A large white cable-stayed bridge over a river with green supports and a forested landscape in the background.

Des Moines County Vacation Rentals

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Our top choices for Des Moines County vacation rentals

A modern kitchen with a central island, bar stools, and a large window offering a view of the outdoors.

1. Brand New Spacious 2 BR Downtown Burlington! Unit 301S

Brand New Spacious 2 BR Downtown Burlington! Unit 301S
Burlington
9.8 out of 10, Exceptional, (18 reviews)
"Great location! Check in easy and check out process simple. Great place for a fun weekend!"
United States
Roxane K.
The price is CA $177
CA $451 total
includes taxes & fees
Oct 27 - Oct 28
Brand New Spacious 2 BR Downtown Burlington! Unit 301S
A covered outdoor seating area with a wooden deck, a sofa, and a table.

2. Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill

Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill
Burlington
10.0 out of 10, Exceptional, (5 reviews)
"Amazing place with a phenomenal host! Very attentive to the small details and making you feel welcome and at home!"
United States
David B.
The price is CA $175
CA $403 total
includes taxes & fees
Oct 28 - Oct 29
Mississippi Muse - 1BR Near Downtown, Outdoor lounge, fire pit & grill
A modern kitchen with wooden cabinets, a black refrigerator, a stainless steel sink, and a bar area with two bar stools.

3. Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N

Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
Burlington
10.0 out of 10, Exceptional, (23 reviews)
"This was our second stay and can’t wait to stay again. Super clean and spacious."
United States
Heather H.
The price is CA $177
CA $451 total
includes taxes & fees
Oct 27 - Oct 28
Brand New SPACIOUS 2 BR Downtown Burlington! Unit 302N
A row of single-family homes with a well-maintained lawn and a tree in the foreground.

4. Nauvoo Vacation Villas & Condos

Nauvoo Vacation Villas & Condos
3.0 star property
Nauvoo
9.8 out of 10, Exceptional, (459 reviews)
"A great place to stay!"
United States
Renae
The price is CA $171
CA $182 total
includes taxes & fees
Nov 26 - Nov 27
Nauvoo Vacation Villas & Condos
A modern living room with a leather sofa, a wooden coffee table, and a blue armchair.

5. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
3.0 star property
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"Rooms were clean and the bed was comfortable! Highly recommend this rental. "
United States
Brennan
The price is CA $210
CA $313 total
includes taxes & fees
Nov 2 - Nov 3
Idyllic Biggsville Vacation Rental: 10 Mi to River
A wooden dock extending into calm water with trees reflecting on the surface, surrounded by a grassy area.

6. Riverside Waterfront on the Mississippi River

Riverside Waterfront on the Mississippi River
Pontoosuc
9.8 out of 10, Exceptional, (28 reviews)
"Great place good location "
United States
willmer m.
The price is CA $214
CA $429 total
includes taxes & fees
Nov 17 - Nov 18
Riverside Waterfront on the Mississippi River
A white door with a small window and the text "Mulholland Garden" on it.

7. Mulholland Garden Apartment

Mulholland Garden Apartment
Nauvoo
9.2 out of 10, Wonderful, (50 reviews)
"Well decorated and clean. Comfy bed. Close to city attractions."
United States
Adam
The price is CA $106
CA $194 total
includes taxes & fees
Nov 2 - Nov 3
Mulholland Garden Apartment
A modern living room with a leather sofa, a wooden coffee table, and a blue armchair.

8. Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
Biggsville
10.0 out of 10, Exceptional, (3 reviews)
"We enjoyed our peaceful stay in this clean, beautiful vacation rental. Perfect for a weekend getaway. "
United States
Lisa S.
The price is CA $154
CA $318 total
includes taxes & fees
Nov 1 - Nov 2
Idyllic Biggsville Vacation Rental: 10 Mi to River
A living room with a grey sofa, a wooden coffee table, and a black metal shelf.

9. Stay in this Unique SE Iowa Apt

Stay in this Unique SE Iowa Apt
Fort Madison
10.0 out of 10, Exceptional, (19 reviews)
"Great place to stay."
United States
Nicholas H.
The price is CA $86
CA $206 total
includes taxes & fees
Oct 27 - Oct 28
Stay in this Unique SE Iowa Apt
A rustic brick interior with a fireplace, a wooden stool, and a checkered rug.

10. Experience Beautiful Pioneer Home In Nauvoo!

Experience Beautiful Pioneer Home In Nauvoo!
Nauvoo
9.8 out of 10, Exceptional, (92 reviews)
"We had a great stay!"
United States
Darin B.
The price is CA $266
CA $534 total
includes taxes & fees
Oct 27 - Oct 28
Experience Beautiful Pioneer Home In Nauvoo!
A spacious living area with a dining table and chairs, a television, and a fireplace.

11. River’s Edge Retro: Cozy Slumber, Grand Views

River’s Edge Retro: Cozy Slumber, Grand Views
Niota
7.0 out of 10, Good, (2 reviews)
"To be very honest the property is not what I expected from the listing. However, after getting settled in and the excellent communication with the host, the 6-week stay was very pleasant. The host was wonderful and checked on us on a regular basis. Host was very quick to fix any issues and was also very quick in all responses. They made us feel welcome. The neighbors were friendly and helpful. I would definitely recommend this property to someone who is looking for a reasonably priced home to...
United States
David B.
The price is CA $139
CA $266 total
includes taxes & fees
Oct 27 - Oct 28
River’s Edge Retro: Cozy Slumber, Grand Views
A single-story house with a front porch, a sliding glass door, and a small deck area.

