Title: Book the Best BUSINESS Hotels in Southern Indiana in 2026 | Expedia.ca

[Southern Indiana Travel Guide](https://expedia.ca/Southern-Indiana.dx6059635)[Hotels in Southern Indiana](https://expedia.ca/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[Vacation Rentals in Southern Indiana](https://expedia.ca/Southern-Indiana-Vacation-Rentals.d6059635.Travel-Guide-VacationRentals)[Flights to Southern Indiana](https://expedia.ca/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[Southern Indiana Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Indiana.d6059635.Car-Rental-Guide)[Southern Indiana Vacation Packages](https://expedia.ca/Southern-Indiana.d6059635.Destination-Travel-Guides)

![Belle of Louisville which includes a bay or harbour and a ferry as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Southern Indiana Business Hotels

Tonight

[Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Tomorrow

[Feb 4 - Feb 5](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-02-04&endDate=2026-02-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

This weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly)

## Our top choices for Southern Indiana business-friendly hotels

![Exterior](https://images.trvl-media.com/lodging/1000000/930000/922000/921978/cb233b58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/930000/922000/921978/ef0e767d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free self-serve breakfast on weekdays](https://images.trvl-media.com/lodging/1000000/930000/922000/921978/9f75b601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/1000000/930000/922000/921978/3fc91a0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Evansville North by IHG

[](https://www.expedia.ca/Evansville-Hotels-Holiday-Inn-Express-Suites-Evansville-North.h921978.Hotel-Information)

Evansville

8.6/10

Excellent

(597 reviews)

"Clean room, good staff, decent breakfast, easy parking "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Phillip

CA $123

CA $142 total

includes taxes & fees

Feb 7 - Feb 8

[](https://www.expedia.ca/Evansville-Hotels-Holiday-Inn-Express-Suites-Evansville-North.h921978.Hotel-Information)

![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/aa5bcd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/63654a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9d86b349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Galt House Hotel Trademark Collection by Wyndham

[](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information)

Downtown Louisville

9.0/10

Wonderful

(4,043 reviews)

"Great hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lazaro

CA $210

CA $248 total

includes taxes & fees

Feb 17 - Feb 18

[](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/870000/869500/869431/d5b848b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 King Bed, 2 room suite, Jetted Tub](https://images.trvl-media.com/lodging/1000000/870000/869500/869431/d9edd5a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/870000/869500/869431/c0a7f8fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free English breakfast on weekends](https://images.trvl-media.com/lodging/1000000/870000/869500/869431/15aa5499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Madison near Clifty Falls

[](https://www.expedia.ca/Madison-Hotels-Comfort-Inn.h869431.Hotel-Information)

Madison

8.8/10

Excellent

(674 reviews)

"Loved our stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katherine

CA $126

CA $145 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Madison-Hotels-Comfort-Inn.h869431.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/27800/27720/de63b369.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/27800/27720/827ea855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/27800/27720/dac9995c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27800/27720/a26a90f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn by Marriott Evansville West

[](https://www.expedia.ca/Evansville-Hotels-Fairfield-Inn-By-Marriott-Evansville-West.h27720.Hotel-Information)

Evansville

8.6/10

Excellent

(270 reviews)

"A nice place to stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

CA $148

CA $171 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Evansville-Hotels-Fairfield-Inn-By-Marriott-Evansville-West.h27720.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42500/42483/0dd01c60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42500/42483/cfbec787.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Suite, 1 King Bed, Non Smoking (Deluxe)](https://images.trvl-media.com/lodging/1000000/50000/42500/42483/8b64147d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42500/42483/80722728.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Evansville

[](https://www.expedia.ca/Evansville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Evansville.h42483.Hotel-Information)

Evansville

8.6/10

Excellent

(1,007 reviews)

"Staff was friendly"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $103

CA $118 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Evansville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Evansville.h42483.Hotel-Information)

![Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/4650cf22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/2ae0a12f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/8aed7381.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/65000000/64420000/64410900/64410808/254e595c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Clarksville - Louisville North

[](https://www.expedia.ca/Louisville-Hotels-Best-Western-Plus-Louisville-North.h64410808.Hotel-Information)

Clarksville

9.0/10

Wonderful

(1,002 reviews)

"Everything was great!! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Barbara

CA $134

CA $151 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Louisville-Hotels-Best-Western-Plus-Louisville-North.h64410808.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 21c Museum Hotel Louisville

[](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information)

Downtown Louisville

9.4/10

Exceptional

(1,009 reviews)

"Location and the staff was fabulous."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Madeline

CA $212

CA $256 total

includes taxes & fees

Feb 19 - Feb 20

[](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/301cfd41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/9454d23f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/7c4eb22a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/660000/659000/658960/3beed854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ramada by Wyndham Sellersburg/Louisville North

[](https://www.expedia.ca/Sellersburg-Hotels-Ramada-By-Wyndham-SellersburgLouisville-North.h658960.Hotel-Information)

Sellersburg

8.4/10

Very good

(1,001 reviews)

"Spotless room, easy check in, great breakfast!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen

CA $103

CA $117 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Sellersburg-Hotels-Ramada-By-Wyndham-SellersburgLouisville-North.h658960.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/04047b8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool, open 9:00 AM to 9:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/162eb275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, in-room safe, individually decorated](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/2ac61b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Golf](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/7f00b921.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Belterra Casino Resort

[](https://www.expedia.ca/Madison-Hotels-Belterra-Casino-Resort.h1152807.Hotel-Information)

Florence

8.6/10

Excellent

(1,001 reviews)

"Nice room, staff curteous"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie L

