Title: Visit South Main: Best of South Main, Houston Travel 2026 | Expedia Tourism - Expedia.ca [Hotels in South Main](https://expedia.ca/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) # South Main ## Houston ![Aerial view of Hermann park in Houston with Japanese Garden, zoo, Space Adventure playground](https://images.trvl-media.com/place/553248635976386992/633bd53d-8369-45ed-9507-93d6ecf02186.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![South Main](https://images.trvl-media.com/place/1503/2eeb9f80-ebf6-42ad-9574-1d77038420db.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit South Main Things to do Hotels Where to stay [Houston travel guide](https://expedia.ca/Houston.dx178265) --- ### Popular places to visit ![The George R. Brown Convention Center](https://images.trvl-media.com/place/6082195/bdb92cbf-3e28-443d-ace9-b082344167d4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### George R. Brown Convention Center During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area. [](https://expedia.ca/George-R-Brown-Convention-Center-Houston.d501247.Vacation-Attraction) ![NRG Stadium](https://images.trvl-media.com/place/1503/e9e0c365-cf4d-4e4b-b714-f9dd65c34baf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### NRG Stadium Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area. [](https://expedia.ca/NRG-Stadium-Astrodome.d553248635929331916.Vacation-Attraction) ![Houston_MinuteMaidPark_6034772_1](https://images.trvl-media.com/place/6034772/6d7d1cbe-28b6-4078-86cd-2bb274c4f722.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Daikin Park Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and lively festivals in this vibrant area. [](https://expedia.ca/Daikin-Park-Downtown-Houston.d6034772.Vacation-Attraction) ![Houston, Texas Reflections ](https://images.trvl-media.com/place/6248539/6889f51a-3f76-4c25-a331-3602ec8e8c5a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### MD Anderson Cancer Center Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here. [](https://expedia.ca/MD-Anderson-Cancer-Center-Texas-Medical-Center.d6248539.Vacation-Attraction) ![www.alamy.com](https://images.trvl-media.com/place/501253/9f806038-e019-4ef0-8e59-8c564c0cb29c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### NASA Johnson Space Center After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event. [](https://expedia.ca/NASA-Johnson-Space-Center-Nassau-Bay.d501253.Vacation-Attraction) ![Toyota Center](https://images.trvl-media.com/place/1503/00b4e1ca-e78a-46ba-93de-a793739a6117.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Toyota Center Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area. [](https://expedia.ca/Toyota-Center-Downtown-Houston.d6082241.Vacation-Attraction) ### Things to do ![Space Center Houston Admission Ticket](https://mediaim.expedia.com/localexpert/1341309/33c4e8ed-9a1e-4ef2-a1e1-0bff8d3b3b3f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Space Center Houston Admission Ticket CA $45 per adult **92%** of travellers recommend [](https://expedia.ca/things-to-do/space-center-houston-admission-ticket.a1341309.activity-details) ![Astroville Tunnel Tour of Downtown Houston](https://mediaim.expedia.com/localexpert/1358845/6701a89c-a4de-4a0b-ba2a-aae33d8a7249.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Astroville Tunnel Tour of Downtown Houston (Air-Conditioned) CA $34 per adult **100%** of travellers recommend [](https://expedia.ca/things-to-do/astroville-tunnel-tour-of-downtown-houston-air-conditioned.a1358845.activity-details) ![Houston: Houston Botanic Garden Entry Ticket](https://mediaim.expedia.com/localexpert/46150646/bfc34474-c86f-4151-a485-5cc63efe2aab.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Houston Botanic Garden Entry Ticket CA $16 per adult **80%** of travellers recommend [](https://expedia.ca/things-to-do/houston-houston-botanic-garden-entry-ticket.a46150646.activity-details) ![Houston: Sloomoo Institute Entry Ticket](https://mediaim.expedia.com/localexpert/48181877/0194cadc-0356-4ecd-a787-6fed90663fc8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Sloomoo Institute Entry Ticket CA $44 per adult [](https://expedia.ca/things-to-do/houston-sloomoo-institute-entry-ticket.a48181877.activity-details) ![Houston Museum of Natural Science: Cockrell Butterfly Center](https://mediaim.expedia.com/localexpert/44625315/13581a0d-ea47-46d7-8fcf-d3fc7aa4909c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Science: Butterfly Center Ticket CA $21 per adult **100%** of travellers recommend [](https://expedia.ca/things-to-do/houston-museum-of-natural-science-butterfly-center-ticket.a44625315.activity-details) ![Houston: Museum of Natural Science General Admission Ticket](https://mediaim.expedia.com/localexpert/44624726/7df2f7a9-1343-48ce-acab-88df62f142d4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Museum of Natural Science General Admission Ticket CA $34 per adult **98%** of travellers recommend [](https://expedia.ca/things-to-do/houston-museum-of-natural-science-general-admission-ticket.a44624726.activity-details) [See all activities in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities) --- ## South Main Hotel Deals ![Wyndham Houston near NRG Park/Medical Center](https://images.trvl-media.com/lodging/1000000/30000/21300/21297/99a71929_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Wyndham Houston near NRG Park/Medical Center 8686 Kirby Drive Houston TX CA $126 CA $147 total Apr 5 - Apr 6 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful staff ... 7/10 Good! (1,279 reviews) Roaches in the room. Curtains black from grim. Broken blinds. Just nasty! Reviewed on Apr 2, 2026 [](https://expedia.ca/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=21297&PinnedHotelID=21297&HadPinnedHotel=true®ionId=553248635976386992) ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/109ddc6c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd Houston TX CA $208 CA $245 total Apr 6 - Apr 7 includes taxes & fees Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ... 