12. Historic 1840s Lamoreaux House / Modern Addition

Historic 1840s Lamoreaux House / Modern Addition
Nauvoo
9.6 out of 10, Exceptional, (27 reviews)
"Plenty of space for our family. Good location."
United States
Chelsea S.
The price is CA $347
CA $505 total
includes taxes & fees
Oct 30 - Oct 31
Historic 1840s Lamoreaux House / Modern Addition
A wooden door with a circular window and two wall-mounted lights.

13. A four bedroom hobbit hole style home five minutes from historic Nauvoo Illinois

A four bedroom hobbit hole style home five minutes from historic Nauvoo Illinois
Nauvoo
10.0 out of 10, Exceptional, (24 reviews)
"This was by far a very unique enjoyable stay! We enjoyed the atmosphere and the cleanliness of the place and oh - what a friendly cat!!! Would definitely stay again! Aldo enjoyed reading the little notes scattered throughout!"
United States
Linda B.
The price is CA $448
CA $562 total
includes taxes & fees
Oct 27 - Oct 28
A four bedroom hobbit hole style home five minutes from historic Nauvoo Illinois
A house with a fire pit in the backyard, a porch, and a blue chair.

14. Cozy House

Cozy House
Biggsville
10.0 out of 10, Exceptional, (8 reviews)
"Great place for our needs!"
United States
jdl j.
The price is CA $120
CA $247 total
includes taxes & fees
Oct 27 - Oct 28
Cozy House
A deck overlooking a body of water with a sunset in the background.

15. View Nauvoo and the Mighty Mississippi/Sidon

View Nauvoo and the Mighty Mississippi/Sidon
Nauvoo
9.6 out of 10, Exceptional, (44 reviews)
"Castle home was amazing! View of the river is incredible. So much room with extra fans and pillows. We loved our stay!!"
United States
Chris P.
The price is CA $132
CA $415 total
includes taxes & fees
Oct 27 - Oct 28
View Nauvoo and the Mighty Mississippi/Sidon
A view through a window with a tree displaying autumn foliage.

16. Nauvoo Windmill Farmhouse 10-12 people

Nauvoo Windmill Farmhouse 10-12 people
Niota
10.0 out of 10, Exceptional, (22 reviews)
"Great stay very peaceful "
United States
larry r.
The price is CA $175
CA $312 total
includes taxes & fees
Oct 27 - Oct 28
Nauvoo Windmill Farmhouse 10-12 people
A kitchen with wooden cabinets, a black refrigerator, a microwave, and a dining table with chairs.

17. Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo

Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
Nauvoo
9.6 out of 10, Exceptional, (28 reviews)
"Everything was fabulous it worked out perfect for what we needed"
United States
Marion
The price is CA $158
CA $288 total
includes taxes & fees
Oct 27 - Oct 28
Full family APT in Nauvoo-Walking distance to Temple and Historic Nauvoo
A living room with a grey sectional sofa, a blue sofa with floral cushions, a patterned rug, and a radiator.

18. Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.

Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
Nauvoo
10.0 out of 10, Exceptional, (11 reviews)
"So close to the temple and other historical sites! Unique experience for sure."
United States
Ryan
The price is CA $63
CA $178 total
includes taxes & fees
Nov 1 - Nov 2
Charming 3-bedroom apartment with WiFi, AC in welcoming Historic Nauvoo.
A small building with a red roof, surrounded by dense greenery and trees.

19. Hayfield Cabin

Hayfield Cabin
Niota
6.8 out of 10, (5 reviews)
"It looked like someone was living there. And saw someone lurking around the outside of the cabin. "
United States
Anthony P.
The price is CA $81
CA $168 total
includes taxes & fees
Oct 27 - Oct 28
Hayfield Cabin
A room with a wooden floor, a fireplace with a mantel, a door with glass panels, and a framed painting on the wall.

20. Grand Victorian on the Mississippi

Grand Victorian on the Mississippi
Fort Madison
9.8 out of 10, Exceptional, (34 reviews)
"Really fun house, with antiques and a lovely ambiance!"
United States
Lauren O.
The price is CA $272
CA $610 total
includes taxes & fees
Oct 27 - Oct 28
Grand Victorian on the Mississippi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Des Moines County Hotel Reviews

AmericInn by Wyndham West Burlington

AmericInn by Wyndham West Burlington

8/10 Good
"The first room we were supposed to be in smelled of cat or dog urine .. the staff member apologized and got us a different room"
Lucille 2-night trip
Posted 6 hours ago
AmericInn by Wyndham West Burlington

Find out more about Des Moines County

Everything you need to know about Des Moines County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Des Moines County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Des Moines County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Des Moines County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Des Moines County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Des Moines County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Des Moines County vacation rentals we have selected for you start as low as CA $168 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Des Moines County rentals

At Expedia, we put the best Des Moines County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Des Moines County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Des Moines County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Des Moines County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.