Title: Book the Best BUSINESS Hotels in Tupelo in 2026 | Expedia.ca [Tupelo Travel Guide](https://expedia.ca/Tupelo.dx6058686)[Hotels in Tupelo](https://expedia.ca/Tupelo-Hotels.d6058686.Travel-Guide-Hotels)[Vacation Rentals in Tupelo](https://expedia.ca/Tupelo-Vacation-Rentals.d6058686.Travel-Guide-VacationRentals)[Flights to Tupelo](https://expedia.ca/Cheap-Flights-To-Tupelo.d6058686.Travel-Guide-Flights)[Tupelo Car Rentals](https://expedia.ca/Car-Rentals-In-Tupelo.d6058686.Car-Rental-Guide)[Tupelo Vacation Packages](https://expedia.ca/Tupelo.d6058686.Destination-Travel-Guides) ![Tupelo, Mississippi City Hall, is a government building in Tupelo.](https://images.trvl-media.com/place/6058686/ae33cefe-d2f1-4bbf-97ff-5fee4a9debb4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Business Hotels in Tupelo, MS from CA $110 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Tupelo Business Hotels Tonight [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=6058686&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=6058686&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6058686&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6058686&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Tupelo business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/5000000/4540000/4537500/4537402/2eb203b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/5000000/4540000/4537500/4537402/b6f62c46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4540000/4537500/4537402/e355fdf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking, Refrigerator & Microwave (with Sofabed)](https://images.trvl-media.com/lodging/5000000/4540000/4537500/4537402/55c64311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Tupelo Inn & Suites [](https://www.expedia.ca/Tupelo-Hotels-Best-Western-Plus-Tupelo-Inn-Suites.h4537402.Hotel-Information) Tupelo 8.6/10 Excellent (1008) "Breakfast was great, bed was cozy, bathroom was clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca CA $116 CA $127 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Tupelo-Hotels-Best-Western-Plus-Tupelo-Inn-Suites.h4537402.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/46d9ec38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/97317942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/5c34c1ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/40000000/39580000/39577100/39577074/d46b15da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Oxford [](https://www.expedia.ca/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) Oxford 9.2/10 Wonderful (921) "Nice place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hilary CA $109 CA $119 total includes taxes & fees Jan 10 - Jan 11, 2026 [](https://www.expedia.ca/Oxford-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Oxford.h39577074.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3030000/3025200/3025105/3bb6afaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3030000/3025200/3025105/4e4a90da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/4000000/3030000/3025200/3025105/ed19956f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/3030000/3025200/3025105/5f491de5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Tupelo [](https://www.expedia.ca/Tupelo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Tupelo.h3025105.Hotel-Information) Tupelo 8.6/10 Excellent (1001) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Winston CA $121 CA $132 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Tupelo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Tupelo.h3025105.Hotel-Information) ![Room, Multiple Beds | Living area](https://images.trvl-media.com/lodging/2000000/1400000/1397800/1397713/f7947b05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1400000/1397800/1397713/26ff2526.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1400000/1397800/1397713/c64252d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1400000/1397800/1397713/ea81cac8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Tupelo [](https://www.expedia.ca/Tupelo-Hotels-Spark-By-Hilton-Tupelo.h1397713.Hotel-Information) Tupelo 8.4/10 Very good (1000) "Very clean place, room was sooooo nice!! Very reasonably priced hotel!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leigh CA $100 CA $110 total includes taxes & fees Jan 11 - Jan 12, 2026 [](https://www.expedia.ca/Tupelo-Hotels-Spark-By-Hilton-Tupelo.h1397713.Hotel-Information) ![Free continental breakfast](https://images.trvl-media.com/lodging/4000000/3840000/3837400/3837320/2e1d5380.