Title: Book The Best Hotels in La Mesa for 2026 from CA $51 - Fully Refundable Options - Expedia.ca [Vacation Rentals in La Mesa](https://expedia.ca/La-Mesa-Vacation-Rentals.d553248635976270713.Travel-Guide-VacationRentals)[La Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesa.d553248635976270713.Car-Rental-Guide)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d553248635976270713.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Jan 21 - Jan 22](https://www.expedia.ca/Hotel-Search?regionId=553248635976270713&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 22 - Jan 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976270713&startDate=2026-01-22&endDate=2026-01-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976270713&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635976270713&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for La Mesa hotels ![Loft](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/8a731937.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/4dccf33f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Loft](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/b6d93b3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Loft | Bathroom](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/b0b1e27d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lofts Independencia Sayula [](https://www.expedia.ca/Sayula-Hotels-Lofts-Independencia-Sayula.h114153710.Hotel-Information) Sayula 5.6/10 (4 reviews) "Not satisfied charges for parking, pool and needed to ask for fresh towels n toilet paper no AC" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ARTURO CA $49 CA $59 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Sayula-Hotels-Lofts-Independencia-Sayula.h114153710.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/a8b0d54c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/7dd4c51e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/2d7bd7cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Triple Room | View from room](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/86c6c882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Capital O Colón, Ciudad Guzmán Jalisco [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Colon.h48709526.Hotel-Information) Zapotlán el Grande 6.8/10 (163 reviews) "Very nice hotel, nice pool, easy to get to the center and clean" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Alex CA $42 CA $55 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Colon.h48709526.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/9000000/8060000/8055700/8055628/a046be8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8060000/8055700/8055628/cbe48a97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/9000000/8060000/8055700/8055628/3d224f1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Mexican cuisine ](https://images.trvl-media.com/lodging/9000000/8060000/8055700/8055628/7542c74e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Casa de los Patios Hotel & Spa [](https://www.expedia.ca/Sayula-Hotels-La-Casa-De-Los-Patios-Hotel-Spa.h8055628.Hotel-Information) Sayula 9.4/10 Exceptional (145 reviews) "The hotel is beautiful and staffing is great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tony [](https://www.expedia.ca/Sayula-Hotels-La-Casa-De-Los-Patios-Hotel-Spa.h8055628.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/111000000/110350000/110349800/110349763/248b22b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/111000000/110350000/110349800/110349763/eb32d057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/111000000/110350000/110349800/110349763/2e211699.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/111000000/110350000/110349800/110349763/89e3b91b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tryp By Wyndham Ciudad Guzman Uttsa [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Tryp-By-Wyndham-Ciudad-Guzman-Uttsa.h110349763.Hotel-Information) Zapotlán el Grande 9.6/10 Exceptional (88 reviews) "Great staff! Extremely clean!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa CA $108 CA $131 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Tryp-By-Wyndham-Ciudad-Guzman-Uttsa.h110349763.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600476/97e893e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600476/30ee37bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, steam room, hot stone massages, facials](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600476/8ec93765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600476/d97ae4af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gran Casa Sayula Hotel & Spa [](https://www.expedia.ca/Sayula-Hotels-Gran-Casa-Sayula-Hotel-Spa.h9600476.Hotel-Information) Sayula 9.4/10 Exceptional (127 reviews) "Great hotel in Sayula!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph [](https://www.expedia.ca/Sayula-Hotels-Gran-Casa-Sayula-Hotel-Spa.h9600476.