8.4/10 Very Good! (3,688 reviews) The hotel is great place to stay just make sure they give you what u pay for such as room with balcony Reviewed on Apr 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=06%2F04%2F2026&endDate=07%2F04%2F2026&selected=20116&PinnedHotelID=20116&HadPinnedHotel=true®ionId=553248635976386992) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/0f950f88_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Zaza Houston Museum District 5701 Main Street Houston TX CA $325 CA $445 total May 2 - May 3 includes taxes & fees Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ... 9/10 Wonderful! (1,001 reviews) Great property! Reviewed on Apr 2, 2026 [](https://expedia.ca/Hotel-Search?startDate=02%2F05%2F2026&endDate=03%2F05%2F2026&selected=3306&PinnedHotelID=3306&HadPinnedHotel=true®ionId=553248635976386992) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/5506d9bf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Royal Sonesta Houston Galleria 2222 West Loop South Houston TX CA $212 CA $248 total Apr 18 - Apr 19 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ... 8.6/10 Excellent! (1,750 reviews) Room was not that clean . Reviewed on Apr 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=18%2F04%2F2026&endDate=19%2F04%2F2026&selected=878652&PinnedHotelID=878652&HadPinnedHotel=true®ionId=553248635976386992) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/d170df91_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Club Quarters Hotel Downtown, Houston 1085 Rusk Street Houston TX CA $134 CA $157 total Apr 7 - Apr 8 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ... 8.6/10 Excellent! (4,054 reviews) Front desk had an insane attitude , when we asked for a safe she said there isn’t one safe in the whole hotel, when we asked if we could upgrade she said no you can get another room exactly the same price and condition as your current room. We asked if she was sure ask there were better rooms and ... Reviewed on Apr 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=07%2F04%2F2026&endDate=08%2F04%2F2026&selected=1156923&PinnedHotelID=1156923&HadPinnedHotel=true®ionId=553248635976386992) ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/w3837h2505x3y0-1cfabad9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Blossom Hotel Houston, Curio Collection by Hilton 7118 Bertner Ave Houston TX CA $242 CA $284 total Apr 12 - Apr 13 includes taxes & fees Book a stay at this spa hotel in Houston. Enjoy a full-service spa, 2 bars/lounges, and a rooftop terrace. Our guests praise the pool and the helpful staff in ... 9/10 Wonderful! (3,746 reviews) The room was gorgeous and all staff was very friendly Reviewed on Apr 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=12%2F04%2F2026&endDate=13%2F04%2F2026&selected=58985846&PinnedHotelID=58985846&HadPinnedHotel=true®ionId=553248635976386992) [See all 6,549 properties in South Main](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=05%2F04%2F2026&endDate=06%2F04%2F2026®ionId=553248635976386992) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check South Main hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-04-04&endDate=2026-04-05)[Apr 4 - Apr 5](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-04-04&endDate=2026-04-05) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-04-05&endDate=2026-04-06)[Apr 5 - Apr 6](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2026-04-05&endDate=2026-04-06) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026)[Apr 10 - Apr 12](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026) --- ### Other neighbourhoods around South Main ![Astrodome](https://images.trvl-media.com/place/1503/18186f36-2267-4279-b375-1bb94762cced.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Astrodome 5/5(1 area review) If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station. [](https://expedia.ca/Houston-Astrodome.dx553248635976007975) ![Aerial view of Hermann park in Houston with Japanese Garden, zoo](https://images.trvl-media.com/place/6143504/f45257e8-ab2c-4d2e-9332-ef0898a9cb17.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Texas Medical Center 4.5/5(2 area reviews) Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience. [](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504) ![Museum District](https://images.trvl-media.com/place/1503/58fd4720-60ea-4071-96b7-0d260c453508.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Museum District Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city. [](https://expedia.ca/Houston-Houston-Museum-District.dx6164045) ![South Central Houston](https://images.trvl-media.com/place/1503/58fd4720-60ea-4071-96b7-0d260c453508.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### South Central Houston 5/5(1 area review) If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station. [](https://expedia.ca/Houston-South-Central-Houston.dx553248635976476176) ![EyeEm Custom Shoots Q4 2018](https://images.trvl-media.com/place/3000663145/5fc14982-6419-4f20-a21b-2dee7a209053.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Montrose 3.5/5(4 area reviews) Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area. [](https://expedia.ca/Houston-Montrose.dx3000663145) ![White Oak and Buffalo Bayou Rivers confluence, Downtown Houston, Texas, United States of America](https://images.trvl-media.com/place/553248635074842911/efd49955-b5d4-4334-9f25-c05c51a02456.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### River Oaks Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area. [](https://expedia.ca/Houston-River-Oaks.dx553248635074842911) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # South Main ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app