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, iron/ironing board](https://images.trvl-media.com/lodging/4000000/3840000/3837400/3837320/7ade6a78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3840000/3837400/3837320/de44d857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/4000000/3840000/3837400/3837320/6a0468cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Fulton by IHG [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Express-Hotel-Suites-Fulton.h3837320.Hotel-Information) Fulton 8.8/10 Excellent (1001) "Staff was nice, clean room, and good breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason CA $114 CA $126 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Express-Hotel-Suites-Fulton.h3837320.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/977300/977294/f02717f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/980000/977300/977294/23557130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/977300/977294/6902bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/980000/977300/977294/5ba41635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Tupelo by IHG [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Express-Hotel-Suites-Tupelo.h977294.Hotel-Information) Tupelo 9.4/10 Exceptional (1002) "Great staff!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory CA $145 CA $158 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Express-Hotel-Suites-Tupelo.h977294.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/5000000/4330000/4326600/4326596/w3840h2558x0y4-3916fa97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen studio suite](https://images.trvl-media.com/lodging/5000000/4330000/4326600/4326596/w3837h2558x3y4-32e89bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar](https://images.trvl-media.com/lodging/5000000/4330000/4326600/4326596/w3837h2558x3y4-20577509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/5000000/4330000/4326600/4326596/w3837h2558x3y4-9cc89f60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Tupelo/Barnes Crossing [](https://www.expedia.ca/Tupelo-Hotels-Hampton-Inn-Suites-TupeloBarnes-Crossing.h4326596.Hotel-Information) Tupelo 9.0/10 Wonderful (778) "The room was spacious and well suited for us and our two large dogs. Staff were all very friendly and welcoming. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $167 CA $183 total includes taxes & fees Jan 18 - Jan 19, 2026 [](https://www.expedia.ca/Tupelo-Hotels-Hampton-Inn-Suites-TupeloBarnes-Crossing.h4326596.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/16100/16073/5221b566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16073/3e72a44d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16100/16073/95988947.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16100/16073/ca43d022.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Tupelo [](https://www.expedia.ca/Tupelo-Hotels-Red-Roof-Inn-Tupelo.h16073.Hotel-Information) Tupelo 8.4/10 Very good (1000) "Older motel, but very clean and maintained. We were just there one night, but the bed was comfortable and the room was warm. Would certainly stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marvin Kelly [](https://www.expedia.ca/Tupelo-Hotels-Red-Roof-Inn-Tupelo.h16073.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/3900/3885/c2002907.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3900/3885/5cc46626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/3900/3885/0b405f3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3900/3885/14c39ddc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Hotel & Suites Tupelo North by IHG [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Hotel-Suites-Tupelo-North.h3885.Hotel-Information) Tupelo 9.2/10 Wonderful (1001) "Room was great very nice hotel, restaurant fantastic!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hailie CA $154 CA $169 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Tupelo-Hotels-Holiday-Inn-Hotel-Suites-Tupelo-North.h3885.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61100/61049/f9319b82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/61100/61049/18cfa99b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/61100/61049/7ca4e8b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/61100/61049/da74061d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western New Albany [](https://www.expedia.ca/Tupelo-Hotels-Best-Western-New-Albany.h61049.Hotel-Information) New Albany 8.6/10 Excellent (1001) "Parking felt safe, easy access. Hotel is convenient to stores, dining, and main highway. Breakfast was hot and good. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $111 CA $121 total includes taxes & fees Dec 31 - Jan 1, 2026 [](https://www.expedia.ca/Tupelo-Hotels-Best-Western-New-Albany.h61049.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-01&endDate=2026-01-02®ionId=6058686&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Tupelo Hotel Reviews ![Quality Inn Tupelo Central](https://images.trvl-media.com/lodging/1000000/30000/21600/21594/a4930614_y.jpg) ### Quality Inn Tupelo Central 10/10 Excellent "Room was good staff very pleasant!" [](https://expedia.ca/Tupelo-Hotels-Quality-Inn.h21594.Hotel-Information) ![Hampton Inn & Suites Tupelo/Barnes Crossing](https://images.trvl-media.com/lodging/5000000/4330000/4326600/4326596/w3840h2558x0y4-3916fa97_y.jpg) ### Hampton Inn & Suites Tupelo/Barnes Crossing 10/10 Excellent "The room was spacious and well suited for us and our two large dogs. Staff were all very friendly and welcoming. " [](https://expedia.ca/Tupelo-Hotels-Hampton-Inn-Suites-TupeloBarnes-Crossing.h4326596.Hotel-Information) ![Best Western Plus Tupelo Inn & Suites](https://images.trvl-media.com/lodging/5000000/4540000/4537500/4537402/2eb203b9_y.jpg) ### Best Western Plus Tupelo Inn & Suites 10/10 Excellent "Good" [](https://expedia.ca/Tupelo-Hotels-Best-Western-Plus-Tupelo-Inn-Suites.h4537402.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Tupelo](https://images.trvl-media.com/lodging/4000000/3030000/3025200/3025105/3bb6afaf_y.jpg) ### La Quinta Inn & Suites by Wyndham Tupelo 10/10 Excellent "Clean rooms good breaks fast " [](https://expedia.ca/Tupelo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Tupelo.h3025105.Hotel-Information) ![Comfort Inn Tupelo Central](https://images.trvl-media.com/lodging/1000000/120000/116600/116523/0ca0a097_y.jpg) ### Comfort Inn Tupelo Central 10/10 Excellent "Excellent stay, friendly staff, clean room, great breakfast food." [](https://expedia.ca/Tupelo-Hotels-Comfort-Inn.h116523.Hotel-Information) ![Spark by Hilton Tupelo](https://images.trvl-media.com/lodging/2000000/1400000/1397800/1397713/f7947b05_y.jpg) ### Spark by Hilton Tupelo 10/10 Excellent "Rooms were very clean and comfortable. Staffbwas friendly. " [](https://expedia.ca/Tupelo-Hotels-Spark-By-Hilton-Tupelo.h1397713.Hotel-Information) ![Baymont by Wyndham Tupelo](https://images.trvl-media.com/lodging/1000000/130000/124500/124475/97b5a707_y.jpg) ### Baymont by Wyndham Tupelo 10/10 Excellent "Everything was top notch!! Clean, friendly staff and breakfast was good " [](https://expedia.ca/Tupelo-Hotels-Baymont-By-Wyndham-Tupelo.h124475.Hotel-Information) ![Holiday Inn Hotel & Suites Tupelo North by IHG](https://images.trvl-media.com/lodging/1000000/10000/3900/3885/c2002907_y.jpg) ### Holiday Inn Hotel & Suites Tupelo North by IHG 10/10 Excellent "Friendly front desk staff, clean room, easy access to our room." [](https://expedia.ca/Tupelo-Hotels-Holiday-Inn-Hotel-Suites-Tupelo-North.h3885.Hotel-Information) ![Hilton Garden Inn Tupelo](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513705/2ecf5fc2_y.jpg) ### Hilton Garden Inn Tupelo 10/10 Excellent "Clean room, close to road. Good breakfast" [](https://expedia.ca/Tupelo-Hotels-Hilton-Garden-Inn-Tupelo.h1513705.Hotel-Information) ## Frequently asked questions ### How much do business-friendly hotels in Tupelo cost? ### What are the best business-friendly hotels in Tupelo? ### How many business-friendly hotels are there in Tupelo? ### What are the best cheap business-friendly hotels in Tupelo? ### What are the top business-friendly motels in Tupelo? ### Are there any family-friendly hotels in Tupelo that are also business friendly? ### Why book your business-friendly hotel in Tupelo with Expedia? ### How can I find cheap business-friendly hotels in Tupelo? ### What is there to do in Tupelo near my business-friendly hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Northeast Mississippi ](https://www.expedia.ca/1Star-Northeast-Mississippi-Hotels.s10-0-d6058679.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Baldwyn ](https://www.expedia.ca/3Star-Baldwyn-Hotels.s30-0-d6354881.Travel-Guide-Filter-Hotels) - 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