A large white cable-stayed bridge over a river with green supports and a forested landscape in the background.

Des Moines County Vacation Rentals

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Our top choices for Des Moines County vacation rentals

A modern living room with a blue sofa, a round wooden coffee table, and abstract wall art. A kitchen with blue cabinets and a dining area with a blue island and chairs are visible in the background.

1. Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill
Burlington
10.0 out of 10, Exceptional, (5 reviews)
"Amazing place with a phenomenal host! Very attentive to the small details and making you feel welcome and at home!"
United States
David B.
The price is CA $178
CA $409 total
includes taxes & fees
Oct 26 - Oct 27
Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill
A modern kitchen with a central island, bar stools, and a large window offering a view of the outdoors.

2. Brand New Spacious 2 BR Downtown Burlington! Unit 301S

Brand New Spacious 2 BR Downtown Burlington! Unit 301S
Burlington
9.8 out of 10, Exceptional, (16 reviews)
"Great location! Check in easy and check out process simple. Great place for a fun weekend!"
United States
Roxane K.
The price is CA $180
CA $457 total
includes taxes & fees
Oct 6 - Oct 7
Brand New Spacious 2 BR Downtown Burlington! Unit 301S
A modern kitchen with wooden cabinets, a black refrigerator, a stainless steel sink, and a bar area with two bar stools.

3. Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
Burlington
10.0 out of 10, Exceptional, (23 reviews)
"This was our second stay and can’t wait to stay again. Super clean and spacious."
United States
Heather H.
The price is CA $180
CA $457 total
includes taxes & fees
Oct 6 - Oct 7
Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
A row of single-family homes with a well-maintained lawn and a tree in the foreground.

4. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
3.0 star property
Nauvoo
9.8 out of 10, Exceptional, (454 reviews)
"A great place to stay!"
United States
Renae
The price is CA $205
CA $217 total
includes taxes & fees
Oct 6 - Oct 7
Nauvoo Vacation Villas & Condos
A modern living room with a leather sofa, a wooden coffee table, and a blue armchair.

5. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"Rooms were clean and the bed was comfortable! Highly recommend this rental. "
United States
Brennan
The price is CA $214
CA $319 total
includes taxes & fees
Oct 6 - Oct 7
Idyllic Biggsville Vacation Rental: 10 Mi to River
A kitchen with granite countertops, a built-in oven, a refrigerator, and a ceiling fan.

6. Lazy Oaks: Charming cabin on pond with A/C in delightful Little York, Illinois

Lazy Oaks: Charming cabin on pond with A/C in delightful Little York, Illinois
Little York
10.0 out of 10, Exceptional, (12 reviews)
"We had a fantastic stay at the property. Very beautiful and relaxing stay."
United States
Gene G.
The price is CA $145
CA $301 total
includes taxes & fees
Oct 6 - Oct 7
Lazy Oaks: Charming cabin on pond with A/C in delightful Little York, Illinois
A living room with a grey sofa, a wooden coffee table, and a black metal shelf.

7. Stay in this Unique SE Iowa Apt

Stay in this Unique SE Iowa Apt
Fort Madison
10.0 out of 10, Exceptional, (18 reviews)
"Great place to stay."
United States
Nicholas H.
The price is CA $88
CA $210 total
includes taxes & fees
Oct 6 - Oct 7
Stay in this Unique SE Iowa Apt
A living room with a grey sectional sofa, a blue sofa with floral cushions, a patterned rug, and a radiator.

8. Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.

Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
Nauvoo
9.8 out of 10, Exceptional, (10 reviews)
"So close to the temple and other historical sites! Unique experience for sure."
United States
Ryan
The price is CA $71
CA $189 total
includes taxes & fees
Nov 1 - Nov 2
Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
A deck overlooking a body of water with a sunset in the background.

9. View Nauvoo and the Mighty Mississippi/Sidon

View Nauvoo and the Mighty Mississippi/Sidon
Nauvoo
9.6 out of 10, Exceptional, (44 reviews)
"Castle home was amazing! View of the river is incredible. So much room with extra fans and pillows. We loved our stay!!"
United States
Chris P.
The price is CA $125
CA $408 total
includes taxes & fees
Oct 6 - Oct 7
View Nauvoo and the Mighty Mississippi/Sidon
A wooden dock extending into calm water with trees reflecting on the surface, surrounded by a grassy area.

10. Riverside Waterfront on the Mississippi River

Riverside Waterfront on the Mississippi River
Pontoosuc
9.8 out of 10, Exceptional, (26 reviews)
"Great place good location "
United States
willmer m.
The price is CA $217
CA $432 total
includes taxes & fees
Oct 19 - Oct 20
Riverside Waterfront on the Mississippi River
A kitchen with a wooden dining table, white appliances, and a decorative sign.