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/a4e14c65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/4766a79c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/cc344917.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/f4bc1a40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zapotlan [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Zapotlan.h101472426.Hotel-Information) Zapotlán el Grande 8.0/10 Very good (253 reviews) "Yes, staff very professional and helpful during my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando CA $42 CA $51 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Zapotlan.h101472426.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/121000000/120390000/120388200/120388195/31c1218a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking, City View | Interior](https://images.trvl-media.com/lodging/121000000/120390000/120388200/120388195/e47d34f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Quadruple Room, Multiple Beds, Non Smoking, City View | Living area](https://images.trvl-media.com/lodging/121000000/120390000/120388200/120388195/71c7d19c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Quadruple Room, Multiple Beds, Non Smoking, City View | Interior](https://images.trvl-media.com/lodging/121000000/120390000/120388200/120388195/852eb608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Uttsa Inn Tamazula [](https://www.expedia.ca/Tamazula-De-Gordiano-Hotels-Hotel-Uttsa-Inn-Tamazula.h120388195.Hotel-Information) Tamazula de Gordiano CA $75 CA $92 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Tamazula-De-Gordiano-Hotels-Hotel-Uttsa-Inn-Tamazula.h120388195.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-04&endDate=2026-02-05®ionId=553248635976270713&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Hotels.d553248635976270713.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Hotels.d553248635976270713.Travel-Guide-Hotels) ## More cheap stays in La Mesa ![Hotel Zapotlan](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/961d196c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Zapotlan Federico del Toro, 61 Zapotlán el Grande JAL CA $42 CA $51 total Jan 22 - Jan 23 includes taxes & fees 8/10 Very Good! (250 reviews) [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Zapotlan.h101472426.Hotel-Information) ![Capital O Colón, Ciudad Guzmán Jalisco](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/37a78592_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Capital O Colón, Ciudad Guzmán Jalisco 655 Avenida Cristobal Colon Zapotlán el Grande JAL CA $42 CA $55 total Jan 22 - Jan 23 includes taxes & fees 6.6/10 (163 reviews) [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Colon.h48709526.Hotel-Information) ![Lofts Independencia Sayula](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/86962876_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Lofts Independencia Sayula 62 Independencia Centro Histórico Sayula Jal. CA $49 CA $59 total Jan 22 - Jan 23 includes taxes & fees 5.6/10 (4 reviews) [](https://expedia.ca/Sayula-Hotels-Lofts-Independencia-Sayula.h114153710.Hotel-Information) ![Tryp By Wyndham Ciudad Guzman Uttsa](https://images.trvl-media.com/lodging/107000000/106200000/106190600/106190588/c92a1940_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Tryp By Wyndham Ciudad Guzman Uttsa Av Jose Maria Gonzalez 552 Col Zapotl Y Fracc Cond Zapotlán el Grande JAL [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F02%2F2026&endDate=05%2F02%2F2026&selected=106190588&PinnedHotelID=106190588&HadPinnedHotel=true®ionId=553248635976270713) 6/10 (2 reviews) [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Tryp-By-Wyndham-Ciudad-Guzman-Uttsa.h106190588.Hotel-Information) ![Cabanas del Volcan](https://images.trvl-media.com/lodging/40000000/39080000/39070700/39070605/f057915e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Cabanas del Volcan La Yerbabuena km 1 Comala COL [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F02%2F2026&endDate=05%2F02%2F2026&selected=39070605&PinnedHotelID=39070605&HadPinnedHotel=true®ionId=553248635976270713) [](https://expedia.ca/Colima-Hotels-Cabanas-Del-Volcan.h39070605.Hotel-Information) ![Casa de Campo con Increíble Vista al Volcán de Colima y un Clima Excepcional.!](https://images.trvl-media.com/lodging/109000000/108420000/108411100/108411042/298a5be6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Casa de Campo con Increíble Vista al Volcán de Colima y un Clima Excepcional.! COFRADIA DE SUCHITLAN, COMALA COL [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F02%2F2026&endDate=05%2F02%2F2026&selected=108411042&PinnedHotelID=108411042&HadPinnedHotel=true®ionId=553248635976270713) [](https://expedia.ca/Villa-De-Alvarez-Hotels-Casa-De-Campo-Con-Increible-Vista-Al-Volcan-De-Colima-Y-Un-Clima-Excepcional.h108411042.Hotel-Information) ## Recent reviews of La Mesa hotels ![Tryp By Wyndham Ciudad Guzman