South Main
Houston
Visit South Main
Things to do
Houston: Space Center Houston Admission Ticket
CA $41
per adult
92% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
CA $137
per adult
92% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
CA $55
per adult
98% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
CA $17
per adult
Houston's Official City & Mural Tour!
CA $55
per adult
88% of travellers recommend
South Main Hotel Deals
Wyndham Houston at Reliant Park & Medical Center
8686 Kirby Drive Houston TX
The price is CA $115 per night from Sep 27 to Sep 28
CA $115
CA $134 total
Sep 27 - Sep 28
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful staff ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
The price is CA $171 per night from Sep 27 to Sep 28
CA $171
CA $201 total
Sep 27 - Sep 28
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very good! (4,523 reviews)
"Great customer service"
Reviewed on Sep 21, 2026
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
The price is CA $346 per night from Sep 29 to Sep 30
CA $346
CA $470 total
Sep 29 - Sep 30
includes taxes & fees
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
The Whitehall Houston
1700 Smith St Houston TX
The price is CA $169 per night from Oct 14 to Oct 15
CA $169
CA $197 total
Oct 14 - Oct 15
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
The price is CA $131 per night from Oct 5 to Oct 6
CA $131
CA $153 total
Oct 5 - Oct 6
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.6/10 Excellent! (4,515 reviews)
"Always have a great time at club quarters. The location is perfect. The staff is super friendly. The room is not huge, but it is perfect for a couple. The price and value are excellent. Didn’t have a chance to use the bar or restaurant, but I heard everything was great there valet was very easy. ..."
Reviewed on Sep 21, 2026
Hyatt Regency Houston West
13210 Katy Fwy Houston TX
The price is CA $133 per night from Sep 25 to Sep 26
CA $133
CA $156 total
Sep 25 - Sep 26
includes taxes & fees
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the restaurant and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