11. Hayfield Cabin

Hayfield Cabin
Niota
6.8 out of 10, (5 reviews)
"It looked like someone was living there. And saw someone lurking around the outside of the cabin. "
United States
Anthony P.
The price is CA $95
CA $176 total
includes taxes & fees
Oct 6 - Oct 7
Hayfield Cabin
A modern living room with a leather sofa, a wooden coffee table, and a blue armchair.

12. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our peaceful stay in this clean, beautiful vacation rental. Perfect for a weekend getaway. "
United States
Lisa S.
The price is CA $157
CA $323 total
includes taxes & fees
Oct 6 - Oct 7
Idyllic Biggsville Vacation Rental: 10 Mi to River
A house with a fire pit in the backyard, a porch, and a blue chair.

13. Cozy House

Cozy House
Biggsville
10.0 out of 10, Exceptional, (8 reviews)
"Great place for our needs!"
United States
jdl j.
The price is CA $122
CA $250 total
includes taxes & fees
Oct 15 - Oct 16
Cozy House
A compact bathroom with a washing machine, a towel rack, a shelf with a plant, and a shower curtain.

14. If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill
Media
10.0 out of 10, Exceptional, (2 reviews)
"Nice little place out in the country. Great place for a getaway!"
United States
Judy W.
The price is CA $143
CA $227 total
includes taxes & fees
Oct 6 - Oct 7
If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill
A stacked washer and dryer unit in a corner of a room with beige walls and a wooden floor.

15. The Red Front Suite - Sleeps 15

The Red Front Suite - Sleeps 15
Nauvoo
9.8 out of 10, Exceptional, (97 reviews)
"Great location, comfortable beds."
United States
Diane P.
The price is CA $93
CA $231 total
includes taxes & fees
Nov 1 - Nov 2
The Red Front Suite - Sleeps 15
A white door with a small window and the text "Mulholland Garden" on it.

16. Mulholland Garden Apartment

Mulholland Garden Apartment
Nauvoo
9.2 out of 10, Wonderful, (48 reviews)
"Very good location, sofa bed mattress was uncomfortable, there are stairs to the bathroom."
United States
Carol
The price is CA $106
CA $188 total
includes taxes & fees
Oct 6 - Oct 7
Mulholland Garden Apartment
A kitchen with a granite countertop, three bar stools, a yellow placemat, and a potted plant.

17. Home Away From Home

Home Away From Home
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"Our stay was exceptional, couldn't have asked for a better home for out 4 day stay. Everything was so clean and roomy. Great kitchen area and 2 living rooms with a very nice TV 📺. I will be rebooking again in the future. The host was most helpful and kind."
United States
Kathy
The price is CA $145
CA $284 total
includes taxes & fees
Oct 13 - Oct 14
Home Away From Home
A room with a table and two chairs, a window with a view of a lake and greenery.

18. Riverfront Cabin With Small Beach Short Drive From Nauvoo

Riverfront Cabin With Small Beach Short Drive From Nauvoo
Niota
8.2 out of 10, Very good, (55 reviews)
"This was such a great getaway spot! We needed peace and we got it."
United States
Anonymous traveller
The price is CA $81
CA $154 total
includes taxes & fees
Oct 20 - Oct 21
Riverfront Cabin With Small Beach Short Drive From Nauvoo
A dining area with a wooden table and benches, white paneled walls, and a ceiling fan.

19. Nauvoo Country Cottage - Sleeps 12

Nauvoo Country Cottage - Sleeps 12
Niota
9.6 out of 10, Exceptional, (94 reviews)
"Great place to stay!!"
United States
Lisa G.
The price is CA $214
CA $359 total
includes taxes & fees
Oct 12 - Oct 13
Nauvoo Country Cottage - Sleeps 12
A kitchen with wooden cabinets, a black refrigerator, a microwave, and a dining table with chairs.

20. Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo

Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Nauvoo
9.8 out of 10, Exceptional, (26 reviews)
"Charming little property on the Main Street into Nauvoo. It was comfortable and cozy. We enjoyed walking into the historical area and to the temple. I would stay again. Easy check-in after great communication. Many thanks to our host."
United States
CoolDave88
The price is CA $163
CA $296 total
includes taxes & fees
Oct 6 - Oct 7
Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Des Moines County Hotel Reviews

Cobblestone Inn & Suites - Fort Madison

Cobblestone Inn & Suites - Fort Madison

10/10 Excellent
"Very clean and comfortable stay."
April 1-night trip
Posted 8 hours ago
Cobblestone Inn & Suites - Fort Madison

Find out more about Des Moines County

Everything you need to know about Des Moines County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Des Moines County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Des Moines County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Des Moines County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Des Moines County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Des Moines County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Des Moines County vacation rentals we have selected for you start as low as CA $154 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Des Moines County rentals

At Expedia, we put the best Des Moines County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Des Moines County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Des Moines County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Des Moines County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.