CA $173

CA $210 total

includes taxes & fees

Feb 4 - Feb 5

[](https://www.expedia.ca/Madison-Hotels-Belterra-Casino-Resort.h1152807.Hotel-Information)

![Breakfast and dinner served](https://images.trvl-media.com/lodging/77000000/76420000/76418000/76417931/6d42a41f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/77000000/76420000/76418000/76417931/1f121f2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/77000000/76420000/76418000/76417931/74f4d732.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/77000000/76420000/76418000/76417931/25d60e0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Garden Inn Jeffersonville Louisville North

[](https://www.expedia.ca/Louisville-Hotels-Hilton-Garden-Inn-Jeffersonville.h76417931.Hotel-Information)

Jeffersonville

9.6/10

Exceptional

(439 reviews)

"nice hotel, nice staff and bar."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

STEVEN

CA $144

CA $163 total

includes taxes & fees

Feb 19 - Feb 20

[](https://www.expedia.ca/Louisville-Hotels-Hilton-Garden-Inn-Jeffersonville.h76417931.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-17&endDate=2026-02-18&regionId=6059635&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true)

## Top Southern Indiana Hotel Reviews

![Hampton Inn Louisville-North/Clarksville](https://images.trvl-media.com/lodging/1000000/90000/85100/85064/2cfb06f6_y.jpg)

### Hampton Inn Louisville-North/Clarksville

10/10 Excellent

"The room was very clean. Staff very welcoming and helpful."

[](https://expedia.ca/Louisville-Hotels-Hampton-Inn-Louisville-NorthClarksville.h85064.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Evansville](https://images.trvl-media.com/lodging/1000000/50000/42500/42483/29ca343a_y.jpg)

### La Quinta Inn & Suites by Wyndham Evansville

10/10 Excellent

"Great location helpful staff super clean"

[](https://expedia.ca/Evansville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Evansville.h42483.Hotel-Information)

![Drury Inn & Suites Evansville East](https://images.trvl-media.com/lodging/1000000/120000/116600/116545/2ba5f829_y.jpg)

### Drury Inn & Suites Evansville East

10/10 Excellent

"Everything very clean. Good variety for breakfast!"

[](https://expedia.ca/Evansville-Hotels-Drury-Inn-Suites-Evansville-East.h116545.Hotel-Information)

![Bally’s Evansville Casino & Hotel](https://images.trvl-media.com/lodging/1000000/70000/67500/67414/a8c75042_y.jpg)

### Bally’s Evansville Casino & Hotel

10/10 Excellent

"The bed was super comfortable."

[](https://expedia.ca/Evansville-Hotels-Tropicana-Evansville-Hotel.h67414.Hotel-Information)

![Sheraton Louisville Riverside by Marriott](https://images.trvl-media.com/lodging/1000000/20000/17900/17862/14fa367c_y.jpg)

### Sheraton Louisville Riverside by Marriott

10/10 Excellent

"Friendly helpful staff, clean rooms, well equipped gym. Easy parking & walkable to restaurants & town. Louisville just over the bridge."

[](https://expedia.ca/Louisville-Hotels-Sheraton-Louisville-Riverside-Hotel.h17862.Hotel-Information)

![Big Splash Adventure Indoor Water Park & Resort](https://images.trvl-media.com/lodging/5000000/4860000/4857100/4857069/63744e7b_y.jpg)

### Big Splash Adventure Indoor Water Park & Resort

10/10 Excellent

"Great service"

[](https://expedia.ca/French-Lick-Hotels-Big-Splash-Adventure-Indoor-Water-Park-Resort.h4857069.Hotel-Information)

![Radisson Hotel Louisville North](https://images.trvl-media.com/lodging/1000000/30000/26400/26306/50b82654_y.jpg)

### Radisson Hotel Louisville North

10/10 Excellent

"The staff is very welcoming and friendly. Such a pleasant check in experience. Ample parking so I was able to park close to the nearest entry closest to my room. Plenty of amenities on site as well as nearby. The room was provided with plenty of towels and washcloths as well as pillows for the bed. Overall, an enjoyable stay and highly recommended. "

[](https://expedia.ca/Louisville-Hotels-Radisson-Hotel-Louisville-North.h26306.Hotel-Information)

![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/eb53eba8_y.jpg)

### Hampton Inn New Albany Louisville West

10/10 Excellent

"nice staff and warm, comfy lobby. "

[](https://expedia.ca/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information)

![Hampton Inn Evansville](https://images.trvl-media.com/lodging/1000000/20000/15400/15372/6afca36a_y.jpg)

### Hampton Inn Evansville

10/10 Excellent

"Staff was awesome! Room was spotless!"

[](https://expedia.ca/Evansville-Hotels-Hampton-Inn-Evansville.h15372.Hotel-Information)

## Frequently asked questions

### How much do business-friendly hotels in Southern Indiana cost?

### What are the best business-friendly hotels in Southern Indiana?

### How many business-friendly hotels are there in Southern Indiana?

### What are the best cheap business-friendly hotels in Southern Indiana?

### What are the top business-friendly motels in Southern Indiana?

### Are there any family-friendly hotels in Southern Indiana that are also business friendly?

### Are there any 5-star business-friendly hotels in Southern Indiana?

### Why book your business-friendly hotel in Southern Indiana with Expedia?

### How can I find cheap business-friendly hotels in Southern Indiana?

### What is there to do in Southern Indiana near my business-friendly hotel?

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- [Kentucky Lake ](https://www.expedia.ca/Kentucky-Lake-United-States-of-America.d6059618.Vacation-Attraction)
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- [Visit Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana.dx6233876)

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