Title: Book the Best Southern Minnesota SPA Resorts - Spa Hotels in Southern Minnesota, MN | Expedia.ca [Southern Minnesota Travel Guide](https://expedia.ca/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Vacation Rentals in Southern Minnesota](https://expedia.ca/Southern-Minnesota-Vacation-Rentals.d6059950.Travel-Guide-VacationRentals)[Flights to Southern Minnesota](https://expedia.ca/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Southern Minnesota Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Minnesota.d6059950.Car-Rental-Guide)[Southern Minnesota Vacation Packages](https://expedia.ca/Southern-Minnesota.d6059950.Destination-Travel-Guides) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Southern Minnesota, MN - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Minnesota Spa Hotels Tonight [Nov 22 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-11-22&endDate=2025-11-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 23 - Nov 24](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-11-23&endDate=2025-11-24&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-11-28&endDate=2025-11-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6059950&startDate=2025-12-05&endDate=2025-12-07&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southern Minnesota Spa Hotels ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=AFFINITY_BF_PROMO_6059950) ## Top Southern Minnesota Hotel Reviews ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "Excellent facility. Wonderful people!" [](https://expedia.ca/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Yes the room was clean and the staff was very curious." [](https://expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "nice and quiet, no problems" [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Because Expedia's calendars indicates days rather than nights, what I thought was a reservation for 3 nights was a reservation for 2 nights and three days, so I had to book a room for an additional night. The staff was very helpful in letting us stay in the same room for that third night." [](https://expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Everything was as expected . Nice tidy unit" [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Hilton Garden Inn Rochester Downtown, MN](https://images.trvl-media.com/lodging/1000000/220000/214700/214679/67ee8968_y.jpg) ### Hilton Garden Inn Rochester Downtown, MN 10/10 Excellent "The valet parking is helpful. " [](https://expedia.ca/Rochester-Hotels-Hilton-Garden-Inn-Rochester-Downtown.h214679.Hotel-Information) ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "Excellent!" [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "The location is great if you have appointments at Mayo clinic. The Gonda building where we had appointments is right across the street, its much easier than trying to find parking or wait for a shuttle. The room was clean and met our needs. There are many close options for getting a meal. I give it a high rating for the convience and reasonable price. " [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/39da8a7c_y.jpg) ### SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys 10/10 Excellent "good" [](https://expedia.ca/Rochester-Hotels-SpringHill-Suites-By-Marriott-Rochester-Mayo-ClinicSt-Marys.h101902.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in Springfield](https://www.expedia.ca/5Star-Springfield-Hotels.s50-0-d6046558.Travel-Guide-Filter-Hotels) - [Farmstay in Butterfield](https://www.expedia.ca/Butterfield-Agritourism.d3000348815-aaAgritourism.Travel-Guide-Accommodation) - [Independent Hotels in Butterfield](https://www.expedia.ca/Butterfield-Hotels-Independent.0-0-d3000348815--bIndependent.Travel-Guide-Filter-Hotels) - [Butterfield Hotels](https://www.expedia.ca/Butterfield-Hotels.d3000348815.Travel-Guide-Hotels) - 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