Santana Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Santana vacation rentals

A modern living room with a white table, blue sofa, ceiling fan, and a small potted plant.

1. Arecibo Hotel 2105

Arecibo Hotel 2105
2.0 star property
Arecibo
7.8 out of 10, Good, (23 reviews)
"The place was clean and the area was quiet most of the time."
United States
Carlos De La
The price is CA $157
CA $225 total
includes taxes & fees
Nov 12 - Nov 13
Arecibo Hotel 2105
A modern infinity pool with a clear view of the ocean and palm trees.

2. Ventana al Atlantico at Arecibo 681 Ocean Drive

Ventana al Atlantico at Arecibo 681 Ocean Drive
2.5 star property
Arecibo
7.0 out of 10, Good, (301 reviews)
"First I rented an ocean veiw room and it wasn't. The check in code was wrong. Room had many spider webs. Mattress was stained. Pool was dirty. Pool area was barely lighted. Door barely closed to room."
United States
Gerald
The price is CA $152
CA $215 total
includes taxes & fees
Dec 6 - Dec 7
Ventana al Atlantico at Arecibo 681 Ocean Drive
A hotel room with a large bed, a desk with a computer, a TV, and a window with curtains.

3. Casita Linda

Casita Linda
2.5 star property
Arecibo
7.2 out of 10, Good, (19 reviews)
"Staff was very responsive and helpful"
United States
John
The price is CA $164
CA $256 total
includes taxes & fees
Dec 5 - Dec 6
Casita Linda
A modern living room with a white dining table, a blue sofa, and a ceiling fan.

4. Arecibo Hotel 2101

Arecibo Hotel 2101
3.0 star property
Arecibo
7.4 out of 10, Good, (15 reviews)
"Loved the location, easy to find close to the beaches we wanted to visit! Easy to follow instructions on how to access the apartment!… will definetly visit again. "
United States
Crystallynn
The price is CA $145
CA $303 total
includes taxes & fees
Nov 29 - Nov 30
Arecibo Hotel 2101
A house with a tiled roof, palm trees, and a clear sky.

5. Casita Manati

Casita Manati
2.0 star property
Manati
8.2 out of 10, Very good, (15 reviews)
"Nice place to stay friendly neighborhood"
United States
Krystal
The price is CA $177
CA $252 total
includes taxes & fees
Nov 7 - Nov 8
Casita Manati
A compact kitchen with dark cabinets, a dining table, and four wall-mounted paintings.

6. Manati Amaizing Studio

Manati Amaizing Studio
3.0 star property
Manati
5.6 out of 10, (5 reviews)
"The room we had was absolutely horrible. There was an electrical plug dangling next to the shower head and There were missing outlet covers. The communication was awesome and once we told them, they understood why we were not staying there any longer. "
United States
Lisa
The price is CA $183
CA $278 total
includes taxes & fees
Nov 7 - Nov 8
Manati Amaizing Studio
A rectangular swimming pool with clear blue water, surrounded by a white wall with decorative panels and a colorful wall to the right.

7. Sea Breeze Tunnel Hideaway 6

Sea Breeze Tunnel Hideaway 6
3.5 star property
Terranova
9.0 out of 10, Wonderful, (11 reviews)
"Amazing stay , community is super friendly! we’d be back again ❤️"
United States
Alexis S
Sea Breeze Tunnel Hideaway 6
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find vacation rentals that suit your style

cabin image
Cabins
Cabins
Apartment image
Apartments
Apartments

Top Santana Hotel Reviews

A hotel room with a bed, a nightstand, a lamp, and a bathroom visible through an open door.
Arecibo Inn

Arecibo Inn

Arecibo Inn
Arecibo

8/10 Good

The Inn was nice and the staff was friendly, I was able to check in later than 3pm without any issues or late check in fee. The room and bathroom were clean and spacious. The only two issues I had were being able to hear the other guests and that my room had no window but I would stay again!
Canada
Viviana
Reviewed May 29, 2025
Arecibo Inn

Find out more about Santana

Everything you need to know about Santana vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santana vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santana vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santana vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santana. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santana vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Santana vacation rentals we have selected for you start as low as CA $104 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Santana rentals

At Expedia, we put the best Santana vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santana rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santana vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santana. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find a vacation rental in Santana?

Yes, we give you a choice of vacation rentals near the most popular local attractions in Santana, or you can choose a secluded option if you're looking for relaxation.

What are some of the best vacation home rentals in Santana?

3-Bedroom House in Quebradillas: This vacation home rental outside Santana is located near the airport and has a terrace, a garden, and free WiFi to put you at ease in your new surroundings. This vacation rental also comes with free parking to give you added peace of mind.

What can I see and do in Santana?

While you're exploring the area, Cano Tiburones Nature Reserve and La Poza Beach are a couple of picturesque spots to get outside and enjoy nature. Arecibo Lighthouse and Cueva Ventana are a couple of places you'll find in the larger area.

What are vacation rentals like in Santana?

Vacation rentals are privately owned accommodations you can stay in for several days or longer in Santana. Vacation rentals feature extras like kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a clean environment, vacation rentals can provide a sense of privacy away from shared hotel elevators and lobbies packed with people while still allowing you to travel. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a great choice for a family trip.