). My room was finally cleaned on the third day."

Super 8 by Wyndham Defiance

10/10 Excellent

"We were very satisfied with the staff and the room. I must comment especially on the staff members, particularly Melissa at the front desk and Christina in housekeeping. Melissa was very friendly and inviting and very helpful. She greeted us every time we passed the desk. Christina was one of the housekeepers that took care of us during our 7-day stay. She was the most kind and helpful housekeeper imaginable. She always asked us if we needed anything such as toilet tissue for towels or washcloths There are other employees that are just as considerate and kind, so I am not diminishing them whatsoever, I just remember these two by name. One slight disappointment was that they do not serve what you would call a hot breakfast but a Continental breakfast. That was a minor detail. The carpeting in our room could use a good shampooing but the room was very clean other than some stains in the carpet. You are not going to get 100% perfect when the property is a bit older. The price was very reasonable and well worth the money."

Quality Inn Defiance

8/10 Good

"There were more amenities than I expected, such as an ironing board, coffee pot, and shower chair that would fold down if needed. The room was clean but outdated. The pool looked well maintained but the door to the pool was in the lobby's Breakfast area. Overall I was happy with the room for what I paid. I would go again."

THE VICTORIAN GUESTHOUSE BED & BREAKFAST - Room 1

10/10 Excellent

"The property was beautiful. My room was clean and had everything needed. They thought of everything. Breakfast was great and displayed beautifully. I loved that the kitchen had labeled cabinets for grocery storage if needed and a full kitchen."

Fountain Inn

8/10 Good

"This motel was very clean!! It has been updated somewhat, hard wood floors, large screen Roku TV, new beds. The mattress was firm, great size, I think it was a king. Remember, it is a very dated establishment, so it does smell a bit musty. They could use some heavier curtains or window blinds for added privacy. But overall, it fit our needs for our weekend stay, just someplace to sleep and shower while visiting with old friends. We would stay here again. "

More cheap stays in Melrose

Super 8 by Wyndham Defiance

1053 Hotel Dr. US Hwy 24 & SR 66 Defiance OH

CA $131

CA $151 total

Jun 28 - Jun 29

includes taxes & fees

7.6/10 Good! (322 reviews)

Hotels in Melrose with star rating

Frequently asked questions

What's the best place to stay in Melrose?

Located 16.8 mi (27.1 km) from the heart of Melrose, Comfort Inn Van Wert is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Quality Inn Defiance and Super 8 by Wyndham Defiance. See all available top hotels, or vacation rentals in Melrose.

What are some of the best vacation home rentals in Melrose?

5 Bedroom with all the amenities of home.: This vacation home rental near Melrose offers a patio, a pool table, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Melrose.

If I need to cancel my hotel reservation in Melrose, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Melrose.

What's it like staying in Melrose?

Visitors are sure to enjoy all that Melrose has to offer. There are 44 hotels and other accommodations in the surrounding area. Find out more about Melrose.

What is there to see in Melrose?

Places to visit in the wider area include Lake Glengary, AuGlaize Village & Farm Museum, and Independence Dam State Park. You'll also find Defiance Public Library and Eagle Rock Golf Club in the area. Check out what more to see and do in Expedia's Melrose guide.

What's the weather like in Melrose?

The hottest months are usually July and August with an average temp of 70°F, while the coldest months are January and February with an average of 32°F. Average annual precipitation for Melrose is 44 inches.

Explore a world of travel with Expedia

Defiance Vacation Rentals

Things to do in Northwest Ohio

Book Hotels in Melrose on Expedia.com

Room 1

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Melrose

Check prices for these dates

Filter by

Guest rating

Star rating

Our top choices for Melrose hotels

1. Quality Inn Defiance

2. Microtel Inn & Suites by Wyndham Delphos

3. Hampton Inn Defiance

4. Holiday Inn Express Hotel & Suites Van Wert by IHG

5. Super 8 by Wyndham Defiance

6. Comfort Inn Van Wert

7. Fountain Inn

8. Holiday Inn Express Hotel & Suites Defiance by IHG

Top Melrose Hotel Reviews

Microtel Inn & Suites by Wyndham Delphos

Holiday Inn Express Hotel & Suites Van Wert by IHG

Holiday Inn Express Hotel & Suites Defiance by IHG

Super 8 by Wyndham Defiance

Quality Inn Defiance

Comfort Inn Van Wert

Hampton Inn Defiance

THE VICTORIAN GUESTHOUSE BED & BREAKFAST - Room 1

Fountain Inn

More cheap stays in Melrose

Super 8 by Wyndham Defiance

Microtel Inn & Suites by Wyndham Delphos

Comfort Inn Van Wert

Quality Inn Defiance

Holiday Inn Express Hotel & Suites Defiance by IHG

Hampton Inn Defiance

Hotels in Melrose with star rating

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app

Find hotels in Melrose, OH from CA $151

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Melrose

Check prices for these dates

Filter by

Guest rating

Star rating

Our top choices for Melrose hotels

1. Quality Inn Defiance

2. Microtel Inn & Suites by Wyndham Delphos

3. Hampton Inn Defiance

4. Holiday Inn Express Hotel & Suites Van Wert by IHG

5. Super 8 by Wyndham Defiance

6. Comfort Inn Van Wert

7. Fountain Inn

8. Holiday Inn Express Hotel & Suites Defiance by IHG

Top Melrose Hotel Reviews

Microtel Inn & Suites by Wyndham Delphos

More cheap stays in Melrose

Super 8 by Wyndham Defiance

Hotels in Melrose with star rating

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app