Uttsa](https://images.trvl-media.com/lodging/111000000/110350000/110349800/110349763/2e211699_y.jpg) ### Tryp By Wyndham Ciudad Guzman Uttsa 5/5 Excellent "Great staff! Extremely clean!" A verified traveller stayed at Tryp By Wyndham Ciudad Guzman Uttsa Posted 3 days ago [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Tryp-By-Wyndham-Ciudad-Guzman-Uttsa.h110349763.Hotel-Information) ![Hotel Zapotlan](https://images.trvl-media.com/lodging/102000000/101480000/101472500/101472426/961d196c_y.jpg) ### Hotel Zapotlan 5/5 Excellent "Yes, staff very professional and helpful during my stay. " A verified traveller stayed at Hotel Zapotlan Posted 10 days ago [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Zapotlan.h101472426.Hotel-Information) ![Basalt hut](https://images.trvl-media.com/lodging/121000000/120150000/120147900/120147816/03374078_y.jpg) ### Basalt hut 5/5 Excellent "Magical, wonderful place and family. I did not want to leave. It’s a very special place. Highly recommended! " A verified traveller stayed at Basalt hut Posted 1 month ago [](https://expedia.ca/Comala-Hotels-Vrbo-Property.h120147816.Hotel-Information) ![Lofts Independencia Sayula](https://images.trvl-media.com/lodging/115000000/114160000/114153800/114153710/86962876_y.jpg) ### Lofts Independencia Sayula 1/5 Terrible "Not satisfied charges for parking, pool and needed to ask for fresh towels n toilet paper no AC" A verified traveller stayed at Lofts Independencia Sayula Posted 2 months ago [](https://expedia.ca/Sayula-Hotels-Lofts-Independencia-Sayula.h114153710.Hotel-Information) ![La Casa de los Patios Hotel & Spa](https://images.trvl-media.com/lodging/9000000/8060000/8055700/8055628/a046be8e_y.jpg) ### La Casa de los Patios Hotel & Spa 5/5 Excellent "Good place" A verified traveller stayed at La Casa de los Patios Hotel & Spa Posted 3 months ago [](https://expedia.ca/Sayula-Hotels-La-Casa-De-Los-Patios-Hotel-Spa.h8055628.Hotel-Information) ![Capital O Colón, Ciudad Guzmán Jalisco](https://images.trvl-media.com/lodging/49000000/48710000/48709600/48709526/37a78592_y.jpg) ### Capital O Colón, Ciudad Guzmán Jalisco 5/5 Excellent "Estancia buena " A verified traveller stayed at Capital O Colón, Ciudad Guzmán Jalisco Posted 3 months ago [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Hotel-Colon.h48709526.Hotel-Information) ![Tryp By Wyndham Ciudad Guzman Uttsa](https://images.trvl-media.com/lodging/107000000/106200000/106190600/106190588/c92a1940_y.jpg) ### Tryp By Wyndham Ciudad Guzman Uttsa 4/5 Good "Stayed for two nights during the Fiestas. Super close to the Féria. However a bit far from the center. Staff was very helpful and room comfortable and clean. Good place to stay if you don’t mind taking a cab into town or driving in and you want some quiet." A verified traveller stayed at Tryp By Wyndham Ciudad Guzman Uttsa Posted 3 months ago [](https://expedia.ca/Zapotlan-El-Grande-Hotels-Tryp-By-Wyndham-Ciudad-Guzman-Uttsa.h106190588.Hotel-Information) ![Gran Casa Sayula Hotel & Spa](https://images.trvl-media.com/lodging/10000000/9610000/9600500/9600476/1ac93655_y.jpg) ### Gran Casa Sayula Hotel & Spa 5/5 Excellent "Great hotel in Sayula!!" A verified traveller stayed at Gran Casa Sayula Hotel & Spa Posted 5 months ago [](https://expedia.ca/Sayula-Hotels-Gran-Casa-Sayula-Hotel-Spa.h9600476.Hotel-Information) ## Frequently asked questions ### Where can I find the best nightlife in La Mesa? > While La Mesa itself is more renowned for its family-friendly environment and traditional dining options, you can venture nearby to find some lively nightlife. Areas like Tlaquepaque and Guadalajara, which are just a short drive away, offer a plethora of bars, clubs, and live music venues that cater to diverse tastes. > > > In Tlaquepaque, you'll find a wonderful mix of artisan shops and vibrant bars, often featuring live mariachi music that adds to the festive atmosphere. Meanwhile, Guadalajara is home to an exciting nightlife scene, with streets like Avenida Chapultepec brimming with trendy bars and clubs where you can dance the night away. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a La Mesa hotel booking with Expedia? ### How much is the nightly rate at a La Mesa hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - More ways to book - [2 Star Hotels in Mazamitla ](https://www.expedia.ca/2Star-Mazamitla-Hotels.s20-0-d6145616.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Chiquilistlan ](https://www.expedia.ca/3Star-Chiquilistlan-Hotels.s30-0-d6266030.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Tamazula de Gordiano ](https://www.expedia.ca/3Star-Tamazula-De-Gordiano-Hotels.s30-0-d6339564.Travel-Guide-Filter-Hotels) - [Apartments in Ajijic ](https://www.expedia.ca/Ajijic-Apartments.d10334-aaApartments.Travel-Guide-Accommodation) - [Condo Rentals in Ajijic ](https://www.expedia.ca/Ajijic-Condos.d10334-aaCondos.Travel-Guide-Accommodation) - 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