A large white cable-stayed bridge over a river with green supports and a forested landscape in the background.

Des Moines County Vacation Rentals

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Our top choices for Des Moines County vacation rentals

1. Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill
Burlington
10.0 out of 10, Exceptional, (5 reviews)
"Amazing place with a phenomenal host! Very attentive to the small details and making you feel welcome and at home!"
United States
David B.
The price is CA $128
CA $315 total
includes taxes & fees
Nov 16 - Nov 17
Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

2. The Emerald Loft - Spa Shower Suite + Outdoor Lounge, fire pit, and Grill

The Emerald Loft - Spa Shower Suite + Outdoor Lounge, fire pit, and Grill
Burlington
10.0 out of 10, Exceptional, (6 reviews)
"Very nice and quiet. It wouldn’t be possible to find a nicer place to stay."
United States
Daniel O.
The price is CA $157
CA $374 total
includes taxes & fees
Dec 6 - Dec 7
The Emerald Loft - Spa Shower Suite + Outdoor Lounge, fire pit, and Grill

3. Brand New Spacious 2 BR Downtown Burlington! Unit 301S

Brand New Spacious 2 BR Downtown Burlington! Unit 301S
Burlington
9.8 out of 10, Exceptional, (18 reviews)
"Great location! Check in easy and check out process simple. Great place for a fun weekend!"
United States
Roxane K.
The price is CA $189
CA $446 total
includes taxes & fees
Nov 16 - Nov 17
Brand New Spacious 2 BR Downtown Burlington! Unit 301S

4. Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
Burlington
10.0 out of 10, Exceptional, (23 reviews)
"This was our second stay and can’t wait to stay again. Super clean and spacious."
United States
Heather H.
The price is CA $189
CA $446 total
includes taxes & fees
Nov 22 - Nov 23
Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

5. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
3.0 star property
Nauvoo
9.8 out of 10, Exceptional, (462 reviews)
"A great place to stay!"
United States
Renae
The price is CA $171
CA $181 total
includes taxes & fees
Nov 23 - Nov 24
Nauvoo Vacation Villas & Condos

6. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"Rooms were clean and the bed was comfortable! Highly recommend this rental. "
United States
Brennan
The price is CA $214
CA $319 total
includes taxes & fees
Nov 16 - Nov 17
Idyllic Biggsville Vacation Rental: 10 Mi to River

7. Mulholland Garden Apartment

Mulholland Garden Apartment
Nauvoo
9.2 out of 10, Wonderful, (50 reviews)
"Well decorated and clean. Comfy bed. Close to city attractions."
United States
Adam
The price is CA $98
CA $175 total
includes taxes & fees
Nov 17 - Nov 18
Mulholland Garden Apartment

8. Red Front Suite - Sleeps 15

Red Front Suite - Sleeps 15
Nauvoo
9.8 out of 10, Exceptional, (100 reviews)
"Great location, comfortable beds."
United States
Diane P.
The price is CA $93
CA $209 total
includes taxes & fees
Nov 16 - Nov 17
Red Front Suite - Sleeps 15

9. View Nauvoo and the Mighty Mississippi/Sidon

View Nauvoo and the Mighty Mississippi/Sidon
Nauvoo
9.6 out of 10, Exceptional, (45 reviews)
"Castle home was amazing! View of the river is incredible. So much room with extra fans and pillows. We loved our stay!!"
United States
Chris P.
The price is CA $157
CA $426 total
includes taxes & fees
Nov 16 - Nov 17
View Nauvoo and the Mighty Mississippi/Sidon

10. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our peaceful stay in this clean, beautiful vacation rental. Perfect for a weekend getaway. "
United States
Lisa S.
The price is CA $157
CA $298 total
includes taxes & fees
Nov 16 - Nov 17
Idyllic Biggsville Vacation Rental: 10 Mi to River

11. Stay in this Unique SE Iowa Apt

Stay in this Unique SE Iowa Apt
Fort Madison
10.0 out of 10, Exceptional, (19 reviews)
"Great place to stay."
United States
Nicholas H.
The price is CA $80
CA $176 total
includes taxes & fees
Nov 23 - Nov 24
Stay in this Unique SE Iowa Apt

12. Cozy House

Cozy House
Biggsville
10.0 out of 10, Exceptional, (9 reviews)
"Great place for our needs!"
United States
jdl j.
The price is CA $122
CA $229 total
includes taxes & fees
Nov 16 - Nov 17
Cozy House

13. Home Away From Home

Home Away From Home
Biggsville
10.0 out of 10, Exceptional, (4 reviews)
"Cozy house only 5 minutes from the barn at fairview acres! Would definitely stay again! Host was excellent with responding to questions I had."
United States
Melanie R.
The price is CA $146
CA $262 total
includes taxes & fees
Nov 16 - Nov 17
Home Away From Home

14. Nauvoo Country Cottage - Sleeps 12

Nauvoo Country Cottage - Sleeps 12
Niota
9.6 out of 10, Exceptional, (95 reviews)
"Great place to stay!!"
United States
Lisa G.
The price is CA $93
CA $207 total
includes taxes & fees
Nov 19 - Nov 20
Nauvoo Country Cottage - Sleeps 12

15. If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill
Media
10.0 out of 10, Exceptional, (2 reviews)
"Nice little place out in the country. Great place for a getaway!"
United States
Judy W.
The price is CA $143
CA $215 total
includes taxes & fees
Nov 23 - Nov 24
If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

16. Hayfield Cabin

Hayfield Cabin
Niota
6.8 out of 10, (5 reviews)
"I really liked the beautiful, quiet country setting. I really disliked the dog hair on all the couches. It has beautiful morning views 😍. "
United States
charles
The price is CA $80
CA $155 total
includes taxes & fees
Nov 16 - Nov 17
Hayfield Cabin

17. Riverfront Cabin With Small Beach Short Drive From Nauvoo

Riverfront Cabin With Small Beach Short Drive From Nauvoo
Niota
8.2 out of 10, Very good, (55 reviews)
"This was such a great getaway spot! We needed peace and we got it."
United States
Anonymous traveller
The price is CA $81
CA $149 total
includes taxes & fees
Nov 16 - Nov 17
Riverfront Cabin With Small Beach Short Drive From Nauvoo

18. 5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs
Nauvoo
9.6 out of 10, Exceptional, (28 reviews)
"Excellent location. Great price for what you get. Only complaint is the metal bunk beds are a little noisy.Would stay here again."
United States
Melissa E.
The price is CA $170
CA $307 total
includes taxes & fees
Nov 16 - Nov 17
5 Minutes to Downtown Nauvoo - Great Spot for Young Families - Some Stairs

19. Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.
Blandinsville
8.6 out of 10, Excellent, (20 reviews)
"We loved how clean the house was. It was good for staying at for commencement at WIU. Mattresses were comfortable. Shower was nice. Very nice place to stay."
United States
Annie
The price is CA $193
CA $262 total
includes taxes & fees
Nov 17 - Nov 18
Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

20. Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo

Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Nauvoo
9.6 out of 10, Exceptional, (29 reviews)
"Everything was fabulous it worked out perfect for what we needed"
United States
Marion
The price is CA $163
CA $274 total
includes taxes & fees
Nov 16 - Nov 17
Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Des Moines County Hotel Reviews

Find out more about Des Moines County

Everything you need to know about Des Moines County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Des Moines County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Des Moines County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Des Moines County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Des Moines County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Des Moines County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Des Moines County vacation rentals we have selected for you start as low as CA $155 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Des Moines County rentals

At Expedia, we put the best Des Moines County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Des Moines County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Des Moines County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Des Moines County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.